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All Studies   Meta Analysis    Recent:   

Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19

Fang et al., Journal of Nanobiotechnology, doi:10.1186/s12951-024-02435-2
Apr 2024  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
In Vitro study showing that nanoparticles coated with both ACE2-containing cell membranes and quercetin (CM-NP-Q) inhibit SARS-CoV-2 infection in human lung cells. Authors developed nanoparticles incorporated with quercetin (NP-Q), ACE2-containing cell membranes (CM-NP), or both (CM-NP-Q). CM-NP-Q showed the strongest antiviral activity by neutralizing extracellular pseudo-SARS-CoV-2 virus in ACE2-expressing H1975, 293T, and BEAS-2B cells, and inhibiting infection of H1299 lung cancer cells by both pseudo-SARS-CoV-2 and SARS-CoV-2/NTU13 virus. NP-Q and free quercetin also inhibited viral infection, but CM-NP-Q was most effective. The enhanced activity of CM-NP-Q is attributed to its ability to both neutralize extracellular virus through its ACE2-containing membrane and inhibit viral entry through quercetin's suppression of the AXL receptor. CM-NP-Q showed no significant cytotoxicity or in vivo toxicity in mice. The results suggest CM-NP-Q has potential as an inhaled therapy to prevent SARS-CoV-2 infection.
2 studies investigate novel formulations of quercetin for improved efficacy Fang, Vaiss
Fang et al., 12 Apr 2024, peer-reviewed, 11 authors. Contact: pcyang@ntu.edu.tw, cychen@mail.cgust.edu.tw.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperQuercetinAll
Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19
Jia-You Fang, Kuo-Yen Huang, Tong-Hong Wang, Zih-Chan Lin, Chin-Chuan Chen, Sui-Yuan Chang, En-Li Chen, Tai-Ling Chao, Shuenn-Chen Yang, Pan-Chyr Yang, Chi-Yuan Chen
Journal of Nanobiotechnology, doi:10.1186/s12951-024-02435-2
Introduction Angiotensin-converting enzyme 2 (ACE2) and AXL tyrosine kinase receptor are known to be involved in the SARS-CoV-2 entry of the host cell. Therefore, targeting ACE2 and AXL should be an effective strategy to inhibit virus entry into cells. However, developing agents that can simultaneously target ACE2 and AXL remains a formidable task. The natural compound quercetin has been shown to inhibit AXL expression. Materials and methods In this study, we employed PLGA nanoparticles to prepare nanoparticles encapsulated with quercetin, coated with ACE2-containing cell membranes, or encapsulated with quercetin and then coated with ACE-2-containing cell membranes. These nanoparticles were tested for their abilities to neutralize or inhibit viral infection. Results Our data showed that nanoparticles encapsulated with quercetin and then coated with ACE2-containing cell membrane inhibited the expression of AXL without causing cytotoxic activity. Nanoparticles incorporated with both quercetin and ACE2-containing cell membrane were found to be able to neutralize pseudo virus infection and were more effective than free quercetin and nanoparticles encapsulated with quercetin at inhibition of pseudo virus and SARS-CoV-2 infection. Conclusions We have shown that the biomimetic nanoparticles incorporated with both ACE-2 membrane and quercetin showed the most antiviral activity and may be further explored for clinical application.
Data availability All data generated for this study are included in the article. Declarations Ethics approval and consent to participate The study involving SARS-CoV-2 was approved by the National Taiwan University Hospital Research Ethics Committee (202002002RIND). All of the mouse experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Chang Gung University (IACUC approval no.: CGU110-015) and Chang Gung Memorial Hospital (IACUC approval no.: 2020121704). Consent for publication Not applicable. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Eur J Pharmacol. 2008;585:325–37.', 'volume': '585', 'year': '2008'}, { 'DOI': '10.3390/biom11091271', 'author': 'K-Y Huang', 'doi-asserted-by': 'crossref', 'first-page': '1271', 'journal-title': 'Biomolecules', 'key': '2435_CR16', 'unstructured': 'Huang K-Y, Wang T-H, Chen C-C, Leu Y-L, Li H-J, Jhong C-L, Chen C-Y. ' 'Growth suppression in Lung Cancer cells harboring EGFR-C797S mutation by ' 'Quercetin. Biomolecules. 2021;11:1271.', 'volume': '11', 'year': '2021'}, { 'DOI': '10.3831/KPI.2015.18.002', 'author': 'A Mukherjee', 'doi-asserted-by': 'crossref', 'first-page': '19', 'journal-title': 'J Pharmacopunct', 'key': '2435_CR17', 'unstructured': 'Mukherjee A, Khuda-Bukhsh AR. Quercetin Down-regulates IL-6/STAT-3 ' 'signals to induce mitochondrial-mediated apoptosis in a nonsmall- cell ' 'lung-cancer cell line, A549. 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J Mater Chem B. 2018;6:1387–93.', 'volume': '6', 'year': '2018'}, { 'author': 'MH Zhao', 'first-page': '5503', 'journal-title': 'Exp Ther Med', 'key': '2435_CR22', 'unstructured': 'Zhao MH, Yuan L, Meng LY, Qiu JL, Wang CB. Quercetin-loaded mixed ' 'micelles exhibit enhanced cytotoxic efficacy in non-small cell lung ' 'cancer in vitro. Exp Ther Med. 2017;14:5503–8.', 'volume': '14', 'year': '2017'}, { 'DOI': '10.1152/ajplung.00348.2012', 'author': 'KH Lee', 'doi-asserted-by': 'crossref', 'first-page': 'L782', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol', 'key': '2435_CR23', 'unstructured': 'Lee KH, Yoo CG. Simultaneous inactivation of GSK-3beta suppresses ' 'quercetin-induced apoptosis by inhibiting the JNK pathway. 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Eur J ' 'Pharm Sci. 2013;49:278–85.', 'volume': '49', 'year': '2013'}, { 'DOI': '10.1038/s41467-018-08074-0', 'author': 'H Taniguchi', 'doi-asserted-by': 'crossref', 'first-page': '259', 'journal-title': 'Nat Commun', 'key': '2435_CR34', 'unstructured': 'Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, ' 'Tanimoto A, Takeuchi S, Araujo LH, Boroni M, et al. AXL confers ' 'intrinsic resistance to osimertinib and advances the emergence of ' 'tolerant cells. Nat Commun. 2019;10:259.', 'volume': '10', 'year': '2019'}, { 'DOI': '10.1126/science.abb7314', 'author': 'B Rockx', 'doi-asserted-by': 'crossref', 'first-page': '1012', 'journal-title': 'Science', 'key': '2435_CR35', 'unstructured': 'Rockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, ' 'de Meulder D, van Amerongen G, van den Brand J, Okba NMA, et al. ' 'Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman ' 'primate model. Science. 2020;368:1012–5.', 'volume': '368', 'year': '2020'}, { 'DOI': '10.1021/acs.jafc.9b04154', 'author': 'WY Oh', 'doi-asserted-by': 'crossref', 'first-page': '10653', 'journal-title': 'J Agric Food Chem', 'key': '2435_CR36', 'unstructured': 'Oh WY, Ambigaipalan P, Shahidi F. Preparation of Quercetin Esters and ' 'their antioxidant activity. J Agric Food Chem. 2019;67:10653–9.', 'volume': '67', 'year': '2019'}, { 'author': 'N Rosita', 'first-page': '11', 'journal-title': 'J Adv Pharm Technol Res', 'key': '2435_CR37', 'unstructured': 'Rosita N, Ambarwati N, Erawati T, Hariyadi DM. Characterization and in ' 'vitro release of inhalation quercetin solid lipid microparticles: Effect ' 'of lipid. 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J Nanomaterials. 2012;2012:145380.', 'volume': '2012', 'year': '2012'}, { 'DOI': '10.1016/j.mehy.2020.110059', 'author': 'AK Singh', 'doi-asserted-by': 'crossref', 'first-page': '110059', 'journal-title': 'Med Hypotheses', 'key': '2435_CR40', 'unstructured': 'Singh AK, Mishra G, Maurya A, Kulkarni GT, Awasthi R. Biofabrication: an ' 'interesting tool to create in vitro model for COVID-19 drug targets. Med ' 'Hypotheses. 2020;144:110059.', 'volume': '144', 'year': '2020'}, { 'DOI': '10.15252/emmm.202012828', 'author': 'KY Huang', 'doi-asserted-by': 'crossref', 'first-page': 'e12828', 'journal-title': 'EMBO Mol Med', 'key': '2435_CR41', 'unstructured': 'Huang KY, Lin MS, Kuo TC, Chen CL, Lin CC, Chou YC, Chao TL, Pang YH, ' 'Kao HC, Huang RS, et al. Humanized COVID-19 decoy antibody effectively ' 'blocks viral entry and prevents SARS-CoV-2 infection. EMBO Mol Med. 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ACS Biomater Sci Eng. 2020;6:71–87.', 'volume': '6', 'year': '2020'}, { 'DOI': '10.2147/IJN.S416966', 'author': 'MJ Tsai', 'doi-asserted-by': 'crossref', 'first-page': '3879', 'journal-title': 'Int J Nanomed', 'key': '2435_CR44', 'unstructured': 'Tsai MJ, Lin CY, Trousil J, Sung CT, Lee MH, Fang JY, Yang SC. ' 'Proteinase K/Retinoic acid-loaded Cationic liposomes as multifunctional ' 'anti-acne therapy to Disorganize Biofilm and regulate keratinocyte ' 'proliferation. Int J Nanomed. 2023;18:3879–96.', 'volume': '18', 'year': '2023'}, { 'DOI': '10.1186/s12951-018-0364-z', 'author': 'FC Liu', 'doi-asserted-by': 'crossref', 'first-page': '35', 'journal-title': 'J Nanobiotechnol', 'key': '2435_CR45', 'unstructured': 'Liu FC, Yu HP, Lin CY, Elzoghby AO, Hwang TL, Fang JY. Use of ' 'cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation ' 'for attenuating acute lung injury: the effect of nanovesicular surface ' 'charge. J Nanobiotechnol. 2018;16:35.', 'volume': '16', 'year': '2018'}, { 'DOI': '10.1038/s41389-020-0225-0', 'author': 'TH Wang', 'doi-asserted-by': 'crossref', 'first-page': '40', 'journal-title': 'Oncogenesis', 'key': '2435_CR46', 'unstructured': 'Wang TH, Wu CC, Huang KY, Chuang WY, Hsueh C, Li HJ, Chen CY. Profiling ' 'of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR ' 'localization. Oncogenesis. 2020;9:40.', 'volume': '9', 'year': '2020'}, { 'DOI': '10.3390/molecules25040941', 'doi-asserted-by': 'crossref', 'key': '2435_CR47', 'unstructured': 'Leu YL, Wang TH, Wu CC, Huang KY, Jiang YW, Hsu YC, Chen CY. ' 'Hydroxygenkwanin suppresses Non-small Cell Lung Cancer Progression by ' 'enhancing EGFR Degradation. Molecules 2020, 25.'}, { 'DOI': '10.1158/0008-5472.CAN-12-4066', 'author': 'CY Chen', 'doi-asserted-by': 'crossref', 'first-page': '4009', 'journal-title': 'Cancer Res', 'key': '2435_CR48', 'unstructured': 'Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM, ' 'Yang PC. Tid1-L inhibits EGFR signaling in lung adenocarcinoma by ' 'enhancing EGFR Ubiquitinylation and degradation. Cancer Res. ' '2013;73:4009–19.', 'volume': '73', 'year': '2013'}, { 'DOI': '10.1186/s12931-014-0150-x', 'author': 'K Takashima', 'doi-asserted-by': 'crossref', 'first-page': '150', 'journal-title': 'Respir Res', 'key': '2435_CR49', 'unstructured': 'Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, ' 'Hasegawa Y, Kawabe T. Protective effects of intratracheally administered ' 'quercetin on lipopolysaccharide-induced acute lung injury. Respir Res. ' '2014;15:150.', 'volume': '15', 'year': '2014'}], 'reference-count': 49, 'references-count': 49, 'relation': {}, 'resource': { 'primary': { 'URL': 'https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-024-02435-2'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [ 'Pharmaceutical Science', 'Applied Microbiology and Biotechnology', 'Biomedical Engineering', 'Molecular Medicine', 'Medicine (miscellaneous)', 'Bioengineering'], 'subtitle': [], 'title': 'Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy ' 'for COVID-19', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'volume': '22'}
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