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The effects of vitamin D on all-cause mortality in different diseases: an evidence-map and umbrella review of 116 randomized controlled trials

Cao et al., Frontiers in Nutrition, doi:10.3389/fnut.2023.1132528
Jun 2023  
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Meta analysis showing significantly lower mortality for COVID-19 patients with vitamin D treatment, however it's not clear why Annweiler et al. is considered an RCT here, or why most of the COVID-19 vitamin D RCTs are not included.
9 meta analyses show significant improvements with vitamin D treatment for mortality Argano, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Shah, Xie, ICU admission Hariyanto, Hosseini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Varikasuvu.
Currently there are 115 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [27‑43%], 16% lower ventilation [-8‑35%], 47% lower ICU admission [29‑61%], 20% lower hospitalization [8‑29%], and 16% fewer cases [7‑23%].
Cao et al., 22 Jun 2023, peer-reviewed, 5 authors.
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This PaperVitamin DAll
The e ects of vitamin D on all-cause mortality in di erent diseases: an evidence-map and umbrella review of randomized controlled trials
Owen Kelly, Rizaldy Taslim Pinzon, Mingyu Cao, Chunrong He, Matthew Gong, Song Wu, Jinshen He
The e ects of vitamin D on all-cause mortality in di erent diseases: an evidence-map and umbrella review of randomized controlled trials.
Author contributions MC and CH performed the data collection. MC conducted the statistical analysis of all data. MC and JH drafted and edited the original manuscript and participated in the conception and design of the original study. MG and SW revised the manuscript and participated the original study design. All authors read and approved the final manuscript. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary Material for this article can be found online at: 1132528/full#supplementary-material
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