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Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections

Vaiss et al., European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2024.106766
Apr 2024  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
In Vitro and Ex Vivo study showing that curcumin and quercetin co-encapsulated in nanoemulsions (NEs) for nasal administration inhibited murine β-coronavirus (MHV-3) infection. MHV-3 belongs to the same family as SARS-CoV-2. Authors found that NEs containing curcumin (CUR) or quercetin (QUE) alone or in combination (CQ) showed up to 99% viral inhibition at a 1:100 dilution, even with brief pretreatment of the virus. The NEs were retained in porcine nasal mucosa, suggesting potential for local delivery to prevent viral entry. No significant permeation of CUR or QUE was detected, indicating suitability for local rather than systemic treatment. Co-administration of CUR and QUE in NEs by nasal route could provide local protection at the site of viral entry, with the two compounds working synergistically to prevent viral adsorption and replication while also reducing inflammation.
2 studies investigate novel formulations of quercetin for improved efficacy Fang, Vaiss
Study covers quercetin and curcumin.
Vaiss et al., 13 Apr 2024, peer-reviewed, 15 authors. Contact: cristianadora@gmail.com, fabio.sonvico@unipr.it.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperQuercetinAll
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Daniela Pastorim Vaiss, Jamile Lima Rodrigues, Virginia Campello Yurgel, Frank Do Carmo Guedes, Lauanda Larissa Mendonça Da Matta, Paula Alice Bezerra Barros, Gustavo Richter Vaz, Raíssa Nunes Dos Santos, Bibiana Franzen Matte, Larine Kupski, Jaqueline Garda-Buffon, Juliana Bidone, Ana Luiza Muccillo-Baisch, Fabio Sonvico, Cristiana Lima Dora
European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2024.106766
One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin (QUE) are two natural compounds that have been widely studied for their health benefits, such as antiviral and antiinflammatory activity. However, poor oral bioavailability limits the clinical applications of these natural compounds. In this work, nanoemulsions (NE) co-encapsulating CUR and QUE designed for nasal administration were developed as promising prophylactic and therapeutic treatments for viral respiratory infections. The NEs were prepared by high-pressure homogenization combined with the phase inversion temperature technique and evaluated for their physical and chemical characteristics. In vitro assays were performed to evaluate the nanoemulsion retention into the porcine nasal mucosa. In addition, the CUR and QUE-loaded NE antiviral activity was tested against a murine β-COV, namely MHV-3. The results evidenced that CUR and QUE loaded NE had a particle size of 400 nm and retention in the porcine nasal mucosa. The antiviral activity of the NEs showed a percentage of inhibition of around 99%, indicating that the developed NEs has interesting properties as a therapeutic and prophylactic treatment against viral respiratory infections.
experiments, analyzed the data, contributed reagents/materials/analysis tools, writingoriginal draft preparation, writing-review and editing, visualization, supervision, project administration and funding acquisition. All authors have read and agreed to the published version of the manuscript. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.
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