The role of vitamin D receptor and IL ‐6 in COVID‐19
Ali Azmi, Maziyar Rismani, Hossein Pourmontaseri, Ebrahim Mirzaii, Sedigheh Niknia, Behnoosh Miladpour
Molecular Genetics & Genomic Medicine, doi:10.1002/mgg3.2172
In December 2019, a new coronavirus was discovered in Wuhan named coronavirus 2019 (COVID-19) by World Health Organization (WHO). COVID-19 spread worldwide in just four months and made the main pandemic of the century (Chang et al., 2020; Guan et al., 2020). The WHO recorded around 255 million confirmed COVID-19 cases and more than 5.1 deaths associated with COVID-19 (World Health Organization, 2021). The severity of COVID-19 is associated with several supplementation disorders, such as vitamin D deficiency (VDD) (Pereira et al., 2020) . Ultraviolet rays of the sun stimulate the conversion of vitamin D3 to 7-dihydro calcium thiol under the influence of enzymatic reactions in the skin. Then, vitamin D (Vit.D) reduces the severity and mortality of viral diseases using different mechanisms,
AUTHOR CONTRIBUTIONS All authors contributed to the study conception and design. Study design, material preparation, data collection and analysis were performed by Behnoosh Miladpour. The first draft of the manuscript was written by Mziyar Rismani and Ali Azmi, experimental were performed by Sedigheh Niknia and Ebrahim Mirzaii and Hossein pourmontaseri. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
FUNDING INFORMATION This study was funded (NO: 97555) by Fasa University of Medical Sciences. Dr. Behnoosh Miladpour is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
References
Al-Anouti, Mousa, Karras, Grant, Alhalwachi et al., Associations between genetic variants in the vitamin D metabolism pathway and severity of COVID-19 among UAE residents, Journal of Infection and Public Health
Chang, Yan, Wang, Coronavirus disease 2019: Coronaviruses and blood safety, Transfusion Medicine Reviews
Charoenngam, Holick, Chen, Leng, Lu et al., Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, The Journal of Biological Chemistry
Evans, Lippman, Febriza, Natzir, Hatta et al., Shining light on the COVID-19 pandemic: A vitamin D receptor checkpoint in defense of unregulated wound healing, Open Microbiology Journal
Freeman, Swartz, Guan, Hu, Liang et al., Clinical characteristics of coronavirus disease 2019 in China, New England Journal of Medicine
Hanna, Rizzo, Halim, El Haddad, Salam et al., Vitamin D status in Hashimoto's thyroiditis and its association with vitamin D receptor genetic variants, The Journal of Steroid Biochemistry and Molecular Biology
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China, The Lancet
Jonas, Kuryłowicz, Bartoszewicz, Lisik, Jonas et al., Vitamin D receptor gene expression in adipose tissue of obese individuals is regulated by miRNA and correlates with the proinflammatory cytokine level, International Journal of Molecular Sciences
Liu, Li, Zhou, Guan, Xiang et al., Effect of high doses of vitamin D supplementation on dengue virus replication, toll-like receptor expression, and cytokine profiles on dendritic cells, Molecular and Cellular Biochemistry,
doi:10.1002/mgg3.2172byCochraneJapanMcnally, Coughlan, Bergsson, Doyle, Taggart et al., Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis, Journal of Cystic Fibrosis
Mokhtari, Hassani, Ghaffari, Ebrahimi, Yarahmadi et al., COVID-19 and multiorgan failure: A narrative review on potential mechanisms, Journal of Molecular Histology
Nikniaz, Ghojazadeh, Nateghian, Nikniaz, Farhangi et al., The interaction effect of aerobic exercise and vitamin D supplementation on inflammatory factors, anti-inflammatory proteins, and lung function in male smokers: A randomized controlled trial, BMC Sports Science, Medicine and Rehabilitation
Orcid, Azmi, None
Pereira, Dantas Damascena, Galvão Azevedo, De Almeida, Da Mota, Vitamin D deficiency aggravates COVID-19: Systematic review and meta-analysis, Critical Reviews in Food Science and Nutrition
Pojednic, Ceglia, Lichtenstein, Dawson-Hughes, Fielding, Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle, Endocrine
Qin, Zhou, Hu, Zhang, Yang et al., Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China, Clinical Infectious Diseases
Quesada-Gomez, Entrenas-Castillo, Bouillon, coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166, The Journal of Steroid Biochemistry and Molecular Biology
Rahmadhani, Zaharan, Mohamed, Moy, Jalaludin et al., The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country, Journal of Internal Medicine
Rismani ; Abdollahzadeh, Shushizadeh, Barazandehrokh, Choopani, Azarnezhad et al., Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients, Infection, Genetics and Evolution
Rondanelli, Miccono, Lamburghini, Avanzato, Riva et al., Self-care for common colds: The pivotal role of vitamin D, vitamin C, zinc, and echinacea in three main immune interactive clusters (physical barriers, innate and adaptive immunity) Alternative Medicine, Journal of Innate Immunity
Wu, Lewis, Pae, Meydani, Xu et al., Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system, Molecular Medicine Reports
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet Respiratory Medicine
Zheng, Yang, Hu, Li, Wang et al., Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition, Molecular Genetics & Genomic Medicine
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'article-title': 'Association of Vitamin D receptor gene polymorphisms and '
'clinical/severe outcomes of COVID‐19 patients',
'volume': '96',
'author': 'Abdollahzadeh R.',
'year': '2021',
'journal-title': 'Infection, Genetics and Evolution.'},
{ 'issue': '11',
'key': 'e_1_2_10_3_1',
'doi-asserted-by': 'crossref',
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'article-title': 'Associations between genetic variants in the vitamin D metabolism '
'pathway and severity of COVID‐19 among UAE residents',
'volume': '13',
'author': 'Al‐Anouti F.',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'issue': '10',
'key': 'e_1_2_10_4_1',
'doi-asserted-by': 'crossref',
'first-page': '1373',
'DOI': '10.1016/j.jiph.2020.06.021',
'article-title': 'Role of vitamin D in preventing of COVID‐19 infection, progression and '
'severity',
'volume': '13',
'author': 'Ali N.',
'year': '2020',
'journal-title': 'Journal of Infection and Public Health.'},
{ 'issue': '2',
'key': 'e_1_2_10_5_1',
'doi-asserted-by': 'crossref',
'first-page': '75',
'DOI': '10.1016/j.tmrv.2020.02.003',
'article-title': 'Coronavirus disease 2019: Coronaviruses and blood safety',
'volume': '34',
'author': 'Chang L.',
'year': '2020',
'journal-title': 'Transfusion Medicine Reviews'},
{ 'issue': '7',
'key': 'e_1_2_10_6_1',
'doi-asserted-by': 'crossref',
'first-page': '2097',
'DOI': '10.3390/nu12072097',
'article-title': 'Immunologic effects of vitamin D on human health and disease',
'volume': '12',
'author': 'Charoenngam N.',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'key': 'e_1_2_10_7_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1017/S0950268820000151',
'article-title': 'Epidemiological features and time‐series analysis of influenza '
'incidence in urban and rural areas of Shenyang, China, 2010–2018',
'volume': '148',
'author': 'Chen Y.',
'year': '2020',
'journal-title': 'Epidemiology & Infection.'},
{ 'issue': '27',
'key': 'e_1_2_10_8_1',
'doi-asserted-by': 'crossref',
'first-page': '19450',
'DOI': '10.1074/jbc.M113.467670',
'article-title': 'Vitamin D receptor inhibits nuclear factor κB activation by interacting '
'with IκB kinase β protein',
'volume': '288',
'author': 'Chen Y.',
'year': '2013',
'journal-title': 'The Journal of Biological Chemistry'},
{ 'key': 'e_1_2_10_9_1',
'doi-asserted-by': 'crossref',
'first-page': '704',
'DOI': '10.1016/j.cmet.2020.09.007',
'article-title': 'Shining light on the COVID‐19 pandemic: A vitamin D receptor checkpoint '
'in defense of unregulated wound healing',
'volume': '32',
'author': 'Evans R. M.',
'year': '2020',
'journal-title': 'Cell Metabolism.'},
{ 'key': 'e_1_2_10_10_1',
'doi-asserted-by': 'crossref',
'first-page': '65',
'DOI': '10.2174/1874285802014010065',
'article-title': 'The role of IL‐6, TNF‐α, and VDR in inhibiting the growth of salmonella '
'typhi: in vivo study',
'volume': '14',
'author': 'Febriza A.',
'year': '2020',
'journal-title': 'Open Microbiology Journal'},
{ 'key': 'e_1_2_10_11_1',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fimmu.2020.01518',
'article-title': 'Targeting the NLRP3 inflammasome in severe COVID‐19',
'volume': '11',
'author': 'Freeman T. L.',
'year': '2020',
'journal-title': 'Frontiers in Immunology.'},
{ 'issue': '18',
'key': 'e_1_2_10_12_1',
'doi-asserted-by': 'crossref',
'first-page': '1708',
'DOI': '10.1056/NEJMoa2002032',
'article-title': 'Clinical characteristics of coronavirus disease 2019 in China',
'volume': '382',
'author': 'Guan W.‐J.',
'year': '2020',
'journal-title': 'New England Journal of Medicine'},
{ 'key': 'e_1_2_10_13_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jsbmb.2021.105922',
'article-title': "Vitamin D status in Hashimoto's thyroiditis and its association with "
'vitamin D receptor genetic variants',
'volume': '212',
'author': 'Hanna H. W. Z.',
'year': '2021',
'journal-title': 'The Journal of Steroid Biochemistry and Molecular Biology.'},
{ 'issue': '10223',
'key': 'e_1_2_10_14_1',
'doi-asserted-by': 'crossref',
'first-page': '497',
'DOI': '10.1016/S0140-6736(20)30183-5',
'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in '
'Wuhan',
'volume': '395',
'author': 'Huang C.',
'year': '2020',
'journal-title': 'China. The Lancet'},
{ 'issue': '21',
'key': 'e_1_2_10_15_1',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/ijms20215272',
'article-title': 'Vitamin D receptor gene expression in adipose tissue of obese '
'individuals is regulated by miRNA and correlates with the '
'pro‐inflammatory cytokine level',
'volume': '20',
'author': 'Jonas M. I.',
'year': '2019',
'journal-title': 'International Journal of Molecular Sciences'},
{ 'key': 'e_1_2_10_16_1',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fimmu.2013.00148',
'article-title': 'The vitamin d receptor and T cell function',
'volume': '4',
'author': 'Kongsbak M.',
'year': '2013',
'journal-title': 'Frontiers in Immunology'},
{ 'issue': '1',
'key': 'e_1_2_10_17_1',
'first-page': '1',
'article-title': 'An observational and mendelian randomisation study on vitamin D and '
'COVID‐19 risk in UK biobank',
'volume': '11',
'author': 'Li X.',
'year': '2021',
'journal-title': 'Scientific Reports'},
{ 'key': 'e_1_2_10_18_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jaut.2020.102452',
'article-title': 'Can we use interleukin‐6 (IL‐6) blockade for coronavirus disease 2019 '
'(COVID‐19)‐induced cytokine release syndrome (CRS)?',
'volume': '111',
'author': 'Liu B.',
'year': '2020',
'journal-title': 'Journal of Autoimmunity'},
{ 'key': 'e_1_2_10_19_1',
'article-title': 'Hall of fame among pro‐inflammatory cytokines: Interleukin‐6 gene and '
'its transcriptional regulation mechanisms',
'volume': '7',
'author': 'Luo Y.',
'year': '2016',
'journal-title': 'Frontiers in Immunology'},
{ 'issue': '1',
'key': 'e_1_2_10_20_1',
'doi-asserted-by': 'crossref',
'first-page': '169',
'DOI': '10.1007/s11010-019-03658-w',
'article-title': 'Effect of high doses of vitamin D supplementation on dengue virus '
'replication, toll‐like receptor expression, and cytokine profiles on '
'dendritic cells',
'volume': '464',
'author': 'Martínez‐Moreno J.',
'year': '2020',
'journal-title': 'Molecular and Cellular Biochemistry'},
{ 'issue': '6',
'key': 'e_1_2_10_21_1',
'doi-asserted-by': 'crossref',
'first-page': '428',
'DOI': '10.1016/j.jcf.2011.06.013',
'article-title': 'Vitamin D receptor agonists inhibit pro‐inflammatory cytokine '
'production from the respiratory epithelium in cystic fibrosis',
'volume': '10',
'author': 'McNally P.',
'year': '2011',
'journal-title': 'Journal of Cystic Fibrosis'},
{ 'issue': '6',
'key': 'e_1_2_10_22_1',
'doi-asserted-by': 'crossref',
'first-page': '613',
'DOI': '10.1007/s10735-020-09915-3',
'article-title': 'COVID‐19 and multiorgan failure: A narrative review on potential '
'mechanisms',
'volume': '51',
'author': 'Mokhtari T.',
'year': '2020',
'journal-title': 'Journal of Molecular Histology'},
{ 'issue': '1',
'key': 'e_1_2_10_23_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1186/s13102-021-00333-w',
'article-title': 'The interaction effect of aerobic exercise and vitamin D '
'supplementation on inflammatory factors, anti‐inflammatory proteins, '
'and lung function in male smokers: A randomized controlled trial',
'volume': '13',
'author': 'Nikniaz L.',
'year': '2021',
'journal-title': 'BMC Sports Science, Medicine and Rehabilitation'},
{ 'key': 'e_1_2_10_24_1',
'first-page': '1',
'article-title': 'Vitamin D deficiency aggravates COVID‐19: Systematic review and '
'meta‐analysis',
'volume': '62',
'author': 'Pereira M.',
'year': '2020',
'journal-title': 'Critical Reviews in Food Science and Nutrition'},
{ 'issue': '2',
'key': 'e_1_2_10_25_1',
'doi-asserted-by': 'crossref',
'first-page': '512',
'DOI': '10.1007/s12020-014-0505-6',
'article-title': 'Vitamin D receptor protein is associated with interleukin‐6 in human '
'skeletal muscle',
'volume': '49',
'author': 'Pojednic R. M.',
'year': '2015',
'journal-title': 'Endocrine'},
{ 'issue': '15',
'key': 'e_1_2_10_26_1',
'doi-asserted-by': 'crossref',
'first-page': '762',
'DOI': '10.1093/cid/ciaa248',
'article-title': 'Dysregulation of immune response in patients with coronavirus 2019 '
'(COVID‐19) in Wuhan, China',
'volume': '71',
'author': 'Qin C.',
'year': '2020',
'journal-title': 'Clinical Infectious Diseases.'},
{ 'key': 'e_1_2_10_27_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jsbmb.2020.105719',
'article-title': 'Vitamin D receptor stimulation to reduce acute respiratory distress '
'syndrome (ARDS) in patients with coronavirus SARS‐CoV‐2 infections: '
'Revised Ms SBMB 2020_166',
'volume': '202',
'author': 'Quesada‐Gomez J. M.',
'year': '2020',
'journal-title': 'The Journal of Steroid Biochemistry and Molecular Biology.'},
{ 'issue': '6',
'key': 'e_1_2_10_28_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0178695',
'article-title': 'The associations between VDR BsmI polymorphisms and risk of vitamin D '
'deficiency, obesity and insulin resistance in adolescents residing in a '
'tropical country',
'volume': '12',
'author': 'Rahmadhani R.',
'year': '2017',
'journal-title': 'PLoS One'},
{ 'issue': '1',
'key': 'e_1_2_10_29_1',
'doi-asserted-by': 'crossref',
'first-page': '97',
'DOI': '10.1111/joim.13149',
'article-title': 'Perspective: Vitamin D deficiency and COVID‐19 severity–plausibly '
'linked by latitude, ethnicity, impacts on cytokines, ACE2 and '
'thrombosis',
'volume': '289',
'author': 'Rhodes J. M.',
'year': '2021',
'journal-title': 'Journal of Internal Medicine'},
{ 'key': 'e_1_2_10_30_1',
'doi-asserted-by': 'crossref',
'first-page': '36',
'DOI': '10.1155/2018/5813095',
'article-title': 'Self‐care for common colds: The pivotal role of vitamin D, vitamin C, '
'zinc, and echinacea in three main immune interactive clusters (physical '
'barriers, innate and adaptive immunity) involved during an episode of '
'common colds—Practical advice on dosages and on the time to take these '
'nutrients/botanicals in order to prevent or treat common colds',
'volume': '2018',
'author': 'Rondanelli M.',
'year': '2018',
'journal-title': 'Evidence‐Based Complementary and Alternative Medicine.'},
{ 'issue': '4',
'key': 'e_1_2_10_31_1',
'doi-asserted-by': 'crossref',
'first-page': '375',
'DOI': '10.1159/000455969',
'article-title': 'Vitamin D promotes pneumococcal killing and modulates inflammatory '
'responses in primary human neutrophils',
'volume': '9',
'author': 'Subramanian K.',
'year': '2017',
'journal-title': 'Journal of Innate Immunity.'},
{ 'key': 'e_1_2_10_32_1',
'unstructured': 'World Health Organization. (2021).WHO Coronavirus (COVID‐19) '
'Dashboard.https://covid19.who.int/'},
{ 'key': 'e_1_2_10_33_1',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fimmu.2018.03160',
'article-title': 'Nutritional modulation of immune function: Analysis of evidence, '
'mechanisms, and clinical relevance',
'volume': '9',
'author': 'Wu D.',
'year': '2019',
'journal-title': 'Frontiers in Immunology.'},
{ 'issue': '5',
'key': 'e_1_2_10_34_1',
'doi-asserted-by': 'crossref',
'first-page': '7432',
'DOI': '10.3892/mmr.2017.7546',
'article-title': 'Vitamin D alleviates lipopolysaccharide‐induced acute lung injury via '
'regulation of the renin‐angiotensin system',
'volume': '16',
'author': 'Xu J.',
'year': '2017',
'journal-title': 'Molecular Medicine Reports.'},
{ 'issue': '4',
'key': 'e_1_2_10_35_1',
'doi-asserted-by': 'crossref',
'first-page': '420',
'DOI': '10.1016/S2213-2600(20)30076-X',
'article-title': 'Pathological findings of COVID‐19 associated with acute respiratory '
'distress syndrome',
'volume': '8',
'author': 'Xu Z.',
'year': '2020',
'journal-title': 'The Lancet Respiratory Medicine.'},
{ 'key': 'e_1_2_10_36_1',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.bcp.2020.113955',
'article-title': 'Vitamin D attenuates lung injury via stimulating epithelial repair, '
'reducing epithelial cell apoptosis and inhibits TGF‐β induced '
'epithelial to mesenchymal transition',
'volume': '177',
'author': 'Zheng S.',
'year': '2020',
'journal-title': 'Biochemical Pharmacology'}],
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