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0 0.5 1 1.5 2+ Ventilation 92% Improvement Relative Risk Zinc for COVID-19  Yasui et al.  Sufficiency Are zinc levels associated with COVID-19 outcomes? Retrospective 29 patients in Japan Lower ventilation with higher zinc levels (p=0.0011) c19early.org Yasui et al., Int. J. Infectious Disea.., Sep 2020 Favors zinc Favors control

Analysis of the predictive factors for a critical illness of COVID-19 during treatment - relationship between serum zinc level and critical illness of COVID-19

Yasui et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.09.008
Sep 2020  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000027 from 43 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Retrospective 62 hospitalized patients, 29 with serum zinc data, showing significantly lower serum zinc levels for severe COVID-19 cases (intubation) compared with mild and moderate cases, p = 0.005. Authors recommend zinc supplementation.
risk of mechanical ventilation, 92.5% lower, RR 0.08, p = 0.001, high zinc levels 1 of 20 (5.0%), low zinc levels 6 of 9 (66.7%), NNT 1.6, zinc >= 70μg/dL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yasui et al., 7 Sep 2020, retrospective, Japan, peer-reviewed, 10 authors.
This PaperZincAll
Analysis of the predictive factors for a critical illness of COVID-19 during treatment - relationship between serum zinc level and critical illness of COVID-19 −
Yukako Yasui, Hiroyuki Yasui, Kumiko Suzuki, Takako Saitou, Yoshiki Yamamoto, Toshihiko Ishizaka, Kouji Nishida, Shingo Yoshihara, Iwao Gohma, Yoshihiko Ogawa
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.09.008
Because most severely ill patients with COVID-19 in our hospital showed zinc deficiency, we aimed to examine the relationship between the patient's serum zinc level and severe cases of COVID-19. Methods: Serum zinc <70 mg/dL was defined as the criterion for hypozincemia, and patients continuously with serum zinc <70 mg/dL were classified in the hypozincemia cohort. To evaluate whether hypozincemia could be a predictive factor for a critical illness of COVID-19, we performed a multivariate analysis by employing logistic regression analysis. Results: Prolonged hypozincemia was found to be a risk factor for a severe case of COVID-19. In evaluating the relationship between the serum zinc level and severity of patients with COVID-19 by multivariate logistic regression analysis, critical illness can be predicted through the sensitivity and false specificity of a ROC curve with an error rate of 10.3% and AUC of 94.2% by only two factors: serum zinc value (P = 0.020) and LDH value (P = 0.026). Conclusions: Proper management of the prediction results in this study can contribute to establishing and maintaining a safe medical system, taking the arrival of the second wave, and the spread of COVID-19 in the future into consideration.
Conflict of interest We declare no conflict of interests, no competing financial interests, or personal relationships that could have influenced this study.
References
Gandhi, Lynch, Rio, Mild or moderate COVID-19, N Engl J Med, doi:10.1056/NEJMcp2009249
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational study of hydroxychloroquine in hospitalized patients with COVID-19, N Engl J Med, doi:10.1056/NEJMoa2012410NEJMoa2012410
Guy, Dipaola, Romanelli, Dutch, Rapid repurposing of drugs for COVID-19, Science
Higurashi, Colorimetric reagent for zinc, ACCURAS AUTO Zn, Biomed Res Trace Elem
Hirano, Murakami, Fukada, Nishida, Yamasaki et al., Roles of zinc and zinc signaling in immunity: Zinc as an intracellular signaling molecule, Adv Immunol, doi:10.1016/S0065-2776(08)00003-5
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Ischia, Bolton, Patel, Why is it worth testing the ability of zinc to protect against ischaemia reperfusion injury for human application, Metallomics
Ischia, Patel, Eutick, World-first trial to test benefit of intravenous zinc in COVID-19 fight
Jordan, Adab, Cheng, COVID-19: risk factors for severe disease and death, BMJ, doi:10.1136/bmj.m1198
Kido, Ishiwata, Suka, Yanagisawa, Inflammatory response under zinc deficiency is exacerbated by dysfunction of the T helper type 2 lymphocyte-M2 macrophage pathway, Immunology
Kitabayashi, Fukada, Kanamoto, Ohashi, Hojyo et al., Zinc suppresses Th17 development via inhibition of STAT3 activation, Int Immunol
Kodama, Itakura, Omori, Sasaki, Sando et al., Guideline for treatment of zinc deficiency, 2016, J Jpn Soc Clin Nutr
Lee, Bang, Lee, Lee, Kang et al., Serum concentrations of trace elements zinc, copper, selenium, and manganese in critically ill patients, Biol Trace Elem Res
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J Allergy Clin Immunol
Liang, Liang, Ou, Chen, Chen et al., Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19, JAMA Intern. Med
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discovery, doi:10.1038/s41421-020-0156-0
Russell, Chapter 96e. Vitamin and trace mineral deficiency and excess
Sakurai, Kojima, Yoshikawa, Kawabe, Yasui, Antidiabetic vanadium(IV) and zinc (II) complexes, Coord Chem Rev
Sakurai, Yoshikawa, Yasui, Current state for the development of metallopharmaceutics and anti-diabetic metal complexes, Chem Soc Rev
Sanders, Monogue, Jodlowski, Cutrell, Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A Review, JAMA, doi:10.1001/jama.2020.6019
Velthuis, Van Den Worm, She, Sims, Baric et al., Zn 2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS Pathog
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in in vitro, Cell Res
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China, JAMA Intern Med, doi:10.1001/jamainternmed.2020.0994
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese center for disease control and prevention, JAMA 2020b
Xue, Moyer, Peng, Wu, Hannafon et al., Chloroquine is a zinc ionophore, PLoS One
Yan, Zhang, Goncalve, Xiao, Wang et al., An interpretable mortality prediction model for COVID-19 patients, Nat Mach Intell
Yang, Yu, Xu, Shu, Xia et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir Med
Zhang, Wang, Jia, Li, Hu et al., Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan. China, Clin Microbiol Infect
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Zhu, She, Cheng, Qin, Zhang et al., Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes, Cell Metab
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