Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All zinc studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchZincZinc (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severityhttps://link.springer.com/10.1007/s12011-021-02946-1

Kocak et al., Biological Trace Element Research, doi:10.1007/s12011-021-02946-1
Oct 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Analysis of 60 COVID-19 patients and 32 healthy controls, showing that zinc and selenium levels were significantly lower in COVID-19 patients compared to controls. Zinc levels decreased with increasing disease severity from asymptomatic to severe disease. Selenium levels were significantly lower in mild and severe COVID-19 patients compared to controls and asymptomatic patients.
Study covers zinc and selenium.
Kocak et al., 4 Oct 2021, retrospective, Turkey, peer-reviewed, 7 authors. Contact: omer.kocak@atauni.edu.tr.
This PaperZincAll
Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity
Omer Faruk Kocak, Fatma Betul Ozgeris, Emine Parlak, Yucel Kadıoglu, Neslihan Yuce, Mehmet Emrah Yaman, Ebubekir Bakan
Biological Trace Element Research, doi:10.1007/s12011-021-02946-1
While the COVID-19 disease progresses mildly or asymptomatically in some people, its progression is severe and symptomatic in others, and it is an issue that requires a scientific response regarding the disease. The present study includes 60 people infected with COVID-19, and the cases were divided into the following groups: asymptomatic, mild, moderate, and severe. Serum Zn, Se, and Cu levels of these groups were analyzed by ICP-MS. All measurements in the patients were compared with those of 32 healthy individuals. When the patient group is compared with the control group, the serum Zn and Se concentrations were statistically low (p < 0.001) in the patient group. Serum Zn level decreased significantly in 4 different patient groups compared to the control group. Although the serum Se level decreased in all four patient groups compared to the control group, the change in Se level was statistically significant only in the severe and mild patient groups. This study examined serum Zn, Se concentrations, and biochemical parameters in patients with different severity of COVID-19, compared them with healthy individuals, and revealed new targets for diagnosis and treatment by revealing those data that may be important.
Consent to Participate Not applicable. Consent for Publication Not applicable. Conflict of Interest The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Anuk, The relation between trace element status (zinc, copper, magnesium) and clinical outcomes in COVID-19 infection during pregnancy, Biol Trace Element Res
Arant, Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study, J Am Coll Cardiol
Bonham, The immune system as a physiological indicator of marginal copper status?, Br J Nutr
Bulut, Kato, Epidemiology of COVID-19, Turkish J Med Sci
Bánfalvi, Cellular effects of heavy metals
Calder, Nutrition, immunity and COVID-19, BMJ Nutrition, Prevention & Health
Calder, Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections, Nutrients
Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published online March 26, BMJ
Chen, Emerging coronaviruses: genome structure, replication, and pathogenesis, J Med Virol
De Jesus, De, Andrade, Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19, Metallomics
Denison, Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events, Virology
Drent, Cobben, Henderson, Wouters, Van Dieijen-Visser, Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation, Eur Resp J
