Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV-2 infection: is there a need to supplement with Zinc COVID-19 patients?
et al., Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2021.01.012
, Low blood zinc concentrations in patients with poor clinical outcome during SARS-CoV-2 infection: is there a.., Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2021.01.012
Retrospective 275 patients showing zinc levels significantly lower in patients with poor outcomes, 840 vs. 970 µg/L, p< 0.0001.
Dubourg et al., 13 Feb 2021, peer-reviewed, 8 authors.
Abstract: Journal of Microbiology, Immunology and Infection 54 (2021) 997e1000
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Short Communication
Low blood zinc concentrations in patients
with poor clinical outcome during SARS-CoV2 infection: is there a need to supplement
with zinc COVID-19 patients?
Grégory Dubourg a,b, Jean-Christophe Lagier a,b,
Philippe Brouqui a,b, Jean-Paul Casalta a,b, Véronique Jacomo c,
Bernard La Scola a,b, Jean-Marc Rolain a,b,**, Didier Raoult a,b,*
a
IHU-Méditerranée Infection, Marseille, France
Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France
c
Eurofins Biomnis, Lyon, France
b
Received 4 September 2020; received in revised form 27 January 2021; accepted 31 January 2021
Available online 13 February 2021
KEYWORDS
Zinc;
SARS-COV-2;
Severe;
Clinical outcome;
Chloroquine;
Azithromycin
Abstract Among 275 patients with COVID-19, we found that median blood zinc level was
significantly lower in patients with poor clinical outcome (N Z 75) as compared to patients
with good clinical outcome (N Z 200) (840 mg/L versus 970 mg/L; p < 0.0001), suggesting that
zinc supplementation could be useful for patients with severe COVID-19.
Copyright ª 2021, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an
open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
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