Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

DOI record: { "DOI": "10.1016/j.biopha.2022.112965", "ISSN": [ "0753-3322" ], "URL": "http://dx.doi.org/10.1016/j.biopha.2022.112965", "alternative-id": [ "S0753332222003547" ], "article-number": "112965", "author": [ { "affiliation": [], "family": "Torres", "given": "Montserrat", "sequence": "first" }, { "affiliation": [], "family": "Casado", "given": "Guiomar", "sequence": "additional" }, { "affiliation": [], "family": "Vigón", "given": "Lorena", "sequence": "additional" }, { "affiliation": [], "family": "Rodríguez-Mora", "given": "Sara", "sequence": "additional" }, { "affiliation": [], "family": "Mateos", "given": "Elena", "sequence": "additional" }, { "affiliation": [], "family": "Ramos-Martín", "given": "Fernando", "sequence": "additional" }, { "affiliation": [], "family": "López-Wolf", "given": "Daniel", "sequence": "additional" }, { "affiliation": [], "family": "Sanz-Moreno", "given": "José", "sequence": "additional" }, { "affiliation": [], "family": "Ryan-Murua", "given": "Pablo", "sequence": "additional" }, { "affiliation": [], "family": "Taboada-Martínez", "given": "María Luisa", "sequence": "additional" }, { "affiliation": [], "family": "López-Huertas", "given": "María Rosa", "sequence": "additional" }, { "affiliation": [], "family": "Cervero", "given": "Miguel", "sequence": "additional" }, { "affiliation": [], "family": "Coiras", "given": "Mayte", "sequence": "additional" }, { "affiliation": [], "family": "Alonso-Menchén", "given": "David", "sequence": "additional" }, { "affiliation": [], "family": "Arévalo Camacho", "given": "Sandra", "sequence": "additional" }, { "affiliation": [], "family": "Avila Calzada", "given": "Cristina", "sequence": "additional" }, { "affiliation": [], "family": "Antonio Barbado Albaladejo", "given": "José", "sequence": "additional" }, { "affiliation": [], "family": "Blanca López", "given": "Natalia", "sequence": "additional" }, { "affiliation": [], "family": "Cañamares Orbis", "given": "Irene", "sequence": "additional" }, { "affiliation": [], "family": "Carrillo Blanco", "given": "Gema", "sequence": "additional" }, { "affiliation": [], "family": "Cascajero Díaz", "given": "Almudena", "sequence": "additional" }, { "affiliation": [], "family": "Teresa Chica Burguillo", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Corrochano García", "given": "Ana", "sequence": "additional" }, { "affiliation": [], "family": "Corredera García", "given": "Sara", "sequence": "additional" }, { "affiliation": [], "family": "Díez Viñas", "given": "Victor", "sequence": "additional" }, { "affiliation": [], "family": "Gómez-Alvarez Domínguez", "given": "Marta", "sequence": "additional" }, { "affiliation": [], "family": "Patricia Fernández Fernández", "given": "Claudia", "sequence": "additional" }, { "affiliation": [], "family": "Fernández Mondelo", "given": "Yanira", "sequence": "additional" }, { "affiliation": [], "family": "Fonseca Aizpuri", "given": "Eva", "sequence": "additional" }, { "affiliation": [], "family": "García Lacalle", "given": "Concepción", "sequence": "additional" }, { "affiliation": [], "family": "García-Pérez", "given": "Javier", "sequence": "additional" }, { "affiliation": [], "family": "Helguera Amezua", "given": "Cristina", "sequence": "additional" }, { "affiliation": [], "family": "José Hidalgo Correas", "given": "Francisco", "sequence": "additional" }, { "affiliation": [], "family": "Lucena Campillo", "given": "Amparo", "sequence": "additional" }, { "affiliation": [], "family": "Matarranz del Amo", "given": "Mariano", "sequence": "additional" }, { "affiliation": [], "family": "Martín Sagarra", "given": "Oriol", "sequence": "additional" }, { "affiliation": [], "family": "José Martínez Martín", "given": "Emilio", "sequence": "additional" }, { "affiliation": [], "family": "Javier Martínez Simón", "given": "José", "sequence": "additional" }, { "affiliation": [], "family": "Novella-Mena", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Pardo Guimera", "given": "Virginia", "sequence": "additional" }, { "affiliation": [], "family": "Luisa Pinillos Pardo", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Ramírez Fuentes", "given": "Fr`ancisca", "sequence": "additional" }, { "affiliation": [], "family": "Renuncio García", "given": "Daniel", "sequence": "additional" }, { "affiliation": [], "family": "Angeles Rodríguez Dávila", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Roger Revilla", "given": "Almudena", "sequence": "additional" }, { "affiliation": [], "family": "Sampablo Valverde", "given": "Lourdes", "sequence": "additional" }, { "affiliation": [], "family": "Sanz Moreno", "given": "José", "sequence": "additional" }, { "affiliation": [], "family": "Torres Perea", "given": "Rafael", "sequence": "additional" }, { "affiliation": [], "family": "Valencia La Rosa", "given": "Jorge", "sequence": "additional" }, { "affiliation": [], "family": "Velasco Arribas", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Villanueva Fernández-Ardavín", "given": "Ana", "sequence": "additional" } ], "container-title": [ "Biomedicine & Pharmacotherapy" ], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 4, 14 ] ], "date-time": "2022-04-14T07:13:33Z", "timestamp": 1649920413000 }, "deposited": { "date-parts": [ [ 2022, 4, 14 ] ], "date-time": "2022-04-14T07:14:18Z", "timestamp": 1649920458000 }, "indexed": { "date-parts": [ [ 2022, 4, 14 ] ], "date-time": "2022-04-14T07:43:21Z", "timestamp": 1649922201025 }, "is-referenced-by-count": 0, "issn-type": [ { "type": "print", "value": "0753-3322" } ], "issued": { "date-parts": [ [ 2022, 4 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 4, 1 ] ], "date-time": "2022-04-01T00:00:00Z", "timestamp": 1648771200000 } }, { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "vor", "delay-in-days": 10, "start": { "date-parts": [ [ 2022, 4, 11 ] ], "date-time": "2022-04-11T00:00:00Z", "timestamp": 1649635200000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S0753332222003547?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S0753332222003547?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "112965", "prefix": "10.1016", "published": { "date-parts": [ [ 2022, 4 ] ] }, "published-print": { "date-parts": [ [ 2022, 4 ] ] }, "publisher": "Elsevier BV", "reference": [ { "article-title": "Characteristics of SARS-CoV-2 and COVID-19", "author": "Hu", "first-page": "1", "journal-title": "Nat. Rev. Microbiol.", "key": "10.1016/j.biopha.2022.112965_bib1", "volume": "19", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30183-5", "article-title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan", "author": "Huang", "doi-asserted-by": "crossref", "first-page": "497", "journal-title": "China. Lancet Lond. Engl.", "key": "10.1016/j.biopha.2022.112965_bib2", "volume": "395", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30628-0", "article-title": "COVID-19: consider cytokine storm syndromes and immunosuppression", "author": "Mehta", "doi-asserted-by": "crossref", "first-page": "1033", "journal-title": "Lancet Lond. Engl", "key": "10.1016/j.biopha.2022.112965_bib3", "volume": "395", "year": "2020" }, { "DOI": "10.1164/rccm.202002-0445OC", "article-title": "COVID-19 with Different Severities: A Multicenter Study of Clinical Features", "author": "Feng", "doi-asserted-by": "crossref", "first-page": "1380", "journal-title": "Am. J. Respir. Crit. Care Med.", "key": "10.1016/j.biopha.2022.112965_bib4", "volume": "201", "year": "2020" }, { "DOI": "10.1002/art.39295", "article-title": "Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome", "author": "Cifaldi", "doi-asserted-by": "crossref", "first-page": "3037", "journal-title": "Arthritis Rheumatol", "key": "10.1016/j.biopha.2022.112965_bib5", "volume": "67", "year": "2015" }, { "DOI": "10.1016/j.ajpath.2020.08.009", "article-title": "Immunopathology of Hyperinflammation in COVID-19", "author": "Gustine", "doi-asserted-by": "crossref", "first-page": "4", "journal-title": "Am. J. Pathol", "key": "10.1016/j.biopha.2022.112965_bib6", "volume": "191", "year": "2021" }, { "DOI": "10.3389/fimmu.2021.603563", "article-title": "Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients", "author": "Ni", "doi-asserted-by": "crossref", "first-page": "59", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib7", "volume": "12", "year": "2021" }, { "DOI": "10.3389/fimmu.2020.00827", "article-title": "Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)", "author": "Diao", "doi-asserted-by": "crossref", "first-page": "827", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib8", "volume": "11", "year": "2020" }, { "article-title": "Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease Severity", "author": "Vigón", "first-page": "1901", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib9", "volume": "12", "year": "2021" }, { "DOI": "10.1016/j.actatropica.2020.105778", "article-title": "One year update on the COVID-19 pandemic: Where are we now?", "author": "Mishra", "doi-asserted-by": "crossref", "journal-title": "Acta Trop", "key": "10.1016/j.biopha.2022.112965_bib10", "volume": "214", "year": "2021" }, { "DOI": "10.1016/j.jpha.2020.03.001", "article-title": "Molecular immune pathogenesis and diagnosis of COVID-19", "author": "Li", "doi-asserted-by": "crossref", "first-page": "102", "journal-title": "J. Pharm. Anal.", "key": "10.1016/j.biopha.2022.112965_bib11", "volume": "10", "year": "2020" }, { "DOI": "10.5501/wjv.v10.i5.217", "article-title": "Scientific evidence in the COVID-19 treatment: A comprehensive review", "author": "Iturricastillo", "doi-asserted-by": "crossref", "first-page": "217", "journal-title": "World J. Virol.", "key": "10.1016/j.biopha.2022.112965_bib12", "volume": "10", "year": "2021" }, { "DOI": "10.1016/S2665-9913(20)30173-9", "article-title": "Tocilizumab in patients with severe COVID-19: a retrospective cohort study", "author": "Guaraldi", "doi-asserted-by": "crossref", "first-page": "e474", "journal-title": "Lancet Rheumatol", "key": "10.1016/j.biopha.2022.112965_bib13", "volume": "2", "year": "2020" }, { "DOI": "10.1056/NEJMoa2021436", "article-title": "Dexamethasone in Hospitalized Patients with Covid-19", "author": "RECOVERY Collaborative Group", "doi-asserted-by": "crossref", "first-page": "693", "journal-title": "N. Engl. J. Med", "key": "10.1016/j.biopha.2022.112965_bib14", "volume": "384", "year": "2021" }, { "article-title": "Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients", "author": "Parums", "journal-title": "Med. Sci. Monit. Int. Med. J. Exp. Clin. Res.", "key": "10.1016/j.biopha.2022.112965_bib15", "volume": "28", "year": "2022" }, { "DOI": "10.1126/science.acx9605", "article-title": "Antiviral pills could change pandemic’s course", "author": "Couzin-Frankel", "doi-asserted-by": "crossref", "first-page": "799", "journal-title": "Science", "key": "10.1016/j.biopha.2022.112965_bib16", "volume": "374", "year": "2021" }, { "article-title": "Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis", "author": "Yang", "first-page": "91", "journal-title": "Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis", "key": "10.1016/j.biopha.2022.112965_bib17", "volume": "94", "year": "2020" }, { "DOI": "10.1210/er.2018-00126", "article-title": "Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions", "author": "Bouillon", "doi-asserted-by": "crossref", "first-page": "1109", "journal-title": "Endocr. Rev", "key": "10.1016/j.biopha.2022.112965_bib18", "volume": "40", "year": "2019" }, { "DOI": "10.3389/fimmu.2016.00697", "article-title": "Vitamin D in autoimmunity: Molecular mechanisms and therapeutic potential", "author": "Dankers", "doi-asserted-by": "crossref", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib19", "volume": "7", "year": "2017" }, { "DOI": "10.3390/nu11092185", "article-title": "Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes", "author": "Infante", "doi-asserted-by": "crossref", "first-page": "2185", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib20", "volume": "11", "year": "2019" }, { "DOI": "10.1136/bmj.i6583", "article-title": "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data", "author": "Martineau", "doi-asserted-by": "crossref", "first-page": "i6583", "journal-title": "BMJ", "key": "10.1016/j.biopha.2022.112965_bib21", "volume": "356", "year": "2017" }, { "DOI": "10.3390/nu13072216", "article-title": "Lung-Centric Inflammation of COVID-19: Potential Modulation by Vitamin D", "author": "Fakhoury", "doi-asserted-by": "crossref", "first-page": "2216", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib22", "volume": "13", "year": "2021" }, { "article-title": "Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory", "author": "Bishop", "journal-title": "JBMR