Conv. Plasma
Nigella Sativa
Peg.. Lambda

All zinc studies
Meta analysis
Home COVID-19 treatment researchZincZinc (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  

Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity

Kocak et al., Biological Trace Element Research, doi:10.1007/s12011-021-02946-1
Oct 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Analysis of 60 COVID-19 patients and 32 healthy controls, showing that zinc and selenium levels were significantly lower in COVID-19 patients compared to controls. Zinc levels decreased with increasing disease severity from asymptomatic to severe disease. Selenium levels were significantly lower in mild and severe COVID-19 patients compared to controls and asymptomatic patients.
This study includes zinc and selenium.
Kocak et al., 4 Oct 2021, retrospective, Turkey, peer-reviewed, 7 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperZincAll
Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity
Omer Faruk Kocak, Fatma Betul Ozgeris, Emine Parlak, Yucel Kadıoglu, Neslihan Yuce, Mehmet Emrah Yaman, Ebubekir Bakan
Biological Trace Element Research, doi:10.1007/s12011-021-02946-1
While the COVID-19 disease progresses mildly or asymptomatically in some people, its progression is severe and symptomatic in others, and it is an issue that requires a scientific response regarding the disease. The present study includes 60 people infected with COVID-19, and the cases were divided into the following groups: asymptomatic, mild, moderate, and severe. Serum Zn, Se, and Cu levels of these groups were analyzed by ICP-MS. All measurements in the patients were compared with those of 32 healthy individuals. When the patient group is compared with the control group, the serum Zn and Se concentrations were statistically low (p < 0.001) in the patient group. Serum Zn level decreased significantly in 4 different patient groups compared to the control group. Although the serum Se level decreased in all four patient groups compared to the control group, the change in Se level was statistically significant only in the severe and mild patient groups. This study examined serum Zn, Se concentrations, and biochemical parameters in patients with different severity of COVID-19, compared them with healthy individuals, and revealed new targets for diagnosis and treatment by revealing those data that may be important.
Consent to Participate Not applicable. Consent for Publication Not applicable. Conflict of Interest The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Anuk, The relation between trace element status (zinc, copper, magnesium) and clinical outcomes in COVID-19 infection during pregnancy, Biol Trace Element Res
Arant, Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study, J Am Coll Cardiol
Bonham, The immune system as a physiological indicator of marginal copper status?, Br J Nutr
Bulut, Kato, Epidemiology of COVID-19, Turkish J Med Sci
Bánfalvi, Cellular effects of heavy metals
Calder, Nutrition, immunity and COVID-19, BMJ Nutrition, Prevention & Health
Calder, Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections, Nutrients
Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published online March 26, BMJ
Chen, Emerging coronaviruses: genome structure, replication, and pathogenesis, J Med Virol
De Jesus, De, Andrade, Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19, Metallomics
Denison, Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events, Virology
Drent, Cobben, Henderson, Wouters, Van Dieijen-Visser, Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation, Eur Resp J
Ersoy, Determination of diagnosis and disease severity, hospital and intensive care unit admission criteria in COVID-19, J Crit Intensive Care
Fung, Liu, Human coronavirus: host-pathogen interaction, Annu Rev Microbiol
Gong, Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia, MedRxiv
Hamasaki, Kawashima, Yanai, Serum Zn/Cu ratio is associated with renal function, glycemic control, and metabolic parameters in Japanese patients with and without type 2 diabetes: a cross-sectional study, Front Endocrinol
Hanaei, Rezaei, COVID-19: developing from an outbreak to a pandemic, Arch Med Res
Harbalioglu, Omer, A COVİD-19 tanısı alan hastalarda yatarak tedavi görmeyi öngörmede 3 prediktör: yaş, laktat dehidrogenaz ve nötrofil/Lenfosit oranı, Pamukkale Tıp Dergisi
Harthill, Micronutrient selenium deficiency influences evolution of some viral infectious diseases, Biol Trace Elem Res
Huang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The Lancet
Iglesias, Selenium and kidney disease, J Nephrol
Jothimani, COVID-19: poor outcomes in patients with zinc deficiency, Int J Infect Dis
Kardos, Copper signalling: causes and consequences, Cell Communication and Signaling
Kocak, Albayrak, Analysis of trace elements in FFPE colon tissue specimens using ICP-MS, Int J Innovative Res Rev
Laur, ICP-MS trace element analysis in serum and whole blood, PloS one
Majeed, An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: the case for adequate selenium status, Nutrition
Marrie, Symptoms and signs plus erythrocyte ESRentation rate or C-reactive protein predicted pneumonia in lower respiratory tract infection Contributions of symptoms, signs, erythrocyte ESRentation rate, and C-reactive protein to a diagnosis of pneumonia in acute lower respiratory tract infection, Evidence-based Med
Pearson, Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population, Eur J Clin Nutr
Raha, Is copper beneficial for COVID-19 patients?, Medical hypotheses
Razzaque, COVID-19 pandemic: can maintaining optimal zinc balance enhance host resistance?, Tohoku J Exp Med
Read, The role of zinc in antiviral immunity, Adv Nutr
Sattar, Three cases of COVID-19 disease with colonic manifestations, Am J Gastroenterol
Shi, COVID-19 infection: the perspectives on immune responses
Taheri, A review on the serum electrolytes and trace elements role in the pathophysiology of COVID-19, Biol Trace Element Res
Tanacan, The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: experience of a pandemic center in Turkey, Eur J Obstet Gynecol Reprod Biol
Tersalvi, Elevated troponin in patients with coronavirus disease 2019 (COVID-19): possible mechanisms, J Cardiac Failure
Wan, Clinical features and treatment of COVID-19 patients in northeast Chongqing, J Med Virol
Wuá, Caiá, Zhouá, Duá, Ál, Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease, JAMA Intern Med
Zabetakis, COVID-19: the inflammation link and the role of nutrition in potential mitigation, Nutrients
Zeng, Urinary trace elements in association with disease severity and outcome in patients with COVID-19, Environ Res
Zhang, Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target, Intensive Care Med
Şahin, Demir, Virüsler, Viral Pandemileri Etkileyen Faktörler ve Sonuçları. Muzaffer Şeker, Ali Özer ve Cem Korkut, Türkiye Bilimler Akademisi
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop