Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Zinc  COVID-19 treatment studies for Zinc  C19 studies: Zinc  Zinc   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 77% Improvement Relative Risk ICU admission 71% Recovery time 68% c19early.org/z Vogel-González et al. Zinc for COVID-19 Sufficiency Are zinc levels associated with COVID-19 outcomes? Retrospective 249 patients in Spain Lower mortality (p=0.00048) and ICU admission (p<0.0001) Vogel-González et al., Nutrients, doi:10.3390/nu13020562 Favors zinc Favors control
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection
Vogel-González et al., Nutrients, doi:10.3390/nu13020562 (date from earlier preprint)
Vogel-González et al., Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection, Nutrients, doi:10.3390/nu13020562 (date from earlier preprint)
Oct 2020   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Retrospective 249 PCR+ hospitalized patients in Spain, 58 with zinc levels on admission <50 μg/dL, showing higher mortality and ICU admission, and slower recovery with low zinc levels.
risk of death, 77.2% lower, RR 0.23, p < 0.001, high zinc levels 9 of 191 (4.7%), low zinc levels 12 of 58 (20.7%), NNT 6.3, ≥50 μg/dL.
risk of ICU admission, 71.3% lower, RR 0.29, p < 0.001, high zinc levels 34 of 191 (17.8%), low zinc levels 36 of 58 (62.1%), NNT 2.3, ≥50 μg/dL.
recovery time, 68.0% lower, relative time 0.32, p < 0.001, high zinc levels 191, low zinc levels 58, ≥50 μg/dL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Vogel-González et al., 11 Oct 2020, retrospective, Spain, peer-reviewed, 16 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperZincAll
Abstract: nutrients Article Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection Marina Vogel-González 1,† , Marc Talló-Parra 2,† , Víctor Herrera-Fernández 1 , Gemma Pérez-Vilaró 2 , Miguel Chillón 3,4,5 , Xavier Nogués 6 , Silvia Gómez-Zorrilla 7 , Inmaculada López-Montesinos 7 , Isabel Arnau-Barrés 7 , Maria Luisa Sorli-Redó 7 , Juan Pablo Horcajada 7 , Natalia García-Giralt 6 , Julio Pascual 8 , Juana Díez 2,‡ , Rubén Vicente 1,‡ and Robert Güerri-Fernández 7, *,‡ 1 2 3 4 5 6 7   8 Citation: Vogel-González, M.; Talló-Parra, M.; Herrera-Fernández, V.; Pérez-Vilaró, G.; Chillón, M.; Nogués, X.; Gómez-Zorrilla, S.; * † ‡ Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain; marina.vogel@upf.edu (M.V.-G.); victor.herrera01@estudiant.upf.edu (V.H.-F.); ruben.vicente@upf.edu (R.V.) Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain; marc.tallo@upf.edu (M.T.-P.); gemma.perez@upf.edu (G.P.-V.); juana.diez@upf.edu (J.D.) Department of Biochemistry and Molecular Biology and Institute of Neurosciences, Edifici H, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; Miguel.Chillon@uab.cat Unitat Mixta UAB-VHIR, Vall d’Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain Institut Català de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain Department of Internal Medicine, Hospital del Mar, Institut Mar d’Investigacions Mediques, 08003 Barcelona, Spain; xnogues@psmar.cat (X.N.); ngarcia@imim.es (N.G.-G.) Department of Infectious Diseases, Hospital del Mar, Institut Mar d’Investigacions Mediques, 08003 Barcelona, Spain; SGomezZorrilla@parcdesalutmar.cat (S.G.-Z.); ilopezmontesinos@psmar.cat (I.L.-M.); iarnau@psmar.cat (I.A.-B.); lsorli@psmar.cat (M.L.S.-R.); jhorcajada@psmar.cat (J.P.H.) Department of Nephrology, Hospital del Mar, Institut Mar d’Investigacions Mediques, Autonomous University of Barcelona, 08003 Barcelona, Spain; JPascualSantos@parcdesalutmar.cat Correspondence: rguerri@psmar.cat; Tel.: +34-932-483-251; Fax: +34-932-483-249 Both authors contributed equally to the work. J.D., R.V. and R.G.-F. are joint senior authors in this work. López-Montesinos, I.; Arnau-Barrés, I.; Sorli-Redó, M.L.; et al. Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection. Nutrients 2021, 13, 562. https://doi.org/10.3390/ nu13020562 Received: 8 January 2021 Accepted: 30 January 2021 Published: 9 February 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Copyright: © 2021 by the authors. Abstract: Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we..
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit