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Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV-2 infection: is there a need to supplement with Zinc COVID-19 patients?
Dubourg et al., Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2021.01.012
Dubourg et al., Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV-2 infection: is there a.., Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2021.01.012
Feb 2021   Source   PDF  
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Retrospective 275 patients showing zinc levels significantly lower in patients with poor outcomes, 840 vs. 970 µg/L, p< 0.0001.
Dubourg et al., 13 Feb 2021, peer-reviewed, 8 authors.
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Abstract: Journal of Microbiology, Immunology and Infection 54 (2021) 997e1000 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.e-jmii.com Short Communication Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV2 infection: is there a need to supplement with zinc COVID-19 patients? Grégory Dubourg a,b, Jean-Christophe Lagier a,b, Philippe Brouqui a,b, Jean-Paul Casalta a,b, Véronique Jacomo c, Bernard La Scola a,b, Jean-Marc Rolain a,b,**, Didier Raoult a,b,* a IHU-Méditerranée Infection, Marseille, France Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France c Eurofins Biomnis, Lyon, France b Received 4 September 2020; received in revised form 27 January 2021; accepted 31 January 2021 Available online 13 February 2021 KEYWORDS Zinc; SARS-COV-2; Severe; Clinical outcome; Chloroquine; Azithromycin Abstract Among 275 patients with COVID-19, we found that median blood zinc level was significantly lower in patients with poor clinical outcome (N Z 75) as compared to patients with good clinical outcome (N Z 200) (840 mg/L versus 970 mg/L; p < 0.0001), suggesting that zinc supplementation could be useful for patients with severe COVID-19. Copyright ª 2021, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
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