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Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction

Sethuram et al., Reproductive Sciences, doi:10.1007/s43032-020-00400-6
Jan 2021  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000027 from 43 studies, recognized in 10 countries.
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3,800+ studies for 60+ treatments. c19early.org
Review of zinc deficiency and supplementation for COVID-19, including potential impacts on reproductive health.
Reviews covering zinc for COVID-19 include Arora, Briassoulis, Derwand, DiGuilio, Foshati, Joachimiak, Schloss, Sethuram.
Sethuram et al., 7 Jan 2021, peer-reviewed, 3 authors.
This PaperZincAll
Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction
Ramya Sethuram, David Bai, Husam M Abu-Soud
Reproductive Sciences, doi:10.1007/s43032-020-00400-6
COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups. Given the established roles of zinc in combating oxidative damage and viral infections, zinc is being trialed as a treatment modality against COVID-19. Zinc also has confirmed roles in both male and female reproduction. The possible depletion of zinc with the oxidative events of COVID-19 is especially relevant to the fertility of affected couples. This review aims to present the pathophysiology of COVID-19, especially in relation to reproductive function; the role of zinc in the COVID-19 disease process; and how zinc depletion in concert with cytokine storm and reactive oxygen species production could affect reproduction. It also highlights research areas to better the understanding of COVID-19 and its impact on fertility and potential ways to mitigate the impact.
Compliance with Ethical Standards Research Involving Human Participants/Animals This manuscript did not make use of human or animal participants or samples. Conflict of Interest The authors declare that they have no conflict of interest. Informed Consent N/A
References
Aldhaheri, Jeelani, Kohan-Ghadr, Khan, Mikhael et al., Dimercapto-1-propanesulfonic acid (DMPS) induces metaphase II mouse oocyte deterioration, Free Radic Biol Med
Azizollahi, Azizollahi, Babaei, Kianinejad, Baneshi et al., Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects, J Assist Reprod Genet
Banerjee, Shaeib, Maitra, Saed, Dai et al., Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro, Fertil Steril
Banerjee, Sharma, Agarwal, Maitra, Diamond et al., IL-6 and mouse oocyte spindle, PLoS One
Cavdar, Babacan, Asik, Arcasoy, Ertem et al., Zinc levels of serum, plasma, erythrocytes and hair in Turkish women with anencephalic babies, Prog Clin Biol Res
Chabosseau, Rutter, Zinc and diabetes, Arch Biochem Biophys
Chen, Guo, Wang, Luo, Yu et al., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records, Lancet. 2020a
Chia, Ong, Chua, Ho, Tay, Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men, J Androl
Chiang, Litingtung, Harris, Simandl, Li et al., Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function, Dev Biol
Croxford, Mccormick, Kelleher, Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice, J Nutr
Dashrath, Wong, Lim, Lim, Li et al., Coronavirus disease 2019 (COVID-19) pandemic and pregnancy, Am J Obstet Gynecol
Eggert-Kruse, Zwick, Batschulat, Rohr, Armbruster et al., Are zinc levels in seminal plasma associated with seminal leukocytes and other determinants of semen quality?, Fertil Steril
Fallah, Mohammad-Hasani, Colagar, Zinc is an essential element for male fertility: a review of Zn roles in men's health, germination, sperm quality, and fertilization, J Reprod Infertil
Ficarelli, Antzin-Anduetza, White, Firth, Sertkaya et al., CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent andindependent mechanisms, J Virol
Golub, Keen, Gershwin, Hendrickx, Developmental zinc deficiency and behavior, J Nutr
Goud, Goud, Diamond, Gonik, Hm, Nitric oxide extends the oocyte temporal window for optimal fertilization, Free Radic Biol Med
Goud, Goud, Diamond, Gonik, Hm, Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acid, Free Radic Biol Med
Haase, Rink, Functional significance of zinc-related signaling pathways in immune cells, Annu Rev Nutr
Hajjar, Soleymani, Vatanchian, Protective effect of vitamin C and zinc as an antioxidant against chemotherapy-induced male reproductive toxicity, J Med Life
Hanna, Clegg, Momma, Daston, Rogers et al., Zinc influences the in vitro development of peri-implantation mouse embryos, Birth Defects Res A Clin Mol Teratol
Hemmens, Goessler, Schmidt, Mayer, Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitricoxide synthase, J Biol Chem
Hunt, Johnson, Herbel, Mullen, Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men, Am J Clin Nutr
Hurley, Shrader, Abnormal development of preimplantation rat eggs after three days of maternal zinc deficiency, Nature
Hurley, Swenerton, Congenital malformations resulting from zinc deficiency in rats, Proc Soc Exp Biol Med
Jarosz, Olbert, Wyszogrodzka, Młyniec, Librowski, Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling, Inflammopharmacology
Khan, Shaeib, Najafi, Kavdia, Gonik et al., D i f f u sed in t r a -oo c y t e h y dr o ge n p e r o xi de a c t i va t e s myeloperoxidase and deteriorates oocyte quality, PLoS One
Kozlowski, Luczkowski, Remelli, Valensin, Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases), Coord Chem Rev
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Maitra, Byun, Andreana, Abdulhamid, Diamond et al., Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release, Free Radic Biol Med
Marreiro, Cruz, Morais, Beserra, Severo et al., Zinc and oxidative stress: current mechanisms, Antioxidants
Meagher, Takata, Gonçalves-Carneiro, Keane, Rebendenne et al., Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences, Proc. Natl. Acad. Sci
Moore, June, Cytokine release syndrome in severe COVID-19, Science
Olechnowicz, Tinkov, Skalny, Suliburska, Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism, J Physiol Sci
Perry, Smyth, Stennicke, Zinc is a potent inhibitor of the apoptotic protease, caspase-3: a novel target for zinc in the inhibition of apoptosis, J Biol Chem
Pisano, Hilas, Zinc and taste disturbances in older adults: a review of the literature, Consult Pharm
Prasad, Discovery of human zinc deficiency: its impact on human health and disease, Adv Nutr
Prasad, Zinc deficiency: its characterization and treatment, Met Ions Biol Syst
Prasad, Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging, J. Trace Elem. Med. Biol
Que, Duncan, Bayer, Philips, Roth et al., Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy, Integr Biol (Camb)
Read, Obeid, Ahlenstiel, Ahlenstiel, The Role of Zinc in Antiviral, Immunity
Ribas-Maynou, Yeste, Salas-Huetos, The relationship between sperm oxidative stress alterations and IVF/ICSI outcomes: a systematic review from nonhuman mammals, Biology
Roth, Richard, Black, Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: meta-analysis and meta-regression of randomized trials, Int J Epidemiol
Roy, Baghel, Mohanty, Mondal, Zinc and male reproduction in domestic animals: a review, Indian J Anim Nutr
Saleh, Agarwal, Kandirali, Sharma, Thomas et al., Leukocytospermia is associated with increased reactive oxygen species production by human spermatozoa, Fertil. Steril
Schoggins, Wilson, Panis, A diverse range of gene products are effectors of the type I interferon antiviral response, Nature
Segars, Katler, Mq, Kotlyar, Glenn et al., American Society for Reproductive Medicine Coronavirus/ COVID-19 Task Force. Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?, Fertil Steril
Sengupta, Banerjee, Nath, Das, Banerjee S Metals and female reproductive toxicity, Hum Exp Toxicol
Shaeib, Banerjee, Maitra, Diamond, Hm, Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality, Free Radic Biol Med
Skalny, Rink, Ajsuvakova, Aschner, Gritsenko et al., Zinc and respiratory tract infections: perspectives for COVID-19 (Review), Int J Mol Med
Tian, Anthony, Neuberger, Diaz, Preconception zinc deficiency disrupts postimplantation fetal and placental development in mice, Biol Reprod
Uriu-Adams, Keen, Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development, Birth Defects Res B Dev Reprod Toxicol
Walker, Rudan, Liu, Nair, Theodoratou et al., Global burden of childhood pneumonia and diarrhoea, Lancet
Wessels, Maywald, Rink, Zinc as a gatekeeper of immune function, Nutrients
Wessels, Rolles, Rink, The potential impact of zinc supplementation on COVID-19 pathogenesis, Front Immunol
Yahfoufi, Bai, Khan, Chatzicharalampous, Kohan-Ghadr et al., Glyphosate induces metaphase II oocyte deterioration and embryo damage by zinc depletion and overproduction of reactive oxygen species, Toxicology
Yanagisawa, Zinc deficiency and clinical practice-validity of zinc preparations, Yakugaku Zasshi
Yao, Paguio, Dee, Tan, Moulick et al., The minimal effect of zinc on the survival of hospitalized patients with Covid-19: an observational study, Chest
Zhang, Duncan, Que, 'halloran, Woodruff, The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development, Sci Rep
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