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All Studies   Meta Analysis    Recent:   

Computational studies to analyze effect of curcumin inhibition on coronavirus D614G mutated spike protein

Singh et al., The Seybold Report, doi:10.17605/OSF.IO/TKEXJ
Sep 2023  
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Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021
 
*, now with p = 0.0000000096 from 27 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
In Silico study showing that curcumin binds strongly to both the SARS-CoV-2 spike protein and ACE2 receptor. Curcumin's binding energy was similar for the wildtype spike protein and a mutated D614G variant.
45 preclinical studies support the efficacy of curcumin for COVID-19:
In Silico studies predict inhibition of SARS-CoV-2 with curcumin or metabolites via binding to the spikeA,5,10,12,18,21 (and specifically the receptor binding domainB,8,11,14), MproC,5,7,9-11,13,14,16,19,21,22,24,35, RNA-dependent RNA polymeraseD,11,20, ACE2E,12,13,15, nucleocapsidF,6,23, nsp10G,23, and helicaseH,25 proteins. In Vitro studies demonstrate inhibition of the spikeA,30 (and specifically the receptor binding domainB,38), MproC,17,30,35,37, ACE2E,38, and TMPRSS2I,38 proteins. In Vitro studies demonstrate efficacy in Calu-3J,36, A549K,30, 293TL,1, HEK293-hACE2M,17,28, 293T/hACE2/TMPRSS2N,29, Vero E6O,7,11,21,28,30-32,34,36, and SH-SY5YP,27 cells. Curcumin is predicted to inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain and the human ACE2 receptor for the delta and omicron variants8, decreases pro-inflammatory cytokines induced by SARS-CoV-2 in peripheral blood mononuclear cells34, and alleviates SARS-CoV-2 spike protein-induced mitochondrial membrane damage and oxidative stress1.
Singh et al., 21 Sep 2023, peer-reviewed, 6 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperCurcuminAll
COMPUTATIONAL STUDIES TO ANALYZE EFFECT OF CURCUMIN INHIBITION ON CORONAVIRUS D614G MUTATED SPIKE PROTEIN
Anjali Singh, Associate Professor, Sanjay Paliwal, Shalin Kumar, Shruti Singh, Natarajan Keerthana, Kumar, Dr Pankaj Singh
doi:10.17605/OSF.IO/TKEXJ
COVID-19 disease created worldwide chaos with millions of causalities worldwide. The infection initiates when the viral spike protein interacts with the human ACE2 receptor. Developing an effective therapeutic drug or vaccine for the disease is a challenging task since the virus can mutate itself. For instance, recently viral spike protein D614G mutation has been identified which makes it more contagious. In this study, we have investigated the efficacy of curcumin, a natural bioactive compound in inhibiting the binding of spike protein to ACE2 protein in native and D614G mutated viruses using molecular docking tool. We have used an I-TASSER server to computationally model virus spike protein. We have obtained a reliable C-score value. The PyMol molecular visualization tool was employed to generate spike protein D614G mutation. The docking studies were performed on a Swiss Dock server and the complex was visualized using JMOL software. The free energy change for curcumin-spike protein complex for native and mutated forms were found to be substantially unaltered. Taken together, our studies indicate that among natural medicinal compounds studied so far curcumin is an ideal candidate to inhibit spike-ACE2 interaction irrespective of the viral mutation.
References
Babaei, Nassiri-Asl, Hosseinzadeh, Curcumin (a constituent of turmeric): New treatment option against COVID-19, Food science & nutrition
Burley, Berman, Kleywegt, Markley, Nakamura et al., Protein Data Bank (PDB): the single global macromolecular structure archive, Protein crystallography: methods and protocols
Fu, Li, Guo, He, Liu et al., Dynamics and correlation among viral positivity, seroconversion, and disease severity in COVID-19: a retrospective study, Annals of Internal Medicine
Hidayati, Nisa, Darmawan, Nisa, Efek Potensial Senyawa Curcumin sebagai Terapi pada Penderita Covid-19: Literature Review, Jurnal Pendidikan Tambusai
Iman, Saadabadi, Davood, Molecular docking analysis and molecular dynamics simulation study of ameltolide analogous as a sodium channel blocker, Turkish Journal of Chemistry
Khanal, Chawla, Praveen, Malik, Malik et al., Study of naturally-derived biomolecules as therapeutics against SARS-CoV-2 viral spike protein, Journal of Pharmaceutical Research International
Raju, Shanmugaraja, Recent researches in fiber reinforced composite materials: A review, Materials Today: Proceedings
Singhal, A review of coronavirus disease-2019 (COVID-19), The indian journal of pediatrics
Soleimani, Sahebkar, Hosseinzadeh, Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances, Phytotherapy Research
Soni, Mehta, Ratre, Tiwari, Amit et al., Curcumin, a traditional spice component, can hold the promise against COVID-19?, European Journal of Pharmacology
Valizadeh, Abdolmohammadi-Vahid, Danshina, Gencer, Ammari et al., Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients, International immunopharmacology
Yang, Yan, Roy, Xu, Poisson et al., The I-TASSER Suite: protein structure and function prediction, Nature methods
Yusuf, Alsaiari, Almehmadi, Kamal, Asif, In Silico Molecular Design of 4-Benzylidene-6-aryl-2, 4, 5-trihydropyridazin-3-one Scaffolds as Antiproliferative Targets, LATIN AMERICAN JOURNAL OF PHARMACY
Zahedipour, Hosseini, Sathyapalan, Majeed, Jamialahmadi et al., Potential effects of curcumin in the treatment of COVID-19 infection, Phytotherapy Research
Zahedipour, Hosseini, Sathyapalan, Majeed, Jamialahmadi et al., Potential effects of curcumin in the treatment of COVID-19 infection, Phytotherapy Research
Zhang, I-TASSER server for protein 3D structure prediction, BMC bioinformatics
Zu, Jiang, Xu, Chen, Ni et al., Coronavirus disease 2019 (COVID-19): a perspective from China, Radiology
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