Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All quercetin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchQuercetinQuercetin (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS CoV2 – An Insilico model

Sai Ramesh et al., International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2023.125553
Jun 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Quercetin for COVID-19
23rd treatment shown to reduce risk in July 2021
 
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
In Silico study finding that quercetin and hederagenin showed very high binding affinities for COVID-19 associated receptors MMP9 and IL6.
58 preclinical studies support the efficacy of quercetin for COVID-19:
In Silico studies predict inhibition of SARS-CoV-2, or minimization of side effects, with quercetin or metabolites via binding to the spikeA,1,2,14,16,17,22,30,31,33,34,51,52, MproB,1,3,5,7,9,10,12,15,16,22,26,28-30,34,35,37,52,53, RNA-dependent RNA polymeraseC,1,24, PLproD,29,37, ACE2E,14,15,20,29,33,52, TMPRSS2F,14, helicaseG,21,26, endoribonucleaseH,31, cathepsin LI,18, Wnt-3J,14, FZDK,14, LRP6L,14, ezrinM,32, ADRPN,30, NRP1O,33, EP300P,8, PTGS2Q,15, HSP90AA1R,8,15, matrix metalloproteinase 9S,23, IL-6T,13,27, IL-10U,13, VEGFAV,27, and RELAW,27 proteins. In Vitro studies demonstrate efficacy in Calu-3X,40, A549Y,13, HEK293-ACE2+Z,47, Huh-7AA,17, Caco-2AB,39, Vero E6AC,11,34,39, mTECAD,42, and RAW264.7AE,42 cells. Animal studies demonstrate efficacy in K18-hACE2 miceAF,44, db/db miceAG,42,50, BALB/c miceAH,49, and rats54. Quercetin reduced proinflammatory cytokines and protected lung and kidney tissue against LPS-induced damage in mice49.
Sai Ramesh et al., 30 Jun 2023, peer-reviewed, 9 authors. Contact: yuvarajdinakarkumar@gmail.com.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperQuercetinAll
Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS CoV2 – An Insilico model
A Sai Ramesh, S Adarshan, Hamad Lohedan, T Naveen Kumar, M R Thasleema Nasrin, G Aarthi Shree, Yuvaraj Dinakarkumar, Jothi Ramalingam Rajabathar, Muthusamy Karnan
International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2023.125553
The COVID-19 pandemic has been a global health crisis for over three years now, with the virus causing widespread illness and death. The urgent need for safe and effective therapeutic drugs has prompted the exploration of alternative medicine systems such as Ayurveda and Siddha. This study focuses on the potential therapeutic properties of the Ayurvedic plant, Mimusops elengi. In silico techniques were employed to analyze the bioactivity of the plant, including target prediction, gene ontology analysis, OMIM analysis, and molecular docking analysis. The results revealed 36 phytocompounds that interacted with 1431 receptors in the human body, and two compounds -hederagenin and quercetin -showed exceptionally high binding affinities toward their corresponding receptors, IL6 and MMP9. These results provide important insight into the potential therapeutic activity of M. elengi and its compounds in combating COVID-19. However, further research and clinical trials are necessary to validate these findings and develop safe and effective drugs. The study highlights the importance of combining traditional medicine with modern scientific methods to find effective treatments for global health challenges.
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: R. Jothi Ramalingam reports financial support was provided by Researchers Supporting Project. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.ijbiomac.2023.125553.
References
Aanouz, Belhassan, El-Khatabi, Lakhlifi, El-Ldrissi et al., Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations, J. Biomol. Struct. Dyn, doi:10.1080/07391102.2020.1758790
Adarshan, Akassh, Avinash, Bharathkumar, Muthuramalingam et al., Transcriptomics, cheminformatics, and systems pharmacology strategies unveil the potential bioactives to combat COVID-19, Molecules, doi:10.3390/molecules27185955
Adarshan, Muthuramalingam, Jeyasri, Lakshmi, Sathishkumar et al., Vitex negundo L. derived specialized molecules unveil the multi-targeted therapeutic avenues against COPD: a systems pharmacology approach, Front. Biosci, doi:10.31083/j.fbl2703087
Aleem, Akbar Samad, Slenker, Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against Coronavirus (COVID-19)
Alsamman, Zayed, The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1, PLoS One, doi:10.1371/journal.pone.0243270
Azevedo, Botelho, Hollanda, Ferreira, Junqueira De Andrade et al., Covid-19 and the cardiovascular system: a comprehensive review, J. Hum. Hypertens, doi:10.1038/s41371-020-0387-4
Bianco, Modica, Drago, Azzolina, Mattina et al., Alteration of smell and taste in asymptomatic and symptomatic COVID-19 patients, Ear Nose Throat J, doi:10.1177/0145561320981447
Flower, Mediated Green Silver Nanoparticles Control Staphylococcus aureus and Acinetobacter baumannii, ApplBiochemBiotechnol, doi:10.1007/s12010-022-03882-z
Freedberg, Chang, Gastrointestinal symptoms in COVID-19: the long and the short of it, Curr. Opin. Gastroenterol, doi:10.1097/MOG.0000000000000876
Gelzo, Cacciapuoti, Pinchera, Rosa, Cernera et al., Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients, doi:10.1038/s41598-021-04677-8
Ghani, Medicinal Plants of Bangladesh
Jeyasri, Muthuramalingam, Suba, Ramesh, Chen, Bacopa monnieri and their bioactive compounds inferred multi-target treatment strategy for neurological diseases: a cheminformatics and system pharmacology approach, Biomolecules, doi:10.3390/biom10040536
Kar, Kumar, Bala, Dolai, Mazumder et al., Evaluation of antitumor activity of Mimusopselengi leaves on Ehrlich's ascites carcinoma-treated mice, J. Diet. Suppl, doi:10.3109/19390211.2012.708714
Kar, Kumar, Karmakar, Dolai, Bala et al., Antioxidant and in vitro anti-inflammatory activities of Mimusopselengi leaves, Asian Pac. J. Trop. Biomed
Katiyar, Gupta, Kanjilal, Katiyar, Drug discovery from plant sources: an integrated approach, Ayu, doi:10.4103/0974-8520.100295
Kirtikar, Basu, Indian Medicinal Plants, 2nd ed
Kumar, Dobos, Rampp, The significance of ayurvedic medicinal plants, J. Evid.-Based Complement. Alternat. Med, doi:10.1177/2156587216671392
Lauder, Jones, Smart, Bloom, Williams et al., Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology, Eur. J. Immunol, doi:10.1002/eji.201243018
Leung, Niikura, Yang, Sin, COVID-19 and COPD, Eur. Respir. J, doi:10.1183/13993003.02108-2020
Long, Brady, Koyfman, Gottlieb, Cardiovascular complications in COVID-19, Am. J. Emerg. Med, doi:10.1016/j.ajem.2020.04.048
Mahavorasirikul, Viyanant, Chaijaroenkul, Itharat, Na-Bangchang, Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro, BMC Complement. Altern. Med
Montazersaheb, Hosseiniyan Khatibi, Hejazi, Tarhriz, Farjami et al., COVID-19 infection: an overview on cytokine storm and related interventions, Virol. J, doi:10.1186/s12985-022-01814-1
Niranjan, Sahu, Koike, Jia, Nikaido, Novel triterpenoid saponins from Mimusopselengi, Tetrahedron, doi:10.1016/0040-4020(95)00879-D
Purnima, Koti, Thippeswamy, Jaji, Swamy et al., Antiinflammatory, analgesic and antipyretic activities of Mimusopselengi Linn, Indian J. Pharm. Sci, doi:10.4103/0250-474X.73908
Rose-John, Winthrop, Calabrese, The role of IL-6 in host defence against infections: immunobiology and clinical implications, Nat. Rev. Rheumatol, doi:10.1038/nrrheum.2017.83
