The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study
Golabi et al.,
The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients..,
Nutrients, doi:10.3390/nu13103368 (date from earlier preprint)
Analysis of vitamin D and zinc levels in 53 PCR+ outpatients and 53 matched controls, showing lower zinc levels in COVID-19 patients, and increased risk of cases and symptoms with vitamin D deficiency. There was no significant difference in the use of supplements between cases and controls. IR.ABADANUMS.REC.1399.073.
Golabi et al., 26 Aug 2021, peer-reviewed, 10 authors.
Abstract: nutrients
Article
The Association between Vitamin D and Zinc Status and the
Progression of Clinical Symptoms among Outpatients Infected
with SARS-CoV-2 and Potentially Non-Infected Participants:
A Cross-Sectional Study
Sahar Golabi 1 , Maryam Adelipour 2 , Sara Mobarak 3 , Maghsud Piri 4 , Maryam Seyedtabib 5 , Reza Bagheri 6 ,
Katsuhiko Suzuki 7 , Damoon Ashtary-Larky 8 , Fatemeh Maghsoudi 9 and Mahshid Naghashpour 10, *
1
2
3
4
5
Citation: Golabi, S.; Adelipour, M.;
Mobarak, S.; Piri, M.; Seyedtabib, M.;
6
Bagheri, R.; Suzuki, K.;
7
Ashtary-Larky, D.; Maghsoudi, F.;
Naghashpour, M. The Association
8
between Vitamin D and Zinc Status
and the Progression of Clinical
Symptoms among Outpatients
Infected with SARS-CoV-2 and
Potentially Non-Infected Participants:
A Cross-Sectional Study. Nutrients
2021, 13, 3368. https://doi.org/
10.3390/nu13103368
Academic Editors: William B. Grant,
Ronan Lordan and Lutz Schomburg
Received: 2 September 2021
Accepted: 21 September 2021
Published: 25 September 2021
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Copyright: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
9
10
*
Department of Medical Physiology, School of Medicine, Abadan University of Medical Sciences,
Abadan 6313833177, Iran; s.golabi@abadanums.ac.ir
Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences,
Ahvaz 6135715794, Iran; adelipour-m@ajums.ac.ir
Department of Infectious Diseases, School of Medicine, Abadan University of Medical Sciences,
Abadan 6313833177, Iran; s.mobarak@abadanums.ac.ir
Vice Chancellor for Health, Abadan University of Medical Sciences, Abadan 6313833177, Iran;
maghsudpiri@gmail.com
Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of
Medical Sciences, Ahvaz 6135715794, Iran; m.stabib3@gmail.com
Department of Exercise Physiology, University of Isfahan, Isfahan 8174673441, Iran; will.fivb@yahoo.com
Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan;
katsu.suzu@waseda.jp
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences,
Ahvaz 6135715794, Iran; damoon_ashtary@yahoo.com
Department of Public Health, School of Health, Abadan University of Medical Sciences,
Abadan 6313833177, Iran; fatemehmagh627@gmail.com
Department of Nutrition, School of Medicine, Abadan University of Medical Sciences,
Abadan 6313833177, Iran
Correspondence: m.naghashpour@abadanums.ac.ir; Tel.: +98-9166157338
Abstract: Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of 25-hydroxyvitamin D (25(OH)D) and zinc in COVID-19 outpatients
with those of potentially non-infected participants. The association of clinical symptoms with vitamin
D and zinc status was also examined. A checklist and laboratory examination were applied to collect
data in a cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration of 25(OH)D were not significantly lower in
patients with moderate illness (19 ± 12 ng/mL) than patients with asymptomatic or mild illness
(29 ± 18 ng/mL), with a trend noted for a lower serum concentration of 25(OH)D in moderate than
asymptomatic or mild illness patients (p = 0.054). Infected patients (101 ±..
golabi
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