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Zinc and COVID-19: Immunity, Susceptibility, Severity and Intervention

Wang et al., Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2022.2119932
Sep 2022  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
*, now with p = 0.00000064 from 45 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments.
Review summarizing the association between zinc deficiency and increased susceptibility, severity, and mortality from COVID-19, and the potential protective role of zinc supplementation in enhancing immunity, decreasing susceptibility, reducing illness duration, and lowering severity of COVID-19. Authors recommend monitoring zinc levels in COVID-19 patients and considering zinc supplementation for groups at risk of zinc deficiency to reduce susceptibility and disease severity.
Reviews covering zinc for COVID-19 include1-13.
Wang et al., 12 Sep 2022, peer-reviewed, 7 authors.
This PaperZincAll
Zinc and COVID-19: Immunity, Susceptibility, Severity and Intervention
Fan Wang, Jiayi Zhong, Rui Zhang, Yongzhi Sun, Yingran Dong, Maoqing Wang, Changhao Sun
Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2022.2119932
During the coronavirus disease 2019 (COviD-19) pandemic and continuing emergence of viral mutants, there has been a lack of effective treatment methods. Zinc maintains immune function, with direct and indirect antiviral activities. Zinc nutritional status is a critical factor in antiviral immune responses. importantly, COviD-19 and zinc deficiency overlap in high-risk population. Hence, the potential effect of zinc as a preventive and adjunct therapy for COviD-19 is intriguing. Here, this review summarizes the immune and antiviral function of zinc, the relationship between zinc levels, susceptibility, and severity of COviD-19, and the effect of zinc supplementation on COviD-19. existing studies have confirmed that zinc deficiency was associated with COviD-19 susceptibility and severity. Zinc supplementation plays a potentially protective role in enhancing immunity, decreasing susceptibility, shortening illness duration, and reducing the severity of COviD-19. we recommend that zinc levels should be monitored, particularly in COviD-19 patients, and zinc as a preventive and adjunct therapy for COviD-19 should be considered for groups at risk of zinc deficiency to reduce susceptibility and disease severity. COVID-19 The ongoing coronavirus disease (COVID-19) pandemic has been caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Huang et al. 2020) . Due to high transmissibility and morbidity, COVID-19 has become a serious public health threat and burden. More than 400 million people have been infected, with more than 5.78 million deaths worldwide by 11 February 2022. Most COVID-19 patients (81%) experience only mild symptoms, including fever, cough, sore throat, impaired smell and taste, general weakness, pain such as aching limbs, runny nose, and in some cases diarrhea (Wu and McGoogan 2020; Hu et al. 2021) . Strikingly, SARS-CoV-2-infected patients demonstrate a high incidence of olfactory dysfunction (Lechien, Chiesa-Estomba, et al. 2020; Lozada-Nur et al. 2020) , which is distinct from other seasonal illnesses that share many of the same symptoms. SARS-CoV-2 infections challenge the immune system with ongoing inflammation. Classic serum proinflammatory cytokines, such as tumor necrosis factor TNF-α, interleukin IL-2, IL-6, IL-7, IL-8, IL-10, and C-reactive protein (CRP) become elevated among COVID-19 patients, which can lead to cytokine storm syndrome (Huang et al. 2020; Ye, Wang, and Mao 2020; Hu et al. 2021) . This in turn may lead to death from subsequent acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome, or other complications. However, treatment of the cytokine storm is complex and good therapeutic options remain limited (Saha et al. 2020; Ye, Wang, and Mao 2020) . The best option for reducing COVID-19 severity and mortality is to prevent the cytokine storm. To date, there remains no definitive curative therapy for COVID-19. Vaccines and reducing transmission in the community through..
Disclosure statement The authors declare no conflict of interest. Author contributions FW, MQW, and CHS: designed research and revised the paper; FW and MQW: wrote the paper; JYZ, RZ, YZS, YRD: research, collected, analyzed data,validation, drew figures and made tables; JYZ, RZ, YZS, YRD: revised the paper for important intellectual content. All authors read and approved the final manuscript.
Abd-Elsalam, Esmail, Khalaf, Abdo, Medhat et al., Hydroxychloroquine in the Treatment of COVID-19: A multicenter randomized controlled study. The at hospital admission, Nutrients, doi:10.3390/nu13103304
Abdelmaksoud, Ghweil, Hassan, Rashad, Khodeary et al., Olfactory disturbances as presenting manifestation among Egyptian patients with COVID-19: Possible role of zinc, Biological Trace Element Research, doi:10.1007/s12011-020-02546-5
Dubourg, Lagier, Brouqui, Casalta, Jacomo et al., Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV-2 infection: Is there a need to supplement with zinc COVID-19 patients?, Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2021.01.012
Elavarasi, Raju, Sagiraju, Garg, Ratre et al., Clinical features, demography, and predictors of outcomes of SARS-CoV-2 infection at a tertiary care hospital in India: A cohort study, Lung India, doi:10.4103/lungindia.lungindia_493_21
Elham, Azam, Azam, Mostafa, Nasrin et al., Serum vitamin D, calcium, and zinc levels in patients with COVID-19, Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2021.03.040
Finzi, Harrington, Zinc treatment of outpatient COVID-19: A retrospective review of 28 consecutive patients, Journal of Medical Virology, doi:10.1002/jmv.26812
Finzi, Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.06.006
Fraker, King, Reprogramming of the immune system during zinc deficiency, Annual Review of Nutrition, doi:10.1146/annurev.nutr.24.012003.132454
Fromonot, Gette, Lassoued, Guéant, Guéant-Rodriguez et al., Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19, Clinical Nutrition, doi:10.1016/j.clnu.2021.04.042
Frontera, Rahimian, Yaghi, Liu, Lewis et al., Treatment with zinc is associated with reduced in-hospital mortality among COVID-19 patients: A multi-center cohort study, Research Square, doi:10.21203/
Gao, Dai, Zhao, Min, Wang, The role of zinc and zinc homeostasis in macrophage function, Journal of Immunology Research, doi:10.1155/2018/6872621
Gheblawi, Wang, Viveiros, Nguyen, Zhong et al., Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th anniversary of the discovery of ACE2, Circulation Research, doi:10.1161/CIRCRESAHA.120.317015
Golabi, Adelipour, Mobarak, Piri, Seyedtabib et al., The association between vitamin D and zinc status and the progression of clinical symptoms among outpatients infected with SARS-CoV-2 and potentially non-infected participants: A cross-sectional study, Nutrients, doi:10.3390/nu13103368
Goncalves, Gonçalves, Guarnieri, Risegato, Guimarães et al., Association between low zinc levels and severity of acute respiratory distress syndrome by new coronavirus SARS-CoV-2, Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Gordon, Hardigan, A case-control study for the effectiveness of oral zinc in the prevention and mitigation of COVID-19, Front Med (Lausanne), doi:10.3389/fmed.2021.756707
Haase, Mocchegiani, Rink, Correlation between zinc status and immune function in the elderly, Biogerontology, doi:10.1007/s10522-006-9057-3
Hambidge, Mild zinc deficiency in human subjects, zinc in human biology
Heller, Sun, Hackler, Seelig, Seibert et al., Prediction of survival odds in COVID-19 by zinc, age and seleno-protein P as composite biomarker, Redox Biology, doi:10.1016/j.redox.2020.101764
Hemila, Zinc lozenges and the common cold: A meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage, JRSM Open, doi:10.1177/2054270417694291
Hemila, a. Vitamin C and infections, Nutrients, doi:10.3390/nu9040339
Hemilä, Chalker, Vitamin C for preventing and treating the common cold, The Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD000980.pub4
Hess, Peerson, King, Brown, Use of serum zinc concentration as an indicator of population zinc status, Food and Nutrition Bulletin, doi:10.1177/15648265070283S303
Hojyo, Fukada, Roles of zinc signaling in the immune system, Journal of Immunology Research, doi:10.1155/2016/6762343
Hooper, Visconti, Garry, Johnson, Zinc lowers high-density lipoprotein-cholesterol levels, JAMA, doi:10.1001/jama.244.17.1960
Hosseini, Moradi, Marhemati, Firouzian, Ildarabadi et al., Comparing serum levels of vitamin D and zinc in novel coronavirus-infected patients and healthy individuals in Northeastern Iran, Infectious Diseases in Clinical Practice, doi:10.1097/IPC.0000000000001051
Hotz, Brown, Identifying populations at risk of zinc deficiency: The use of supplementation trials, Nutrition Reviews, doi:10.1111/j.1753-4887.2001.tb06992.x
Hu, Guo, Zhou, Shi, Characteristics of SARS-CoV-2 and COVID-19, Nature Reviews. Microbiology, doi:10.1038/s41579-020-00459-7
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Hunter, Arentz, Goldenberg, Yang, Beardsley et al., Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: A rapid systematic review and meta-analysis of randomised controlled trials, BMJ Open, doi:10.1136/bmjopen-2020-047474
Im, Je, Baek, Chung, Kwon et al., Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, doi:10.1016/j.ijid.2020.08.018
Israel, Schäffer, Cicurel, Cheng, Sinha et al., Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population, Elife, doi:10.1101/2020.10.13.20211953
Iwata, Incefy, Tanaka, Fernandes, Menendez-Botet et al., Circulating thymic hormone levels in zinc deficiency, Cellular Immunology, doi:10.1016/0008-8749(79)90318-6
Joachimiak, Zinc against COVID-19? Symptom surveillance and deficiency risk groups, PLoS Neglected Tropical Diseases, doi:10.1371/journal.pntd.0008895
Jothimani, Kailasam, Danielraj, Nallathambi, Ramachandran et al., COVID-19: Poor outcomes in patients with zinc deficiency, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.09.014
Kahmann, Uciechowski, Warmuth, Plümäkers, Gressner et al., Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions, Rejuvenation Research, doi:10.1089/rej.2007.0613
Kaplan, Wang, Reeves, Scanlan, Nunn et al., Resveratrol and zinc in the treatment of outpatients with COVID-19 -The reszinate study -A phase 1/2 randomized clinical trial utilizing home patient-obtained nasal and saliva viral sampling, Social Science Electronic Publishing, doi:10.2139/ssrn.3934228
King, Frentzel, Mann, Fraker, Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained, Journal of the American College of Nutrition, doi:10.1080/07315724.2005.10719495
Knoell, Julian, Bao, Besecker, Macre et al., Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis, Critical Care Medicine, doi:10.1097/CCM.0b013e31819cefe4
Kocak, Ozgeris, Parlak, Kadıoglu, Yuce et al., Evaluation of serum trace element levels and biochemical parameters of COVID-19 patients according to disease severity, Biological Trace Element Research, doi:10.1007/s12011-021-02946-1
Kulik, Maywald, Kloubert, Wessels, Rink, Zinc deficiency drives Th17 polarization and promotes loss of Treg cell function, The Journal of Nutritional Biochemistry, doi:10.1016/j.jnutbio.2018.09.011
Kumar, Kubota, Chernov, Kasuya, Potential role of zinc supplementation in prophylaxis and treatment of COVID-19, Medical Hypotheses, doi:10.1016/j.mehy.2020.109848
Leal-Martinez, Abarca-Bernal, García-Pérez, González-Tolosa, Cruz-Cázares et al., Effect of a nutritional support system to increase survival and reduce mortality in patients with COVID-19 in stage III and comorbidities: A blinded randomized controlled clinical trial, International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19031172
Lechien, Chiesa-Estomba, Hans, Barillari, Jouffe et al., Loss of smell and taste in 2013 European patients with mild to moderate COVID-19, Annals of Internal Medicine, doi:10.7326/M20-2428
Lechien, Hopkins, Saussez, Letter to the Editor about the Beltran-Corbellini et al. publication: ' Acute-onset smell and taste disorders in the context of Covid-19: A pilot multicenter PCR-based case-control study, European Journal of Neurology, doi:10.1111/ene.14273
Lee, Chen, Tsai-Wu, Hsu, Lin, Zinc supplementation augments the suppressive effects of repurposed NF-kappaB inhibitors on ACE2 expression in human lung cell lines, Life Sciences, doi:10.1016/j.lfs.2021.119752
Lewis, Kokan, Zinc gluconate: Acute ingestion, Journal of Toxicology. Clinical Toxicology, doi:10.3109/15563659809162595
Li, Moore, Vasilieva, Sui, Wong et al., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature, doi:10.1038/nature02145
Lonergan, Skaar, Nutrient zinc at the host-pathogen interface, Trends in Biochemical Sciences, doi:10.1016/j.tibs.2019.06.010
Louca, Murray, Klaser, Graham, Mazidi et al., Modest effects of dietary supplements during the COVID-19 pandemic: Insights from 445 850 users of the COVID-19 Symptom Study app, BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2021-000250
Lozada-Nur, Chainani-Wu, Fortuna, Sroussi, Dysgeusia in COVID-19: possible mechanisms and implications, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, doi:10.1016/j.oooo.2020.06.016
Lukacik, Thomas, Aranda, A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea, Pediatrics, doi:10.1542/peds.2007-0921
Lyckholm, Heddinger, Parker, Coyne, Ramakrishnan et al., A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders, Journal of Pain & Palliative Care Pharmacotherapy, doi:10.3109/15360288.2012.676618
Majeed, Nagabhushanam, Shah, Mundkur, A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of a nutritional supplement (ImmuActive(TM)) for COVID-19 patients. Evidence-Based Complementary and Alternative Medicine, eCAM, doi:10.1155/2021/8447545
Mayor-Ibarguren, Busca-Arenzana, Robles-Marhuenda, A hypothesis for the possible role of zinc in the immunological pathways related to COVID-19 infection, Frontiers in Immunology, doi:10.3389/fimmu.2020.01736
Mcmahon, Tomashek, Dodd, Remdesivir for the treatment of COVID-19 -Preliminary report, New England Journal of Medicine, doi:10.1056/NEJMc2022236
Meydani, Barnett, Dallal, Fine, Jacques et al., Serum zinc and pneumonia in nursing home elderly, The American Journal of Clinical Nutrition, doi:10.1093/ajcn/86.4.1167
Moein, Hashemian, Mansourafshar, Khorram-Tousi, Tabarsi et al., Smell dysfunction: A biomarker for COVID-19, International Forum of Allergy & Rhinology, doi:10.1002/alr.22587
Mossink, Zinc as nutritional intervention and prevention measure for COVID-19 disease, BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2020-000095
Muhammad, Kani, Iliya, Muhammad, Binji et al., Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria, SAGE Open Medicine, doi:10.1177/2050312121991246
Mulhem, Oleszkowicz, Lick, 3219 hospitalised patients with COVID-19 in Southeast Michigan: A retrospective case cohort study, BMJ Open, doi:10.1136/bmjopen-2020-042042
Notz, Herrmann, Schlesinger, Helmer, Sudowe et al., Clinical significance of micronutrient supplementation in critically ill COVID-19 patients with severe ARDS, Nutrients, doi:10.3390/nu13062113
Ollig, Kloubert, Taylor, Rink, B cell activation and proliferation increase intracellular zinc levels, The Journal of Nutritional Biochemistry, doi:10.1016/j.jnutbio.2018.10.008
Oyagbemi, Ajibade, Aboua, Gbadamosi, Adedapo et al., Potential health benefits of zinc supplementation for the management of COVID-19 pandemic, Journal of Food Biochemistry, doi:10.1111/jfbc.13604
Pal, Squitti, Picozza, Pawar, Rongioletti et al., Zinc and COVID-19: Basis of current clinical trials, Biological Trace Element Research, doi:10.1007/s12011-020-02437-9
Patel, Chinni, El-Khoury, Perera, Neto et al., A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patients, Journal of Medical Virology, doi:10.1002/jmv.26895
Prasad, Beck, Bao, Fitzgerald, Snell et al., Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress, The American Journal of Clinical Nutrition, doi:10.1093/ajcn/85.3.837
Prasad, Lessons learned from experimental human model of zinc deficiency, Journal of Immunology Research, doi:10.1155/2020/9207279
Prasad, Zinc deficiency in women, infants and children, Journal of the American College of Nutrition, doi:10.1080/07315724.1996.10718575
Rabail, Saleem, Tanveer, Patching, Khalid et al., Nutritional and lifestyle changes required for minimizing the recovery period in home quarantined COVID-19 patients of Punjab, Pakistan, Food Science & Nutrition, doi:10.1002/fsn3.2458
Read, Obeid, Ahlenstiel, Ahlenstiel, The role of zinc in antiviral immunity, Advances in Nutrition, doi:10.1093/advances/nmz013
Reeves, O'dell, Effects of dietary zinc deprivation on the activity of angiotensin-converting enzyme in serum of rats and guinea pigs, The Journal of Nutrition, doi:10.1093/jn/116.1.128
Richardson, Lovegrove, Nutritional status of micronutrients as a possible and modifiable risk factor for COVID-19: A UK perspective, The British Journal of Nutrition, doi:10.1017/S000711452000330X
Ried, Binjemain, Sali, Therapies to prevent progression of COVID-19, including hydroxychloroquine, azithromycin, zinc, and vitamin D3 with or without intravenous vitamin C: An international, multicenter, randomized trial, Cureus, doi:10.7759/cureus.19902
Rios-Lugo, Madrigal-Arellano, Gaytán-Hernández, Hernández-Mendoza, Romero-Guzmán, Association of serum zinc levels in overweight and obesity, Biological Trace Element Research, doi:10.1007/s12011-020-02060-8
Rochon, Gurwitz, Sykora, Mamdani, Streiner et al., Reader's guide to critical appraisal of cohort studies: 1. Role and design, BMJ (Clinical Research, doi:10.1136/bmj.330.7496.895
Rolles, Maywald, Rink, Influence of zinc deficiency and supplementation on NK cell cytotoxicity, Journal of Functional Foods, doi:10.1016/j.jff.2018.07.027
Rosas, Bräu, Waters, Go, Hunter et al., Tocilizumab in hospitalized patients with severe COVID-19 pneumonia, The New England Journal of Medicine, doi:10.1056/NEJMoa2028700
Russell, Cox, Solomons, Zinc and the special senses, Annals of Internal Medicine, doi:10.7326/0003-4819-99-2-227
Saha, Sharma, Bhattacharya, Sharma, Lee et al., Tocilizumab: A therapeutic option for the treatment of cytokine storm syndrome in COVID-19, Archives of Medical Research, doi:10.1016/j.arcmed.2020.05.009
Salgo, COVID-19: Zinc and angiotensin-converting enzyme 2 (ACE2) deficiencies as determinants of risk and severity of disease: A narrative review, Infectious Diseases and Therapy, doi:10.1007/s40121-021-00478-8
Sanderson, COVID vaccines protect against Delta, but their effectiveness wanes, Nature, doi:10.1038/d41586-021-02261-8
Sandstead, Zinc nutrition from discovery to global health impact, Advances in Nutrition, doi:10.3945/an.112.002485
Science, Johnstone, Roth, Guyatt, Loeb, Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials, Canadian Medical Association Journal, doi:10.1503/cmaj.111990
Seet, Quek, Ooi, Sengupta, Lakshminarasappa et al., Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial, International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, doi:10.1016/j.ijid.2021.04.035
Shakeri, Azimian, Ghasemzadeh-Moghaddam, Safdari, Haresabadi et al., Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID-19, Journal of Medical Virology, doi:10.1002/jmv.27277
Shils, Modern nutrition in health and disease, doi:10.1097/00007611-196012000-00031
Singh, Covariation of zinc deficiency with COVID19 infections and mortality in European countries: Is zinc deficiency a risk factor for COVID-19, Journal of Scientific Research, doi:10.37398/JSR.2020.640222
Singh, Diwaker, Singh, Singh, Nutritional immunity, zinc sufficiency, and COVID-19 mortality in socially similar European populations, Frontiers in Immunology, doi:10.3389/fimmu.2021.699389
Skalny, Rink, Ajsuvakova, Aschner, Gritsenko et al., Zinc and respiratory tract infections: Perspectives for COVID19 (Review), International Journal of Molecular Medicine, doi:10.3892/ijmm.2020.4575
Skalny, Timashev, Aschner, Aaseth, Chernova et al., Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markers, Metabolites, doi:10.3390/metabo11040244
Talha, Patwary, Alam, Ali, Ahmed et al., Case-control study to evaluate zinc deficiency as a risk factor for oxygen requirement in patients with COVID-19, Mymensingh Medical Journal: MMJ
Tamura, Freeberg, Johnston, Keen, In vitro zinc stimulation of angiotensin-converting enzyme activities in various tissues of zinc-deficient rats, Nutrition Research, doi:10.1016/S0271-5317(05)80492-0
Thomas, Patel, Bittel, Wolski, Wang et al., Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: The COVID A to Z randomized clinical trial, JAMA Network Open, doi:10.1001/jamanetworkopen.2021.0369
Tomasa-Irriguible, Bielsa-Berrocal, Bordejé-Laguna, Tural-Llàcher, Barallat et al., Low levels of few micronutrients may impact COVID-19 disease progression: An observational study on the first wave, Metabolites, doi:10.3390/metabo11090565
Velthuis, Van Den Worm, Sims, Baric, Snijder et al., Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS Pathogens, doi:10.1371/journal.ppat.1001176
Verschelden, Noeparast, Noparast, Goossens, Lauwers et al., Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study, International Immunopharmacolog y, doi:10.1016/j.intimp.2021.108163
Vincent, Bergeron, Benjannet, Erickson, Rollin et al., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virology Journal, doi:10.1186/1743-422X-2-69
Vogel-Gonzalez, Talló-Parra, Herrera-Fernández, Pérez-Vilaró, Chillón et al., Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection, Nutrients, doi:10.3390/nu13020562
Wang, Fan, Wei, Wang, Yu et al., May Integrated multi-omics uncovers reliable potential biomarkers and adverse effects of zinc deficiency, Clinical Nutrition, doi:10.1016/j.clnu.2021.03.019
Wessells, Brown, Estimating the global prevalence of zinc deficiency: Results based on zinc availability in national food supplies and the prevalence of stunting, PLoS One, doi:10.1371/journal.pone.0050568
Wessels, Cousins, Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation, American Journal of Physiology Gastrointestinal and Liver Physiology, doi:10.1152/ajpgi.00179.2015
Wessels, Haase, Engelhardt, Rink, Uciechowski, Zinc deficiency induces production of the proinflammatory cytokines IL-1beta and TNFalpha in promyeloid cells via epigenetic and redox-dependent mechanisms, The Journal of Nutritional Biochemistry, doi:10.1016/j.jnutbio.2012.06.007
Wessels, Maywald, Rink, Zinc as a Gatekeeper of Immune Function, Nutrients, doi:10.3390/nu9121286
Wessels, Pupke, Von Trotha, Gombert, Himmelsbach et al., Zinc supplementation ameliorates lung injury by reducing neutrophil recruitment and activity, Thorax, doi:10.1136/thoraxjnl-2019-213357
Wessels, Rolles, Rink, The potential impact of zinc supplementation on COVID-19 pathogenesis, Frontiers in Immunology, doi:10.3389/fimmu.2020.01712
Wessels, Rolles, Slusarenko, Rink, Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19, The British Journal of Nutrition, doi:10.1017/S0007114521000738
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention, JAMA, doi:10.1001/jama.2020.2648
Xue, Moyer, Peng, Wu, Hannafon et al., Chloroquine is a zinc ionophore, PloS One, doi:10.1371/journal.pone.0109180
Yan, Zhang, Li, Xia, Guo et al., Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2, Science, doi:10.1126/science.abb2762
Yao, Paguio, Dee, Tan, Moulick et al., The minimal effect of zinc on the survival of hospitalized patients with COVID-19: An observational study, Chest, doi:10.1016/j.chest.2020.06.082
Yasui, Yasui, Suzuki, Saitou, Yamamoto et al., Analysis of the predictive factors for a critical illness of COVID-19 during treatment relationship between serum zinc level and critical illness of COVID-19, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.09.008
Ye, Wang, Mao, The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19, The Journal of Infection, doi:10.1016/j.jinf.2020.03.037
Zeng, Yang, Yuan, Wang, Cheng, Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, doi:10.1096/fj.202002346RR
Zhao, Li, Ge, Shi, Lv et al., Evaluation of nutrition risk and its association with mortality risk in severely and critically Ill COVID-19 patients, Journal of Parenteral and Enteral Nutrition, doi:10.1002/jpen.1953
Ziegler, Allon, Nyquist, Mbano, Miao et al., SARS-CoV-2 Receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues, Cell, doi:10.1016/j.cell.2020.04.035
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