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The role of vitamin D receptor and IL‐6 in COVID‐19

Azmi et al., Molecular Genetics & Genomic Medicine, doi:10.1002/mgg3.2172
Apr 2023  
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Retrospective 120 hospitalized COVID-19 patients and 120 controls, showing no significant difference in vitamin D levels, however vitamin D receptor gene expression was significantly lower in COVID-19 patients.
Vitamin D receptor (VDR) gene expression refers to the process by which the vitamin D receptor protein is produced in cells from the instructions encoded in the VDR gene. The vitamin D receptor is a protein that binds to the active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3). VDR functions as a transcription factor, regulating the expression of various target genes involved in immune system function and other biological processes.
Azmi et al., 6 Apr 2023, Iran, peer-reviewed, survey, mean age 38.3, 6 authors.
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The role of vitamin D receptor and IL ‐6 in COVID‐19
Ali Azmi, Maziyar Rismani, Hossein Pourmontaseri, Ebrahim Mirzaii, Sedigheh Niknia, Behnoosh Miladpour
Molecular Genetics & Genomic Medicine, doi:10.1002/mgg3.2172
In December 2019, a new coronavirus was discovered in Wuhan named coronavirus 2019 (COVID-19) by World Health Organization (WHO). COVID-19 spread worldwide in just four months and made the main pandemic of the century (Chang et al., 2020; Guan et al., 2020). The WHO recorded around 255 million confirmed COVID-19 cases and more than 5.1 deaths associated with COVID-19 (World Health Organization, 2021). The severity of COVID-19 is associated with several supplementation disorders, such as vitamin D deficiency (VDD) (Pereira et al., 2020) . Ultraviolet rays of the sun stimulate the conversion of vitamin D3 to 7-dihydro calcium thiol under the influence of enzymatic reactions in the skin. Then, vitamin D (Vit.D) reduces the severity and mortality of viral diseases using different mechanisms,
AUTHOR CONTRIBUTIONS All authors contributed to the study conception and design. Study design, material preparation, data collection and analysis were performed by Behnoosh Miladpour. The first draft of the manuscript was written by Mziyar Rismani and Ali Azmi, experimental were performed by Sedigheh Niknia and Ebrahim Mirzaii and Hossein pourmontaseri. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. FUNDING INFORMATION This study was funded (NO: 97555) by Fasa University of Medical Sciences. Dr. Behnoosh Miladpour is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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