Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All quercetin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchQuercetinQuercetin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Active ingredient and mechanistic analysis of traditional Chinese medicine formulas for the prevention and treatment of COVID-19: Insights from bioinformatics and in vitro experiments

Yang et al., Medicine, doi:10.1097/MD.0000000000036238
Dec 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Analysis of TCM treatments for COVID-19 including In Silico and In Vitro analysis of quercetin, a common ingredient in TCM treatments. Results suggest that quercetin may help alleviate COVID-19-associated inflammation by reducing levels of the proinflammatory cytokine IL-6 and increasing levels of the anti-inflammatory cytokine IL-10. Molecular docking analysis indicates that quercetin can directly bind to and modulate IL-6 and IL-10. In TNF-⍺ induced inflammation of cultured lung cells, quercetin treatment prevented increases in IL-6 and enhanced IL-10 levels. These computational predictions and cell culture data indicate that quercetin may help control aberrant inflammatory responses in COVID-19 through effects on key regulatory cytokines.
In Silico studies predict inhibition of SARS-CoV-2, or minimization of side effects, with quercetin or metabolites via binding to the spike Note A, Alavi, Azmi (B), Chandran, Kandeil, Mandal, Moschovou, Nguyen, Pan, Thapa (B), Şimşek, Mpro Note B, Akinwumi, Alanzi, Ibeh, Kandeil, Mandal, Moschovou, Nguyen, Qin, Rehman, Sekiou (B), Singh, Thapa (B), Wang, Zhang, RNA-dependent RNA polymerase Note C, Corbo, PLpro Note D, Ibeh, Zhang, ACE2 Note E, Chandran, Ibeh, Qin, Thapa (B), Şimşek, Alkafaas, TMPRSS2 Note F, Chandran, helicase Note G, Alanzi, Singh (B), endoribonuclease Note H, Alavi, cathepsin L Note I, Ahmed, Wnt-3 Note J, Chandran, FZD Note K, Chandran, LRP6 Note L, Chandran, ezrin Note M, Chellasamy, ADRP Note N, Nguyen, NRP1 Note O, Şimşek, PTGS2 Note P, Qin, HSP90AA1 Note Q, Qin, matrix metalloproteinase 9 Note R, Sai Ramesh, IL-6 Note S, Yang, Yang (B), IL-10 Note T, Yang, VEGFA Note U, Yang (B), and RELA Note V, Yang (B) proteins. In Vitro studies demonstrate efficacy in Calu-3 Note W, DiGuilio, A549 Note X, Yang, HEK293-ACE2+ Note Y, Singh (C), Huh-7 Note Z, Pan, Caco-2 Note AA, Roy, Vero E6 Note AB, Kandeil, El-Megharbel, Roy, mTEC Note AC, Wu, and RAW264.7 Note AD, Wu cells. Animal studies demonstrate efficacy in K18-hACE2 mice Note AE, Aguado, rats El-Megharbel (B), and db/db mice Note AF, Wu, Wu (B).
Yang et al., 1 Dec 2023, peer-reviewed, 4 authors. Contact: liuxl@qlu.edu.cn.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperQuercetinAll
Active ingredient and mechanistic analysis of traditional Chinese medicine formulas for the prevention and treatment of COVID-19: Insights from bioinformatics and in vitro experiments
ME a Jiakai Yang, PhD Qianqian Zhuang, ME a , Chi Zhang, PhD Xinli Liu
Medicine, doi:10.1097/md.0000000000036238
Coronavirus disease 2019 (COVID-19 ) is an acute infectious disease caused by a novel coronavirus. Traditional Chinese medicine (TCM) has been proven to have a potential curative effect on COVID-19. This study preliminarily analyzed the existing TCM prescription's key components and action mechanisms for preventing and treating COVID-19 using bioinformatic and experimental methods. Association and clustering analysis reveals that the "HQ + FF + BZ" drug combination had a strong correlation and confidence in 93 TCM prescriptions and may affect the progression of COVID-19 through inflammatory pathways such as the TNF signaling pathway. Further molecular docking revealed that quercetin has a higher affinity for IL6 and IL10 in the TNF signaling pathway associated with COVID-19. In vitro experiments demonstrated that quercetin could effectively reduce the levels of the inflammatory factor IL-6 and increase the anti-inflammatory factor IL-10, alleviating inflammation impact on cells. Our results provide a new understanding of the molecular mechanism of TCM prevention and treatment of COVID-19, which is helpful to the development of new diagnosis and treatment schemes for COVID-19.
Author contributions Conceptualization: Jiakai Yang. Data curation: Jiakai Yang, Chi Zhang.
