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Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc

Abdelmaksoud et al., Biological Trace Element Research, doi:10.1007/s12011-020-02546-5
Jan 2021  
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134 COVID-19 patients, 49 treated with zinc, showing faster recovery of olfactory function in patients treated with zinc (median 7 vs. 18 days). There was no difference in overall recovery time. There were 4 deaths but authors do not indicate zinc treatment status. There was no significant difference in zinc levels based on severity. SVU-MED-MBC004-2020-04.
Abdelmaksoud et al., 7 Jan 2021, peer-reviewed, 9 authors, study period 1 May, 2020 - 31 August, 2020.
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Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Aida A Abdelmaksoud, Ali A Ghweil, Mohammed H Hassan, Alaa Rashad, Ashraf Khodeary, Zaky F Aref, Mennatallah Ali Abdelrhman Sayed, Mahmoud K Elsamman, Shamardan E S Bazeed
Biological Trace Element Research, doi:10.1007/s12011-020-02546-5
COVID-19 is a severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). Deficiency of zinc has been supposed to contribute to loss of smell and taste in COVID-19 patients. Our study aimed to assess the serum zinc levels among patients with COVID-19 of various severities, with and without olfaction dysfunction, and to evaluate the effect of zinc therapy in recovery of smell dysfunction among such patients. This study included 134 patients; real-time reverse transcription-polymerase chain reaction (rRT-PCR) proved SARS-CoV-2. Serum zinc levels were measured for all infected patients. One hundred and five patients were detected to have anosmia and/or hyposmia and were categorized randomly into 2 groups; the first group included 49 patients who received zinc therapy and the second group included 56 patients who did not received zinc. All patients were followed up for the recovery duration of olfactory and gustatory symptoms and duration of complete recovery of COVID-19. Olfactory dysfunction was reported in 105 patients (78.4%). Serum zinc levels were not significantly different between the patient subgroups regarding disease severity or the presence or absence of olfactory and/or gustatory dysfunction (p ˃ 0.05). The median duration of recovery of gustatory and/or olfactory function was significantly shorter among patients who received zinc therapy than those who did not received zinc (p < 0.001), while the median duration of complete recovery from COVID-19 was not significantly different among the two groups (p ˃ 0.05). Although the zinc status of COVID-19 patients did not exhibit a significant role in development of anosmia and/or hyposmia or disease severity, zinc therapy may have a significant role in shortening the duration of smell recovery in those patients without affecting the total recovery duration from COVID-19.
Authors' Contributions Study concept and design: AAA, MHH, AAG, ZFA, and SESB; patient selection and clinical evaluation and follow-up of patients: AAA, ZFA, AR, and MKE; blood sampling, molecular and biochemical assays: MHH and AK; statistical analysis: AAA, MHH, SESB, AR, MKE, and MAAS; literature research: AAA, SESB, MHH, MAAS, AR, and ZFA; first manuscript drafting: AAA, SESB, and MHH. The authors approved the final version of the manuscript. Competing Interests The authors declare that they have no conflict of interest. Ethics Approval and Consent to Participate The study was approved by the local Ethics Committee of Medical Research of the Faculty of Medicine, South Valley University, Qena, Egypt (ethical approval code: SVU-MED-MBC004-2020-04), and was conducted in accordance with the Declaration of Helsinki. Informed written consent was obtained from every participant who was anonymously enrolled.
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