In Vitro study
Yan and associated response from the original authors
Xu, collectively showing that quercetin and echinatin had weak SARS-CoV-2 protease inhibition in SDS-PAGE assays
Xu, despite false positive FRET results from MCA-AVLQ quenching
Xu, Yan. Authors note that the compounds may act via other targets to achieve reported anti-COVID-19 effects
Xu, and underscore the importance of meticulous validation with multiple assays when identifying SARS-CoV-2 protease inhibitors
Xu, Yan.
Yan et al., 5 Sep 2023, peer-reviewed, 5 authors.
Contact:
yanchang.wang@med.fsu.edu, chenyunyu1984@163.com.