Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All quercetin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchQuercetinQuercetin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications

Singh et al., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, doi:10.1016/j.bbadis.2021.166322
Dec 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
In Vitro study transfecting SARS-CoV-2 viral spike protein in kidney cell lines, showing syncytia formation and upregulation of the cytoprotective gene HO-1, and that quercetin, which induces HO-1, can reduce syncytia formation. Authors conclude that quercetin may be protective for AKI in COVID-19.
In Silico studies predict inhibition of SARS-CoV-2, or minimization of side effects, with quercetin or metabolites via binding to the spike Note A, Alavi, Azmi (B), Chandran, Kandeil, Mandal, Moschovou, Nguyen, Pan, Thapa (B), Şimşek, Mpro Note B, Akinwumi, Alanzi, Ibeh, Kandeil, Mandal, Moschovou, Nguyen, Qin, Rehman, Sekiou (B), Singh, Thapa (B), Wang, Zhang, Shaik, Waqas, Nalban, Irfan, RNA-dependent RNA polymerase Note C, Corbo, PLpro Note D, Ibeh, Zhang, ACE2 Note E, Chandran, Ibeh, Qin, Thapa (B), Şimşek, Alkafaas, TMPRSS2 Note F, Chandran, helicase Note G, Alanzi, Singh (B), endoribonuclease Note H, Alavi, cathepsin L Note I, Ahmed, Wnt-3 Note J, Chandran, FZD Note K, Chandran, LRP6 Note L, Chandran, ezrin Note M, Chellasamy, ADRP Note N, Nguyen, NRP1 Note O, Şimşek, EP300 Note P, Hasanah, PTGS2 Note Q, Qin, HSP90AA1 Note R, Qin, Hasanah, matrix metalloproteinase 9 Note S, Sai Ramesh, IL-6 Note T, Yang, Yang (B), IL-10 Note U, Yang, VEGFA Note V, Yang (B), and RELA Note W, Yang (B) proteins. In Vitro studies demonstrate efficacy in Calu-3 Note X, DiGuilio, A549 Note Y, Yang, HEK293-ACE2+ Note Z, Singh (C), Huh-7 Note AA, Pan, Caco-2 Note AB, Roy, Vero E6 Note AC, Kandeil, El-Megharbel, Roy, mTEC Note AD, Wu, and RAW264.7 Note AE, Wu cells. Animal studies demonstrate efficacy in K18-hACE2 mice Note AF, Aguado, db/db mice Note AG, Wu, Wu (B), BALB/c mice Note AH, Shaker, and rats El-Megharbel (B). Quercetin reduced proinflammatory cytokines and protected lung and kidney tissue against LPS-induced damage in mice Shaker.
Singh et al., 14 Dec 2021, peer-reviewed, 9 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperQuercetinAll
The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications
Ph.D Raman Deep Singh, Ph.D Michael A Barry, Anthony J Croatt, M.S Allan W Ackerman, M.D Joseph P Grande, Ph.D Rosa M Diaz, Ph.D Richard G Vile, M.D Anupam Agarwal, MB. ChB Karl A Nath
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, doi:10.1016/j.bbadis.2021.166322
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Authors' contributions Raman Deep Singh: Conceptualisation, data curation, formal analysis, investigation, methodology, project administration, resources, software, validation, visualisation, writingoriginal draft, and writingreview & editing. Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J o u r n a l P r e -p r o o f
References
Agarwal, Bolisetty, Adaptive responses to tissue injury: role of heme oxygenase-1, Trans Am Clin Climatol Assoc
Batra, Souza, Batra, Raetz, Yu, The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19), Int J Mol Sci
Bortolotti, Gentili, Rizzo, Rotola, Rizzo, SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway, Cells
Braun, Lutgehetmann, Pfefferle, Wong, Carsten et al., SARS-CoV-2 renal tropism associates with acute kidney injury, Lancet
Buchrieser, Dufloo, Hubert, Monel, Planas et al., Syncytia formation by SARS-CoV-2-infected cells, Embo j
Buzhdygan, Deore, Baldwin-Leclair, Bullock, Mcgary et al., The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier, Neurobiol Dis
Caceres, Savickas, Murray, Umanath, Uduman et al., High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19
Diniz, Souza, Duarte, Sousa, Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury, Molecules
Fakhouri, Peterson, Kothari, Shapiro, Abraham, Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm, Antioxidants
Funes, Rios, Fernández-Fierro, Covián, Bueno et al., Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases, Front Immunol
Furuichi, Wada, Iwata, Kitagawa, Kobayashi et al., CCR2 signaling contributes to ischemia-reperfusion injury in kidney, J Am Soc Nephrol
Furuichi, Wada, Iwata, Kitagawa, Kobayashi et al., Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury, J Am Soc Nephrol
Gao, Zeng, Jia, Stavenhagen, Matsumoto et al., SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors
George, Pal, Gagnon, Timalsina, Singh et al., Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 patients, doi:Kidney360.2021:10.34067/KID.0002172021
Gu, Zhang, Cen, Wu, Lu et al., Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study, PLoS One
Gupta, Madhavan, Sehgal, Nair, Mahajan et al., Extrapulmonary manifestations of COVID-19, Nat Med
Han, Pandey, ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial Plasminogen Activator Inhibitor-1, Am J Respir Cell Mol Biol
Hoffmann, Kleine-Weber, Schroeder, Kruger, Herrler et al., SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell
J O U R N A L P R E, -p r o o f Journal Pre-proof
J O U R N A L P R E, -p r o o f Journal Pre-proof
Kelly, Williams, Colvin, Bonventre, Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury, Proc Natl Acad Sci U S A
Kelly, Williams, Colvin, Meehan, Springer et al., Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury, J Clin Invest
Khan, Chen, Yang, Raghuram, Khundmiri et al., Does SARS-CoV-2 Infect the Kidney?, J Am Soc Nephrol
Lei, Zhang, Schiavon, He, Chen et al., SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2, Circ Res
Musarrat, Chouljenko, Dahal, Nabi, Chouljenko et al., The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 J o u r n a l P r e -p r o o f Journal Pre-proof spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections, J Med Virol
Nadim, Forni, Mehta, Connor, Liu et al., COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup, Nat Rev Nephrol
Nath, Garovic, Grande, Croatt, Ackerman et al., Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex, Am J Physiol Renal Physiol
Nath, Grande, Belcher, Garovic, Croatt et al., Antithrombotic effects of heme-degrading and heme-binding proteins, Am J Physiol Heart Circ Physiol
Nath, Heme oxygenase-1 and acute kidney injury, Curr Opin Nephrol Hypertens
Ou, Liu, Lei, Li, Mi et al., Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV, Nat Commun
Paola, Genovese, Impellizzeri, Ahmad, Cuzzocrea et al., The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment, Eur J Pharmacol
Puelles, Lutgehetmann, Lindenmeyer, Sperhake, Wong et al., Multiorgan and Renal Tropism of SARS-CoV-2, N Engl J Med
Ratajczak, Bujko, Ciechanowicz, Sielatycka, Cymer et al., SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(-) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome, Stem Cell Rev Rep
Rivero, Merino-López, Olmedo, Garrido-Roldan, Moguel et al., Association between Postmortem Kidney Biopsy Findings and Acute Kidney Injury from Patients with SARS-CoV-2 (COVID-19), Clin J Am Soc Nephrol
Rossi, Piagnerelli, Van Meerhaeghe, Boudjeltia, Heme oxygenase-1 (HO-1) cytoprotective pathway: A potential treatment strategy against coronavirus disease 2019 (COVID-19)-induced cytokine storm syndrome, Med Hypotheses
Saeedi-Boroujeni, Mr, Anti-inflammatory potential of Quercetin in COVID-19 treatment, J Inflamm (Lond)
Shoskes, Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents, Transplantation
Singh, Wasan, Reeta, Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications, Free Radic Biol Med
Sparks, South, Badley, Baker-Smith, Batlle et al., Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices, Hypertension
Su, Lin, Hang, Wu, Cheng et al., Desaturation and heme elevation during COVID-19 infection: A potential prognostic factor of heme oxygenase-1, J Microbiol Immunol Infect
Vijayan, Humphreys, SARS-CoV-2 in the kidney: bystander or culprit?, Nat Rev Nephrol
Wagener, Pickkers, Peterson, Immenschuh, Abraham, Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections, Antioxidants
Xia, Shen, He, Pan, Liu et al., SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Cell Res
Yu, Yuan, Chen, Chaturvedi, Braunstein et al., Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition, Blood
{ 'DOI': '10.1016/j.bbadis.2021.166322', 'ISSN': ['0925-4439'], 'URL': 'http://dx.doi.org/10.1016/j.bbadis.2021.166322', 'alternative-id': ['S0925443921002556'], 'article-number': '166322', 'author': [ {'affiliation': [], 'family': 'Singh', 'given': 'Raman Deep', 'sequence': 'first'}, {'affiliation': [], 'family': 'Barry', 'given': 'Michael A.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Croatt', 'given': 'Anthony J.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ackerman', 'given': 'Allan W.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Grande', 'given': 'Joseph P.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Diaz', 'given': 'Rosa M.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Vile', 'given': 'Richard G.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Agarwal', 'given': 'Anupam', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nath', 'given': 'Karl A.', 'sequence': 'additional'}], 'container-title': ['Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease'], 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': { 'date-parts': [[2021, 12, 14]], 'date-time': '2021-12-14T17:10:51Z', 'timestamp': 1639501851000}, 'deposited': { 'date-parts': [[2021, 12, 14]], 'date-time': '2021-12-14T17:11:27Z', 'timestamp': 1639501887000}, 'indexed': { 'date-parts': [[2021, 12, 16]], 'date-time': '2021-12-16T08:31:03Z', 'timestamp': 1639643463725}, 'is-referenced-by-count': 0, 'issn-type': [{'type': 'print', 'value': '0925-4439'}], 'issued': {'date-parts': [[2021, 12]]}, 'language': 'en', 'license': [ { 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 12, 1]], 'date-time': '2021-12-01T00:00:00Z', 'timestamp': 1638316800000}}], 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0925443921002556?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0925443921002556?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'member': '78', 'original-title': [], 'page': '166322', 'prefix': '10.1016', 'published': {'date-parts': [[2021, 12]]}, 'published-print': {'date-parts': [[2021, 12]]}, 'publisher': 'Elsevier BV', 'reference': [ { 'DOI': '10.1038/s41591-020-0968-3', 'article-title': 'Extrapulmonary manifestations of COVID-19', 'author': 'Gupta', 'doi-asserted-by': 'crossref', 'first-page': '1017', 'issue': '7', 'journal-title': 'Nat. Med.', 'key': '10.1016/j.bbadis.2021.166322_bb0005', 'volume': '26', 'year': '2020'}, { 'DOI': '10.1038/s41581-020-00356-5', 'article-title': 'COVID-19-associated acute kidney injury: consensus report of the 25th ' 'acute disease quality initiative (ADQI) workgroup', 'author': 'Nadim', 'doi-asserted-by': 'crossref', 'first-page': '747', 'issue': '12', 'journal-title': 'Nat. Rev. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0010', 'volume': '16', 'year': '2020'}, { 'DOI': '10.1161/HYPERTENSIONAHA.120.15948', 'article-title': 'Severe acute respiratory syndrome coronavirus 2, COVID-19, and the ' 'renin-angiotensin system: pressing needs and best research practices', 'author': 'Sparks', 'doi-asserted-by': 'crossref', 'first-page': '1350', 'issue': '5', 'journal-title': 'Hypertension', 'key': '10.1016/j.bbadis.2021.166322_bb0015', 'volume': '76', 'year': '2020'}, { 'DOI': '10.1016/j.cell.2020.02.052', 'article-title': 'SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a ' 'clinically proven protease inhibitor', 'author': 'Hoffmann', 'doi-asserted-by': 'crossref', 'first-page': '271', 'issue': '2', 'journal-title': 'Cell', 'key': '10.1016/j.bbadis.2021.166322_bb0020', 'volume': '181', 'year': '2020'}, { 'DOI': '10.1038/s41467-020-15562-9', 'article-title': 'Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and ' 'its immune cross-reactivity with SARS-CoV', 'author': 'Ou', 'doi-asserted-by': 'crossref', 'first-page': '1620', 'issue': '1', 'journal-title': 'Nat. Commun.', 'key': '10.1016/j.bbadis.2021.166322_bb0025', 'volume': '11', 'year': '2020'}, { 'article-title': 'SARS-CoV-2 spike protein interacts with multiple innate immune ' 'receptors', 'author': 'Gao', 'journal-title': 'bioRxiv.', 'key': '10.1016/j.bbadis.2021.166322_bb0030', 'year': '2020'}, { 'DOI': '10.1007/s12015-019-09951-x', 'article-title': 'SARS-CoV-2 entry receptor ACE2 is expressed on very small CD45(-) ' 'precursors of hematopoietic and endothelial cells and in response to ' 'virus spike protein activates the Nlrp3 inflammasome', 'author': 'Ratajczak', 'doi-asserted-by': 'crossref', 'first-page': '1', 'journal-title': 'Stem Cell Rev. Rep.', 'key': '10.1016/j.bbadis.2021.166322_bb0035', 'year': '2020'}, { 'DOI': '10.1182/blood.2020008248', 'article-title': 'Direct activation of the alternative complement pathway by SARS-CoV-2 ' 'spike proteins is blocked by factor D inhibition', 'author': 'Yu', 'doi-asserted-by': 'crossref', 'first-page': '2080', 'issue': '18', 'journal-title': 'Blood', 'key': '10.1016/j.bbadis.2021.166322_bb0040', 'volume': '136', 'year': '2020'}, { 'DOI': '10.1016/j.nbd.2020.105131', 'article-title': 'The SARS-CoV-2 spike protein alters barrier function in 2D static and ' '3D microfluidic in-vitro models of the human blood-brain barrier', 'author': 'Buzhdygan', 'doi-asserted-by': 'crossref', 'journal-title': 'Neurobiol. Dis.', 'key': '10.1016/j.bbadis.2021.166322_bb0045', 'volume': '146', 'year': '2020'}, { 'DOI': '10.1161/CIRCRESAHA.121.318902', 'article-title': 'SARS-CoV-2 spike protein impairs endothelial function via ' 'downregulation of ACE 2', 'author': 'Lei', 'doi-asserted-by': 'crossref', 'first-page': '1323', 'issue': '9', 'journal-title': 'Circ. Res.', 'key': '10.1016/j.bbadis.2021.166322_bb0050', 'volume': '128', 'year': '2021'}, { 'DOI': '10.1165/rcmb.2020-0544OC', 'article-title': 'ZMPSTE24 regulates SARS-CoV-2 spike protein-enhanced expression of ' 'endothelial plasminogen activator Inhibitor-1', 'author': 'Han', 'doi-asserted-by': 'crossref', 'journal-title': 'Am. J. Respir. Cell Mol. Biol.', 'key': '10.1016/j.bbadis.2021.166322_bb0055', 'year': '2021'}, { 'DOI': '10.3390/cells9091975', 'article-title': 'SARS-CoV-2 spike 1 protein controls natural killer cell activation via ' 'the HLA-E/NKG2A pathway', 'author': 'Bortolotti', 'doi-asserted-by': 'crossref', 'first-page': '15', 'issue': '9', 'journal-title': 'Cells', 'key': '10.1016/j.bbadis.2021.166322_bb0060', 'volume': '9', 'year': '2020'}, { 'DOI': '10.1016/S0140-6736(20)31759-1', 'article-title': 'SARS-CoV-2 renal tropism associates with acute kidney injury', 'author': 'Braun', 'doi-asserted-by': 'crossref', 'first-page': '597', 'issue': '10251', 'journal-title': 'Lancet', 'key': '10.1016/j.bbadis.2021.166322_bb0065', 'volume': '396', 'year': '2020'}, { 'DOI': '10.1681/ASN.2020081229', 'article-title': 'Does SARS-CoV-2 infect the Kidney?', 'author': 'Khan', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Am. Soc. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0070', 'year': '2020'}, { 'DOI': '10.1056/NEJMc2011400', 'article-title': 'Multiorgan and renal tropism of SARS-CoV-2', 'author': 'Puelles', 'doi-asserted-by': 'crossref', 'first-page': '590', 'issue': '6', 'journal-title': 'N. Engl. J. Med.', 'key': '10.1016/j.bbadis.2021.166322_bb0075', 'volume': '383', 'year': '2020'}, { 'DOI': '10.1038/s41581-020-00354-7', 'article-title': 'SARS-CoV-2 in the kidney: bystander or culprit?', 'author': 'Vijayan', 'doi-asserted-by': 'crossref', 'first-page': '703', 'issue': '12', 'journal-title': 'Nat. Rev. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0080', 'volume': '16', 'year': '2020'}, { 'DOI': '10.1681/ASN.2021010059', 'article-title': 'High SARS-CoV-2 viral load in urine sediment correlates with acute ' 'kidney injury and poor COVID-19 outcome', 'author': 'Caceres', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Am. Soc. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0085', 'year': '2021'}, { 'article-title': 'Evidence for SARS-CoV-2 spike protein in the urine of COVID-19 patients', 'author': 'George', 'journal-title': 'Kidney', 'key': '10.1016/j.bbadis.2021.166322_bb0090', 'volume': '360', 'year': '2021'}, { 'DOI': '10.1152/ajpheart.00280.2019', 'article-title': 'Antithrombotic effects of heme-degrading and heme-binding proteins', 'author': 'Nath', 'doi-asserted-by': 'crossref', 'issue': '3', 'journal-title': 'Am J Physiol Heart Circ Physiol.', 'key': '10.1016/j.bbadis.2021.166322_bb0095', 'volume': '318', 'year': '2020'}, { 'DOI': '10.1152/ajprenal.00085.2019', 'article-title': 'Heme oxygenase-2 protects against ischemic acute kidney injury: ' 'influence of age and sex', 'author': 'Nath', 'doi-asserted-by': 'crossref', 'first-page': 'F695', 'issue': '3', 'journal-title': 'Am. J. Physiol. Renal. Physiol.', 'key': '10.1016/j.bbadis.2021.166322_bb0100', 'volume': '317', 'year': '2019'}, { 'DOI': '10.1038/s41422-021-00519-4', 'article-title': 'SARS-CoV-2 envelope protein causes acute respiratory distress syndrome ' '(ARDS)-like pathological damages and constitutes an antiviral target', 'author': 'Xia', 'doi-asserted-by': 'crossref', 'first-page': '847', 'issue': '8', 'journal-title': 'Cell Res.', 'key': '10.1016/j.bbadis.2021.166322_bb0105', 'volume': '31', 'year': '2021'}, { 'DOI': '10.3389/fimmu.2020.01467', 'article-title': 'Naturally derived heme-oxygenase 1 inducers and their therapeutic ' 'application to immune-mediated diseases', 'author': 'Funes', 'doi-asserted-by': 'crossref', 'first-page': '1467', 'journal-title': 'Front. Immunol.', 'key': '10.1016/j.bbadis.2021.166322_bb0110', 'volume': '11', 'year': '2020'}, { 'DOI': '10.2215/CJN.16281020', 'article-title': 'Association between postmortem kidney biopsy findings and acute kidney ' 'injury from patients with SARS-CoV-2 (COVID-19)', 'author': 'Rivero', 'doi-asserted-by': 'crossref', 'journal-title': 'Clin. J. Am. Soc. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0115', 'year': '2021'}, { 'DOI': '10.15252/embj.2020106267', 'article-title': 'Syncytia formation by SARS-CoV-2-infected cells', 'author': 'Buchrieser', 'doi-asserted-by': 'crossref', 'journal-title': 'EMBO J.', 'key': '10.1016/j.bbadis.2021.166322_bb0120', 'year': '2020'}, { 'DOI': '10.1002/jmv.25985', 'article-title': 'The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor ' 'of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein ' 'warranting further evaluation as an antiviral against COVID-19 ' 'infections', 'author': 'Musarrat', 'doi-asserted-by': 'crossref', 'journal-title': 'J. Med. Virol.', 'key': '10.1016/j.bbadis.2021.166322_bb0125', 'year': '2020'}, { 'DOI': '10.1016/j.ejphar.2012.11.066', 'article-title': 'The renal injury and inflammation caused by ischemia-reperfusion are ' 'reduced by genetic inhibition of TNF-αR1: a comparison with infliximab ' 'treatment', 'author': 'Di Paola', 'doi-asserted-by': 'crossref', 'first-page': '134', 'issue': '1–3', 'journal-title': 'Eur. J. Pharmacol.', 'key': '10.1016/j.bbadis.2021.166322_bb0130', 'volume': '700', 'year': '2013'}, { 'DOI': '10.1097/01.ASN.0000059339.14780.E4', 'article-title': 'Gene therapy expressing amino-terminal truncated monocyte ' 'chemoattractant protein-1 prevents renal ischemia-reperfusion injury', 'author': 'Furuichi', 'doi-asserted-by': 'crossref', 'first-page': '1066', 'issue': '4', 'journal-title': 'J. Am. Soc. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0135', 'volume': '14', 'year': '2003'}, { 'DOI': '10.1097/01.ASN.0000089563.63641.A8', 'article-title': 'CCR2 signaling contributes to ischemia-reperfusion injury in kidney', 'author': 'Furuichi', 'doi-asserted-by': 'crossref', 'first-page': '2503', 'issue': '10', 'journal-title': 'J. Am. Soc. Nephrol.', 'key': '10.1016/j.bbadis.2021.166322_bb0140', 'volume': '14', 'year': '2003'}, { 'DOI': '10.1073/pnas.91.2.812', 'article-title': 'Antibody to intercellular adhesion molecule 1 protects the kidney ' 'against ischemic injury', 'author': 'Kelly', 'doi-asserted-by': 'crossref', 'first-page': '812', 'issue': '2', 'journal-title': 'Proc. Natl. Acad. Sci. U. S. A.', 'key': '10.1016/j.bbadis.2021.166322_bb0145', 'volume': '91', 'year': '1994'}, { 'DOI': '10.1172/JCI118498', 'article-title': 'Intercellular adhesion molecule-1-deficient mice are protected against ' 'ischemic renal injury', 'author': 'Kelly', 'doi-asserted-by': 'crossref', 'first-page': '1056', 'issue': '4', 'journal-title': 'J. Clin. Invest.', 'key': '10.1016/j.bbadis.2021.166322_bb0150', 'volume': '97', 'year': '1996'}, { 'article-title': 'Adaptive responses to tissue injury: role of heme oxygenase-1', 'author': 'Agarwal', 'first-page': '111', 'journal-title': 'Trans. Am. Clin. Climatol. Assoc.', 'key': '10.1016/j.bbadis.2021.166322_bb0155', 'volume': '124', 'year': '2013'}, { 'DOI': '10.1097/01.mnh.0000437613.88158.d3', 'article-title': 'Heme oxygenase-1 and acute kidney injury', 'author': 'Nath', 'doi-asserted-by': 'crossref', 'first-page': '17', 'issue': '1', 'journal-title': 'Curr. Opin. Nephrol. Hypertens.', 'key': '10.1016/j.bbadis.2021.166322_bb0160', 'volume': '23', 'year': '2014'}, { 'DOI': '10.3390/ijms21176412', 'article-title': 'The HMOX1 pathway as a promising target for the treatment and ' 'prevention of SARS-CoV-2 of 2019 (COVID-19)', 'author': 'Batra', 'doi-asserted-by': 'crossref', 'issue': '17', 'journal-title': 'Int. J. Mol. Sci.', 'key': '10.1016/j.bbadis.2021.166322_bb0165', 'volume': '21', 'year': '2020'}, { 'article-title': 'Genetic polymorphisms complicate COVID-19 therapy: pivotal role of HO-1 ' 'in cytokine storm', 'author': 'Fakhouri', 'issue': '7', 'journal-title': 'Antioxidants (Basel)', 'key': '10.1016/j.bbadis.2021.166322_bb0170', 'volume': '9', 'year': '2020'}, { 'DOI': '10.1016/j.mehy.2020.110242', 'article-title': 'Heme oxygenase-1 (HO-1) cytoprotective pathway: a potential treatment ' 'strategy against coronavirus disease 2019 (COVID-19)-induced cytokine ' 'storm syndrome', 'author': 'Rossi', 'doi-asserted-by': 'crossref', 'journal-title': 'Med. Hypotheses', 'key': '10.1016/j.bbadis.2021.166322_bb0175', 'volume': '144', 'year': '2020'}, { 'DOI': '10.1016/j.freeradbiomed.2020.10.016', 'article-title': 'Heme oxygenase-1 modulation: a potential therapeutic target for ' 'COVID-19 and associated complications', 'author': 'Singh', 'doi-asserted-by': 'crossref', 'first-page': '263', 'journal-title': 'Free Radic. Biol. Med.', 'key': '10.1016/j.bbadis.2021.166322_bb0180', 'volume': '161', 'year': '2020'}, { 'article-title': 'Targeting the heme-heme oxygenase system to prevent severe ' 'complications following COVID-19 infections', 'author': 'Wagener', 'issue': '6', 'journal-title': 'Antioxidants (Basel)', 'key': '10.1016/j.bbadis.2021.166322_bb0185', 'volume': '9', 'year': '2020'}, { 'DOI': '10.1016/j.jmii.2020.10.001', 'article-title': 'Desaturation and heme elevation during COVID-19 infection: a potential ' 'prognostic factor of heme oxygenase-1', 'author': 'Su', 'doi-asserted-by': 'crossref', 'first-page': '113', 'issue': '1', 'journal-title': 'J. Microbiol. Immunol. Infect.', 'key': '10.1016/j.bbadis.2021.166322_bb0190', 'volume': '54', 'year': '2021'}, { 'DOI': '10.1186/s12950-021-00268-6', 'article-title': 'Anti-inflammatory potential of quercetin in COVID-19 treatment', 'author': 'Saeedi-Boroujeni', 'doi-asserted-by': 'crossref', 'first-page': '3', 'issue': '1', 'journal-title': 'J. Inflamm. (Lond).', 'key': '10.1016/j.bbadis.2021.166322_bb0195', 'volume': '18', 'year': '2021'}, { 'DOI': '10.1097/00007890-199807270-00001', 'article-title': 'Effect of bioflavonoids quercetin and curcumin on ischemic renal ' 'injury: a new class of renoprotective agents', 'author': 'Shoskes', 'doi-asserted-by': 'crossref', 'first-page': '147', 'issue': '2', 'journal-title': 'Transplantation', 'key': '10.1016/j.bbadis.2021.166322_bb0200', 'volume': '66', 'year': '1998'}, { 'DOI': '10.3390/molecules25235772', 'article-title': 'Mechanistic aspects and therapeutic potential of quercetin against ' 'COVID-19-associated acute kidney injury', 'author': 'Diniz', 'doi-asserted-by': 'crossref', 'issue': '23', 'journal-title': 'Molecules', 'key': '10.1016/j.bbadis.2021.166322_bb0205', 'volume': '25', 'year': '2020'}, { 'DOI': '10.1371/journal.pone.0245209', 'article-title': 'Quercetin as a potential treatment for COVID-19-induced acute kidney ' 'injury: based on network pharmacology and molecular docking study', 'author': 'Gu', 'doi-asserted-by': 'crossref', 'issue': '1', 'journal-title': 'PLoS One', 'key': '10.1016/j.bbadis.2021.166322_bb0210', 'volume': '16', 'year': '2021'}], 'reference-count': 42, 'references-count': 42, 'relation': {}, 'score': 1, 'short-container-title': ['Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease'], 'short-title': [], 'source': 'Crossref', 'subject': ['Molecular Biology', 'Molecular Medicine'], 'subtitle': [], 'title': ['The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications'], 'type': 'journal-article'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit