Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
Torres et al.,
Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose..,
Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112965
RCT comparing 41 patients treated with 10,000IU/day cholecalciferol and 44 treated with 2,000IU/day in Spain, showing significantly shorter hospitalization for ARDS patients with the higher dose. There was also an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells. Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was over 4-fold higher in patients receiving the higher dose.
risk of death, 7.3% higher, RR 1.07, p = 1.00, treatment 1 of 41 (2.4%), control 1 of 44 (2.3%).
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risk of ICU admission, 57.1% lower, RR 0.43, p = 0.44, treatment 2 of 41 (4.9%), control 5 of 44 (11.4%), NNT 15.
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risk of ARDS, 28.5% lower, RR 0.72, p = 0.74, treatment 4 of 41 (9.8%), control 6 of 44 (13.6%), NNT 26.
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hospitalization time, 31.2% lower, relative time 0.69, treatment 41, control 44.
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hospitalization time, 72.6% lower, relative time 0.27, p = 0.04, ARDS patients.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Torres et al., 14 Apr 2022, Single Blind Randomized Controlled Trial, Spain, peer-reviewed, median age 65.0, 51 authors, study period June 2020 - March 2021, average treatment delay 7.0 days, dosage 10,000IU days 1-14.
Abstract: Journal Pre-proof
Changes in the immune response against SARSCoV-2 in individuals with severe COVID-19
treated
with
high
dose
of
vitamin
DImmunomodulatory effect of vitamin D
supplementation in patients with COVID-19
Montserrat Torres, Guiomar Casado, Lorena
Vigón, Sara Rodríguez-Mora, Elena Mateos,
Fernando Ramos-Martín, Daniel López-Wolf, José
Sanz-Moreno, Pablo Ryan-Murua, María Luisa
Taboada-Martínez, María Rosa López-Huertas,
Miguel Cervero, Mayte Coiras
PII:
S0753-3322(22)00354-7
DOI:
https://doi.org/10.1016/j.biopha.2022.112965
Reference:
BIOPHA112965
To appear in: Biomedicine & Pharmacotherapy
Received date: 1 March 2022
Revised date: 4 April 2022
Accepted date: 11 April 2022
Please cite this article as: Montserrat Torres, Guiomar Casado, Lorena Vigón,
Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel LópezWolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez,
María Rosa López-Huertas, Miguel Cervero and Mayte Coiras, Changes in the
immune response against SARS-CoV-2 in individuals with severe COVID-19
treated with high dose of vitamin DImmunomodulatory effect of vitamin D
supplementation in patients with COVID-19, Biomedicine & Pharmacotherapy,
(2022) doi:https://doi.org/10.1016/j.biopha.2022.112965
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© 2022 Published by Elsevier.
Changes in the immune response against SARS-CoV-2 in individuals with
severe COVID-19 treated with high dose of vitamin D
Montserrat Torres1,#,*, Guiomar Casado1,#, Lorena Vigón1,#, Sara Rodríguez-Mora1,2, ,
Elena Mateos1,2, Fernando Ramos-Martín1, Daniel López-Wolf3, José Sanz-Moreno4,
Pablo Ryan-Murua5, María Luisa Taboada-Martínez6, María Rosa López-Huertas1,2,*,
Miguel Cervero7,&, Mayte Coiras1,2,&,*, on behalf of Multidisciplinary Group of Study of
Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III,
ro
1
of
COVID-19 (MGS-COVID)#
Madrid, Spain.
Biomedical Research Center Network in Infectious Diseases (CIBERINFEC), Spain.
3
Internal Medicine Service, Hospital Universitario Fundación Alcorcón, Alcorcón,
re
-p
2
Spain
Internal Medicine Service, Hospital Universitario Príncipe de Asturias, Alcalá Henares,
lP
4
rn
a
Spain
Internal Medicine Service, Hospital Universitario Infanta Leonor, Madrid, Spain
6
Internal Medicine Service, Hospital Universitario de Cabueñes, Gijón, Spain
7
Internal Medicine Service, Hospital Universitario Severo Ochoa, Leganés, Spain
#
These authors contributed equally to this study.
Jo
u
5
&
These authors contributed equally to this study.
Running title: Immunomodulatory effect of vitamin D supplementation in patients with
COVID-19
Keywords: COVID-19; SARS-CoV-2; Vitamin D supplementation; Immune cytotoxic
response.
No. of tables: 3
No. of references: 63
Word count of the abstract: 252
ro
of
Word count of the text: 4849
*Correspondence to:
-p
Montserrat Torres, Immunopathology Unit, National Center of..
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