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Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS CoV2 – An Insilico model

Sai Ramesh et al., International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2023.125553
Jun 2023  
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In Silico study finding that quercetin and hederagenin showed very high binding affinities for COVID-19 associated receptors MMP9 and IL6.
Sai Ramesh et al., 30 Jun 2023, peer-reviewed, 9 authors.
Contact: yuvarajdinakarkumar@gmail.com.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
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Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS CoV2 – An Insilico model
A Sai Ramesh, S Adarshan, Hamad Lohedan, T Naveen Kumar, M R Thasleema Nasrin, G Aarthi Shree, Yuvaraj Dinakarkumar, Jothi Ramalingam Rajabathar, Muthusamy Karnan
International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2023.125553
The COVID-19 pandemic has been a global health crisis for over three years now, with the virus causing widespread illness and death. The urgent need for safe and effective therapeutic drugs has prompted the exploration of alternative medicine systems such as Ayurveda and Siddha. This study focuses on the potential therapeutic properties of the Ayurvedic plant, Mimusops elengi. In silico techniques were employed to analyze the bioactivity of the plant, including target prediction, gene ontology analysis, OMIM analysis, and molecular docking analysis. The results revealed 36 phytocompounds that interacted with 1431 receptors in the human body, and two compounds -hederagenin and quercetin -showed exceptionally high binding affinities toward their corresponding receptors, IL6 and MMP9. These results provide important insight into the potential therapeutic activity of M. elengi and its compounds in combating COVID-19. However, further research and clinical trials are necessary to validate these findings and develop safe and effective drugs. The study highlights the importance of combining traditional medicine with modern scientific methods to find effective treatments for global health challenges.
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: R. Jothi Ramalingam reports financial support was provided by Researchers Supporting Project. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.ijbiomac.2023.125553.
References
Aanouz, Belhassan, El-Khatabi, Lakhlifi, El-Ldrissi et al., Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations, J. Biomol. Struct. Dyn, doi:10.1080/07391102.2020.1758790
Adarshan, Akassh, Avinash, Bharathkumar, Muthuramalingam et al., Transcriptomics, cheminformatics, and systems pharmacology strategies unveil the potential bioactives to combat COVID-19, Molecules, doi:10.3390/molecules27185955
Adarshan, Muthuramalingam, Jeyasri, Lakshmi, Sathishkumar et al., Vitex negundo L. derived specialized molecules unveil the multi-targeted therapeutic avenues against COPD: a systems pharmacology approach, Front. Biosci, doi:10.31083/j.fbl2703087
Aleem, Akbar Samad, Slenker, Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against Coronavirus (COVID-19)
Alsamman, Zayed, The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1, PLoS One, doi:10.1371/journal.pone.0243270
Azevedo, Botelho, Hollanda, Ferreira, Junqueira De Andrade et al., Covid-19 and the cardiovascular system: a comprehensive review, J. Hum. Hypertens, doi:10.1038/s41371-020-0387-4
Bianco, Modica, Drago, Azzolina, Mattina et al., Alteration of smell and taste in asymptomatic and symptomatic COVID-19 patients, Ear Nose Throat J, doi:10.1177/0145561320981447
Flower, Mediated Green Silver Nanoparticles Control Staphylococcus aureus and Acinetobacter baumannii, ApplBiochemBiotechnol, doi:10.1007/s12010-022-03882-z
Freedberg, Chang, Gastrointestinal symptoms in COVID-19: the long and the short of it, Curr. Opin. Gastroenterol, doi:10.1097/MOG.0000000000000876
Gelzo, Cacciapuoti, Pinchera, Rosa, Cernera et al., Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients, doi:10.1038/s41598-021-04677-8
Ghani, Medicinal Plants of Bangladesh
Jeyasri, Muthuramalingam, Suba, Ramesh, Chen, Bacopa monnieri and their bioactive compounds inferred multi-target treatment strategy for neurological diseases: a cheminformatics and system pharmacology approach, Biomolecules, doi:10.3390/biom10040536
Kar, Kumar, Bala, Dolai, Mazumder et al., Evaluation of antitumor activity of Mimusopselengi leaves on Ehrlich's ascites carcinoma-treated mice, J. Diet. Suppl, doi:10.3109/19390211.2012.708714
Kar, Kumar, Karmakar, Dolai, Bala et al., Antioxidant and in vitro anti-inflammatory activities of Mimusopselengi leaves, Asian Pac. J. Trop. Biomed
Katiyar, Gupta, Kanjilal, Katiyar, Drug discovery from plant sources: an integrated approach, Ayu, doi:10.4103/0974-8520.100295
Kirtikar, Basu, Indian Medicinal Plants, 2nd ed
Kumar, Dobos, Rampp, The significance of ayurvedic medicinal plants, J. Evid.-Based Complement. Alternat. Med, doi:10.1177/2156587216671392
Lauder, Jones, Smart, Bloom, Williams et al., Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology, Eur. J. Immunol, doi:10.1002/eji.201243018
Leung, Niikura, Yang, Sin, COVID-19 and COPD, Eur. Respir. J, doi:10.1183/13993003.02108-2020
Long, Brady, Koyfman, Gottlieb, Cardiovascular complications in COVID-19, Am. J. Emerg. Med, doi:10.1016/j.ajem.2020.04.048
Mahavorasirikul, Viyanant, Chaijaroenkul, Itharat, Na-Bangchang, Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro, BMC Complement. Altern. Med
Montazersaheb, Hosseiniyan Khatibi, Hejazi, Tarhriz, Farjami et al., COVID-19 infection: an overview on cytokine storm and related interventions, Virol. J, doi:10.1186/s12985-022-01814-1
Niranjan, Sahu, Koike, Jia, Nikaido, Novel triterpenoid saponins from Mimusopselengi, Tetrahedron, doi:10.1016/0040-4020(95)00879-D
Purnima, Koti, Thippeswamy, Jaji, Swamy et al., Antiinflammatory, analgesic and antipyretic activities of Mimusopselengi Linn, Indian J. Pharm. Sci, doi:10.4103/0250-474X.73908
Rose-John, Winthrop, Calabrese, The role of IL-6 in host defence against infections: immunobiology and clinical implications, Nat. Rev. Rheumatol, doi:10.1038/nrrheum.2017.83
Rose-John, Winthrop, Calabrese, The role of IL-6 in host defence against infections: immunobiology and clinical implications, Nat. Rev. Rheumatol, doi:10.1038/nrrheum.2017.83
Salamanna, Maglio, Landini, Fini, Body localization of ACE-2: on the trail of the keyhole of SARS-CoV-2, Front. Med, doi:10.3389/fmed.2020.594495
Shaik, Khasim, Naidu, Protective activity of ethanolic leaf extract of Mimusopselengi Linn. on lipid peroxidation and antioxidant enzymes in experimental diabetic rats, Int. J. Adv. Pharm. Sci
Shannon, Markiel, Ozier, Baliga, Wang et al., Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res
Sharma, Kabra, Rao, Prajapati, Herbal and holistic solutions for neurodegenerative and depressive disorders: leads from Ayurveda, Curr. Pharm. Des, doi:10.2174/1381612824666180821165741
Simpson, Hammacher, Smith, Matthews, Ward, Interleukin-6: structure-function relationships, Protein Sci, doi:10.1002/pro.5560060501
Song, Hui, Hull, Birring, Mcgarvey et al., Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses, Lancet Respir. Med, doi:10.1016/S2213-2600(21)00125-9
Spudich, Nath, Nervous system consequences of COVID-19, Science, doi:10.1126/science.abm2052
Trott, Olson, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem
Veeresham, Natural products derived from plants as a source of drugs, J. Adv. Pharm. Technol. Res, doi:10.4103/2231-4040.104709
Velazquez-Salinas, Verdugo-Rodriguez, Rodriguez, Borca, The role of interleukin 6 during viral infections, Front. Microbiol, doi:10.3389/fmicb.2019.01057
Villapol, Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome, Transl. Res, doi:10.1016/j.trsl.2020.08.004
Yabluchanskiy, Ma, Iyer, Hall, Lindsey, Matrix metalloproteinase-9: many shades of function in cardiovascular disease, Physiology (Bethesda), doi:10.1152/physiol.00029.2013
Yazdanpanah, Rezaei, Autoimmune complications of COVID-19, J. Med. Virol, doi:10.1002/jmv.27292
Ye, Wang, Mao, Cytokine storm in COVID-19 and treatment, J. Inf. Secur
Zhang, Onakpoya, Posadzki, Eddouks, The safety of herbal medicine: from prejudice to evidence, Evid. Based Complement. Alternat. Med, doi:10.1155/2015/316706
Zhou, Chi, Lv, Wang, Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19), Diabetes Metab. Res. Rev, doi:10.1002/dmrr.3377
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