Torres: Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Torres et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112965

Torres et al., Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose.., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112965

Apr 2022 Source PDF

Twitter
Facebook

All Studies Meta

RCT comparing 41 patients treated with 10,000IU/day cholecalciferol and 44 treated with 2,000IU/day in Spain, showing significantly shorter hospitalization for ARDS patients with the higher dose. There was also an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells. Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was over 4-fold higher in patients receiving the higher dose.

Important missing comments or errors? Let us know.

risk of death, 7.3% higher, RR 1.07, p = 1.00, treatment 1 of 41 (2.4%), control 1 of 44 (2.3%).

risk of ICU admission, 57.1% lower, RR 0.43, p = 0.44, treatment 2 of 41 (4.9%), control 5 of 44 (11.4%), NNT 15.

risk of ARDS, 28.5% lower, RR 0.72, p = 0.74, treatment 4 of 41 (9.8%), control 6 of 44 (13.6%), NNT 26.

hospitalization time, 31.2% lower, relative time 0.69, treatment 41, control 44.

hospitalization time, 72.6% lower, relative time 0.27, p = 0.04, ARDS patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Torres et al., 14 Apr 2022, Single Blind Randomized Controlled Trial, Spain, peer-reviewed, median age 65.0, 51 authors, study period June 2020 - March 2021, average treatment delay 7.0 days, dosage 10,000IU days 1-14.

All Studies Meta Analysis Submit Updates or Corrections

This Paper Vitamin D All

Abstract: Journal Pre-proof Changes in the immune response against SARSCoV-2 in individuals with severe COVID-19 treated with high dose of vitamin DImmunomodulatory effect of vitamin D supplementation in patients with COVID-19 Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras PII: S0753-3322(22)00354-7 DOI: https://doi.org/10.1016/j.biopha.2022.112965 Reference: BIOPHA112965 To appear in: Biomedicine & Pharmacotherapy Received date: 1 March 2022 Revised date: 4 April 2022 Accepted date: 11 April 2022 Please cite this article as: Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel LópezWolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero and Mayte Coiras, Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin DImmunomodulatory effect of vitamin D supplementation in patients with COVID-19, Biomedicine & Pharmacotherapy, (2022) doi:https://doi.org/10.1016/j.biopha.2022.112965 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier. Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D Montserrat Torres1,#,*, Guiomar Casado1,#, Lorena Vigón1,#, Sara Rodríguez-Mora1,2, , Elena Mateos1,2, Fernando Ramos-Martín1, Daniel López-Wolf3, José Sanz-Moreno4, Pablo Ryan-Murua5, María Luisa Taboada-Martínez6, María Rosa López-Huertas1,2,*, Miguel Cervero7,&, Mayte Coiras1,2,&,*, on behalf of Multidisciplinary Group of Study of Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, ro 1 of COVID-19 (MGS-COVID)# Madrid, Spain. Biomedical Research Center Network in Infectious Diseases (CIBERINFEC), Spain. 3 Internal Medicine Service, Hospital Universitario Fundación Alcorcón, Alcorcón, re -p 2 Spain Internal Medicine Service, Hospital Universitario Príncipe de Asturias, Alcalá Henares, lP 4 rn a Spain Internal Medicine Service, Hospital Universitario Infanta Leonor, Madrid, Spain 6 Internal Medicine Service, Hospital Universitario de Cabueñes, Gijón, Spain 7 Internal Medicine Service, Hospital Universitario Severo Ochoa, Leganés, Spain # These authors contributed equally to this study. Jo u 5 & These authors contributed equally to this study. Running title: Immunomodulatory effect of vitamin D supplementation in patients with COVID-19 Keywords: COVID-19; SARS-CoV-2; Vitamin D supplementation; Immune cytotoxic response. No. of tables: 3 No. of references: 63 Word count of the abstract: 252 ro of Word count of the text: 4849 *Correspondence to: -p Montserrat Torres, Immunopathology Unit, National Center of..

Late treatment
is less effective

Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit