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All Studies   Meta Analysis    Recent:   

Evaluation of the Effect of Zinc, Quercetin, Bromelain and Vitamin C on COVID-19 Patients

Ahmed et al., International Journal of Diabetes Management, doi:10.61797/ijdm.v2i2.259, NCT04468139
Oct 2023  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Case series of 22 hospitalized COVID-19 patients showing that a combination of quercetin 800mg, bromelain 165mg, zinc acetate 50mg and vitamin C 1g daily for 3-5 days was safe when given with other treatments.
Authors include In Silico molecular docking analysis showing that the natural compounds quercetin and bromelain bind strongly to the active site of human cathepsin L protein, indicating they may act as inhibitors. Quercetin exhibited a binding energy of -5.15 kcal/mol with 5 hydrogen bonds and 1 pi-interaction. Bromelain had a binding energy of -5.65 kcal/mol with 7 hydrogen bonds. As human cathepsin L is involved in inflammatory pathways, the results suggest quercetin and bromelain could potentially help prevent COVID-19 progression to severe inflammation and cytokine storm.
In Silico studies predict inhibition of SARS-CoV-2, or minimization of side effects, with quercetin or metabolites via binding to the spike Note A, Alavi, Azmi (B), Chandran, Kandeil, Mandal, Moschovou, Nguyen, Pan, Thapa (B), Şimşek, Mpro Note B, Akinwumi, Alanzi, Ibeh, Kandeil, Mandal, Moschovou, Nguyen, Qin, Rehman, Sekiou (B), Singh, Thapa (B), Wang, Zhang, RNA-dependent RNA polymerase Note C, Corbo, PLpro Note D, Ibeh, Zhang, ACE2 Note E, Chandran, Ibeh, Qin, Thapa (B), Şimşek, Alkafaas, TMPRSS2 Note F, Chandran, helicase Note G, Alanzi, Singh (B), endoribonuclease Note H, Alavi, cathepsin L Note I, Ahmed, Wnt-3 Note J, Chandran, FZD Note K, Chandran, LRP6 Note L, Chandran, ezrin Note M, Chellasamy, ADRP Note N, Nguyen, NRP1 Note O, Şimşek, PTGS2 Note P, Qin, HSP90AA1 Note Q, Qin, matrix metalloproteinase 9 Note R, Sai Ramesh, IL-6 Note S, Yang, Yang (B), IL-10 Note T, Yang, VEGFA Note U, Yang (B), and RELA Note V, Yang (B) proteins. In Vitro studies demonstrate efficacy in Calu-3 Note W, DiGuilio, A549 Note X, Yang, HEK293-ACE2+ Note Y, Singh (C), Huh-7 Note Z, Pan, Caco-2 Note AA, Roy, Vero E6 Note AB, Kandeil, El-Megharbel, Roy, mTEC Note AC, Wu, and RAW264.7 Note AD, Wu cells. Animal studies demonstrate efficacy in K18-hACE2 mice Note AE, Aguado, db/db mice Note AF, Wu, Wu (B), BALB/c mice Note AG, Shaker, and rats El-Megharbel (B). Quercetin reduced proinflammatory cytokines and protected lung and kidney tissue against LPS-induced damage in mice Shaker.
Study covers quercetin, vitamin C, and zinc.
Ahmed et al., 6 Oct 2023, Saudi Arabia, peer-reviewed, mean age 49.3, 6 authors, study period June 2020 - September 2020, trial NCT04468139 (history). Contact: drmedahmed@gmail.com.
This PaperQuercetinAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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