Treatment with Quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by blocking Smad3-dependent G1 cell cycle arrest
Wu et al.,
Treatment with Quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by blocking Smad3-dependent..,
Molecular Therapy, doi:10.1016/j.ymthe.2022.12.002
Mouse study showing quercetin can significantly inhibit SARS-CoV-2 induced acute kidney injury via blocking of SARS-CoV-2 N-Smad3-mediated cell death.
Wu et al., 12 Dec 2022, China, peer-reviewed, 9 authors.
Contact:
hylan@cuhk.edu.hk, yuxueqing@gdph.org.cn, wangxiao773@hotmail.com.
Abstract: Journal Pre-proof
Treatment with Quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury
by blocking Smad3-dependent G1 cell cycle arrest
Wenjing Wu, Wenbiao Wang, Liying Liang, Junzhe Chen, Biao Wei, Xiao-Ru Huang,
Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan
PII:
S1525-0016(22)00706-7
DOI:
https://doi.org/10.1016/j.ymthe.2022.12.002
Reference:
YMTHE 5967
To appear in:
Molecular Therapy
Received Date: 10 October 2022
Accepted Date: 8 December 2022
Please cite this article as: Wu W, Wang W, Liang L, Chen J, Wei B, Huang X-R, Wang X, Yu X,
Lan H-Y, Treatment with Quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by
blocking Smad3-dependent G1 cell cycle arrest, Molecular Therapy (2023), doi: https://doi.org/10.1016/
j.ymthe.2022.12.002.
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© 2022 The American Society of Gene and Cell Therapy.
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Treatment with Quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury
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by blocking Smad3-dependent G1 cell cycle arrest
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Wenjing Wu1,2,3,4, Wenbiao Wang1, Liying Liang2, Junzhe Chen2,5, Biao Wei2, Xiao-Ru
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Huang1,2, Xiaoqin Wang3,4, Xueqing Yu1, and Hui-Yao Lan1,2
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1. Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney
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Disease, Departments of Nephrology and Pathology, Guangdong Provincial People’s
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Hospital, Guangdong Academy of Medical Science, Guangzhou, China.
2. Departments of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, Lui
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Che Woo Institute of Innovative Medicine, and The Chinese University of Hong Kong
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(CUHK) - Guangdong Academy of Medical Sciences / Guangdong Provincial People’s
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Hospital (GAMS/GPPH) Joint Research Laboratory on Immunological and Genetic
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Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China.
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3. Hubei University of Chinese Medicine, Wuhan, China.
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4. Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine,
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Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China.
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5. Department of Nephrology, The Third Affiliated hospital, Southern Medical University,
Guangzhou, China.
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Correspondence: Professor Hui-Yao Lan, Departments of Medicine & Therapeutics, Li Ka
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Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
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E-mail: hylan@cuhk.edu.hk; Professor Xueqing Yu, Guangdong Academy of Medical Science,
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Guangdong
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yuxueqing@gdph.org.cn; and Professor Xiaoqin Wang, Department of Nephrology, Hubei
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Provincial Hospital of Traditional Chinese Medicine, Hubei Province Academy of Traditional
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Chinese Medicine, Wuhan, China, E-mail: wangxiao773@hotmail.com
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Guangzhou,
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Abstract
Increasing evidence shows that SARS-CoV-2 can infect kidneys and cause acute kidney
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injury..
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