Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Vitamin D  COVID-19 treatment studies for Vitamin D  C19 studies: Vitamin D  Vitamin D   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  

Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

Caballero-García et al., Medicina, doi:10.3390/medicina57101079
Caballero-García et al., Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection, Medicina, doi:10.3390/medicina57101079
Oct 2021   Source   PDF  
  All Studies   Meta
Small RCT with 30 patients examining the effect of vitamin D supplementation on muscle status in elderly recovering COVID-19 patients, showing serum creatine kinase levels returned to optimal values, however there was no significant difference in physical test results.
Caballero-García et al., 9 Oct 2021, peer-reviewed, 7 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperVitamin DAll
Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection
Alberto Caballero-García, Daniel Pérez-Valdecantos, Pablo Guallar, Aurora Caballero-Castillo, Enrique Roche, David C Noriega, Alfredo Córdova
Medicina, doi:10.3390/medicina57101079
Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection. Materials and Methods: This pilot study was conducted at the Soria Norte Health Center. The study consisted of a double-blind trial with two groups of men (placebo and vitamin D-supplemented) (n = 15/group). Treatment with vitamin D (cholecalciferol: 2000 IU/day) and placebo was carried out for 6 weeks. Circulating hematological and biochemical parameters (total protein, glucose, vitamin D, urea, uric acid, aspartate aminotransferase/glutamicoxaloacetic transaminase, alanine aminotransferase/glutamic-pyruvic transaminase, creatine kinase, lactate dehydrogenase, aldolase, gamma-glutamyl transferase and myoglobin) and the hormones cortisol and testosterone were determined. As for respiratory function tests, FEV1 and respiratory flow were also studied. For physical fitness tests, the "six-minute walk test" (6MWT) was used. Results: After vitamin D supplementation, we observed that serum creatine kinase levels returned to optimal values. This change suggests a protective role of vitamin D against muscle catabolism compared to placebo. In terms of physical test results, we observed only slight non-significant improvements, although patients reported feeling better. Conclusions: Vitamin D supplementation produces decreases in indicators of muscle damage, which may ultimately contribute to improving the health status and quality of life of patients who have suffered from COVID-19, during the recovery process.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J. Infect. Public Health
Amer, Qayyum, Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006), Am. J. Cardiol, doi:10.1016/j.amjcard.2011.08.032
Aronson, Ferner, Biomarkers-A General Review, Curr. Protoc. Pharmacol, doi:10.1002/cpph.19
Baeke, Takiishi, Korf, Gysemans, Mathieu et al., Modulator of the immune system, Curr. Opin. Pharmacol, doi:10.1016/j.coph.2010.04.001
Balla, Merugu, Konala, Sangani, Kondakindi et al., Back to basics: Review on vitamin D and respiratory viral infections including COVID-19, J. Community Hosp. Intern. Med. Perspect, doi:10.1080/20009666.2020.1811074
Bjerk, Edgington, Rector, Kunisaki, Supplemental vitamin D and physical performance in COPD: A pilot randomized trial, Int. J. Chronic Obstr. Pulm. Dis, doi:10.2147/COPD.S40885
Caballero-García, Córdova-Martínez, Vicente-Salar, Roche, Pérez-Valdecantos et al., its role in recovery after muscular damage following exercise, Nutrients, doi:10.3390/nu13072336
Cai, Huang, Yu, Zhu, Xia et al., COVID-19: Abnormal liver function tests, J. Hepatol, doi:10.1016/j.jhep.2020.04.006
Cruz-Jentoft, Bahat, Bauer, Boirie, Bruyère et al., Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: Revised European consensus on definition and diagnosis, Age Ageing, doi:10.1093/ageing/afy169
Córdova, Alvarez De Mon, Inmunidad en el Deporte; Gymnos
Dinarello, Anti-cytokine therapeutics and infections, Vaccine, doi:10.1016/S0264-410X(03)00196-8
Gaudio, Murabito, Agodi, Montineri, Castellino et al., Vitamin D levels are reduced at the rime of hospital admission in Sicilian SARS-CoV-2-positive patients, Int. J. Environ. Res. Public Health, doi:10.3390/ijerph18073491
Goyal, Choi, Pinheiro, Schenck, Chen et al., Clinical characteristics of Covid-19 in New York City, N. Engl. J. Med, doi:10.1056/NEJMc2010419
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with COVID-19 in China: A nationwide analysis, Eur. Respir. J, doi:10.1183/13993003.00547-2020
Guzik, Mohiddin, Dimarco, Patel, Savvatis et al., COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options, Cardiovasc. Res, doi:10.1093/cvr/cvaa106
Han, Xie, Liu, Yang, Liu et al., Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China, J. Med. Virol, doi:10.1002/jmv.25809
Henry, Lippi, Plebania, Laboratory abnormalities in children with novel coronavirus disease 2019, Clin. Chem. Lab. Med, doi:10.1515/cclm-2020-0272
Hewison, Vitamin D and innate and adaptive immunity, Vitam. Horm, doi:10.1016/B978-0-12-386960-9.00002-2
Hornikx, Van Remoortel, Lehouck, Mathieu, Maes et al., Vitamin D supplementation during rehabilitation in COPD: A secondary analysis of a randomized trial, Respir. Res
Jiehao, Jin, Daojiong, Zhi, Lei et al., A case series of children with 2019 novel coronavirus infection: Clinical and epidemiological features, Clin. Infect. Dis
Khan, Rhabdomyolysis: A review of the literature, Neth. J. Med
Knochel, Mechanisms of rhabdomyolysis, Curr. Opin. Rheumatol, doi:10.1097/00002281-199305060-00006
Lee, Nair, Eisman, Center, Vitamin D deficiency in the intensive care unit: An invisible accomplice to morbidity and mortality?, Intensive Care Med, doi:10.1007/s00134-009-1642-x
Lippi, Plebani, A modern and pragmatic definition of laboratory medicine, Clin. Chem. Lab. Med, doi:10.1515/cclm-2020-0114
Lippi, Plebani, Laboratory abnormalities in patients with COVID-2019 infection, Clin. Chem. Lab. Med, doi:10.1515/cclm-2020-0198
Malik, Patel, Mehta, Patel, Kelkar et al., Biomarkers and outcomes of COVID-19 hospitalisations: Systematic review and meta-analysis, BMJ Evid.-Based Med, doi:10.1136/bmjebm-2020-111536
Mehta, Mcauley, Brown, Sánchez, Tattersall et al., COVID-19: Consider cytokine storm syndromes and immunosuppression, Lancet, doi:10.1016/S0140-6736(20)30628-0
Quesada-Gomez, Entrenas-Castillo, Bouillon, Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105719
Regueiro, López, González, Martínez, Inmunología, Biología y Patología del Sistema Inmunitario
Ruan, Yang, Wang, Jiang, Song, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive Care Med, doi:10.1007/s00134-020-05991-x
Shi, Liu, Fu, Xu, Wu et al., Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acutelung injury by maintaining the integrity of the pulmonary epithelial barrier, Mol. Med. Rep, doi:10.3892/mmr.2015.4685
Sproston, Ashworth, Role of C-Reactive Protein at sites of inflammation and infection, Front. Immunol, doi:10.3389/fimmu.2018.00754
Stegeman, Ochodo, Guleid, Holtman, Yang et al., -19 Diagnostic Test Accuracy Group. Routine laboratory testing to determine if a patient has COVID-19, Cochrane Database Syst. Rev, doi:10.1002/14651858.CD013787
Stockton, Mengersen, Paratz, Kandiah, Bennell, Effect of vitamin D supplementation on muscle strength: A systematic review and meta-analysis, Osteoporos. Int, doi:10.1007/s00198-010-1407-y
Wang, Hou, Luo, Tang, Wu et al., The laboratory tests and host immunity of COVID-19 patients with different severity of illness, JCI Insight, doi:10.1172/jci.insight.137799
Yang, Li, Tao, Yang, Wang et al., Infection with SARS-CoV-2 causes abnormal laboratory results of multiple organs in patients, Aging, doi:10.18632/aging.103255
Zdrenghea, Makrinioti, Bagacean, Bush, Johnston et al., Vitamin D modulation of innate immune responses to respiratory viral infections, Rev. Med. Virol, doi:10.1002/rmv.1909
Zhang, Shan, Minalyan, O'sullivan, Nace, A rare presentation of coronavirus disease 2019 (COVID-19) induced viral myositis with subsequent rhabdomyolysis, Cureus, doi:10.7759/cureus.8074
Álvarez-Mon, Ortega, Gasullaet, Fortuny-Profitós, Mazaira-Font et al., A predictive model and risk factors for case fatality of COVID-19, J. Pers. Med
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop