Interaction of Epigallocatechin Gallate and Quercetin with Spike Glycoprotein (S-Glycoprotein) of SARS-CoV-2: In Silico Study
Alavi et al.,
Interaction of Epigallocatechin Gallate and Quercetin with Spike Glycoprotein (S-Glycoprotein) of SARS-CoV-2:..,
Biomedicines, doi:10.3390/biomedicines10123074
In Silico study suggesting efficacy of epigallocatechin gallate and quercetin for SARS-CoV-2.
Alavi et al., 29 Nov 2022, Iran, peer-reviewed, 6 authors.
Contact:
mehranbio83@gmail.com (corresponding author), dr.m.r.mozafari@gmail.com.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: biomedicines
Article
Interaction of Epigallocatechin Gallate and Quercetin with
Spike Glycoprotein (S-Glycoprotein) of SARS-CoV-2:
In Silico Study
Mehran Alavi 1,2, * , M. R. Mozafari 3, * , Saba Ghaemi 4 , Morahem Ashengroph 1 ,
Fatemeh Hasanzadeh Davarani 5 and Mohammadreza Mohammadabadi 6
1
2
3
4
5
6
*
Citation: Alavi, M.; Mozafari, M.R.;
Ghaemi, S.; Ashengroph, M.;
Hasanzadeh Davarani, F.;
Mohammadabadi, M. Interaction of
Epigallocatechin Gallate and
Quercetin with Spike Glycoprotein
(S-Glycoprotein) of SARS-CoV-2: In
Silico Study. Biomedicines 2022, 10,
3074. https://doi.org/10.3390/
biomedicines10123074
Academic Editor: Santiago
Garcia-Vallve
Received: 11 October 2022
Accepted: 19 November 2022
Published: 29 November 2022
Department of Biological Science, Faculty of Science, University of Kurdistan, Kurdistan 6617715175, Iran
Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University,
Kermanshah 6714414971, Iran
Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO,
Clayton, VIC 3168, Australia
Research Committee of Medical School, Alborz University of Medical Science, Karaj 3149779453, Iran
Department of Plant Pathology, Rafsanjan Branch, Islamic Azad University, Rafsanjan 7718897111, Iran
Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman,
Kerman 7616913439, Iran
Correspondence: mehranbio83@gmail.com (M.A.); dr.m.r.mozafari@gmail.com (M.R.M.)
Abstract: Severe acute respiratory syndrome (SARS)-CoV-2 from the family Coronaviridae is the
cause of the outbreak of severe pneumonia, known as coronavirus disease 2019 (COVID-19), which
was first recognized in 2019. Various potential antiviral drugs have been presented to hinder SARSCoV-2 or treat COVID-19 disease. Side effects of these drugs are among the main complicated issues
for patients. Natural compounds, specifically primary and secondary herbal metabolites, may be
considered as alternative options to provide therapeutic activity and reduce cytotoxicity. Phenolic
materials such as epigallocatechin gallate (EGCG, polyphenol) and quercetin have shown antibacterial,
antifungal, antiviral, anticancer, and anti-inflammatory effects in vitro and in vivo. Therefore, in
this study, molecular docking was applied to measure the docking property of epigallocatechin
gallate and quercetin towards the transmembrane spike (S) glycoprotein of SARS-CoV-2. Results
of the present study showed Vina scores of −9.9 and −8.3 obtained for EGCG and quercetin by
CB-Dock. In the case of EGCG, four hydrogen bonds of OG1, OD2, O3, and O13 atoms interacted
with the Threonine (THR778) and Aspartic acid (ASP867) amino acids of the spike glycoprotein
(6VSB). According to these results, epigallocatechin gallate and quercetin can be considered potent
therapeutic compounds for addressing viral diseases.
Keywords: SARS-CoV-2; transmembrane spike glycoprotein; severe pneumonia; natural compounds;
antiviral activity
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