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Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality—A systematic review and meta-analysis

Santa et al., Frontiers in Nutrition, doi:10.3389/fnut.2024.1465324
Oct 2024  
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Diet for COVID-19
23rd treatment shown to reduce risk in June 2021, now with p < 0.00000000001 from 29 studies.
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Comparative analysis of COVID-19 responses in Japan and Africa, focusing on diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality. Authors conducted a systematic review and meta-analysis to investigate the unexpectedly low COVID-19 mortality rates in Africa despite challenging health conditions. They found that a healthy diet rich in phytochemicals, particularly polyphenols and flavonoids, was effective against COVID-19. Blood vitamin D levels were associated with COVID-19 mortality, with Africa having higher average levels than many other regions. The gut microbiota was also linked to COVID-19 outcomes, with African populations showing a more diverse and healthier gut microbiome. Authors highlight the potential protective effects of these factors in Africa's lower COVID-19 mortality rates compared to developed countries. They note that the Japanese diet, similar to the Mediterranean diet, is associated with lower rates of underlying lifestyle-related diseases, potentially contributing to better COVID-19 outcomes. The review also examined the effects of vitamin D supplementation, finding statistically significant differences in vitamin D levels, hospitalization time, and cases. Authors suggest that maintaining adequate blood vitamin D levels and consuming phytochemicals are associated with a healthy gut microbiota and improved immune responses, correlating with lower COVID-19 mortality rates.
Reviews covering diet for COVID-19 include1-4.
2 meta analyses show significant improvements with diet for hospitalization5, severity6, and cases5,6.
Review covers diet, vitamin D, and probiotics.
Santa et al., 6 Oct 2024, peer-reviewed, 4 authors.
This PaperDietAll
Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality—A systematic review and meta-analysis
Kazuki Santa, Raita Tamaki, Kenji Watanabe, Isao Nagaoka
Frontiers in Nutrition, doi:10.3389/fnut.2024.1465324
Background: As the novel coronavirus disease 2019 (COVID-19) pandemic subsides, the clinical sequelae are becoming more problematic. Interestingly, the statistical data indicate that Africa has experienced the lowest number of cases and deaths, with an unexpected phenomenon where the number of deaths from COVID-19 has not increased significantly. Several studies have investigated the relationship between diet and coronavirus. However, no systematic review/ meta-analysis has conclusively linked diet (phytochemicals and vitamin D) and the gut microbiota in the context of COVID-19. Methods: This study examined the responses to COVID-19 in Japan and Africa, formulating the following hypotheses: (1) a healthy diet is effective against COVID-19, (2) blood vitamin D levels are associated with COVID-19 mortality, and (3) COVID-19 is associated with the gut microbiota. To investigate these hypotheses, a keyword search and meta-analysis were conducted using PubMed, and each hypothesis was tested. Results: This study found that a healthy diet, particularly rich in phytochemicals such as polyphenols and flavonoids, is effective against COVID-19. An association was detected between blood vitamin D levels and COVID-19 mortality. The gut microbiota was linked to COVID-19 and its amelioration. These findings may have significant implications for not only understanding COVID-19 but also future prevention of pneumonia.
Ethics statement Ethical approval was not required for the studies involving humans because all data used are publicly available. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants' legal guardians/ next of kin in accordance with the national legislation and institutional requirements because all data used are publicly available. Author contributions Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnut.2024.1465324/ full#supplementary-material Frontiers in Nutrition 20 frontiersin.org
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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