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Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients

Finzi et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.06.006
Jun 2020  
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Case report on 4 patients treated with high dose zinc. All patients experienced significant improvement after one day.
Finzi et al., 6 Jun 2020, peer-reviewed, 1 author.
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Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients
Eric Finzi
Coronavirus 2019 (COVID-19) is a pandemic with substantial mortality and no accepted therapy. We report here on four consecutive outpatients with clinical characteristics (CDC case definition) of and/or laboratory-confirmed COVID-19 who were treated with high dose zinc salt oral lozenges. All four patients experienced significant improvement in objective and symptomatic disease measures after one day of high dose therapy suggesting that zinc therapy was playing a role in clinical recovery. A mechanism for zinc's effects is proposed based on previously published studies on SARS-CoV-1, and randomized controlled trials assessing zinc shortening of common cold duration. The limited sample size and study design preclude a definitive statement about the effectiveness of zinc as a treatment for COVID-19 but suggest the variables to be addressed to confirm these initial findings in future trials.
Funding No funding was provided for this study. Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
References
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Eby, Zinc lozenges as cure for the common cold -A review and hypothesis, Med Hypotheis
Eby, Zinc lozenges: cold cure or candy? Solution chemistry determinations, Biosci Rep
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Lanke, Krenn, Melchers, Seipelt, Van Kuppeveld, PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells, J Gen Virol
Prasad, Fitzgerald, Bao, Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial, Ann Int Med
Shittu, Afolami, Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives -A better synergy for future COVID-19 clinical trials, Infez Med. Ahead of print
Skalny, Rink, Ajsuvakova, Zinc and respiratory tract infections: Perspectives for COVID-19 (Review), Int J Mol Med
Velthuis, Van Den Worm, She, Sims, Baric et al., Zn (2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLOS Pathog
Late treatment
is less effective
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