Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, María Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras, David Alonso-Menchén, Sandra Arévalo Camacho, Cristina Avila Calzada, José Antonio Barbado Albaladejo, Natalia Blanca López, Irene Cañamares Orbis, Gema Carrillo Blanco, Almudena Cascajero Díaz, María Teresa Chica Burguillo, Ana Corrochano García, Sara Corredera García, Victor Díez Viñas, Marta Gómez-Alvarez Domínguez, Claudia Patricia Fernández Fernández, Yanira Fernández Mondelo, Eva Fonseca Aizpuri, Concepción García Lacalle, Javier García-Pérez, Cristina Helguera Amezua, Francisco José Hidalgo Correas, Amparo Lucena Campillo, Mariano Matarranz Del Amo, Oriol Martín Sagarra, Emilio José Martínez Martín, José Javier Martínez Simón, María Novella-Mena, Virginia Pardo Guimera, María Luisa Pinillos Pardo, Fr`ancisca Ramírez Fuentes, Daniel Renuncio García, María Angeles Rodríguez Dávila, Almudena Roger Revilla, Lourdes Sampablo Valverde, José Sanz Moreno, Rafael Torres Perea, Jorge Valencia La Rosa, María Velasco Arribas, Ana Villanueva Fernández-Ardavín
Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112965
Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin DImmunomodulatory effect of vitamin D supplementation in patients with COVID-19, Biomedicine & Pharmacotherapy,
Drug Cholecalciferol (vitamin D) used in the study was donated by Italfarmaco Group (Cholecalciferol 25,000IU/2,5ml oral solution). Italfarmaco Group had no role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or the preparation, review, or approval of the manuscript.
Conflicts of interest The authors declare no conflict of interest.
Author Contributions MCer and MCo conceptualized the project. MT, GC and MCo wrote the manuscript. MT, GC and LV performed the study of cytotoxicity. MT, GC and SRM performed the analysis of cell populations by flow cytometry with technical assistance from EM.
J o u r n a l P r e -p r o o f MRLH and GC performed the analysis of cytokines in plasma. FR and EM processed and stored all blood samples. DLW, MNM, PRM, MLTM and MCer identified, selected, and recruited the patients, and also collected the blood samples. MT, MCer and MRLH collected and analyzed the clinical data. All co-authors read and approved the final version of the manuscript.
Author Contributions MCer and MCo conceptualized the project. MT, GC and MCo wrote the manuscript. MT, GC and LV performed the study of cytotoxicity. MT, GC and SRM performed the analysis of cell populations by flow cytometry with technical assistance from EM. MRLH and GC performed the analysis of cytokines in plasma. Anti-inflammatory cytokine IL-10 was significantly increased in 10,000 IU/day group. Individuals who received 10,000..
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