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Implications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation

Castle et al., Journal of Inflammation Research, doi:10.2147/JIR.S323356
Sep 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Review of the effects of COVID-19 on inflammatory markers, and the effects on those markers of standard treatments vs. vitamin D, melatonin, and meditation, showing comparable or superior effects with the non-standard treatments. The standard treatments in this study were remdesivir and tocilizumab. We note that standard treatments vary widely around the world, for example vitamin D is a standard treatment in many locations.
Reviews covering vitamin D for COVID-19 include1-28.
Study covers melatonin and vitamin D.
Castle et al., 22 Sep 2021, peer-reviewed, 8 authors.
This PaperVitamin DAll
Implications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation
Ryan D Castle, Michelle A Williams, William C Bushell, J Adam Rindfleisch, Christine Tara Peterson, James Marzolf, Kimberly Brouwer, Paul J Mills
Journal of Inflammation Research, doi:10.2147/jir.s323356
Introduction: COVID-19 poses a chronic threat to inflammatory systems, reinforcing the need for efficient anti-inflammatory strategies. The purpose of this review and analysis was to determine the efficacy of various interventions upon the inflammatory markers most affected by COVID-19. The focus was on the markers associated with COVID-19, not the etiology of the virus itself. Methods: Based on 27 reviewed papers, information was extracted on the effects of COVID-19 upon inflammatory markers, then the effects of standard treatments (Remdesivir, Tocilizumab) and adjunctive interventions (vitamin D 3 , melatonin, and meditation) were extracted for those markers. These data were used to approximate effect sizes for the disease or interventions via standardized mean differences (SMD). Results: The data that were available indicated that adjunctive interventions affected 68.4% of the inflammatory markers impacted by COVID-19, while standard pharmaceutical medication affected 26.3%. Discussion: Nonstandard adjunctive care appeared to have comparable or superior effects in comparison to Remdesivir and Tocilizumab on the inflammatory markers most impacted by COVID-19. Alongside standards of care, melatonin, vitamin D 3 , and meditation should be considered for treatment of SARS-COV-2 infection and COVID-19 disease.
Disclosure The authors report no conflicts of interest for this work. Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/2i2QG5lT0JI Journal of Inflammation Research Dovepress
References
Aiswarya, Arumugam, Dineshkumar, Use of remdesivir in patients with COVID-19 on hemodialysis: a Study of Safety and Tolerance, Kidney Int Rep, doi:10.1016/j.ekir.2020.12.003
Akbari, Tabrizi, Lankarani, The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, Life Sci, doi:10.1016/j.lfs.2020.118167
Alamdari, Mahdavi, Roshanravan, Placebo-controlled trial related to the effects of melatonin on oxidative stress and inflammatory parameters of obese women, Horm Metab Res, doi:10.1055/s-0034-1384587
Ali, Katz, Disease prevention and health promotion, Am J Prev Med, doi:10.1016/j.amepre.2015.07.019
Amiri-Dashatan, Koushki, Ghorbani, Naderi, Increased inflammatory markers correlate with liver damage and predict severe COVID-19: a systematic review and meta-analysis, Gastroenterol Hepatol Bed Bench
Bartels, Jørgensen, Bendix, 25-hydroxy vitamin D3 modulates dendritic cell phenotype and function in crohn's disease, Inflammopharmacology, doi:10.1007/s10787-012-0168-y
Black, Stress and the inflammatory response: a review of neurogenic inflammation, Brain Behav Immun, doi:10.1016/s0889-1591(02)00021-1
Bower, Crosswell, Stanton, Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial, Cancer, doi:10.1002/cncr.29194
Bushell, Castle, Williams, Meditation and yoga practices as potential adjunctive treatment of SARS-CoV-2 infection and COVID-19: a brief overview of key subjects, Journal of Inflammation Research, doi:10.1089/acm.2020.0177
Bushell, Theise, Toward a unified field of study: longevity, regeneration, and protection of health through meditation and related practices, Ann N Y Acad Sci, doi:10.1111/j.1749-6632.2009.04959.x
Ca, Kip, Post-White, Lymphocyte recovery after breast cancer treatment and mindfulness-based stress reduction (MBSR) therapy, Biol Res Nurs, doi:10.1177/1099800411419245
Cahn, Goodman, Peterson, Maturi, Mills, Yoga, meditation and mind-body health: increased BDNF, cortisol awakening response, and altered inflammatory marker expression after a 3-month yoga and meditation retreat, Front Hum Neurosci, doi:10.3389/fnhum.2017.00315
Carlson, Speca, Faris, Patel, One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients, Brain Behav Immun, doi:10.1016/j.bbi.2007.04.002
Carlson, Speca, Patel, Goodey, Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients, Psychoneuroendocrinology, doi:10.1016/s0306-4530(03)00054-4
Carlson, Speca, Patel, Goodey, Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients, Psychosom Med, doi:10.1097/01.psy.0000074003.35911.41
Castillo, Costa, Barrios, Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2020.105751
Celinski, Konturek, Slomka, Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease-14 months follow up, J Physiol Pharmacol
Chen, Liu, Liu, Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia, Zhonghua Jie He He Hu Xi Za Zhi, doi:10.3760/cma.j.issn.1001-0939.2020.0005
Chen, Wu, Guo, Clinical and immunological features of severe and moderate coronavirus disease 2019, J Clin Invest, doi:10.1172/JCI137244
Chen, Zheng, Yu, Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage, EMBO J, doi:10.15252/embj.2020105896
Choudhary, Sharma, Silakari, The interplay between inflammatory pathways and COVID-19: a critical review on pathogenesis and therapeutic options, Microb Pathog, doi:10.1016/j.micpath.2020.104673
Cichoz-Lach, Celinski, Konturek, Konturek, Slomka, The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis, J Physiol Pharmacol
Conti, Ronconi, Caraffa, Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies, J Biol Regul Homeost Agents, doi:10.23812/CONTI-E
Epel, Puterman, Lin, Meditation and vacation effects have an impact on disease-associated molecular phenotypes, Transl Psychiatry, doi:10.1038/tp.2016.164
Faraone, Interpreting estimates of treatment effects, P T
Feitosa, Júnior, Neto, COVID-19: rational discovery of the therapeutic potential of melatonin as a SARS-CoV-2 main protease inhibitor, Int J Med Sci, doi:10.7150/ijms.48053
Gonzalez-Garcia, Ferrer, Borras, Effectiveness of mindfulness-based cognitive therapy on the quality of life, emotional status, and CD4 cell count of patients aging with HIV infection, AIDS Behav, doi:10.1007/s10461-013-0612-z
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Gustine, Jones, Immunopathology of hyperinflammation in COVID-19, Am J Pathol, doi:10.1016/j.ajpath.2020.08.009
Hu, Huang, Alleviation of inflammatory response of pulmonary fibrosis in acute respiratory distress syndrome by puerarin via Transforming Growth Factor (TGF-beta1), Med Sci Monit, doi:10.12659/MSM.915570
Hunter, The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment, EMBO Rep, doi:10.1038/embor.2012.142
Isik, Ozuguz, Tutuncu, Serum transforming growth factor-beta levels in patients with vitamin D deficiency, Eur J Intern Med, doi:10.1016/j.ejim.2011.09.017
Javanmard, Heshmat-Ghahdarijani, Mirmohammad-Sadeghi, Sonbolestan, Ziayi, The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery, Adv Biomed Res, doi:10.4103/2277-9175.194801
Jolliffe, Camargo, Sluyter, Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Kapepula, Kabengele, Kingombe, Artemisia Spp. derivatives for COVID-19 treatment: anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials, Am J Trop Med Hyg, doi:10.4269/ajtmh.20-0820
Leijte, Wagemaker, Van Kraaij, Mortality and re-admission after hospitalization with COVID-19, Ned Tijdschr Geneeskd
Li, Wang, Jou, SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS/p38 MAPK/STAT3 pathway, Sci Rep, doi:10.1038/srep25754
Li, Zhang, Guan, SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation, Signal Transduct Target Ther, doi:10.1038/s41392-020-00334-0
Libby, Inflammatory mechanisms: the molecular basis of inflammation and disease, Nutr Rev, doi:10.1111/j.1753-4887.2007.tb00352.x
Lin, Wu, Xie, Clinical study of artesunate in the treatment of coronavirus disease, doi:10.3760/cma.j.cn121430-20200312-00412
Ling, Broad, Murphy, High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: a Cross-Sectional Multi-Centre Observational Study, Nutrients, doi:10.3390/nu12123799
Magro, SARS-CoV-2 and COVID-19: is interleukin-6 (IL-6) the 'culprit lesion' of ARDS onset? What is there besides tocilizumab? SGP130Fc, Cytokine X, doi:10.1016/j.cytox.2020.100029
Mak, Ho, Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease, Respir Med, doi:10.1016/j.rmed.2009.01.005
Mcdonald, Healing after COVID-19: are survivors at risk for pulmonary fibrosis?, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.00238.2020
Mendelson, Nel, Blumberg, Long-COVID: an evolving problem with an extensive impact, S Afr Med J, doi:10.7196/SAMJ.2020.v111i11.15433
Meng, Xiao, Zhang, Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension, Emerg Microbes Infect, doi:10.1080/22221751.2020.1746200
Mihara M 1, Kasutani, Okazaki, Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family, Int Immunopharmacol, doi:10.1016/j.intimp.2005.05.010
Morgan, Irwin, Chung, Wang, Bacurau, The effects of mind-body therapies on the immune system: meta-analysis, PLoS One, doi:10.1371/journal.pone.0100903
Mu, Ding, Li, Chen, Ma, Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-beta/Smad signaling pathway, Thromb Res, doi:10.1016/j.thromres.2011.10.003
O'sullivan, Long-term sequelae following previous coronavirus epidemics, Clin Med, doi:10.7861/clinmed.2020-0204
Panigrahy, Gilligan, Huang, Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?, Cancer Metastasis Rev, doi:10.1007/s10555-020-09889-4
Pittet, Griffiths, Geiser, TGF-beta is a critical mediator of acute lung injury, J Clin Invest, doi:10.1172/JCI11963
Pollard, Morran, Al, The COVID-19 pandemic: a global health crisis, Physiol Genomics, doi:10.1152/physiolgenomics.00089.2020
Pum, Ennemoser, Adage, Kungl, Cytokines and chemokines in SARS-CoV-2 infections-therapeutic strategies targeting cytokine storm, Biomolecules, doi:10.3390/biom11010091
Qin, Zhou, Hu, Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect Dis, doi:10.1093/cid/ciaa248
Ramezani, Simani, Karimialavijeh, Rezaei, Hajiesmaeili et al., The role of anxiety and cortisol in outcomes of patients with covid-19, Basic Clin Neurosci, doi:10.32598/bcn.11.covid19.1168.2
Rausch-Fan, Leutmezer, Willheim, Regulation of cytokine production in human peripheral blood mononuclear cells and allergen-specific th cell clones by 1alpha,25-dihydroxyvitamin D3, Int Arch Allergy Immunol, doi:10.1159/000058001
Raygan, Ostadmohammadi, Bahmani, Reiter, Asemi, Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: a randomized, double-blind, placebo-controlled trial, Clin Nutr, doi:10.1016/j.clnu.2017.12.004
Rea, Gibson, Mcgilligan, Mcnerlan, Alexander et al., Age and age-related diseases: role of inflammation triggers and cytokines, Front Immunol, doi:10.3389/fimmu.2018.00586
Renu, Prasanna, Valsala Gopalakrishnan, Coronaviruses pathogenesis, comorbidities and multi-organ damage -A review, Life Sci, doi:10.1016/j.lfs.2020.117839
Rosenkranz, Lutz, Perlman, Reduced stress and inflammatory responsiveness in experienced meditators compared to a matched healthy control group, Psychoneuroendocrinology, doi:10.1016/j.psyneuen.2016.02.013
Saklayen, The global epidemic of the metabolic syndrome, Curr Hypertens Rep, doi:10.1007/s11906-018-0812-z
Shakoor, Feehan, Dhaheri, Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19?, Maturitas, doi:10.1016/j.maturitas.2020.08.003
Sheppard, Laskou, Stapleton, Hadavi, Dasgupta, Tocilizumab (Actemra), Hum Vaccin Immunother, doi:10.1080/21645515.2017.1316909
Shete, Verma, Kulkarni, Bhogal, Effect of yoga training on inflammatory cytokines and C-reactive protein in employees of small-scale industries, J Educ Health Promot, doi:10.4103/jehp.jehp_65_17
Singh, Gillies, Singh, Prevalence of co-morbidities and their association with mortality in patients with COVID-19: a systematic review and meta-analysis, Diabetes Obes Metab, doi:10.1111/dom.14124
Smolen, Beaulieu, Rubbert-Roth, Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial, Lancet, doi:10.1016/S0140-6736(08)60453-5
Uckun, Saund, Windlass, Trieu, Repurposing anti-malaria phytomedicine artemisinin as a COVID-19 drug, Front Pharmacol, doi:10.3389/fphar.2021.649532
Verkhratsky, Li, Melino, Melino, Shi, Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?, Biol Direct, doi:10.1186/s13062-020-00282-3
Wang, Kream, Stefano, Long-term respiratory and neurological sequelae of COVID-19, Med Sci Monit, doi:10.12659/MSM.928996
Wang, Lu, Li, SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-beta1 signaling, Virus Res, doi:10.1016/j.virusres.2017.04.008
Wang, Nie, Wang, Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia, J Infect Dis, doi:10.1093/infdis/jiaa150
Wang, Zhang, Du, Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, Lancet, doi:10.1016/S0140-6736(20)31022-9
Wasserstein, Lazar, The ASA statement on p-values: context, process, and purpose, Am Stat, doi:10.1080/00031305.2016.1154108
Witek-Janusek, Albuquerque, Chroniak, Chroniak, Durazo-Arvizu et al., Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer, Brain Behav Immun, doi:10.1016/j.bbi.2008.01.012
Woods, Tazi, Chesarino, Amer, Davis, TGF-betainduced IL-6 prevents development of acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.00078.2015
Xiong, Liu, Cao, Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients, Emerg Microbes Infect, doi:10.1080/22221751.2020.1747363
Zabetakis, Lordan, Norton, Tsoupras, COVID-19: the inflammation link and the role of nutrition in potential mitigation, Nutrients, doi:10.3390/nu12051466
Zerr, Vollath, Palumbo-Zerr, Vitamin D receptor regulates TGF-beta signalling in systemic sclerosis, Ann Rheum Dis, doi:10.1136/annrheumdis-2013-204378
Zhang, Wang, Ni, COVID-19: melatonin as a potential adjuvant treatment, Life Sci, doi:10.1016/j.lfs.2020.117583
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Avaiable from: ' 'https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports. 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Available from: ' 'https://www.nih.gov/about-nih/who-we-are/nih-director/statements/nih-launches-new-initiative-study-long-covid. ' 'Accessed March 30, 2021.'}, { 'key': 'ref22', 'doi-asserted-by': 'publisher', 'first-page': '235', 'DOI': '10.1038/s41392-020-00334-0', 'volume': '5', 'author': 'Li', 'year': '2020', 'journal-title': 'Signal Transduct Target Ther'}, { 'key': 'ref23', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.3390/biom11010091', 'volume': '11', 'author': 'Pum', 'year': '2021', 'journal-title': 'Biomolecules'}, { 'key': 'ref24', 'doi-asserted-by': 'publisher', 'first-page': '104673', 'DOI': '10.1016/j.micpath.2020.104673', 'volume': '150', 'author': 'Choudhary', 'year': '2021', 'journal-title': 'Microb Pathog'}, { 'key': 'ref25', 'doi-asserted-by': 'publisher', 'first-page': 'e105896', 'DOI': '10.15252/embj.2020105896', 'volume': '39', 'author': 'Chen', 'year': '2020', 'journal-title': 'EMBO J'}, { 'key': 'ref26', 'doi-asserted-by': 'publisher', 'first-page': '1083', 'DOI': '10.1016/j.rmed.2009.01.005', 'volume': '103', 'author': 'Mak', 'year': '2009', 'journal-title': 'Respir Med'}, { 'key': 'ref27', 'doi-asserted-by': 'publisher', 'first-page': '761', 'DOI': '10.1080/22221751.2020.1747363', 'volume': '9', 'author': 'Xiong', 'year': '2020', 'journal-title': 'Emerg Microbes Infect'}, { 'key': 'ref28', 'doi-asserted-by': 'publisher', 'first-page': 'L1136', 'DOI': '10.1152/ajplung.00078.2015', 'volume': '308', 'author': 'Woods', 'year': '2015', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol'}, { 'key': 'ref29', 'doi-asserted-by': 'publisher', 'first-page': '479', 'DOI': '10.1016/j.thromres.2011.10.003', 'volume': '129', 'author': 'Mu', 'year': '2012', 'journal-title': 'Thromb Res'}, { 'key': 'ref30', 'doi-asserted-by': 'publisher', 'first-page': '1537', 'DOI': '10.1172/JCI11963', 'volume': '107', 'author': 'Pittet', 'year': '2001', 'journal-title': 'J Clin Invest'}, { 'key': 'ref31', 'doi-asserted-by': 'publisher', 'first-page': '1954', 'DOI': '10.7150/ijbs.46891', 'volume': '16', 'author': 'Chen', 'year': '2020', 'journal-title': 'Int J Biol Sci'}, { 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