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All Studies   Meta Analysis    Recent:   

Evaluation of the Effect of Zinc, Quercetin, Bromelain and Vitamin C on COVID-19 Patients

Ahmed et al., International Journal of Diabetes Management, doi:10.61797/ijdm.v2i2.259, NCT04468139
Oct 2023  
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Quercetin for COVID-19
23rd treatment shown to reduce risk in July 2021
 
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Case series of 22 hospitalized COVID-19 patients showing that a combination of quercetin 800mg, bromelain 165mg, zinc acetate 50mg and vitamin C 1g daily for 3-5 days was safe when given with other treatments.
Authors include In Silico molecular docking analysis showing that the natural compounds quercetin and bromelain bind strongly to the active site of human cathepsin L protein, indicating they may act as inhibitors. Quercetin exhibited a binding energy of -5.15 kcal/mol with 5 hydrogen bonds and 1 pi-interaction. Bromelain had a binding energy of -5.65 kcal/mol with 7 hydrogen bonds. As human cathepsin L is involved in inflammatory pathways, the results suggest quercetin and bromelain could potentially help prevent COVID-19 progression to severe inflammation and cytokine storm.
Bioavailability. Quercetin has low bioavailability and studies typically use advanced formulations to improve bioavailability which may be required to reach therapeutic concentrations.
59 preclinical studies support the efficacy of quercetin for COVID-19:
In Silico studies predict inhibition of SARS-CoV-2, or minimization of side effects, with quercetin or metabolites via binding to the spikeA,2,3,15,17,18,23,31,32,34,35,52,53, MproB,2,4,6,8,10,11,13,16,17,23,27,29-31,35,36,38,53,54, RNA-dependent RNA polymeraseC,2,25, PLproD,30,38, ACE2E,15,16,21,30,34,53, TMPRSS2F,15, helicaseG,22,27, endoribonucleaseH,32, cathepsin LI,19, Wnt-3J,15, FZDK,15, LRP6L,15, ezrinM,33, ADRPN,31, NRP1O,34, EP300P,9, PTGS2Q,16, HSP90AA1R,9,16, matrix metalloproteinase 9S,24, IL-6T,14,28, IL-10U,14, VEGFAV,28, and RELAW,28 proteins. In Vitro studies demonstrate efficacy in Calu-3X,41, A549Y,14, HEK293-ACE2+Z,48, Huh-7AA,18, Caco-2AB,40, Vero E6AC,12,35,40, mTECAD,43, and RAW264.7AE,43 cells. Animal studies demonstrate efficacy in K18-hACE2 miceAF,45, db/db miceAG,43,51, BALB/c miceAH,50, and rats55. Quercetin reduced proinflammatory cytokines and protected lung and kidney tissue against LPS-induced damage in mice50.
Study covers quercetin, vitamin C, and zinc.
Ahmed et al., 6 Oct 2023, Saudi Arabia, peer-reviewed, mean age 49.3, 6 authors, study period June 2020 - September 2020, trial NCT04468139 (history). Contact: drmedahmed@gmail.com.
This PaperQuercetinAll
{ 'indexed': { 'date-parts': [[2023, 12, 31]], 'date-time': '2023-12-31T00:28:40Z', 'timestamp': 1703982520565}, 'reference-count': 0, 'publisher': None, 'issue': '2', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new strain ' 'of coronavirus. There are three phases of COVID-19: early infection stage, pulmonary stage ' 'and hyper-inflammation stage respectively. It is important to prevent lung or other organs ' 'injuries by preventing phase-II and phase-III via pharmacological or non-pharmacological ' 'treatments. This was a case series study done on twenty-two patients confirmed to be infected ' 'with SARS-CoV-2 and diagnosed with COVID-19. Patients in this study have been used quercetin ' '800 mg, bromelain 165 mg, zinc acetate 50 mg and ascorbic acid 1 g once daily as supplements ' 'for 3 to 5 days during SARS-CoV-2 infection. The aim of this study is to evaluate the safety ' 'and efficacy of quercetin, bromelain, zinc and ascorbic acid combination supplements on ' 'patients with COVID-19. The mean levels of WBC, ANC, ALC, AMC and AST were normal among all ' 'included patients before and after taking quercetin, bromelain, zinc and ascorbic acid ' 'supplements (P-value &gt;0.05). Quercetin 800 mg, bromelain 165 mg, zinc acetate 50 mg and ' 'ascorbic acid 1 g once daily supplements were safe for patients infected with SARS-CoV-2 and ' 'may prevent poor prognosis. Randomized clinical trials needed in the future to ensure the ' 'efficacy of quercetin, bromelain, zinc and vitamin C combination.</jats:p>', 'DOI': '10.61797/ijdm.v2i2.259', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 12, 30]], 'date-time': '2023-12-30T14:56:19Z', 'timestamp': 1703948179000}, 'page': '29-37', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Evaluation of the Effect of Zinc, Quercetin, Bromelain and Vitamin C on COVID-19 Patients', 'prefix': '10.61797', 'volume': '2', 'author': [ {'given': 'Amr', 'family': 'Ahmed', 'sequence': 'first', 'affiliation': []}, {'given': 'Heba', 'family': 'Abdelseed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hassan', 'family': 'Shora', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yousef', 'family': 'Albalawi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eman', 'family': 'Aslsalameen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Abdullah', 'family': 'Alkattan', 'sequence': 'additional', 'affiliation': []}], 'member': None, 'published-online': {'date-parts': [[2023, 12, 30]]}, 'container-title': 'International Journal of Diabetes Management', 'original-title': [], 'deposited': { 'date-parts': [[2023, 12, 30]], 'date-time': '2023-12-30T14:56:19Z', 'timestamp': 1703948179000}, 'score': 1, 'resource': {'primary': {'URL': 'https://researchlakejournals.com/index.php/IJDM/article/view/259'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 12, 30]]}, 'references-count': 0, 'journal-issue': {'issue': '2', 'published-online': {'date-parts': [[2023, 12, 30]]}}, 'URL': 'http://dx.doi.org/10.61797/ijdm.v2i2.259', 'relation': {}, 'ISSN': ['2564-324X'], 'container-title-short': 'Int J Diabetes Manag', 'published': {'date-parts': [[2023, 12, 30]]}}
Late treatment
is less effective
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