Ersoy, Determination of diagnosis and disease severity, hospital and intensive care unit admission criteria in COVID-19, J Crit Intensive Care
Fung, Liu, Human coronavirus: host-pathogen interaction, Annu Rev Microbiol
Gong, Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia, MedRxiv
Hamasaki, Kawashima, Yanai, Serum Zn/Cu ratio is associated with renal function, glycemic control, and metabolic parameters in Japanese patients with and without type 2 diabetes: a cross-sectional study, Front Endocrinol
Hanaei, Rezaei, COVID-19: developing from an outbreak to a pandemic, Arch Med Res
Harbalioglu, Omer, A COVİD-19 tanısı alan hastalarda yatarak tedavi görmeyi öngörmede 3 prediktör: yaş, laktat dehidrogenaz ve nötrofil/Lenfosit oranı, Pamukkale Tıp Dergisi
Harthill, Micronutrient selenium deficiency influences evolution of some viral infectious diseases, Biol Trace Elem Res
Huang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The Lancet
Iglesias, Selenium and kidney disease, J Nephrol
Jothimani, COVID-19: poor outcomes in patients with zinc deficiency, Int J Infect Dis
Kardos, Copper signalling: causes and consequences, Cell Communication and Signaling
Kocak, Albayrak, Analysis of trace elements in FFPE colon tissue specimens using ICP-MS, Int J Innovative Res Rev
Laur, ICP-MS trace element analysis in serum and whole blood, PloS one
Majeed, An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: the case for adequate selenium status, Nutrition
Marrie, Symptoms and signs plus erythrocyte ESRentation rate or C-reactive protein predicted pneumonia in lower respiratory tract infection Contributions of symptoms, signs, erythrocyte ESRentation rate, and C-reactive protein to a diagnosis of pneumonia in acute lower respiratory tract infection, Evidence-based Med
Pearson, Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population, Eur J Clin Nutr
Raha, Is copper beneficial for COVID-19 patients?, Medical hypotheses
Razzaque, COVID-19 pandemic: can maintaining optimal zinc balance enhance host resistance?, Tohoku J Exp Med
Read, The role of zinc in antiviral immunity, Adv Nutr
Sattar, Three cases of COVID-19 disease with colonic manifestations, Am J Gastroenterol
Shi, COVID-19 infection: the perspectives on immune responses
Taheri, A review on the serum electrolytes and trace elements role in the pathophysiology of COVID-19, Biol Trace Element Res
Tanacan, The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: experience of a pandemic center in Turkey, Eur J Obstet Gynecol Reprod Biol
Tersalvi, Elevated troponin in patients with coronavirus disease 2019 (COVID-19): possible mechanisms, J Cardiac Failure
Wan, Clinical features and treatment of COVID-19 patients in northeast Chongqing, J Med Virol
Wuá, Caiá, Zhouá, Duá, Ál, Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease, JAMA Intern Med
Zabetakis, COVID-19: the inflammation link and the role of nutrition in potential mitigation, Nutrients
Zeng, Urinary trace elements in association with disease severity and outcome in patients with COVID-19, Environ Res
Zhang, Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target, Intensive Care Med
Şahin, Demir, Virüsler, Viral Pandemileri Etkileyen Faktörler ve Sonuçları. Muzaffer Şeker, Ali Özer ve Cem Korkut, Türkiye Bilimler Akademisi
