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All Studies   Meta Analysis    Recent:   

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

Weinreich et al., NEJM, doi:10.1056/NEJMoa2108163 (date from preprint), NCT04425629
May 2021  
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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk Mortality (b) 67% Mortality (c) -2% Death/hospitalization 71% Death/hospitalization (b) 70% Recovery time 29% Recovery time (b) 29% Casirivimab/i..  Weinreich et al.  EARLY TREATMENT  RCT Is early treatment with casirivimab/imdevimab beneficial for COVID-19? RCT 4,180 patients in the USA (September 2020 - January 2021) Lower death/hosp. (p=0.001) and faster recovery (p=0.001) c19early.org Weinreich et al., NEJM, May 2021 Favors casirivimab/im.. Favors control
16th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.000055 from 29 studies, recognized in 45 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 4,057 outpatients with >=1 risk factor for severe disease, showing significantly lower combined hospitalization/death, and significantly faster recovery with treatment. Median time from onset of symptoms 3 days.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants1-6.
risk of death, 50.0% lower, RR 0.50, p = 0.45, treatment 2 of 2,091 (0.1%), control 4 of 2,089 (0.2%), NNT 1044, Table S9.
risk of death, 67.0% lower, RR 0.33, p = 0.37, treatment 1 of 1,355 (0.1%), control 3 of 1,341 (0.2%), NNT 667, 2400mg,Table S9.
risk of death, 1.6% higher, RR 1.02, p = 1.00, treatment 1 of 736 (0.1%), control 1 of 748 (0.1%), 1200mg,Table S9.
risk of death/hospitalization, 71.3% lower, RR 0.29, p < 0.001, treatment 18 of 1,355 (1.3%), control 62 of 1,341 (4.6%), NNT 30, 2400mg.
risk of death/hospitalization, 70.4% lower, RR 0.30, p = 0.002, treatment 7 of 736 (1.0%), control 24 of 748 (3.2%), NNT 44, 1200mg.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 1,355, control 1,341, 2400mg.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 736, control 748, 1200mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Weinreich et al., 21 May 2021, Randomized Controlled Trial, USA, peer-reviewed, 40 authors, study period 24 September, 2020 - 17 January, 2021, average treatment delay 3.0 days, trial NCT04425629 (history).
This PaperCasirivimab/i..All
REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19
David M Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Jing Xiao, Andrea T Hooper, Jennifer D Hamilton, Bret J Musser, Diana Rofail, Mohamed Hussein, Joseph Im, Dominique Y Atmodjo, Christina Perry, Cynthia Pan, Adnan Mahmood, Romana Hosain, John D Davis, Kenneth C Turner, Alina Baum, Christos A Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Lilia Roque-Guerrero, Gerard Acloque, Hessam Aazami, Kevin Cannon, J Abraham Simón-Campos, Joseph A Bocchini, Bari Kowal, A Thomas Dicioccio, Yuhwen Soo, Gregory P Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos
New England Journal of Medicine, doi:10.1056/nejmoa2108163
BACKGROUND In the phase 1-2 portion of an adaptive trial, REGEN-COV, a combination of the monoclonal antibodies casirivimab and imdevimab, reduced the viral load and number of medical visits in patients with coronavirus disease 2019 (Covid-19). REGEN-COV has activity in vitro against current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. METHODS In the phase 3 portion of an adaptive trial, we randomly assigned outpatients with Covid-19 and risk factors for severe disease to receive various doses of intravenous REGEN-COV or placebo. Patients were followed through day 29. A prespecified hierarchical analysis was used to assess the end points of hospitalization or death and the time to resolution of symptoms. Safety was also evaluated. RESULTS Covid-19-related hospitalization or death from any cause occurred in 18 of 1355 patients in the REGEN-COV 2400-mg group (1.3%) and in 62 of 1341 patients in the placebo group who underwent randomization concurrently (4.6%) (relative risk reduction [1 minus the relative risk], 71.3%; P<0.001); these outcomes occurred in 7 of 736 patients in the REGEN-COV 1200-mg group (1.0%) and in 24 of 748 patients in the placebo group who underwent randomization concurrently (3.2%) (relative risk reduction, 70.4%; P = 0.002). The median time to resolution of symptoms was 4 days shorter with each REGEN-COV dose than with placebo (10 days vs. 14 days; P<0.001 for both comparisons). REGEN-COV was efficacious across various subgroups, including patients who were SARS-CoV-2 serum antibody-positive at baseline. Both REGEN-COV doses reduced viral load faster than placebo; the least-squares mean difference in viral load from baseline through day 7 was −0.71 log 10 copies per milliliter (95% confidence interval [CI], −0.90 to −0.53) in the 1200-mg group and −0.86 log 10 copies per milliliter (95% CI, −1.00 to −0.72) in the 2400-mg group. Serious adverse events occurred more frequently in the placebo group (4.0%) than in the 1200-mg group (1.1%) and the 2400-mg group (1.3%); infusion-related reactions of grade 2 or higher occurred in less than 0.3% of the patients in all groups. CONCLUSIONS REGEN-COV reduced the risk of Covid-19-related hospitalization or death from any cause, and it resolved symptoms and reduced the SARS-CoV-2 viral load more rapidly than placebo. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials .gov number, NCT04425629.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. We thank the trial participants; their families; the investigational site members involved in this trial (principal and subprincipal investigators, listed in the Supplementary Appendix); the Regeneron trial team (members listed in the Supplementary Appendix); the members of the independent data and safety monitoring committee; Brian Head, Ph.D., Caryn Trbovic, Ph.D., and S. Balachandra Dass, Ph.D., of Regeneron Pharmaceuticals for assistance with development of an earlier version of the manuscript; and Prime for assistance with the formatting and copy editing of an earlier version of the manuscript. Appendix The authors' full names and academic degrees are as follows: David M. Weinreich
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S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Christina', 'family': 'Perry', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Cynthia', 'family': 'Pan', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Adnan', 'family': 'Mahmood', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Romana', 'family': 'Hosain', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6282-1670', 'authenticated-orcid': False, 'given': 'John D.', 'family': 'Davis', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Kenneth C.', 'family': 'Turner', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Alina', 'family': 'Baum', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Christos A.', 'family': 'Kyratsous', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Yunji', 'family': 'Kim', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Amanda', 'family': 'Cook', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Wendy', 'family': 'Kampman', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Lilia', 'family': 'Roque-Guerrero', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Gerard', 'family': 'Acloque', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Hessam', 'family': 'Aazami', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Kevin', 'family': 'Cannon', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'J. Abraham', 'family': 'Simón-Campos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Joseph A.', 'family': 'Bocchini', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Bari', 'family': 'Kowal', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'A. Thomas', 'family': 'DiCioccio', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Yuhwen', 'family': 'Soo', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Gregory P.', 'family': 'Geba', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Neil', 'family': 'Stahl', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Leah', 'family': 'Lipsich', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Ned', 'family': 'Braunstein', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'Gary', 'family': 'Herman', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}, { 'given': 'George D.', 'family': 'Yancopoulos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown (D.M.W., T.N., S.A., ' 'H.G., R.B., J.X., A.T.H., J.D.H., B.J.M., D.R., M.H., J.I., ' 'D.Y.A., C. Perry, C. Pan, A.M., R.H., J.D.D., K.C.T., A.B., ' 'C.A.K., Y.K., A.C., W.K., B.K., A.T.D., Y. S., G.P.G., N.S., ' 'L.L., N.B., G.H., G.D.Y.) and Excision BioTherapeutics, New York ' '(S.S.) — both in New York; Bio-Medical Research (L.R.-G.) and ' 'Universal Medical and Research Center (G.A.) — both in Miami; ' 'Hope Clinical Research, Canoga Park, CA (H.A.); PMG Research of ' 'Wilmington,...'}]}], 'member': '150', 'reference': [ { 'key': 'r3', 'first-page': '1775', 'volume': '323', 'author': 'Onder G', 'year': '2020', 'journal-title': 'JAMA'}, {'key': 'r4', 'doi-asserted-by': 'publisher', 'DOI': '10.15585/mmwr.mm6924e2'}, {'key': 'r5', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-020-2521-4'}, {'key': 'r6', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.2648'}, {'key': 'r7', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.n579'}, {'key': 'r8', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abg3055'}, {'key': 'r9', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-021-03398-2'}, {'key': 'r10', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41591-021-01270-4'}, {'key': 'r11', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abd0827'}, {'key': 'r12', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abd0831'}, {'key': 'r13', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abe2402'}, {'key': 'r14', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cell.2021.06.002'}, {'key': 'r16', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2035002'}, {'key': 'r18', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/sim.4780091208'}, {'key': 'r19', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.19719'}, {'key': 'r20', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2021.0830'}, {'key': 'r21', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41591-021-01283-z'}], 'container-title': 'New England Journal of Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nejm.org/doi/pdf/10.1056/NEJMoa2108163', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 10, 20]], 'date-time': '2022-10-20T18:07:05Z', 'timestamp': 1666289225000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.nejm.org/doi/10.1056/NEJMoa2108163'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 12, 2]]}, 'references-count': 17, 'journal-issue': {'issue': '23', 'published-print': {'date-parts': [[2021, 12, 2]]}}, 'alternative-id': ['10.1056/NEJMoa2108163'], 'URL': 'http://dx.doi.org/10.1056/NEJMoa2108163', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.1101/2021.05.19.21257469', 'asserted-by': 'object'}]}, 'ISSN': ['0028-4793', '1533-4406'], 'subject': ['General Medicine'], 'container-title-short': 'N Engl J Med', 'published': {'date-parts': [[2021, 12, 2]]}}
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