Rose-John, Winthrop, Calabrese, The role of IL-6 in host defence against infections: immunobiology and clinical implications, Nat. Rev. Rheumatol, doi:10.1038/nrrheum.2017.83
Salamanna, Maglio, Landini, Fini, Body localization of ACE-2: on the trail of the keyhole of SARS-CoV-2, Front. Med, doi:10.3389/fmed.2020.594495
Shaik, Khasim, Naidu, Protective activity of ethanolic leaf extract of Mimusopselengi Linn. on lipid peroxidation and antioxidant enzymes in experimental diabetic rats, Int. J. Adv. Pharm. Sci
Shannon, Markiel, Ozier, Baliga, Wang et al., Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res
Sharma, Kabra, Rao, Prajapati, Herbal and holistic solutions for neurodegenerative and depressive disorders: leads from Ayurveda, Curr. Pharm. Des, doi:10.2174/1381612824666180821165741
Simpson, Hammacher, Smith, Matthews, Ward, Interleukin-6: structure-function relationships, Protein Sci, doi:10.1002/pro.5560060501
Song, Hui, Hull, Birring, Mcgarvey et al., Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses, Lancet Respir. Med, doi:10.1016/S2213-2600(21)00125-9
Spudich, Nath, Nervous system consequences of COVID-19, Science, doi:10.1126/science.abm2052
Trott, Olson, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem
Veeresham, Natural products derived from plants as a source of drugs, J. Adv. Pharm. Technol. Res, doi:10.4103/2231-4040.104709
Velazquez-Salinas, Verdugo-Rodriguez, Rodriguez, Borca, The role of interleukin 6 during viral infections, Front. Microbiol, doi:10.3389/fmicb.2019.01057
Villapol, Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome, Transl. Res, doi:10.1016/j.trsl.2020.08.004
Yabluchanskiy, Ma, Iyer, Hall, Lindsey, Matrix metalloproteinase-9: many shades of function in cardiovascular disease, Physiology (Bethesda), doi:10.1152/physiol.00029.2013
Yazdanpanah, Rezaei, Autoimmune complications of COVID-19, J. Med. Virol, doi:10.1002/jmv.27292
Ye, Wang, Mao, Cytokine storm in COVID-19 and treatment, J. Inf. Secur
Zhang, Onakpoya, Posadzki, Eddouks, The safety of herbal medicine: from prejudice to evidence, Evid. Based Complement. Alternat. Med, doi:10.1155/2015/316706
Zhou, Chi, Lv, Wang, Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19), Diabetes Metab. Res. Rev, doi:10.1002/dmrr.3377
{ 'indexed': {'date-parts': [[2023, 6, 25]], 'date-time': '2023-06-25T04:37:19Z', 'timestamp': 1687667839525}, 'reference-count': 42, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-017'}, { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-037'}, { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-012'}, { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-029'}, { 'start': { 'date-parts': [[2023, 6, 1]], 'date-time': '2023-06-01T00:00:00Z', 'timestamp': 1685577600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-004'}], 'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 6]]}, 'DOI': '10.1016/j.ijbiomac.2023.125553', 'type': 'journal-article', 'created': {'date-parts': [[2023, 6, 24]], 'date-time': '2023-06-24T16:32:29Z', 'timestamp': 1687624349000}, 'page': '125553', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS ' 'CoV2 – An Insilico model', 'prefix': '10.1016', 'author': [ {'given': 'A.', 'family': 'Sai Ramesh', 'sequence': 'first', 'affiliation': []}, {'given': 'S.', 'family': 'Adarshan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hamad', 'family': 'Lohedan', 'sequence': 'additional', 'affiliation': []}, {'given': 'T.', 'family': 'Naveen Kumar', 'sequence': 'additional', 'affiliation': []}, {'given': 'M.R.', 'family': 'Thasleema Nasrin', 'sequence': 'additional', 'affiliation': []}, {'given': 'G.', 'family': 'Aarthi Shree', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yuvaraj', 'family': 'Dinakarkumar', 'sequence': 'additional', 'affiliation': []}, {'given': 'R. Jothi', 'family': 'Ramalingam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Muthusamy', 'family': 'Karnan', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '5', 'key': '10.1016/j.ijbiomac.2023.125553_bb0005', 'doi-asserted-by': 'crossref', 'first-page': '533', 'DOI': '10.1016/S2213-2600(21)00125-9', 'article-title': 'Confronting COVID-19-associated cough and the post-COVID syndrome: role ' 'of viral neurotropism, neuroinflammation, and neuroimmune responses', 'volume': '9', 'author': 'Song', 'year': '2021', 'journal-title': 'Lancet Respir. Med.'}, { 'issue': '6', 'key': '10.1016/j.ijbiomac.2023.125553_bb0010', 'doi-asserted-by': 'crossref', 'first-page': '555', 'DOI': '10.1097/MOG.0000000000000876', 'article-title': 'Gastrointestinal symptoms in COVID-19: the long and the short of it', 'volume': '38', 'author': 'Freedberg', 'year': '2022', 'journal-title': 'Curr. Opin. Gastroenterol.'}, { 'issue': '2_suppl', 'key': '10.1016/j.ijbiomac.2023.125553_bb0015', 'doi-asserted-by': 'crossref', 'first-page': '182S', 'DOI': '10.1177/0145561320981447', 'article-title': 'Alteration of smell and taste in asymptomatic and symptomatic COVID-19 ' 'patients in Sicily, Italy', 'volume': '100', 'author': 'Bianco', 'year': '2021', 'journal-title': 'Ear Nose Throat J.'}, { 'issue': '2', 'key': '10.1016/j.ijbiomac.2023.125553_bb0020', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/dmrr.3377', 'article-title': 'Obesity and diabetes as high-risk factors for severe coronavirus ' 'disease 2019 (Covid-19)', 'volume': '37', 'author': 'Zhou', 'year': '2021', 'journal-title': 'Diabetes Metab. Res. Rev.'}, { 'issue': '1', 'key': '10.1016/j.ijbiomac.2023.125553_bb0025', 'doi-asserted-by': 'crossref', 'first-page': '54', 'DOI': '10.1002/jmv.27292', 'article-title': 'Autoimmune complications of COVID-19', 'volume': '94', 'author': 'Yazdanpanah', 'year': '2022', 'journal-title': 'J. Med. Virol.'}, { 'issue': '2', 'key': '10.1016/j.ijbiomac.2023.125553_bb0030', 'doi-asserted-by': 'crossref', 'first-page': '2002108', 'DOI': '10.1183/13993003.02108-2020', 'article-title': 'COVID-19 and COPD', 'volume': '56', 'author': 'Leung', 'year': '2020', 'journal-title': 'Eur. Respir. J.'}, { 'issue': '1', 'key': '10.1016/j.ijbiomac.2023.125553_bb0035', 'doi-asserted-by': 'crossref', 'first-page': '4', 'DOI': '10.1038/s41371-020-0387-4', 'article-title': 'Covid-19 and the cardiovascular system: a comprehensive review', 'volume': '35', 'author': 'Azevedo', 'year': '2021', 'journal-title': 'J. Hum. Hypertens.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0040', 'first-page': '607', 'article-title': 'Cytokine storm in COVID-19 and treatment', 'volume': '80', 'author': 'Ye', 'year': '2020', 'journal-title': 'J. Inf. Secur.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0045', 'unstructured': 'COVID-19 infection: an overview on cytokine storm and related ' 'interventions.'}, { 'issue': '22', 'key': '10.1016/j.ijbiomac.2023.125553_bb0050', 'doi-asserted-by': 'crossref', 'first-page': '2597', 'DOI': '10.2174/1381612824666180821165741', 'article-title': 'Herbal and holistic solutions for neurodegenerative and depressive ' 'disorders: leads from Ayurveda', 'volume': '24', 'author': 'Sharma', 'year': '2018', 'journal-title': 'Curr. Pharm. Des.'}, { 'issue': '4', 'key': '10.1016/j.ijbiomac.2023.125553_bb0055', 'doi-asserted-by': 'crossref', 'first-page': '200', 'DOI': '10.4103/2231-4040.104709', 'article-title': 'Natural products derived from plants as a source of drugs', 'volume': '3', 'author': 'Veeresham', 'year': '2012', 'journal-title': 'J. Adv. Pharm. Technol. Res.'}, { 'issue': '1', 'key': '10.1016/j.ijbiomac.2023.125553_bb0060', 'doi-asserted-by': 'crossref', 'first-page': '10', 'DOI': '10.4103/0974-8520.100295', 'article-title': 'Drug discovery from plant sources: an integrated approach', 'volume': '33', 'author': 'Katiyar', 'year': '2012', 'journal-title': 'Ayu'}, { 'issue': '3', 'key': '10.1016/j.ijbiomac.2023.125553_bb0065', 'doi-asserted-by': 'crossref', 'first-page': '87', 'DOI': '10.31083/j.fbl2703087', 'article-title': 'Vitex negundo L. derived specialized molecules unveil the ' 'multi-targeted therapeutic avenues against COPD: a systems pharmacology ' 'approach', 'volume': '27', 'author': 'Adarshan', 'year': '2022', 'journal-title': 'Front. Biosci.'}, { 'issue': '18', 'key': '10.1016/j.ijbiomac.2023.125553_bb0070', 'doi-asserted-by': 'crossref', 'first-page': '5955', 'DOI': '10.3390/molecules27185955', 'article-title': 'Transcriptomics, cheminformatics, and systems pharmacology strategies ' 'unveil the potential bioactives to combat COVID-19', 'volume': '27', 'author': 'Adarshan', 'year': '2022', 'journal-title': 'Molecules (Basel, Switzerland)'}, { 'issue': '48', 'key': '10.1016/j.ijbiomac.2023.125553_bb0075', 'doi-asserted-by': 'crossref', 'first-page': '13435', 'DOI': '10.1016/0040-4020(95)00879-D', 'article-title': 'Novel triterpenoid saponins from Mimusopselengi', 'volume': '51', 'author': 'Sahu', 'year': '1995', 'journal-title': 'Tetrahedron'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0080', 'unstructured': 'Kar B, Kumar RBS, Karmakar I, Dolai N, Bala A, Mazumder UK, Haldar PK. ' 'Antioxidant and in vitro anti-inflammatory activities of Mimusopselengi ' 'leaves. Asian Pac. J. Trop. Biomed., (in press).'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0085', 'first-page': '264', 'article-title': 'Protective activity of ethanolic leaf extract of Mimusopselengi Linn. ' 'on lipid peroxidation and antioxidant enzymes in experimental diabetic ' 'rats', 'volume': '2', 'author': 'Shaik', 'year': '2011', 'journal-title': 'Int. J. Adv. Pharm. Sci.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0090', 'doi-asserted-by': 'crossref', 'first-page': '55', 'DOI': '10.1186/1472-6882-10-55', 'article-title': 'Cytotoxic activity of Thai medicinal plants against human ' 'cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro', 'volume': '10', 'author': 'Mahavorasirikul', 'year': '2010', 'journal-title': 'BMC Complement. Altern. Med.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0095', 'series-title': 'Mimusopselengi Flower-Mediated Green Silver Nanoparticles Control ' 'Staphylococcus aureus and Acinetobacter baumannii. ApplBiochemBiotechnol', 'first-page': '3066', 'volume': '194', 'author': 'J, C.N., S, R. & S, H', 'year': '2022'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0100', 'series-title': 'Medicinal Plants of Bangladesh', 'first-page': '303', 'author': 'Ghani', 'year': '2003'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0105', 'series-title': 'Indian Medicinal Plants', 'first-page': '1494', 'author': 'Kirtikar', 'year': '1988'}, { 'issue': '3', 'key': '10.1016/j.ijbiomac.2023.125553_bb0110', 'doi-asserted-by': 'crossref', 'first-page': '166', 'DOI': '10.3109/19390211.2012.708714', 'article-title': "Evaluation of antitumor activity of Mimusopselengi leaves on Ehrlich's " 'ascites carcinoma-treated mice', 'volume': '9', 'author': 'Kar', 'year': '2012', 'journal-title': 'J. Diet. Suppl.'}, { 'issue': '4', 'key': '10.1016/j.ijbiomac.2023.125553_bb0115', 'doi-asserted-by': 'crossref', 'first-page': '480', 'DOI': '10.4103/0250-474X.73908', 'article-title': 'Antiinflammatory, analgesic and antipyretic activities of ' 'Mimusopselengi Linn', 'volume': '72', 'author': 'Purnima', 'year': '2010', 'journal-title': 'Indian J. Pharm. Sci.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0120', 'doi-asserted-by': 'crossref', 'unstructured': 'Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, ' 'Schwikowski B, Ideker T. Cytoscape: a software environment for ' 'integrated models of biomolecular interaction networks. Genome Res., ' '13(11), 2498–504.', 'DOI': '10.1101/gr.1239303'}, { 'issue': '2', 'key': '10.1016/j.ijbiomac.2023.125553_bb0125', 'first-page': '455', 'article-title': 'AutoDock Vina: improving the speed and accuracy of docking with a new ' 'scoring function, efficient optimization, and multithreading', 'volume': '31', 'author': 'Trott', 'year': '2010', 'journal-title': 'J. Comput. Chem.'}, { 'issue': '12', 'key': '10.1016/j.ijbiomac.2023.125553_bb0130', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0243270', 'article-title': 'The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, ' 'EBOV, and H1N1', 'volume': '15', 'author': 'Alsamman', 'year': '2020', 'journal-title': 'PLoS One'}, { 'issue': '7', 'key': '10.1016/j.ijbiomac.2023.125553_bb0135', 'doi-asserted-by': 'crossref', 'first-page': '1504', 'DOI': '10.1016/j.ajem.2020.04.048', 'article-title': 'Cardiovascular complications in COVID-19', 'volume': '38', 'author': 'Long', 'year': '2020', 'journal-title': 'Am. J. Emerg. Med.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0140', 'doi-asserted-by': 'crossref', 'first-page': '57', 'DOI': '10.1016/j.trsl.2020.08.004', 'article-title': 'Gastrointestinal symptoms associated with COVID-19: impact on the gut ' 'microbiome', 'volume': '226', 'author': 'Villapol', 'year': '2020', 'journal-title': 'Transl. Res.'}, { 'issue': '6578', 'key': '10.1016/j.ijbiomac.2023.125553_bb0145', 'doi-asserted-by': 'crossref', 'first-page': '267', 'DOI': '10.1126/science.abm2052', 'article-title': 'Nervous system consequences of COVID-19', 'volume': '375', 'author': 'Spudich', 'year': '2022', 'journal-title': 'Science'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0150', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2020.594495', 'article-title': 'Body localization of ACE-2: on the trail of the keyhole of SARS-CoV-2', 'volume': '7', 'author': 'Salamanna', 'year': '2020', 'journal-title': 'Front. Med.'}, { 'issue': '3', 'key': '10.1016/j.ijbiomac.2023.125553_bb0155', 'doi-asserted-by': 'crossref', 'first-page': '494', 'DOI': '10.1177/2156587216671392', 'article-title': 'The significance of ayurvedic medicinal plants', 'volume': '22', 'author': 'Kumar', 'year': '2017', 'journal-title': 'J. Evid.-Based Complement. Alternat. Med.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0160', 'article-title': 'The safety of herbal medicine: from prejudice to evidence', 'volume': '2015', 'author': 'Zhang', 'year': '2015', 'journal-title': 'Evid. Based Complement. Alternat. Med.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0165', 'series-title': 'Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against ' 'Coronavirus (COVID-19)', 'author': 'Aleem', 'year': '2022'}, { 'issue': '3', 'key': '10.1016/j.ijbiomac.2023.125553_bb0170', 'doi-asserted-by': 'crossref', 'first-page': '87', 'DOI': '10.31083/j.fbl2703087', 'article-title': 'Vitex negundo L. derived specialized molecules unveil the ' 'multi-targeted therapeutic avenues against COPD: a systems pharmacology ' 'approach', 'volume': '27', 'author': 'Adarshan', 'year': '2022', 'journal-title': 'Front. Biosci.'}, { 'issue': '18', 'key': '10.1016/j.ijbiomac.2023.125553_bb0175', 'doi-asserted-by': 'crossref', 'first-page': '5955', 'DOI': '10.3390/molecules27185955', 'article-title': 'Transcriptomics, cheminformatics, and systems pharmacology strategies ' 'unveil the potential bioactives to combat COVID-19', 'volume': '27', 'author': 'Adarshan', 'year': '2022', 'journal-title': 'Molecules.'}, { 'issue': '5', 'key': '10.1016/j.ijbiomac.2023.125553_bb0180', 'doi-asserted-by': 'crossref', 'first-page': '929', 'DOI': '10.1002/pro.5560060501', 'article-title': 'Interleukin-6: structure-function relationships', 'volume': '6', 'author': 'Simpson', 'year': '1997', 'journal-title': 'Protein Sci.'}, { 'issue': '7', 'key': '10.1016/j.ijbiomac.2023.125553_bb0185', 'doi-asserted-by': 'crossref', 'first-page': '399', 'DOI': '10.1038/nrrheum.2017.83', 'article-title': 'The role of IL-6 in host defence against infections: immunobiology and ' 'clinical implications', 'volume': '13', 'author': 'Rose-John', 'year': '2017', 'journal-title': 'Nat. Rev. Rheumatol.'}, { 'issue': '7', 'key': '10.1016/j.ijbiomac.2023.125553_bb0190', 'doi-asserted-by': 'crossref', 'first-page': '399', 'DOI': '10.1038/nrrheum.2017.83', 'article-title': 'The role of IL-6 in host defence against infections: immunobiology and ' 'clinical implications', 'volume': '13', 'author': 'Rose-John', 'year': '2017', 'journal-title': 'Nat. Rev. Rheumatol.'}, { 'key': '10.1016/j.ijbiomac.2023.125553_bb0195', 'doi-asserted-by': 'crossref', 'first-page': '1057', 'DOI': '10.3389/fmicb.2019.01057', 'article-title': 'The role of interleukin 6 during viral infections', 'volume': '10', 'author': 'Velazquez-Salinas', 'year': '2019', 'journal-title': 'Front. Microbiol.'}, { 'issue': '10', 'key': '10.1016/j.ijbiomac.2023.125553_bb0200', 'doi-asserted-by': 'crossref', 'first-page': '2613', 'DOI': '10.1002/eji.201243018', 'article-title': 'Interleukin-6 limits influenza-induced inflammation and protects ' 'against fatal lung pathology', 'volume': '43', 'author': 'Lauder', 'year': '2013', 'journal-title': 'Eur. J. Immunol.'}, { 'issue': '1', 'key': '10.1016/j.ijbiomac.2023.125553_bb0205', 'doi-asserted-by': 'crossref', 'first-page': '1212', 'DOI': '10.1038/s41598-021-04677-8', 'article-title': 'Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in ' 'COVID-19 patients', 'volume': '12', 'author': 'Gelzo', 'year': '2022', 'journal-title': 'Sci. Rep.'}, { 'issue': '6', 'key': '10.1016/j.ijbiomac.2023.125553_bb0210', 'first-page': '391', 'article-title': 'Matrix metalloproteinase-9: many shades of function in cardiovascular ' 'disease', 'volume': '28', 'author': 'Yabluchanskiy', 'year': '2013', 'journal-title': 'Physiology (Bethesda)'}], 'container-title': 'International Journal of Biological Macromolecules', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0141813023024479?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0141813023024479?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2023, 6, 24]], 'date-time': '2023-06-24T16:33:09Z', 'timestamp': 1687624389000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0141813023024479'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 6]]}, 'references-count': 42, 'alternative-id': ['S0141813023024479'], 'URL': 'http://dx.doi.org/10.1016/j.ijbiomac.2023.125553', 'relation': {}, 'ISSN': ['0141-8130'], 'subject': ['Molecular Biology', 'General Medicine', 'Biochemistry', 'Structural Biology'], 'container-title-short': 'International Journal of Biological Macromolecules', 'published': {'date-parts': [[2023, 6]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Computational analysis of the phytocompounds of Mimusops elengi against spike ' 'protein of SARS CoV2 – An Insilico model', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'International Journal of Biological Macromolecules', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.ijbiomac.2023.125553', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2023 Elsevier B.V. All rights reserved.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '125553'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit