The e ects of vitamin D on all-cause mortality in di erent diseases: an evidence-map and umbrella review of randomized controlled trials
Owen Kelly, Rizaldy Taslim Pinzon, Mingyu Cao, Chunrong He, Matthew Gong, Song Wu, Jinshen He
The e ects of vitamin D on all-cause mortality in di erent diseases: an evidence-map and umbrella review of randomized controlled trials.
Author contributions MC and CH performed the data collection. MC conducted the statistical analysis of all data. MC and JH drafted and edited the original manuscript and participated in the conception and design of the original study. MG and SW revised the manuscript and participated the original study design. All authors read and approved the final manuscript.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnut.2023. 1132528/full#supplementary-material
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doi:10.1016/j.clinre.2011.02.003{ 'indexed': {'date-parts': [[2023, 6, 25]], 'date-time': '2023-06-25T04:38:14Z', 'timestamp': 1687667894900},
'reference-count': 218,
'publisher': 'Frontiers Media SA',
'license': [ { 'start': { 'date-parts': [[2023, 6, 22]],
'date-time': '2023-06-22T00:00:00Z',
'timestamp': 1687392000000},
'content-version': 'vor',
'delay-in-days': 0,
'URL': 'https://creativecommons.org/licenses/by/4.0/'}],
'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True},
'abstract': '<jats:sec><jats:title>Purpose</jats:title><jats:p>To conduct a solid evidence by synthesizing '
'meta-analyses and updated RCTs about the effects of vitamin D on all-cause mortality in '
'different health '
'conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data '
'sources: Pubmed, Embase, Web of Science, the Cochrane Library, Google Scholar from inception '
'until 25th April, 2022. Study selection: English-language, meta-analyses and updated RCTs '
'assessing the relationships between vitamin D and all-cause mortality. Data synthesis: '
'Information of study characteristics, mortality, supplementation were extracted, estimating '
'with fixed-effects model. A Measurement Tool to Assess Systematic Reviews, Grading of '
'Recommendations Assessment, Development and Evaluation, and funnel plot was used to assess '
'risk of bias. Main outcomes: All-cause mortality, cancer mortality, cardiovascular disease '
'mortality.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In total of '
'27 meta-analyses and 19 updated RCTs were selected, with a total of 116 RCTs and 149, 865 '
'participants. Evidence confirms that vitamin D reduces respiratory cancer mortality (RR, 0.56 '
'[95%CI, 0.33 to 0.96]). All-cause mortality is decreased in patients with COVID-19 (RR, '
'0.54[95%CI, 0.33 to 0.88]) and liver diseases (RR, 0.64 [95%CI, 0.50 to 0.81]), especially in '
'liver cirrhosis (RR, 0.63 [95%CI, 0.50 to 0.81]). As for other health conditions, such as the '
'general health, chronic kidney disease, critical illness, cardiovascular diseases, '
'musculoskeletal diseases, sepsis, type 2 diabetes, no significant association was found '
'between vitamin D and all-cause '
'mortality.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Vitamin D '
'may reduce respiratory cancer mortality in respiratory cancer patients and all-cause '
"mortality in COVID-19 and liver disorders' patients. No benefits showed in all-cause "
'mortality after vitamin D intervention among other health conditions. The hypothesis of '
'reduced mortality with vitamin D still requires '
'exploration.</jats:p></jats:sec><jats:sec><jats:title>Systematic review '
'registration</jats:title><jats:p><jats:ext-link>https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=252921</jats:ext-link>, '
'identifier: CRD42021252921.</jats:p></jats:sec>',
'DOI': '10.3389/fnut.2023.1132528',
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