Plus", "key": "10.1016/j.biopha.2022.112965_bib23", "year": "2020" }, { "DOI": "10.1165/rcmb.2017-0064ED", "article-title": "Vitamin D in Host Defense: Implications for Future", "author": "Weiss", "doi-asserted-by": "crossref", "first-page": "692", "journal-title": "Research. Am. J. Respir. Cell Mol. Biol.", "key": "10.1016/j.biopha.2022.112965_bib24", "volume": "56", "year": "2017" }, { "DOI": "10.1136/bmj.m810", "article-title": "Preventing a covid-19 pandemic", "author": "Watkins", "doi-asserted-by": "crossref", "first-page": "m810", "journal-title": "BMJ", "key": "10.1016/j.biopha.2022.112965_bib25", "volume": "368", "year": "2020" }, { "DOI": "10.1007/s00394-020-02372-4", "article-title": "Vitamin D and COVID-19 infection and mortality in UK Biobank", "author": "Hastie", "doi-asserted-by": "crossref", "first-page": "545", "journal-title": "Eur. J. Nutr.", "key": "10.1016/j.biopha.2022.112965_bib26", "volume": "60", "year": "2021" }, { "DOI": "10.1007/s40520-020-01570-8", "article-title": "The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality", "author": "Ilie", "doi-asserted-by": "crossref", "first-page": "1195", "journal-title": "Aging Clin. Exp. Res.", "key": "10.1016/j.biopha.2022.112965_bib27", "volume": "32", "year": "2020" }, { "DOI": "10.1002/jmv.20770", "article-title": "A new strategy based on recombinant viruses as a tool for assessing drug susceptibility of human immunodeficiency virus type 1", "author": "Garcia-Perez", "doi-asserted-by": "crossref", "first-page": "127", "journal-title": "J. Med. Virol.", "key": "10.1016/j.biopha.2022.112965_bib28", "volume": "79", "year": "2007" }, { "DOI": "10.1038/s41467-020-15562-9", "article-title": "Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV", "author": "Ou", "doi-asserted-by": "crossref", "first-page": "1620", "journal-title": "Nat. Commun.", "key": "10.1016/j.biopha.2022.112965_bib29", "volume": "11", "year": "2020" }, { "DOI": "10.1038/s41598-020-75848-2", "article-title": "Explaining among-country variation in COVID-19 case fatality rate", "author": "Sorci", "doi-asserted-by": "crossref", "first-page": "18909", "journal-title": "Sci. Rep.", "key": "10.1016/j.biopha.2022.112965_bib30", "volume": "10", "year": "2020" }, { "DOI": "10.1111/joim.13149", "article-title": "Perspective: Vitamin D deficiency and COVID-19 severity – plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis", "author": "Rhodes", "doi-asserted-by": "crossref", "first-page": "97", "journal-title": "J. Intern. Med.", "key": "10.1016/j.biopha.2022.112965_bib31", "volume": "289", "year": "2021" }, { "article-title": "Insufficient evidence for vitamin D use in COVID-19: A rapid systematic review", "author": "da Rocha", "first-page": "14649", "journal-title": "Int. J. Clin. Pract.", "key": "10.1016/j.biopha.2022.112965_bib32", "volume": "e14649", "year": "2021" }, { "DOI": "10.1007/s11154-021-09705-6", "article-title": "Association of vitamin D status with COVID-19 and its severity", "author": "Bae", "doi-asserted-by": "crossref", "journal-title": "Rev. Endocr. Metab. Disord.", "key": "10.1016/j.biopha.2022.112965_bib33", "year": "2022" }, { "DOI": "10.3390/nu12113377", "article-title": "Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study", "author": "Annweiler", "doi-asserted-by": "crossref", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib34", "volume": "12", "year": "2020" }, { "DOI": "10.1007/s40520-021-01894-z", "article-title": "Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review", "author": "Raisi-Estabragh", "doi-asserted-by": "crossref", "first-page": "2031", "journal-title": "Aging Clin. Exp. Res.", "key": "10.1016/j.biopha.2022.112965_bib35", "volume": "33", "year": "2021" }, { "DOI": "10.3390/nu9020168", "article-title": "Reported Dietary Intake, Disparity between the Reported Consumption and the Level Needed for Adequacy and Food Sources of Calcium, Phosphorus, Magnesium and Vitamin D in the Spanish Population: Findings from the ANIBES Study †", "author": "Olza", "doi-asserted-by": "crossref", "first-page": "168", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib36", "volume": "9", "year": "2017" }, { "DOI": "10.4321/S1889-836X2014000500002", "article-title": "Deficiencia de vitamina D en España: ¿realidad o mito?", "author": "Navarro Valverde", "doi-asserted-by": "crossref", "first-page": "5", "journal-title": "Rev. Osteoporos. Metab. Miner", "key": "10.1016/j.biopha.2022.112965_bib37", "volume": "6", "year": "2014" }, { "key": "10.1016/j.biopha.2022.112965_bib38", "unstructured": "Recomendaciones de la SEIOMM en la prevención y tratamiento del déficit de vitamina D. Revista de Osteoporosis y Metabolismo Mineral · Publicación Oficial SEIOMM 〈http://revistadeosteoporosisymetabolismomineral.com/2021/07/08/recomendaciones-la-seiomm-la-prevencion-tratamiento-del-deficit-vitamina-d/〉 (2021)." }, { "DOI": "10.1001/jama.2020.26848", "article-title": "Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial", "author": "Murai", "doi-asserted-by": "crossref", "first-page": "1053", "journal-title": "JAMA", "key": "10.1016/j.biopha.2022.112965_bib39", "volume": "325", "year": "2021" }, { "DOI": "10.3390/nu13072170", "article-title": "Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial", "author": "Sabico", "doi-asserted-by": "crossref", "first-page": "2170", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib40", "volume": "13", "year": "2021" }, { "DOI": "10.1016/j.amjms.2021.06.005", "article-title": "Low Serum Levels of 25-Hydroxyvitamin D Accompany Severe COVID-19 Because it is a Negative Acute Phase Reactant", "author": "Antonelli", "doi-asserted-by": "crossref", "first-page": "333", "journal-title": "Am. J. Med. Sci.", "key": "10.1016/j.biopha.2022.112965_bib41", "volume": "362", "year": "2021" }, { "DOI": "10.1097/00003246-199207000-00007", "article-title": "Blood vitamin concentrations during the acute-phase response", "author": "Louw", "doi-asserted-by": "crossref", "first-page": "934", "journal-title": "Crit. Care Med.", "key": "10.1016/j.biopha.2022.112965_bib42", "volume": "20", "year": "1992" }, { "DOI": "10.3390/nu13103596", "article-title": "COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis", "author": "Borsche", "doi-asserted-by": "crossref", "first-page": "3596", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib43", "volume": "13", "year": "2021" }, { "DOI": "10.3389/fpubh.2021.736665", "article-title": "Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes", "author": "Chiodini", "doi-asserted-by": "crossref", "journal-title": "Front. Public Health", "key": "10.1016/j.biopha.2022.112965_bib44", "volume": "9", "year": "2021" }, { "article-title": "Dexamethasone in Hospitalized Patients with Covid-19", "author": "Group", "first-page": "693", "journal-title": "N. Engl. J. Med.", "key": "10.1016/j.biopha.2022.112965_bib45", "volume": "384", "year": "2020" }, { "DOI": "10.1016/j.coph.2010.04.001", "article-title": "Vitamin D: modulator of the immune system", "author": "Baeke", "doi-asserted-by": "crossref", "first-page": "482", "journal-title": "Curr. Opin. Pharmacol.", "key": "10.1016/j.biopha.2022.112965_bib46", "volume": "10", "year": "2010" }, { "DOI": "10.1111/j.1365-2249.2009.03961.x", "article-title": "Phenotypic and functional markers for 1α,25-dihydroxyvitamin D3-modified regulatory dendritic cells", "author": "Pedersen", "doi-asserted-by": "crossref", "first-page": "48", "journal-title": "Clin. Exp. Immunol", "key": "10.1016/j.biopha.2022.112965_bib47", "volume": "157", "year": "2009" }, { "article-title": "Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration", "author": "Chen", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib48", "volume": "12", "year": "2021" }, { "DOI": "10.3389/fcimb.2021.679878", "article-title": "COVID-19: Lung-Centric Immunothrombosis", "author": "Kvietys", "doi-asserted-by": "crossref", "journal-title": "Front. Cell. Infect. Microbiol.", "key": "10.1016/j.biopha.2022.112965_bib49", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.jns.2017.04.017", "article-title": "Vitamin D3 supplementation in multiple sclerosis: Symptoms and biomarkers of depression", "author": "Rolf", "doi-asserted-by": "crossref", "first-page": "30", "journal-title": "J. Neurol. Sci.", "key": "10.1016/j.biopha.2022.112965_bib50", "volume": "378", "year": "2017" }, { "DOI": "10.3390/nu12092518", "article-title": "High-Dose Vitamin D Supplementation Improves Microcirculation and Reduces Inflammation in Diabetic Neuropathy Patients", "author": "Karonova", "doi-asserted-by": "crossref", "first-page": "2518", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib51", "volume": "12", "year": "2020" }, { "DOI": "10.1016/j.cyto.2018.01.001", "article-title": "Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression", "author": "Ramos-Martínez", "doi-asserted-by": "crossref", "first-page": "239", "journal-title": "Cytokine", "key": "10.1016/j.biopha.2022.112965_bib52", "volume": "108", "year": "2018" }, { "DOI": "10.1097/MJT.0000000000001222", "article-title": "Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series", "author": "Ohaegbulam", "doi-asserted-by": "crossref", "first-page": "e485", "journal-title": "Am. J. Ther", "key": "10.1016/j.biopha.2022.112965_bib53", "volume": "27", "year": "2020" }, { "article-title": "Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)", "author": "Diao", "journal-title": "Front. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib54", "volume": "0", "year": "2020" }, { "DOI": "10.3390/nu7043011", "article-title": "Vitamin D and 1,25(OH)2D Regulation of T cells", "author": "Cantorna", "doi-asserted-by": "crossref", "first-page": "3011", "journal-title": "Nutrients", "key": "10.1016/j.biopha.2022.112965_bib55", "volume": "7", "year": "2015" }, { "DOI": "10.1111/j.1365-2036.2010.04463.x", "article-title": "Vitamin D3 treatment of Crohn’s disease patients increases stimulated T cell IL-6 production and proliferation", "author": "Bendix-Struve", "doi-asserted-by": "crossref", "first-page": "1364", "journal-title": "Aliment. Pharmacol. Ther", "key": "10.1016/j.biopha.2022.112965_bib56", "volume": "32", "year": "2010" }, { "key": "10.1016/j.biopha.2022.112965_bib57", "unstructured": "Sani, M. et al. Reduced CD4+ terminally differentiated effector memory T cells in moderate-severe house dust mites sensitized allergic rhinitis patients. Asian Pac J Allergy Immunol 9." }, { "DOI": "10.1038/s41467-017-01728-5", "article-title": "Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA", "author": "Tian", "doi-asserted-by": "crossref", "first-page": "1473", "journal-title": "Nat. Commun.", "key": "10.1016/j.biopha.2022.112965_bib58", "volume": "8", "year": "2017" }, { "DOI": "10.1038/s41423-020-0402-2", "article-title": "Functional exhaustion of antiviral lymphocytes in COVID-19 patients", "author": "Zheng", "doi-asserted-by": "crossref", "first-page": "533", "journal-title": "Cell. Mol. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib59", "volume": "17", "year": "2020" }, { "DOI": "10.3945/jn.114.202895", "article-title": "Vitamin D Receptor Signals Regulate Effector and Memory CD8 T Cell Responses to Infections in Mice", "author": "Yuzefpolskiy", "doi-asserted-by": "crossref", "first-page": "2073", "journal-title": "J. Nutr", "key": "10.1016/j.biopha.2022.112965_bib60", "volume": "144", "year": "2014" }, { "DOI": "10.1111/aji.13243", "article-title": "Potential impact of maternal vitamin D status on peripheral blood and endometrium cellular immunity in women with recurrent implantation failure", "author": "Chen", "doi-asserted-by": "crossref", "journal-title": "Am. J. Reprod. Immunol.", "key": "10.1016/j.biopha.2022.112965_bib61", "volume": "84", "year": "2020" }, { "DOI": "10.3390/toxins5111932", "article-title": "Effects of Vitamin D3, Calcipotriol and FTY720 on the Expression of Surface Molecules and Cytolytic Activities of Human Natural Killer Cells and Dendritic Cells", "author": "Al-Jaderi", "doi-asserted-by": "crossref", "first-page": "1932", "journal-title": "Toxins", "key": "10.1016/j.biopha.2022.112965_bib62", "volume": "5", "year": "2013" }, { "DOI": "10.1016/j.jnutbio.2018.01.004", "article-title": "Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice", "author": "Lee", "doi-asserted-by": "crossref", "first-page": "178", "journal-title": "J. Nutr. Biochem.", "key": "10.1016/j.biopha.2022.112965_bib63", "volume": "55", "year": "2018" } ], "reference-count": 63, "references-count": 63, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0753332222003547" } }, "score": 1, "short-container-title": [ "Biomedicine & Pharmacotherapy" ], "short-title": [], "source": "Crossref", "subject": [ "Pharmacology", "General Medicine" ], "subtitle": [], "title": [ "Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D" ], "type": "journal-article" }