Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The role of vitamin D receptor and IL‐6 in COVID‐19

Azmi et al., Molecular Genetics & Genomic Medicine, doi:10.1002/mgg3.2172
Apr 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 120 hospitalized COVID-19 patients and 120 controls, showing no significant difference in vitamin D levels, however vitamin D receptor gene expression was significantly lower in COVID-19 patients.
Vitamin D receptor (VDR) gene expression refers to the process by which the vitamin D receptor protein is produced in cells from the instructions encoded in the VDR gene. The vitamin D receptor is a protein that binds to the active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3). VDR functions as a transcription factor, regulating the expression of various target genes involved in immune system function and other biological processes.
Azmi et al., 6 Apr 2023, Iran, peer-reviewed, survey, mean age 38.3, 6 authors. Contact: miladpour90@yahoo.com.
This PaperVitamin DAll
The role of vitamin D receptor and IL ‐6 in COVID‐19
Ali Azmi, Maziyar Rismani, Hossein Pourmontaseri, Ebrahim Mirzaii, Sedigheh Niknia, Behnoosh Miladpour
Molecular Genetics & Genomic Medicine, doi:10.1002/mgg3.2172
In December 2019, a new coronavirus was discovered in Wuhan named coronavirus 2019 (COVID-19) by World Health Organization (WHO). COVID-19 spread worldwide in just four months and made the main pandemic of the century (Chang et al., 2020; Guan et al., 2020). The WHO recorded around 255 million confirmed COVID-19 cases and more than 5.1 deaths associated with COVID-19 (World Health Organization, 2021). The severity of COVID-19 is associated with several supplementation disorders, such as vitamin D deficiency (VDD) (Pereira et al., 2020) . Ultraviolet rays of the sun stimulate the conversion of vitamin D3 to 7-dihydro calcium thiol under the influence of enzymatic reactions in the skin. Then, vitamin D (Vit.D) reduces the severity and mortality of viral diseases using different mechanisms,
AUTHOR CONTRIBUTIONS All authors contributed to the study conception and design. Study design, material preparation, data collection and analysis were performed by Behnoosh Miladpour. The first draft of the manuscript was written by Mziyar Rismani and Ali Azmi, experimental were performed by Sedigheh Niknia and Ebrahim Mirzaii and Hossein pourmontaseri. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. FUNDING INFORMATION This study was funded (NO: 97555) by Fasa University of Medical Sciences. Dr. Behnoosh Miladpour is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
References
Al-Anouti, Mousa, Karras, Grant, Alhalwachi et al., Associations between genetic variants in the vitamin D metabolism pathway and severity of COVID-19 among UAE residents, Journal of Infection and Public Health
Chang, Yan, Wang, Coronavirus disease 2019: Coronaviruses and blood safety, Transfusion Medicine Reviews
Charoenngam, Holick, Chen, Leng, Lu et al., Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, The Journal of Biological Chemistry
Evans, Lippman, Febriza, Natzir, Hatta et al., Shining light on the COVID-19 pandemic: A vitamin D receptor checkpoint in defense of unregulated wound healing, Open Microbiology Journal
Freeman, Swartz, Guan, Hu, Liang et al., Clinical characteristics of coronavirus disease 2019 in China, New England Journal of Medicine
Hanna, Rizzo, Halim, El Haddad, Salam et al., Vitamin D status in Hashimoto's thyroiditis and its association with vitamin D receptor genetic variants, The Journal of Steroid Biochemistry and Molecular Biology
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China, The Lancet
Jonas, Kuryłowicz, Bartoszewicz, Lisik, Jonas et al., Vitamin D receptor gene expression in adipose tissue of obese individuals is regulated by miRNA and correlates with the proinflammatory cytokine level, International Journal of Molecular Sciences
Liu, Li, Zhou, Guan, Xiang et al., Effect of high doses of vitamin D supplementation on dengue virus replication, toll-like receptor expression, and cytokine profiles on dendritic cells, Molecular and Cellular Biochemistry, doi:10.1002/mgg3.2172byCochraneJapan
Mcnally, Coughlan, Bergsson, Doyle, Taggart et al., Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis, Journal of Cystic Fibrosis
Mokhtari, Hassani, Ghaffari, Ebrahimi, Yarahmadi et al., COVID-19 and multiorgan failure: A narrative review on potential mechanisms, Journal of Molecular Histology
Nikniaz, Ghojazadeh, Nateghian, Nikniaz, Farhangi et al., The interaction effect of aerobic exercise and vitamin D supplementation on inflammatory factors, anti-inflammatory proteins, and lung function in male smokers: A randomized controlled trial, BMC Sports Science, Medicine and Rehabilitation
Orcid, Azmi, None
Pereira, Dantas Damascena, Galvão Azevedo, De Almeida, Da Mota, Vitamin D deficiency aggravates COVID-19: Systematic review and meta-analysis, Critical Reviews in Food Science and Nutrition
Pojednic, Ceglia, Lichtenstein, Dawson-Hughes, Fielding, Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle, Endocrine
Qin, Zhou, Hu, Zhang, Yang et al., Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China, Clinical Infectious Diseases
Quesada-Gomez, Entrenas-Castillo, Bouillon, coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166, The Journal of Steroid Biochemistry and Molecular Biology
Rahmadhani, Zaharan, Mohamed, Moy, Jalaludin et al., The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country, Journal of Internal Medicine
Rismani ; Abdollahzadeh, Shushizadeh, Barazandehrokh, Choopani, Azarnezhad et al., Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients, Infection, Genetics and Evolution
Rondanelli, Miccono, Lamburghini, Avanzato, Riva et al., Self-care for common colds: The pivotal role of vitamin D, vitamin C, zinc, and echinacea in three main immune interactive clusters (physical barriers, innate and adaptive immunity) Alternative Medicine, Journal of Innate Immunity
Wu, Lewis, Pae, Meydani, Xu et al., Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system, Molecular Medicine Reports
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet Respiratory Medicine
Zheng, Yang, Hu, Li, Wang et al., Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition, Molecular Genetics & Genomic Medicine
{ 'indexed': {'date-parts': [[2023, 4, 8]], 'date-time': '2023-04-08T04:57:38Z', 'timestamp': 1680929858816}, 'reference-count': 35, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2023, 4, 6]], 'date-time': '2023-04-06T00:00:00Z', 'timestamp': 1680739200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100006402', 'name': 'Fasa University of Medical Sciences', 'doi-asserted-by': 'publisher', 'award': ['97555']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'DOI': '10.1002/mgg3.2172', 'type': 'journal-article', 'created': {'date-parts': [[2023, 4, 7]], 'date-time': '2023-04-07T05:14:15Z', 'timestamp': 1680844455000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The role of vitamin D receptor and\n <scp>IL</scp>\n ‐6 in COVID‐19', 'prefix': '10.1002', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-1719-4089', 'authenticated-orcid': False, 'given': 'Ali', 'family': 'Azmi', 'sequence': 'first', 'affiliation': [ { 'name': 'Student Research Committee, Fasa University of Medical Sciences ' 'Fasa Iran'}, { 'name': 'Department of Biochemistry Fasa University of Medical Sciences ' 'Fasa Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6997-8304', 'authenticated-orcid': False, 'given': 'Maziyar', 'family': 'Rismani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Student Research Committee, Fasa University of Medical Sciences ' 'Fasa Iran'}, { 'name': 'Department of Biochemistry Fasa University of Medical Sciences ' 'Fasa Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-9629-2284', 'authenticated-orcid': False, 'given': 'Hossein', 'family': 'Pourmontaseri', 'sequence': 'additional', 'affiliation': [ { 'name': 'Student Research Committee, Fasa University of Medical Sciences ' 'Fasa Iran'}, { 'name': 'Bitab Knowledge Enterprise, Fasa University of Medical Sciences ' 'Fasa Iran'}]}, { 'given': 'Ebrahim', 'family': 'Mirzaii', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biochemistry Fasa University of Medical Sciences ' 'Fasa Iran'}]}, { 'given': 'Sedigheh', 'family': 'Niknia', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biochemistry Fasa University of Medical Sciences ' 'Fasa Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1978-1201', 'authenticated-orcid': False, 'given': 'Behnoosh', 'family': 'Miladpour', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biochemistry Fasa University of Medical Sciences ' 'Fasa Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 4, 6]]}, 'reference': [ { 'key': 'e_1_2_10_2_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.meegid.2021.105098', 'article-title': 'Association of Vitamin D receptor gene polymorphisms and ' 'clinical/severe outcomes of COVID‐19 patients', 'volume': '96', 'author': 'Abdollahzadeh R.', 'year': '2021', 'journal-title': 'Infection, Genetics and Evolution.'