{ 'DOI': '10.1007/s12011-021-02946-1', 'ISSN': ['0163-4984', '1559-0720'], 'URL': 'http://dx.doi.org/10.1007/s12011-021-02946-1', 'alternative-id': ['2946'], 'assertion': [ { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Received', 'name': 'received', 'order': 1, 'value': '7 July 2021'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Accepted', 'name': 'accepted', 'order': 2, 'value': '30 September 2021'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'First Online', 'name': 'first_online', 'order': 3, 'value': '4 October 2021'}, {'group': {'label': 'Declarations', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 1}, { 'group': {'label': 'Ethical Approval', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 2, 'value': 'This study has been approved by the clinical research ethics committee of ' 'Ataturk University, Faculty of Medicine and Turkish Ministry of Health (No: ' 'B.30.2.ATA.0.01.00/295).'}, { 'group': {'label': 'Consent to Participate', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 3, 'value': 'Not applicable.'}, { 'group': {'label': 'Consent for Publication', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 4, 'value': 'Not applicable.'}, { 'group': {'label': 'Conflict of Interest', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 5, 'value': 'The authors declare no competing interests.'}, { 'label': 'Free to read', 'name': 'free', 'value': 'This content has been made available to all.'}], 'author': [ {'affiliation': [], 'family': 'Kocak', 'given': 'Omer Faruk', 'sequence': 'first'}, {'affiliation': [], 'family': 'Ozgeris', 'given': 'Fatma Betul', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Parlak', 'given': 'Emine', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kadıoglu', 'given': 'Yucel', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Yuce', 'given': 'Neslihan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Yaman', 'given': 'Mehmet Emrah', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Bakan', 'given': 'Ebubekir', 'sequence': 'additional'}], 'container-title': 'Biological Trace Element Research', 'container-title-short': 'Biol Trace Elem Res', 'content-domain': {'crossmark-restriction': False, 'domain': ['link.springer.com']}, 'created': {'date-parts': [[2021, 10, 5]], 'date-time': '2021-10-05T11:46:32Z', 'timestamp': 1633434392000}, 'deposited': { 'date-parts': [[2022, 6, 16]], 'date-time': '2022-06-16T02:18:36Z', 'timestamp': 1655345916000}, 'indexed': {'date-parts': [[2023, 8, 4]], 'date-time': '2023-08-04T00:41:03Z', 'timestamp': 1691109663914}, 'is-referenced-by-count': 12, 'issue': '7', 'issued': {'date-parts': [[2021, 10, 4]]}, 'journal-issue': {'issue': '7', 'published-print': {'date-parts': [[2022, 7]]}}, 'language': 'en', 'license': [ { 'URL': 'https://www.springer.com/tdm', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 10, 4]], 'date-time': '2021-10-04T00:00:00Z', 'timestamp': 1633305600000}}, { 'URL': 'https://www.springer.com/tdm', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 10, 4]], 'date-time': '2021-10-04T00:00:00Z', 'timestamp': 1633305600000}}], 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-021-02946-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s12011-021-02946-1/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-021-02946-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '297', 'original-title': [], 'page': '3138-3146', 'prefix': '10.1007', 'published': {'date-parts': [[2021, 10, 4]]}, 'published-online': {'date-parts': [[2021, 10, 4]]}, 'published-print': {'date-parts': [[2022, 7]]}, 'publisher': 'Springer Science and Business Media LLC', 'reference': [ { 'key': '2946_CR1', 'unstructured': 'Şahin F and Demir S (2020) Virüsler, Viral Pandemileri Etkileyen ' 'Faktörler ve Sonuçları. Muzaffer Şeker, Ali Özer ve Cem Korkut. Türkiye ' 'Bilimler Akademisi 55–76'}, { 'key': '2946_CR2', 'unstructured': '“ICTV