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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 82% Improvement Relative Risk Zinc for COVID-19  Gonçalves et al.  ICU PATIENTS Are zinc levels associated with COVID-19 outcomes? Retrospective 269 patients in Brazil Lower severe cases with higher zinc levels (p=0.001) c19early.org Gonçalves et al., Nutrition in Clinica.., Dec 2020 Favors zinc Favors control

Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2

Gonçalves et al., Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Dec 2020  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 169 ICU patients in Brazil, 214 with low zinc levels, showing an association between low zinc levels and severe ARDS. CAAE 30608,020.9.0000.8114.
risk of severe case, 82.3% lower, RR 0.18, p < 0.001, high zinc levels 7 of 55 (12.7%), low zinc levels 145 of 214 (67.8%), NNT 1.8, adjusted per study, inverted to make RR<1 favor high zinc levels, odds ratio converted to relative risk, ≥70 μg/dL, logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gonçalves et al., 23 Dec 2020, retrospective, Brazil, peer-reviewed, 9 authors.
This PaperZincAll
Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS‐CoV‐2
Thiago Jose Martins Gonçalves, Sandra Elisa Adami Batista Gonçalves, MD Andreia Guarnieri, MD; Maysa Rodrigo Cristovão Risegato, Maysa Penteado Guimarães, Daniella Cabral Freitas, Alvaro Razuk‐filho, Pedro Batista Benedito Junior, MD Eduardo Fagundes Parrillo
Nutrition in Clinical Practice, doi:10.1002/ncp.10612
Background: We verify the prevalence of low zinc levels among critically ill patients infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS). Methods: This is an observational study composed of patients admitted to the ICU. Demographics, anthropometric data for calculating body mass index (BMI), and laboratory data were obtained at admission: blood count, ferritin, arterial blood gas, serum zinc levels, and C-reactive protein. Also, arterial oxygen tension (PaO 2 ) divided by fractional inspired oxygen (FiO 2 ) was calculated by the first arterial blood gas after intubation. A diagnosis of severe ARDS was determined if the PaO 2 /FiO 2 ratio was ≤100 mm Hg. Low zinc levels were established if zinc levels were <70 μg/dL. Results: A total of 269 patients met inclusion criteria; 51.3% were men; median age was 74 (66-81) years; 91.1% (245 of 269) were elderly. The median BMI was 30.1 (24.7-32.1) kg/m 2 , with 59.9% (161 of 269) of patients having overweight and obesity. The prevalence of low zinc levels was 79.6% (214 of 269) and severe ARDS was 56.5% (152 of 269). There was an association of low zinc levels and severe ARDS (odds ratio [OR], 14.4; 95% CI, 6.2-33.5; P < .001), even after adjusting for baseline variables (OR, 15.4; 95% CI, 6.5-36.3; P < .001). Conclusion: Critically ill patients infected by SARS-CoV-2 with severe ARDS have a high prevalence of low serum zinc levels.
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