}, { 'issue': '11', 'key': 'e_1_2_10_3_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu13113680', 'article-title': 'Associations between genetic variants in the vitamin D metabolism ' 'pathway and severity of COVID‐19 among UAE residents', 'volume': '13', 'author': 'Al‐Anouti F.', 'year': '2021', 'journal-title': 'Nutrients'}, { 'issue': '10', 'key': 'e_1_2_10_4_1', 'doi-asserted-by': 'crossref', 'first-page': '1373', 'DOI': '10.1016/j.jiph.2020.06.021', 'article-title': 'Role of vitamin D in preventing of COVID‐19 infection, progression and ' 'severity', 'volume': '13', 'author': 'Ali N.', 'year': '2020', 'journal-title': 'Journal of Infection and Public Health.'}, { 'issue': '2', 'key': 'e_1_2_10_5_1', 'doi-asserted-by': 'crossref', 'first-page': '75', 'DOI': '10.1016/j.tmrv.2020.02.003', 'article-title': 'Coronavirus disease 2019: Coronaviruses and blood safety', 'volume': '34', 'author': 'Chang L.', 'year': '2020', 'journal-title': 'Transfusion Medicine Reviews'}, { 'issue': '7', 'key': 'e_1_2_10_6_1', 'doi-asserted-by': 'crossref', 'first-page': '2097', 'DOI': '10.3390/nu12072097', 'article-title': 'Immunologic effects of vitamin D on human health and disease', 'volume': '12', 'author': 'Charoenngam N.', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': 'e_1_2_10_7_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1017/S0950268820000151', 'article-title': 'Epidemiological features and time‐series analysis of influenza ' 'incidence in urban and rural areas of Shenyang, China, 2010–2018', 'volume': '148', 'author': 'Chen Y.', 'year': '2020', 'journal-title': 'Epidemiology & Infection.'}, { 'issue': '27', 'key': 'e_1_2_10_8_1', 'doi-asserted-by': 'crossref', 'first-page': '19450', 'DOI': '10.1074/jbc.M113.467670', 'article-title': 'Vitamin D receptor inhibits nuclear factor κB activation by interacting ' 'with IκB kinase β protein', 'volume': '288', 'author': 'Chen Y.', 'year': '2013', 'journal-title': 'The Journal of Biological Chemistry'}, { 'key': 'e_1_2_10_9_1', 'doi-asserted-by': 'crossref', 'first-page': '704', 'DOI': '10.1016/j.cmet.2020.09.007', 'article-title': 'Shining light on the COVID‐19 pandemic: A vitamin D receptor checkpoint ' 'in defense of unregulated wound healing', 'volume': '32', 'author': 'Evans R. M.', 'year': '2020', 'journal-title': 'Cell Metabolism.'}, { 'key': 'e_1_2_10_10_1', 'doi-asserted-by': 'crossref', 'first-page': '65', 'DOI': '10.2174/1874285802014010065', 'article-title': 'The role of IL‐6, TNF‐α, and VDR in inhibiting the growth of salmonella ' 'typhi: in vivo study', 'volume': '14', 'author': 'Febriza A.', 'year': '2020', 'journal-title': 'Open Microbiology Journal'}, { 'key': 'e_1_2_10_11_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2020.01518', 'article-title': 'Targeting the NLRP3 inflammasome in severe COVID‐19', 'volume': '11', 'author': 'Freeman T. L.', 'year': '2020', 'journal-title': 'Frontiers in Immunology.'}, { 'issue': '18', 'key': 'e_1_2_10_12_1', 'doi-asserted-by': 'crossref', 'first-page': '1708', 'DOI': '10.1056/NEJMoa2002032', 'article-title': 'Clinical characteristics of coronavirus disease 2019 in China', 'volume': '382', 'author': 'Guan W.‐J.', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'key': 'e_1_2_10_13_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jsbmb.2021.105922', 'article-title': "Vitamin D status in Hashimoto's thyroiditis and its association with " 'vitamin D receptor genetic variants', 'volume': '212', 'author': 'Hanna H. W. Z.', 'year': '2021', 'journal-title': 'The Journal of Steroid Biochemistry and Molecular Biology.'}, { 'issue': '10223', 'key': 'e_1_2_10_14_1', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan', 'volume': '395', 'author': 'Huang C.', 'year': '2020', 'journal-title': 'China. The Lancet'}, { 'issue': '21', 'key': 'e_1_2_10_15_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ijms20215272', 'article-title': 'Vitamin D receptor gene expression in adipose tissue of obese ' 'individuals is regulated by miRNA and correlates with the ' 'pro‐inflammatory cytokine level', 'volume': '20', 'author': 'Jonas M. I.', 'year': '2019', 'journal-title': 'International Journal of Molecular Sciences'}, { 'key': 'e_1_2_10_16_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2013.00148', 'article-title': 'The vitamin d receptor and T cell function', 'volume': '4', 'author': 'Kongsbak M.', 'year': '2013', 'journal-title': 'Frontiers in Immunology'}, { 'issue': '1', 'key': 'e_1_2_10_17_1', 'first-page': '1', 'article-title': 'An observational and mendelian randomisation study on vitamin D and ' 'COVID‐19 risk in UK biobank', 'volume': '11', 'author': 'Li X.', 'year': '2021', 'journal-title': 'Scientific Reports'}, { 'key': 'e_1_2_10_18_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaut.2020.102452', 'article-title': 'Can we use interleukin‐6 (IL‐6) blockade for coronavirus disease 2019 ' '(COVID‐19)‐induced cytokine release syndrome (CRS)?', 'volume': '111', 'author': 'Liu B.', 'year': '2020', 'journal-title': 'Journal of Autoimmunity'}, { 'key': 'e_1_2_10_19_1', 'article-title': 'Hall of fame among pro‐inflammatory cytokines: Interleukin‐6 gene and ' 'its transcriptional regulation mechanisms', 'volume': '7', 'author': 'Luo Y.', 'year': '2016', 'journal-title': 'Frontiers in Immunology'}, { 'issue': '1', 'key': 'e_1_2_10_20_1', 'doi-asserted-by': 'crossref', 'first-page': '169', 'DOI': '10.1007/s11010-019-03658-w', 'article-title': 'Effect of high doses of vitamin D supplementation on dengue virus ' 'replication, toll‐like receptor expression, and cytokine profiles on ' 'dendritic cells', 'volume': '464', 'author': 'Martínez‐Moreno J.', 'year': '2020', 'journal-title': 'Molecular and Cellular Biochemistry'}, { 'issue': '6', 'key': 'e_1_2_10_21_1', 'doi-asserted-by': 'crossref', 'first-page': '428', 'DOI': '10.1016/j.jcf.2011.06.013', 'article-title': 'Vitamin D receptor agonists inhibit pro‐inflammatory cytokine ' 'production from the respiratory epithelium in cystic fibrosis', 'volume': '10', 'author': 'McNally P.', 'year': '2011', 'journal-title': 'Journal of Cystic Fibrosis'}, { 'issue': '6', 'key': 'e_1_2_10_22_1', 'doi-asserted-by': 'crossref', 'first-page': '613', 'DOI': '10.1007/s10735-020-09915-3', 'article-title': 'COVID‐19 and multiorgan failure: A narrative review on potential ' 'mechanisms', 'volume': '51', 'author': 'Mokhtari T.', 'year': '2020', 'journal-title': 'Journal of Molecular Histology'}, { 'issue': '1', 'key': 'e_1_2_10_23_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s13102-021-00333-w', 'article-title': 'The interaction effect of aerobic exercise and vitamin D ' 'supplementation on inflammatory factors, anti‐inflammatory proteins, ' 'and lung function in male smokers: A randomized controlled trial', 'volume': '13', 'author': 'Nikniaz L.', 'year': '2021', 'journal-title': 'BMC Sports Science, Medicine and Rehabilitation'}, { 'key': 'e_1_2_10_24_1', 'first-page': '1', 'article-title': 'Vitamin D deficiency aggravates COVID‐19: Systematic review and ' 'meta‐analysis', 'volume': '62', 'author': 'Pereira M.', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '2', 'key': 'e_1_2_10_25_1', 'doi-asserted-by': 'crossref', 'first-page': '512', 'DOI': '10.1007/s12020-014-0505-6', 'article-title': 'Vitamin D receptor protein is associated with interleukin‐6 in human ' 'skeletal muscle', 'volume': '49', 'author': 'Pojednic R. M.', 'year': '2015', 'journal-title': 'Endocrine'}, { 'issue': '15', 'key': 'e_1_2_10_26_1', 'doi-asserted-by': 'crossref', 'first-page': '762', 'DOI': '10.1093/cid/ciaa248', 'article-title': 'Dysregulation of immune response in patients with coronavirus 2019 ' '(COVID‐19) in Wuhan, China', 'volume': '71', 'author': 'Qin C.', 'year': '2020', 'journal-title': 'Clinical Infectious Diseases.'}, { 'key': 'e_1_2_10_27_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jsbmb.2020.105719', 'article-title': 'Vitamin D receptor stimulation to reduce acute respiratory distress ' 'syndrome (ARDS) in patients with coronavirus SARS‐CoV‐2 infections: ' 'Revised Ms SBMB 2020_166', 'volume': '202', 'author': 'Quesada‐Gomez J. M.', 'year': '2020', 'journal-title': 'The Journal of Steroid Biochemistry and Molecular Biology.'}, { 'issue': '6', 'key': 'e_1_2_10_28_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0178695', 'article-title': 'The associations between VDR BsmI polymorphisms and risk of vitamin D ' 'deficiency, obesity and insulin resistance in adolescents residing in a ' 'tropical country', 'volume': '12', 'author': 'Rahmadhani R.', 'year': '2017', 'journal-title': 'PLoS One'}, { 'issue': '1', 'key': 'e_1_2_10_29_1', 'doi-asserted-by': 'crossref', 'first-page': '97', 'DOI': '10.1111/joim.13149', 'article-title': 'Perspective: Vitamin D deficiency and COVID‐19 severity–plausibly ' 'linked by latitude, ethnicity, impacts on cytokines, ACE2 and ' 'thrombosis', 'volume': '289', 'author': 'Rhodes J. M.', 'year': '2021', 'journal-title': 'Journal of Internal Medicine'}, { 'key': 'e_1_2_10_30_1', 'doi-asserted-by': 'crossref', 'first-page': '36', 'DOI': '10.1155/2018/5813095', 'article-title': 'Self‐care for common colds: The pivotal role of vitamin D, vitamin C, ' 'zinc, and echinacea in three main immune interactive clusters (physical ' 'barriers, innate and adaptive immunity) involved during an episode of ' 'common colds—Practical advice on dosages and on the time to take these ' 'nutrients/botanicals in order to prevent or treat common colds', 'volume': '2018', 'author': 'Rondanelli M.', 'year': '2018', 'journal-title': 'Evidence‐Based Complementary and Alternative Medicine.'}, { 'issue': '4', 'key': 'e_1_2_10_31_1', 'doi-asserted-by': 'crossref', 'first-page': '375', 'DOI': '10.1159/000455969', 'article-title': 'Vitamin D promotes pneumococcal killing and modulates inflammatory ' 'responses in primary human neutrophils', 'volume': '9', 'author': 'Subramanian K.', 'year': '2017', 'journal-title': 'Journal of Innate Immunity.'}, { 'key': 'e_1_2_10_32_1', 'unstructured': 'World Health Organization. (2021).WHO Coronavirus (COVID‐19) ' 'Dashboard.https://covid19.who.int/'}, { 'key': 'e_1_2_10_33_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2018.03160', 'article-title': 'Nutritional modulation of immune function: Analysis of evidence, ' 'mechanisms, and clinical relevance', 'volume': '9', 'author': 'Wu D.', 'year': '2019', 'journal-title': 'Frontiers in Immunology.'}, { 'issue': '5', 'key': 'e_1_2_10_34_1', 'doi-asserted-by': 'crossref', 'first-page': '7432', 'DOI': '10.3892/mmr.2017.7546', 'article-title': 'Vitamin D alleviates lipopolysaccharide‐induced acute lung injury via ' 'regulation of the renin‐angiotensin system', 'volume': '16', 'author': 'Xu J.', 'year': '2017', 'journal-title': 'Molecular Medicine Reports.'}, { 'issue': '4', 'key': 'e_1_2_10_35_1', 'doi-asserted-by': 'crossref', 'first-page': '420', 'DOI': '10.1016/S2213-2600(20)30076-X', 'article-title': 'Pathological findings of COVID‐19 associated with acute respiratory ' 'distress syndrome', 'volume': '8', 'author': 'Xu Z.', 'year': '2020', 'journal-title': 'The Lancet Respiratory Medicine.'}, { 'key': 'e_1_2_10_36_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.bcp.2020.113955', 'article-title': 'Vitamin D attenuates lung injury via stimulating epithelial repair, ' 'reducing epithelial cell apoptosis and inhibits TGF‐β induced ' 'epithelial to mesenchymal transition', 'volume': '177', 'author': 'Zheng S.', 'year': '2020', 'journal-title': 'Biochemical Pharmacology'}], 'container-title': 'Molecular Genetics &amp; Genomic Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/mgg3.2172', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 4, 7]], 'date-time': '2023-04-07T05:14:50Z', 'timestamp': 1680844490000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1002/mgg3.2172'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 4, 6]]}, 'references-count': 35, 'alternative-id': ['10.1002/mgg3.2172'], 'URL': 'http://dx.doi.org/10.1002/mgg3.2172', 'relation': {}, 'ISSN': ['2324-9269', '2324-9269'], 'subject': ['Genetics (clinical)', 'Genetics', 'Molecular Biology'], 'container-title-short': 'Molec Gen &amp; Gen Med', 'published': {'date-parts': [[2023, 4, 6]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit