Hunt68%0.32 · 0.15–0.67death Hassan (RCT)−40%1.40 · 0.48–4.12hosp.7/505/50 Hassan (RCT)4%0.96 · 0.68–1.37no recov.27/5028/50 Inokuchi (RCT)67%0.33 · 0.03–3.29hosp.1/232/15OT¹ CT² Inokuchi (RCT)24%0.76 · 0.35–1.67no recov.8/216/12OT¹ CT² Inokuchi (RCT)−17%1.17 · 0.66–2.07recov. time21 (n)12 (n)OT¹ CT² Deftereos (RCT)77%0.23 · 0.03–1.97death1/554/50GRECCO-19 Deftereos (RCT)82%0.18 · 0.02–1.50ventilation1/555/50GRECCO-19 Deftereos (RCT)87%0.13 · 0.01–0.97progression1/557/50GRECCO-19 Lopes (DB RCT)80%0.20 · 0.01–4.03death0/362/36 Lopes (DB RCT)50%0.50 · 0.10–2.56ICU2/364/36 Lopes (DB RCT)22%0.78 · 0.64–0.94hosp. time36 (n)36 (n) Brunetti (PSM)73%0.27 · 0.08–0.89death3/3311/33 Brunetti (PSM)73%0.27 · 0.08–0.89no disch.3/3311/33 Scarsi85%0.15 · 0.06–0.37death122 (n)140 (n) Salehzadeh (RCT)23%0.77 · 0.66–0.90hosp. time50 (n)50 (n) Pinzón35%0.65 · 0.34–1.21death14/14523/156 Sandhu42%0.58 · 0.40–0.85death16/3463/78 Sandhu53%0.47 · 0.33–0.67ventilation16/3468/68 Sandhu42%0.58 · 0.40–0.85no disch.16/3463/78 Rodriguez-Nava6%0.94 · 0.61–1.47death16/5285/261 Mahale−7%1.07 · 0.59–1.96death11/3925/95 Valerio Pas.. (ICU)23%0.77 · 0.31–1.94death5/3512/30ICU patients CT² Valerio Pas.. (ICU)40%0.60 · 0.38–0.95ICU35 (n)30 (n)ICU patients CT² Tardif (DB RCT)44%0.56 · 0.19–1.67death5/2,2359/2,253COLCORONA Tardif (DB RCT)20%0.80 · 0.62–1.03death/hosp.104/2,235131/2,253COLCORONA Tardif (DB RCT)47%0.53 · 0.25–1.09ventilation11/2,23521/2,253COLCORONA Tardif (DB RCT)20%0.80 · 0.61–1.03hosp.101/2,235128/2,253COLCORONA Mareev80%0.20 · 0.01–4.01death0/212/22 Mareev50%0.50 · 0.24–1.04no recov.21 (n)22 (n) Mareev71%0.29 · 0.13–0.63no recov.21 (n)22 (n) Mareev67%0.33 · 0.10–1.07no recov.21 (n)22 (n) Mareev26%0.74 · 0.53–1.04hosp. time21 (n)22 (n) Manenti (PSW)76%0.24 · 0.09–0.67death71 (n)70 (n) Manenti (PSW)44%0.56 · 0.31–1.00no recov.71 (n)70 (n) Horby (RCT)−1%1.01 · 0.94–1.08death1,394/5,6101,408/5,730RECOVERY Horby (RCT)−1%1.01 · 0.93–1.10death1,173/5,6101,190/5,730RECOVERY Horby (RCT)−18%1.18 · 0.99–1.40ventilation259/3,815228/3,962RECOVERY Horby (RCT)−2%1.02 · 0.96–1.09death/int.1,344/5,3421,343/5,469RECOVERY Horby (RCT)−2%1.02 · 0.97–1.06no disch.1,709/5,6101,698/5,730RECOVERY Hueda-Zavaleta54%0.46 · 0.23–0.91death10/50109/301 Gaitán-Dua.. (RCT)22%0.78 · 0.44–1.36death22/15328/161CT² Pascual-Fi.. (RCT)80%0.20 · 0.01–4.03death0/522/51 Pascual-Fi.. (RCT)80%0.20 · 0.01–4.03ventilation0/522/51 Pascual-Fi.. (RCT)51%0.49 · 0.09–2.56ICU2/524/51 Pascual-Fi.. (RCT)87%0.13 · 0.01–0.717-point status3/527/51 Pascual-Fi.. (RCT)80%0.20 · 0.01–4.037-point status0/522/51 Pascual-Fi.. (RCT)−15%1.15 · 0.87–1.51hosp. time52 (n)51 (n) Dorward (RCT)70%0.30 · 0.01–7.37death0/1561/120PRINCIPLE Dorward (RCT)−30%1.30 · 0.42–3.84death/hosp.6/1564/133PRINCIPLE Dorward (RCT)22%0.78 · 0.30–1.73death/hosp.6/156119/1,145PRINCIPLE Dorward (RCT)−6%1.06 · 0.81–1.39no recov.156 (n)133 (n)PRINCIPLE Absalón-.. (DB RCT)29%0.71 · 0.21–2.40death4/566/60 Absalón-.. (DB RCT)17%0.83 · 0.35–1.93progression56 (n)60 (n) Absalón-.. (DB RCT)−13%1.13 · 0.76–1.66no recov.56 (n)60 (n) Diaz (RCT)12%0.88 · 0.70–1.12death131/640142/639 Diaz (RCT)17%0.83 · 0.67–1.02death/int.160/640184/639 Diaz (RCT)52%0.48 · 0.18–1.27death/int.6/9313/102 Diaz (RCT)17%0.83 · 0.64–1.07death98/515140/634 Diaz (RCT)25%0.75 · 0.60–0.95death/int.117/515181/634 Alsultan (RCT)36%0.64 · 0.20–2.07death3/147/21 Karakaş13%0.87 · 0.46–1.64death16/16519/171 Karakaş16%0.84 · 0.55–1.29ICU30/16537/171 Karakaş25%0.75 · 0.65–0.87hosp. time165 (n)171 (n) Pourdowlat (RCT)73%0.27 · 0.11–0.71hosp.5/10218/100 Pourdowlat (RCT)38%0.62 · 0.41–0.94no recov.89 (n)63 (n) Pourdowlat (RCT)22%0.78 · 0.60–1.00no recov.89 (n)63 (n) Gorial (RCT)67%0.33 · 0.04–3.14death1/803/80 Gorial (RCT)63%0.37 · 0.21–0.67no recov.80 (n)80 (n) Pimenta B.. (RCT)79%0.21 · 0.01–4.05death0/142/16STRUCK Pimenta B.. (RCT)85%0.15 · 0.01–2.69no improv.0/143/16STRUCK Jalal (RCT)24%0.76 · 0.62–0.93hosp. time36 (n)44 (n) Cecconi (DB RCT)29%0.71 · 0.28–1.79death7/11910/120 Cecconi (DB RCT)50%0.50 · 0.18–1.43ventilation5/11910/120 Cecconi (DB RCT)21%0.79 · 0.38–1.67ICU11/11914/120 Cecconi (DB RCT)15%0.85 · 0.50–1.43NIV/ICU/vent./death21/11925/120 Eikelboom (RCT)−8%1.08 · 0.91–1.29death264/1,304249/1,307ACT inpatient Eikelboom (RCT)−4%1.04 · 0.90–1.21progression368/1,304356/1,307ACT inpatient Eikelboom (RCT)2%0.98 · 0.82–1.17progression246/1,304252/1,307ACT inpatient Eikelboom (RCT)−9%1.09 · 0.48–2.47death12/1,93911/1,942ACT outpatient Eikelboom (RCT)−2%1.02 · 0.72–1.43death/hosp.66/1,93965/1,942ACT outpatient Eikelboom (RCT)−2%1.02 · 0.71–1.45hosp.62/1,93961/1,942ACT outpatient Perricone (RCT)−36%1.36 · 0.45–4.11death7/775/75COLVID-19 Perricone (RCT)−7%1.07 · 0.48–2.37progression11/7710/75COLVID-19 Perricone (RCT)−30%1.30 · 0.30–5.61ventilation4/773/75COLVID-19 Perricone (RCT)76%0.24 · 0.03–2.13ICU1/774/75COLVID-19 Perricone (RCT)4%0.96 · 0.79–1.17hosp. time77 (n)75 (n)COLVID-19 Rahman (DB RCT)71%0.29 · 0.10–0.92death4/14613/146 Rahman (DB RCT)71%0.29 · 0.10–0.92progression4/14613/146 Rahman (DB RCT)61%0.39 · 0.08–2.02death2/1465/146 Rahman (DB RCT)51%0.49 · 0.09–2.68ventilation2/1464/146 Rahman (DB RCT)56%0.44 · 0.13–1.43progression4/1469/146 Hueda-Zavaleta−33%1.33 · 0.75–2.36death18/5233/148Ventilated patients Haroon (RCT)34%0.66 · 0.40–1.10no recov.48 (n)48 (n) Kasiri (DB RCT)7%0.93 · 0.32–2.69death6/556/51 Kasiri (DB RCT)7%0.93 · 0.32–2.69ventilation6/556/51 Kasiri (DB RCT)−24%1.24 · 0.57–2.69ICU12/559/51 Kasiri (DB RCT)28%0.72 · 0.29–1.79no recov.7/559/51 Kasiri (DB RCT)12%0.88 · 0.55–1.43no recov.20/5521/51 Kasiri (DB RCT)14%0.86 · 0.73–1.01recov. time55 (n)51 (n) Sunil Naik (RCT)−169%2.69 · 0.11–64.60death1/620/43 Sunil Naik (RCT)−108%2.08 · 0.22–19.34progression3/621/43 Sunil Naik (RCT)7%0.93 · 0.82–1.04no recov.62 (n)43 (n) Sunil Naik (RCT)15%0.85 · 0.73–0.99no recov.49/6240/43 Sunil Naik (RCT)24%0.76 · 0.60–0.95no recov.62 (n)43 (n) Shah (RCT)−75%1.75 · 0.53–5.83death7/1254/125COLSTATCT² Shah (RCT)−100%2.00 · 0.51–7.82death6/1253/125COLSTATCT² Shah (RCT)−200%3.00 · 0.62–14.58ventilation6/1252/125COLSTATCT² Shah (RCT)−46%1.46 · 0.76–2.83severe case19/12513/125COLSTATCT² Shah (RCT)−73%1.73 · 0.86–3.48severe case19/12511/125COLSTATCT² Villamañán42%0.58 · 0.33–0.96death19/11132/111 Mehrizi−13%1.13 · 1.08–1.19deathpopulation-based cohort Yadollahza.. (RCT)33%0.67 · 0.28–1.60death6/269/26 Vaziri (RCT)81%0.19 · 0.04–0.88death2/1087/71CT² Vaziri (RCT)89%0.11 · 0.01–0.89death1/1086/71CT² Vaziri (RCT)87%0.13 · 0.03–0.58ICU2/10810/71CT² Vaziri (RCT)35%0.65 · 0.58–0.73hosp. time108 (n)71 (n)CT² Gertner (RCT)65%0.35 · 0.10–1.27ICU67 (n)70 (n)COLTREXONE Gertner (RCT)43%0.57 · 0.27–1.20no recov.67 (n)70 (n)COLTREXONE Gertner (RCT)24%0.76 · 0.55–1.10no recov.67 (n)70 (n)COLTREXONE Gertner (RCT)34%0.66 · 0.28–1.53oxygen67 (n)70 (n)COLTREXONE Gertner (RCT)20%0.80 · 0.59–1.07hosp. time67 (n)70 (n)COLTREXONE Landi (RCT)−4%1.04 · 0.06–16.56hosp.30 (n)29 (n)CONVINCE Landi (RCT)−5%1.05 · 0.07–16.68oxygen30 (n)29 (n)CONVINCE Landi (RCT)40%0.60 · 0.23–1.54misc.30 (n)29 (n)CONVINCE Landi (RCT)11%0.89 · 0.41–1.93viral+30 (n)29 (n)CONVINCE Madrid-García−37%1.37 · 0.48–3.90deathn/an/a Madrid-García−137%2.37 · 0.64–8.73hosp.n/an/a Ozcifci4%0.96 · 0.75–1.22cases130/61685/421 Monserrat .. (PSM)80%0.20 · 0.02–0.93deathn/an/a Topless23%0.77 · 0.56–1.07deathpopulation-based cohort Oztas−406%5.06 · 0.59–43.22hosp.5/6351/643 Oztas−73%1.73 · 0.96–3.11symp. case29/63517/643 Oztas−24%1.24 · 0.81–1.92cases43/63535/643 Avanoglu Guler79%0.21 · 0.04–0.83oxygen6/663/7 Correa-Rodríguez−150%2.50 · 0.10–60.63oxygen1/1630/81 Correa-Rodríguez−150%2.50 · 0.10–60.63hosp.1/1630/81 Correa-Rodríguez7%0.93 · 0.51–1.70no recov.13/247/12 Correa-Rodríguez1%0.99 · 0.52–1.88cases24/16312/81 Sáenz-Aldea−8%1.08 · 0.76–1.53hosp.case-control study Sáenz-Aldea−12%1.12 · 0.91–1.37casescase-control study Chevalier−28%1.28 · 0.51–2.35death5/21111/569 Chevalier8%0.92 · 0.36–1.78hosp.15/116180/1,097