References
Adasme, Linnemann, Bolz, PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA, Nucleic Acids Res
Burley, Bhikadiya, Bi, RCSB protein data bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences, Nucleic Acids Res
Catherine, Robert, Robin, Severity of omicron (B11529) and DELTA (B16172) SARS-CoV-2 infection among hospitalized adults: a prospective cohort study in Bristol, United Kingdom, Lancet Reg Health Eur
Dong, Study on the Anti-inflammatory Effect of Quercetin on Lipopolysaccharide-INDUCED enteritis
Edgar, Domrachev, Lash, Gene expression omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res
Eun, Jun, Jin, Anti-inflammatory effect of taxifolin in TNF-α/IL-17A/IFN-γ induced HaCaT human keratinocytes, Appl Biol Chem
Eva, Ján, Kristína, Quercetin ameliorates testicular damage in Zucker diabetic fatty rats through its antioxidant, anti-inflammatory, and anti-apoptotic properties, Int J Mol Sci
Georgia, Eleni, Coagulation profile of COVID-19 patients, Life
Gil, Naomi, Inbar, The GeneCards suite: from gene data mining to disease genome sequence analyses, Curr Protoc Bioinform
Hai-Yu, Yan-Qiong, Zhen-Ming, ETCM: an encyclopedia of traditional Chinese medicine, Nucleic Acids Res
He, Li, Zeng, Feasibility of Yupingfeng powder in preventing and treating COVID-19 infection in children with deficiency syndrome of spontaneous perspiration aged 1 to 6 years based on "preventing disease before it occurs" theory, China Folk Med
Hoffmann, Kleine-Weber, Schroeder, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Hoffmann, Kleine-Weber, Schroeder, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Hojyo, Uchida, Tanaka, How COVID-19 induces cytokine storm with high mortality, Inflamm Regen
Huang Da, Sherman, Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protocols
Janet, Manuel, Josep, The DisGeNET knowledge platform for disease genomics: 2019 update, Nucleic Acids Res
Jiang, Deng, Zhang, Review of the clinical characteristics of coronavirus disease 2019 (COVID-19), J Gen Intern Med
Jiménez, Doerr, Martínez-Rosell, New Bioinformatics Study Results Reported from the University of Pompeu Fabra (DeepSite: Protein binding site predictor using 3D-convolutional neural networks), Network Weekly News
Laskowski, Swindells, LigPlot+: multiple ligand-protein interaction diagrams for drug discovery, J Chem Inf Model
Lei, Chen, Li, Quercetin C inhibits TNFα-induced endothelial cell inflammation by upregulating Krüppel-like factor 2, Acta Pharmaceutica Sinica
Li, Li, Gu, Retrospection and reflection on the prevention and treatment of COVID-19 with traditional Chinese medicine based on the theory of "preventing disease before it occurs, Chin J Med Mater
Li, Shen, Wan, Pharmaceutical evaluation of Lianhua Qingwen granules combined with other drugs on clinical efficacy of COVID-19 caused by Omicron variant, Tradit Chin Med
Li, Zhang, Xia, Clinical observation of Xuanfei Baidu decoction in the treatment of severe COVID-19 cases, Chin J Tradit Chin Med
Ma, Huang, Zhu, Investigation of the mechanism of Hunan COVID-19 formula 2 in preventing influenza virus in immunosuppressed mice based on network pharmacology and experimental verification, Chin J Immunol
Nie, Xu, Wang, BDNF regulates airway ASMC inflammation via the TrkB-PKC-Ca2+ signaling pathway, Chin J Immunol
Pang, Michael, Vipin, Introduction to data mining
Paul, Andrew, Owen, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res
Philippe, Jérôme, Frédéric, jvenn: an interactive Venn diagram viewer, BMC Bioinf
Preventive, Association, COVID-19 Control Expert Group. Latest understanding of the epidemiological characteristics of COVID-19, Chin J Viral Dis
Ru, Li, Wang, TCMSP: a database of systems pharmacology for drug discovery from herbal medicines, J Cheminf
Sasidharan, Patra, Khan, Differential expression of inflammatory cytokines, prostaglandin synthases and secretory leukocyte protease inhibitor in the endometrium and circulation in different graded CEH-pyometra in bitch, Theriogenology
Sherman, Hao, Qiu, DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update), Nucleic Acids Res
Shi, Zeng, Huang, Research progress of antiviral activity of quercetin and its derivatives, Chin J Mod Appl Pharmacy
Van De Berg, Mulder, Alnima, MaastrICCht Collaborators. Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: observations from maastricht intensive care COVID cohort&#13, Front Cardiovasc Med
Wang, Horby, Hayden, A novel coronavirus outbreak of global health concern, Lancet
Wang, Li, Guo, A retrospective study on the clinical efficacy of Qingfei Paidu decoction combined with conventional Western medicine in treating 157 elderly patients with COVID-19
Wang, Liu, Xing, Overview of K-means clustering algorithm research, J East China Jiaotong Univ
Wei, Su, Observation on the clinical efficacy of Yupingfeng granules in the treatment of asthma in children during the remission period, Mod Tradit Chin Med
Who, WHO Coronavirus (COVID-19) dashboard
Wilson, Kealy, James, Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19, iScience
Wishart, Knox, Guo, DrugBank: a comprehensive resource for in silico drug discovery and exploration, Nucleic Acids Res
Wu, Focus on the latest research progress of epidemiology at the 2022 Shanghai Infectious Disease Forum, Shanghai and Technology News
Wu, Wang, Liu, Abnormal coagulation function in patients with COVID-19 and its possible mechanisms and treatment strategies, J Shanghai Univ Tradit Chin Med
Wu, Wei, Sang, Global development and prospects of antiviral drug research, Chin J Biotechnol
Xiangjing, Yanling, Yishan, Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine, a natural product from Nelumbo nucifera Gaertn, Cell J
Xu, Zhong, Deng, High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of the oral mucosa, Int J Oral Sci
Xue, Yuanjian, Shuwei, Data mining and network pharmacology analysis of kidney-tonifying herbs on the treatment of renal osteodystrophy based on the theory of "Kidney Governing Bones" in traditional Chinese medicine, Evid-Based Complement Alternat Med
Ying, Yintao, Xichen, Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents, Nucleic Acids Res
Yu, Qiu, Zhong, Latest research and development progress of drugs for COVID-19, China Pharm Ind J
Zhang, Xiao, Xu, Clinical application observation of Yupingfeng granules in children with Mycoplasma pneumoniae pneumonia, Contemp Med
Zheng, Lu, Clinical observation of modified Xiaochaihu decoction combined with Yupingfeng powder in the treatment of suspected COVID-19 cases, J Liaoning Univ Tradit Chin Med
Zhongyang, Feifei, Yong, BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional Chinese medicine, Sci Rep
Zhou, Yang, Wang, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit