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0 0.5 1 1.5 2+ Mortality 68% Improvement Relative Risk Symptomatic case 85% c19early.org/z Gordon et al. Zinc for COVID-19 Prophylaxis Favors zinc Favors control
A Case-Control Study for the Effectiveness of Oral Zinc in the Prevention and Mitigation of COVID-19
Gordon et al., Frontiers in Medicine, doi:10.3389/fmed.2021.756707
13 Dec 2021    Source   PDF   Share   Tweet
Prospective study of zinc supplementation with 104 patients randomized to receive 10mg, 25mg, or 50mg of zinc picolinate daily, and a matched sample of 96 control patients from the adjacent clinic that did not routinely recommend/use zinc, showing significantly lower symptomatic COVID-19 with treatment.
risk of death, 67.6% lower, RR 0.32, p = 0.48, treatment 0 of 104 (0.0%), control 1 of 96 (1.0%), NNT 96, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 85.3% lower, RR 0.15, p = 0.02, treatment 2 of 104 (1.9%), control 9 of 96 (9.4%), NNT 13, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gordon et al., 13 Dec 2021, prospective, USA, peer-reviewed, 2 authors.
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