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0 0.5 1 1.5 2+ Ventilation -14% Improvement Relative Risk ICU admission -14% Hospitalization -14% Zinc  Reszinate  LATE TREATMENT  RCT Is late treatment with zinc + resveratrol beneficial for COVID-19? RCT 30 patients in the USA (September 2020 - January 2021) Trial underpowered to detect differences Kaplan et al., SSRN, 10.2139/ssrn.3934.., Oct 2021 Favors zinc Favors control

Resveratrol and Zinc in the Treatment of Outpatients With COVID-19 – The Reszinate Study - A Phase 1/2 Randomized Clinical Trial Utilizing Home Patient-Obtained Nasal and Saliva Viral Sampling

Kaplan et al., SSRN, 10.2139/ssrn.3934228, Reszinate, NCT04542993
Oct 2021  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Small RCT of zinc plus resveratrol in COVID-19+ outpatients, showing no significant differences in viral clearance or symptoms. Although the treatment group was older (46.3 vs. 38.5) and had more severe baseline symptoms, they had similar symptomatic recovery by the second week.
risk of mechanical ventilation, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
risk of ICU admission, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
risk of hospitalization, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kaplan et al., 1 Oct 2021, Randomized Controlled Trial, USA, preprint, 12 authors, study period 21 September, 2020 - 22 January, 2021, average treatment delay 5.9 days, this trial uses multiple treatments in the treatment arm (combined with resveratrol) - results of individual treatments may vary, trial NCT04542993 (history) (Reszinate).
This PaperZincAll
Zinc and resveratrol treatment of outpatients with COVID-19 -The Reszinate study. A Phase 1/2 randomized clinical trial utilizing home patient-obtained nasal and saliva viral sampling
MD Henry G Kaplan, PhD Kai Wang, Kimberly M Reeves, James M Scanlan, MD Christopher C Nunn, BSNMT Douglas A Kieper, PharmD Joshua L Mark, PhD Inyoul Lee, BS Rachel Liu, MD Ruyun Jin, MD, PhD Michael J Bolton, MD, MPH Jason D Goldman
Background Safe, effective, inexpensive treatment for COVID-19 is an urgent unmet medical need. Zinc and resveratrol have been reported to have antiviral activity and resveratrol may increase zinc activity at the site of replication by increasing intracellular zinc concentrations. Methods A 1:1 randomized, placebo-controlled trial of zinc 150 mg plus resveratrol 4 grams daily for 5 days versus placebos in SARS-CoV-2 positive outpatients was carried out 9/21/2020 -1/22/2021 in Seattle, Washington. Patients were enrolled within four days of testing positive if they had no chronic liver, kidney, or lung disease and did not have hypoxia requiring supplemental oxygen. Viral shedding was followed at days 1-7,10, and 14 with patient self-collected nasal and saliva samples by measuring qRT-PCR for SARS-CoV-2 N gene. Patients filled out a web-based questionnaire on days 1-14 to report symptoms, vital signs and adherence to study intervention. Findings 45 persons consented to enrollment, and 30 (14 treatment; 16 placebo) had ≥1 day of the protocol treatment and were evaluable for the primary or secondary outcome. There was no difference in viral shedding between groups. There was a nonstatistically significant trend toward more rapid decrease in symptoms in the treatment group. Viral shedding was similar between patient self-collected mid-turbinate nasal swabs and expectorated saliva samples with good correlation, R= 0.67, p<0.001. Interpretation SARS-CoV-2 shedding and COVID-19 symptoms were not statistically significantly decreased by treatment in this small Phase 1/2 pilot study. Viral shedding correlates well between patient-obtained home nasal swab and saliva sampling.
Author contributions: Conceptualization: HGK, CCN, DAK, JMS, JDG. Data Curation: HGK, KW, KMR, JMS, RJ. Analysis: JMS, RJ. Investigation: all authors. Funding: HGK. Methodology: HGK, KW, CCN, JMS, RJ, JDG. Supervision: HGK, JDG. Writing -original draft: HGK. Writing -review and editing: all authors. Final approval of the manuscript: all authors. Supporting information: CONSORT checklist Figure 1
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Late treatment
is less effective
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