Master Species List 2013 v2” ' 'http://talk.ictvonline.org/files/ictv_documents/m/msl/4911.aspx. ' 'Accessed 8 Sept 2021'}, { 'DOI': '10.3906/sag-2004-172', 'author': 'C Bulut', 'doi-asserted-by': 'publisher', 'first-page': '563', 'issue': 'SI-1', 'journal-title': 'Turkish J Med Sci', 'key': '2946_CR3', 'unstructured': 'Bulut C, Kato Y (2020) Epidemiology of COVID-19. Turkish J Med Sci ' '50(SI-1):563–570', 'volume': '50', 'year': '2020'}, { 'DOI': '10.1002/jmv.25681', 'author': 'Y Chen', 'doi-asserted-by': 'publisher', 'first-page': '418', 'issue': '4', 'journal-title': 'J Med Virol', 'key': '2946_CR4', 'unstructured': 'Chen Y et al (2020) Emerging coronaviruses: genome structure, ' 'replication, and pathogenesis. J Med Virol 92(4):418–423', 'volume': '92', 'year': '2020'}, { 'DOI': '10.1146/annurev-micro-020518-115759', 'author': 'TS Fung', 'doi-asserted-by': 'publisher', 'first-page': '529', 'journal-title': 'Annu Rev Microbiol', 'key': '2946_CR5', 'unstructured': 'Fung TS, Liu DX (2019) Human coronavirus: host-pathogen interaction. ' 'Annu Rev Microbiol 73:529–557', 'volume': '73', 'year': '2019'}, { 'DOI': '10.1016/S0140-6736(20)30183-5', 'author': 'C Huang', 'doi-asserted-by': 'publisher', 'first-page': '497', 'issue': '10223', 'journal-title': 'China The Lancet', 'key': '2946_CR6', 'unstructured': 'Huang C et al (2020) Clinical features of patients infected with 2019 ' 'novel coronavirus in Wuhan. China The Lancet 395(10223):497–506', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1016/j.arcmed.2020.04.021', 'doi-asserted-by': 'crossref', 'key': '2946_CR7', 'unstructured': 'Hanaei S and Rezaei N (2020) COVID-19: developing from an outbreak to a ' 'pandemic. Arch Med Res'}, { 'DOI': '10.1136/bmjnph-2020-000085', 'author': 'PC Calder', 'doi-asserted-by': 'publisher', 'first-page': '74', 'issue': '1', 'journal-title': 'BMJ Nutrition, Prevention & Health', 'key': '2946_CR8', 'unstructured': 'Calder PC (2020) Nutrition, immunity and COVID-19. BMJ Nutrition, ' 'Prevention & Health 3(1):74', 'volume': '3', 'year': '2020'}, { 'author': 'OF Kocak', 'first-page': '10', 'issue': '1', 'journal-title': 'Int J Innovative Res Rev', 'key': '2946_CR9', 'unstructured': 'Kocak OF, Albayrak M (2021) Analysis of trace elements in FFPE colon ' 'tissue specimens using ICP-MS. Int J Innovative Res Rev 5(1):10–14', 'volume': '5', 'year': '2021'}, { 'DOI': '10.1007/978-94-007-0428-2_1', 'doi-asserted-by': 'crossref', 'key': '2946_CR10', 'unstructured': 'Bánfalvi G (2011) Cellular effects of heavy metals. Springer Science & ' 'Business Media. pp. 3–28, New York-ABD'}, { 'DOI': '10.1039/d0mt00220h', 'author': 'JR de Jesus', 'doi-asserted-by': 'publisher', 'first-page': '1912', 'issue': '12', 'journal-title': 'Metallomics', 'key': '2946_CR11', 'unstructured': 'de Jesus JR, de Araújo Andrade T (2020) Understanding the relationship ' 'between viral infections and trace elements from a metallomics ' 'perspective: implications for COVID-19. Metallomics 12(12):1912–1930', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1620/tjem.251.175', 'author': 'MS Razzaque', 'doi-asserted-by': 'publisher', 'first-page': '175', 'issue': '3', 'journal-title': 'Tohoku J Exp Med', 'key': '2946_CR12', 'unstructured': 'Razzaque MS (2020) COVID-19 pandemic: can maintaining optimal zinc ' 'balance enhance host resistance? Tohoku J Exp Med 251(3):175–181', 'volume': '251', 'year': '2020'}, { 'DOI': '10.3390/nu12041181', 'author': 'PC Calder', 'doi-asserted-by': 'publisher', 'first-page': '1181', 'issue': '4', 'journal-title': 'Nutrients', 'key': '2946_CR13', 'unstructured': 'Calder PC et al (2020) Optimal nutritional status for a well-functioning ' 'immune system is an important factor to protect against viral ' 'infections. Nutrients 12(4):1181', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1007/s12011-020-02377-4', 'doi-asserted-by': 'crossref', 'key': '2946_CR14', 'unstructured': 'Taheri M, et al (2020) A review on the serum electrolytes and trace ' 'elements role in the pathophysiology of COVID-19. Biol Trace Element Res ' '1–7'}, { 'DOI': '10.5301/jn.5000213', 'author': 'P Iglesias', 'doi-asserted-by': 'publisher', 'first-page': '266', 'issue': '2', 'journal-title': 'J Nephrol', 'key': '2946_CR15', 'unstructured': 'Iglesias P et al (2012) Selenium and kidney disease. J Nephrol ' '26(2):266–272', 'volume': '26', 'year': '2012'}, { 'DOI': '10.1079/BJN2002558', 'author': 'M Bonham', 'doi-asserted-by': 'publisher', 'first-page': '393', 'issue': '5', 'journal-title': 'Br J Nutr', 'key': '2946_CR16', 'unstructured': 'Bonham M et al (2002) The immune system as a physiological indicator of ' 'marginal copper status? Br J Nutr 87(5):393–403', 'volume': '87', 'year': '2002'}, { 'DOI': '10.1038/sj.ejcn.1602209', 'author': 'P Pearson', 'doi-asserted-by': 'publisher', 'first-page': '1043', 'issue': '9', 'journal-title': 'Eur J Clin Nutr', 'key': '2946_CR17', 'unstructured': 'Pearson P et al (2005) Lung function and blood levels of copper, ' 'selenium, vitamin C and vitamin E in the general population. Eur J Clin ' 'Nutr 59(9):1043–1048', 'volume': '59', 'year': '2005'}, { 'DOI': '10.3390/nu12051466', 'author': 'I Zabetakis', 'doi-asserted-by': 'publisher', 'first-page': '1466', 'issue': '5', 'journal-title': 'Nutrients', 'key': '2946_CR18', 'unstructured': 'Zabetakis I et al (2020) COVID-19: the inflammation link and the role of ' 'nutrition in potential mitigation. Nutrients 12(5):1466', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1016/j.mehy.2020.109814', 'doi-asserted-by': 'crossref', 'key': '2946_CR19', 'unstructured': 'Raha S et al (2020) Is copper beneficial for COVID-19 patients?. Medical ' 'hypotheses 142:109814'}, { 'key': '2946_CR20', 'unstructured': 'Shi Y et al (2020) COVID-19 infection: the perspectives on immune ' 'responses. Nature Publishing Group'}, { 'DOI': '10.1016/j.ijid.2020.09.014', 'author': 'D Jothimani', 'doi-asserted-by': 'publisher', 'first-page': '343', 'journal-title': 'Int J Infect Dis', 'key': '2946_CR21', 'unstructured': 'Jothimani D et al (2020) COVID-19: poor outcomes in patients with zinc ' 'deficiency. Int J Infect Dis 100:343–349', 'volume': '100', 'year': '2020'}, { 'DOI': '10.1016/j.envres.2020.110670', 'author': 'HL Zeng', 'doi-asserted-by': 'publisher', 'first-page': '110670', 'journal-title': 'Environ Res', 'key': '2946_CR22', 'unstructured': 'Zeng HL et al (2021) Urinary trace elements in association with disease ' 'severity and outcome in patients with COVID-19. Environ Res 194:110670', 'volume': '194', 'year': '2021'}, { 'DOI': '10.1016/j.nut.2020.111053', 'author': 'M Majeed', 'doi-asserted-by': 'publisher', 'first-page': '111053', 'journal-title': 'Nutrition', 'key': '2946_CR23', 'unstructured': 'Majeed M et al (2021) An exploratory study of selenium status in healthy ' 'individuals and in patients with COVID-19 in a south Indian population: ' 'the case for adequate selenium status. Nutrition 82:111053', 'volume': '82', 'year': '2021'}, { 'DOI': '10.1007/s12011-020-02496-y', 'doi-asserted-by': 'crossref', 'key': '2946_CR24', 'unstructured': 'Anuk AT et al (2020) The relation between trace element status (zinc, ' 'copper, magnesium) and clinical outcomes in COVID-19 infection during ' 'pregnancy. Biol Trace Element Res 1–10'}, { 'DOI': '10.1016/j.ejogrb.2020.07.051', 'author': 'A Tanacan', 'doi-asserted-by': 'publisher', 'first-page': '31', 'journal-title': 'Eur J Obstet Gynecol Reprod Biol', 'key': '2946_CR25', 'unstructured': 'Tanacan A et al (2020) The rate of SARS-CoV-2 positivity in asymptomatic ' 'pregnant women admitted to hospital for delivery: experience of a ' 'pandemic center in Turkey. Eur J Obstet Gynecol Reprod Biol 253:31–34', 'volume': '253', 'year': '2020'}, { 'DOI': '10.1371/journal.pone.0233357', 'author': 'N Laur', 'doi-asserted-by': 'publisher', 'first-page': 'e0233357', 'issue': '5', 'journal-title': 'PloS one', 'key': '2946_CR26', 'unstructured': 'Laur N et al (2020) ICP-MS trace element analysis in serum and whole ' 'blood. PloS one 15(5):e0233357', 'volume': '15', 'year': '2020'}, { 'key': '2946_CR27', 'unstructured': 'Ersoy EO (2020) Determination of diagnosis and disease severity, ' 'hospital and intensive care unit admission criteria in COVID-19. J Crit ' 'Intensive Care 11(Supp.):4'}, { 'DOI': '10.1093/advances/nmz013', 'author': 'SA Read', 'doi-asserted-by': 'publisher', 'first-page': '696', 'issue': '4', 'journal-title': 'Adv Nutr', 'key': '2946_CR28', 'unstructured': 'Read SA et al (2019) The role of zinc in antiviral immunity. Adv Nutr ' '10(4):696–710', 'volume': '10', 'year': '2019'}, { 'DOI': '10.1016/0042-6822(92)90703-R', 'author': 'MR Denison', 'doi-asserted-by': 'publisher', 'first-page': '274', 'issue': '1', 'journal-title': 'Virology', 'key': '2946_CR29', 'unstructured': 'Denison MR et al (1992) Intracellular processing of the N-terminal ORF ' '1a proteins of the coronavirus MHV-A59 requires multiple proteolytic ' 'events. Virology 189(1):274–284', 'volume': '189', 'year': '1992'}, { 'DOI': '10.14309/ajg.0000000000000692', 'doi-asserted-by': 'crossref', 'key': '2946_CR30', 'unstructured': 'Sattar Y et al (2020) Three cases of COVID-19 disease with colonic ' 'manifestations. Am J Gastroenterol'}, { 'DOI': '10.1007/s00134-020-05985-9', 'author': 'H Zhang', 'doi-asserted-by': 'publisher', 'first-page': '586', 'issue': '4', 'journal-title': 'Intensive Care Med', 'key': '2946_CR31', 'unstructured': 'Zhang H et al (2020) Angiotensin-converting enzyme 2 (ACE2) as a ' 'SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic ' 'target. Intensive Care Med 46(4):586–590', 'volume': '46', 'year': '2020'}, { 'DOI': '10.1007/s12011-011-8977-1', 'author': 'M Harthill', 'doi-asserted-by': 'publisher', 'first-page': '1325', 'issue': '3', 'journal-title': 'Biol Trace Elem Res', 'key': '2946_CR32', 'unstructured': 'Harthill M (2011) Micronutrient selenium deficiency influences evolution ' 'of some viral infectious diseases. Biol Trace Elem Res 143(3):1325–1336', 'volume': '143', 'year': '2011'}, { 'DOI': '10.1183/09031936.96.09081736', 'author': 'M Drent', 'doi-asserted-by': 'publisher', 'first-page': '1736', 'journal-title': 'Eur Resp J', 'key': '2946_CR33', 'unstructured': 'Drent M, Cobben N, henderson RF, Wouters EFM, van Dieijen-Visser M ' '(1996) Usefulness of lactate dehydrogenase and its isoenzymes as ' 'indicators of lung damage or inflammation. Eur Resp J 9:1736–1742', 'volume': '9', 'year': '1996'}, { 'key': '2946_CR34', 'unstructured': 'Harbalioglu H, Omer G, and Yildirim A COVİD-19 tanısı alan hastalarda ' 'yatarak tedavi görmeyi öngörmede 3 prediktör: yaş, laktat dehidrogenaz ' 've nötrofil/Lenfosit oranı. Pamukkale Tıp Dergisi 14(1):7–7'}, { 'key': '2946_CR35', 'unstructured': 'Chen T, et al (2020) Clinical characteristics of 113 deceased patients ' 'with coronavirus disease 2019: retrospective study [published online ' 'March 26, 2020]. BMJ'}, { 'key': '2946_CR36', 'unstructured': 'Wuá CC and Caiá YX, Zhouá X, Duá C et ál (2020) Risk factors associated ' 'with acute respiratory distress syndrome and death in patients with ' 'coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med ' '180:1-11'}, { 'DOI': '10.1002/jmv.25783', 'author': 'S Wan', 'doi-asserted-by': 'publisher', 'first-page': '797', 'issue': '7', 'journal-title': 'J Med Virol', 'key': '2946_CR37', 'unstructured': 'Wan S et al (2020) Clinical features and treatment of COVID-19 patients ' 'in northeast Chongqing. J Med Virol 92(7):797–806', 'volume': '92', 'year': '2020'}, { 'DOI': '10.1016/j.cardfail.2020.04.009', 'doi-asserted-by': 'crossref', 'key': '2946_CR38', 'unstructured': 'Tersalvi G, et al (2020) Elevated troponin in patients with coronavirus ' 'disease 2019 (COVID-19): possible mechanisms. J Cardiac Failure'}, { 'DOI': '10.1136/ebm.9.2.55', 'doi-asserted-by': 'crossref', 'key': '2946_CR39', 'unstructured': 'Marrie T, et al (2004) Symptoms and signs plus erythrocyte ESRentation ' 'rate or C-reactive protein predicted pneumonia in lower respiratory ' 'tract infection Contributions of symptoms, signs, erythrocyte ' 'ESRentation rate, and C-reactive protein to a diagnosis of pneumonia in ' 'acute lower respiratory tract infection. Evidence-based Med 9(2)'}, { 'DOI': '10.1101/2020.02.25.20025643', 'doi-asserted-by': 'crossref', 'key': '2946_CR40', 'unstructured': 'Gong J, et al (2020) Correlation analysis between disease severity and ' 'inflammation-related parameters in patients with COVID-19 pneumonia. ' 'MedRxiv'}, { 'DOI': '10.1186/s12964-017-0212-z', 'author': 'J Kardos', 'doi-asserted-by': 'publisher', 'first-page': '1', 'issue': '1', 'journal-title': 'Cell Communication and Signaling', 'key': '2946_CR41', 'unstructured': 'Kardos J et al (2018) Copper signalling: causes and consequences. Cell ' 'Communication and Signaling 16(1):1–22', 'volume': '16', 'year': '2018'}, { 'DOI': '10.3389/fendo.2016.00147', 'author': 'H Hamasaki', 'doi-asserted-by': 'publisher', 'first-page': '147', 'journal-title': 'Front Endocrinol', 'key': '2946_CR42', 'unstructured': 'Hamasaki H, Kawashima Y, Yanai H (2016) Serum Zn/Cu ratio is associated ' 'with renal function, glycemic control, and metabolic parameters in ' 'Japanese patients with and without type 2 diabetes: a cross-sectional ' 'study. Front Endocrinol 7:147', 'volume': '7', 'year': '2016'}, { 'DOI': '10.1016/j.jacc.2004.01.038', 'author': 'CB Arant', 'doi-asserted-by': 'publisher', 'first-page': '2009', 'issue': '11', 'journal-title': 'J Am Coll Cardiol', 'key': '2946_CR43', 'unstructured': 'Arant CB et al (2004) Hemoglobin level is an independent predictor for ' 'adverse cardiovascular outcomes in women undergoing evaluation for chest ' 'pain: results from the National Heart, Lung, and Blood Institute Women’s ' 'Ischemia Syndrome Evaluation Study. J Am Coll Cardiol 43(11):2009–2014', 'volume': '43', 'year': '2004'}], 'reference-count': 43, 'references-count': 43, 'relation': {}, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s12011-021-02946-1'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [ 'Biochemistry (medical)', 'Inorganic Chemistry', 'Clinical Biochemistry', 'General Medicine', 'Biochemistry', 'Endocrinology, Diabetes and Metabolism'], 'subtitle': [], 'title': 'Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients ' 'According to Disease Severity', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'volume': '200'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit