Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?

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COVID-19 drug therapy potential options. ' 'Clinical drug information, clinical solutions. ' 'https://www.elsevier.com/__data/assets/pdf_file/0007/988648/COVID-19-Drug-Therapy_Mar-2020.pdf ' '[consulted on 2020-03-28].'}, { 'key': '10.1016/j.mehy.2020.109815_b0025', 'doi-asserted-by': 'crossref', 'article-title': 'Chloroquine and hydroxychloroquine as available weapons to fight ' 'COVID-19', 'author': 'Colson', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents', 'DOI': '10.1016/j.ijantimicag.2020.105932'}, { 'issue': '1', 'key': '10.1016/j.mehy.2020.109815_b0030', 'doi-asserted-by': 'crossref', 'first-page': '72', 'DOI': '10.5582/bst.2020.01047', 'article-title': 'Breakthrough: chloroquine phosphate has shown apparent efficacy in ' 'treatment of COVID-19 associated pneumonia in clinical studies', 'volume': '14', 'author': 'Gao', 'year': '2020', 'journal-title': 'Biosci Trends'}, { 'key': '10.1016/j.mehy.2020.109815_b0035', 'doi-asserted-by': 'crossref', 'article-title': 'Hydroxychloroquine and azithromycin as a treatment of COVID-19: results ' 'of an open-label non-randomized clinical trial', 'author': 'Gautret', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents.', 'DOI': '10.1016/j.ijantimicag.2020.105949'}, { 'key': '10.1016/j.mehy.2020.109815_b0040', 'doi-asserted-by': 'crossref', 'unstructured': 'Kearney J. Chloroquine as a potential treatment and prevention measure ' 'for the 2019 novel coronavirus: a review. Preprints 2020. Doi: ' '10.20944/preprints202003.0275.v1. published online Mar 17.', 'DOI': '10.20944/preprints202003.0275.v1'}, { 'key': '10.1016/j.mehy.2020.109815_b0045', 'article-title': 'WHO launches global megatrial of the four most promising coronavirus ' 'treatments', 'author': 'Kupferschmidt', 'year': '2020', 'journal-title': 'Science'}, { 'key': '10.1016/j.mehy.2020.109815_b0050', 'doi-asserted-by': 'crossref', 'article-title': 'A trial of lopinavir-ritonavir in adults hospitalized with severe ' 'Covid-19', 'author': 'Cao', 'year': '2020', 'journal-title': 'N Engl J Med', 'DOI': '10.1056/NEJMoa2001282'}, { 'issue': '4', 'key': '10.1016/j.mehy.2020.109815_b0055', 'doi-asserted-by': 'crossref', 'first-page': '297', 'DOI': '10.1016/j.ijantimicag.2007.05.015', 'article-title': 'Recycling of chloroquine and its hydroxyl analogue to face bacterial, ' 'fungal and viral infections in the 21st century', 'volume': '30', 'author': 'Rolain', 'year': '2007', 'journal-title': 'Int J Antimicrob Agents'}, { 'issue': '10', 'key': '10.1016/j.mehy.2020.109815_b0060', 'doi-asserted-by': 'crossref', 'first-page': '1724', 'DOI': '10.7150/ijbs.45498', 'article-title': 'Targeting the endocytic pathway and autophagy process as a novel ' 'therapeutic strategy in COVID-19', 'volume': '16', 'author': 'Yang', 'year': '2020', 'journal-title': 'Int J Biol Sci'}, { 'key': '10.1016/j.mehy.2020.109815_b0065', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0109180', 'article-title': 'Chloroquine is a zinc ionophore', 'volume': '9', 'author': 'Xue', 'year': '2014', 'journal-title': 'PLoS One'}, { 'key': '10.1016/j.mehy.2020.109815_b0070', 'doi-asserted-by': 'crossref', 'first-page': '696', 'DOI': '10.1093/advances/nmz013', 'article-title': 'The role of zinc in antiviral immunity', 'volume': '10', 'author': 'Read', 'year': '2019', 'journal-title': 'Adv Nutr'}, { 'key': '10.1016/j.mehy.2020.109815_b0075', 'doi-asserted-by': 'crossref', 'DOI': '10.1128/JVI.00754-17', 'article-title': 'Zinc salts block hepatitis E virus replication by inhibiting the ' 'activity of viral RNA-dependent RNA polymerase', 'volume': '91', 'author': 'Kaushik', 'year': '2017', 'journal-title': 'J Virol'}, { 'key': '10.1016/j.mehy.2020.109815_b0080', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.ppat.1001176', 'article-title': 'Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in ' 'vitro and zinc ionophores block the replication of these viruses in ' 'cell culture', 'volume': '6', 'author': 'te Velthuis', 'year': '2010', 'journal-title': 'PLoS Pathog'}, { 'key': '10.1016/j.mehy.2020.109815_b0085', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.1111/ijcp.12040', 'article-title': 'Pharmaco-nutrient interactions – a systematic review of zinc and ' 'antihypertensive therapy', 'volume': '67', 'author': 'Braun', 'year': '2013', 'journal-title': 'Int J Clin Pract'}, { 'issue': '3', 'key': '10.1016/j.mehy.2020.109815_b0090', 'doi-asserted-by': 'crossref', 'first-page': '212', 'DOI': '10.1080/07315724.2001.10719034', 'article-title': 'Potential antioxidant effects of zinc and chromium supplementation in ' 'people with type 2 diabetes mellitus', 'volume': '20', 'author': 'Anderson', 'year': '2001', 'journal-title': 'J Am Coll Nutr'}, { 'issue': '11', 'key': '10.1016/j.mehy.2020.109815_b0095', 'doi-asserted-by': 'crossref', 'first-page': '3422', 'DOI': '10.1093/jn/132.11.3422', 'article-title': 'Mineral intakes of elderly adult supplement and non-supplement users in ' 'the third national health and nutrition examination survey', 'volume': '132', 'author': 'Ervin', 'year': '2002', 'journal-title': 'J Nutr'}, { 'key': '10.1016/j.mehy.2020.109815_b0100', 'unstructured': 'National Institutes of Health. Office of dietary supplements. ' 'https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/#en2 ' '[consulted on 2020-03-29].'}, { 'issue': '3', 'key': '10.1016/j.mehy.2020.109815_b0105', 'doi-asserted-by': 'crossref', 'first-page': '837', 'DOI': '10.1093/ajcn/85.3.837', 'article-title': 'Zinc supplementation decreases incidence of infections in the elderly: ' 'effect of zinc on generation of cytokines and oxidative stress', 'volume': '85', 'author': 'Prasad', 'year': '2007', 'journal-title': 'Am J Clin Nutr'}, { 'key': '10.1016/j.mehy.2020.109815_b0110', 'unstructured': 'https://www.ema.europa.eu/en/news/covid-19-chloroquine-hydroxychloroquine-only-be-used-clinical-trials-emergency-use-programmes ' '[consulted on 2020-04-02].'}], 'container-title': 'Medical Hypotheses', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0306987720306435?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0306987720306435?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2020, 10, 6]], 'date-time': '2020-10-06T21:01:40Z', 'timestamp': 1602018100000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0306987720306435'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 9]]}, 'references-count': 22, 'alternative-id': ['S0306987720306435'], 'URL': 'http://dx.doi.org/10.1016/j.mehy.2020.109815', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.20944/preprints202004.0124.v1', 'asserted-by': 'object'}]}, 'ISSN': ['0306-9877'], 'subject': ['General Medicine'], 'container-title-short': 'Medical Hypotheses', 'published': {'date-parts': [[2020, 9]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Does zinc supplementation enhance the clinical efficacy of ' "chloroquine/hydroxychloroquine to win today's battle against COVID-19?", 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Medical Hypotheses', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.mehy.2020.109815', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2020 The Authors. 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