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0 0.5 1 1.5 2+ Severe case 82% Improvement Relative Risk Gonçalves et al. Zinc for COVID-19 ICU PATIENTS Sufficiency Are zinc levels associated with COVID-19 outcomes? Retrospective 269 patients in Brazil Lower severe cases with higher zinc levels (p=0.001) Gonçalves et al., Nutrition in Clinical Practice, doi:10.1002/ncp.10612 Favors zinc Favors control

Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2

Gonçalves et al., Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Gonçalves et al., Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus.., Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Dec 2020   Source   PDF  
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Retrospective 169 ICU patients in Brazil, 214 with low zinc levels, showing an association between low zinc levels and severe ARDS. CAAE 30608,020.9.0000.8114.
risk of severe case, 82.3% lower, RR 0.18, p < 0.001, high zinc levels 7 of 55 (12.7%), low zinc levels 145 of 214 (67.8%), NNT 1.8, adjusted per study, inverted to make RR<1 favor high zinc levels, odds ratio converted to relative risk, ≥70 μg/dL, logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gonçalves et al., 23 Dec 2020, retrospective, Brazil, peer-reviewed, 9 authors.
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Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS‐CoV‐2
Thiago Jose Martins Gonçalves, Sandra Elisa Adami Batista Gonçalves, MD Andreia Guarnieri, MD; Maysa Rodrigo Cristovão Risegato, Maysa Penteado Guimarães, Daniella Cabral Freitas, Alvaro Razuk‐filho, Pedro Batista Benedito Junior, MD Eduardo Fagundes Parrillo
Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Background: We verify the prevalence of low zinc levels among critically ill patients infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS). Methods: This is an observational study composed of patients admitted to the ICU. Demographics, anthropometric data for calculating body mass index (BMI), and laboratory data were obtained at admission: blood count, ferritin, arterial blood gas, serum zinc levels, and C-reactive protein. Also, arterial oxygen tension (PaO 2 ) divided by fractional inspired oxygen (FiO 2 ) was calculated by the first arterial blood gas after intubation. A diagnosis of severe ARDS was determined if the PaO 2 /FiO 2 ratio was ≤100 mm Hg. Low zinc levels were established if zinc levels were <70 μg/dL. Results: A total of 269 patients met inclusion criteria; 51.3% were men; median age was 74 (66-81) years; 91.1% (245 of 269) were elderly. The median BMI was 30.1 (24.7-32.1) kg/m 2 , with 59.9% (161 of 269) of patients having overweight and obesity. The prevalence of low zinc levels was 79.6% (214 of 269) and severe ARDS was 56.5% (152 of 269). There was an association of low zinc levels and severe ARDS (odds ratio [OR], 14.4; 95% CI, 6.2-33.5; P < .001), even after adjusting for baseline variables (OR, 15.4; 95% CI, 6.5-36.3; P < .001). Conclusion: Critically ill patients infected by SARS-CoV-2 with severe ARDS have a high prevalence of low serum zinc levels.
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