The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
Ramos et al.,
The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy,
Antioxidants, doi:10.3390/antiox10071152 (Review)
Review of melatonin for COVID-19 discussing mechanisms of action and ongoing trials.
Ramos et al., 20 Jul 2021, peer-reviewed, 10 authors.
Abstract: antioxidants
Review
The Coronavirus Disease 2019 (COVID-19): Key Emphasis on
Melatonin Safety and Therapeutic Efficacy
Eva Ramos 1 , Francisco López-Muñoz 2,3,4,5 , Emilio Gil-Martín 6 , Javier Egea 7,8 , Iris Álvarez-Merz 9,10 ,
Sakshi Painuli 11 , Prabhakar Semwal 11,12 , Natália Martins 13,14 , Jesús M. Hernández-Guijo 9,10
and Alejandro Romero 1, *
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5
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Citation: Ramos, E.; López-Muñoz,
F.; Gil-Martín, E.; Egea, J.;
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8
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Álvarez-Merz, I.; Painuli, S.; Semwal,
P.; Martins, N.; Hernández-Guijo,
10
J.M.; Romero, A. The Coronavirus
Disease 2019 (COVID-19): Key
11
Emphasis on Melatonin Safety and
Therapeutic Efficacy. Antioxidants
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2021, 10, 1152. https://doi.org/
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10.3390/antiox10071152
Academic Editors: Helen Galley and
Juan Carlos Mayo
Received: 19 June 2021
Accepted: 14 July 2021
Published: 20 July 2021
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This article is an open access article
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*
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of
Madrid, 28040 Madrid, Spain; eva.ramos@ucm.es
Faculty of Health Sciences, University Camilo José Cela, C/Castillo de Alarcón 49, Villanueva de la Cañada,
28692 Madrid, Spain; flopez@ucjc.edu
Neuropsychopharmacology Unit, Hospital 12 de Octubre Research Institute (i + 12), Avda. Córdoba, s/n,
28041 Madrid, Spain
Portucalense Institute of Neuropsychology and Cognitive and Behavioural Neurosciences (INPP),
Portucalense University, R. Dr. António Bernardino de Almeida 541, 4200-072 Porto, Portugal
Thematic Network for Cooperative Health Research (RETICS), Addictive Disorders Network, Health Institute
Carlos III, MICINN and FEDER, 28029 Madrid, Spain
Nutrition, Food & Plant Science Group NF1, Department of Biochemistry, Genetics and Immunology,
Faculty of Biology, University of Vigo, 36310 Vigo, Spain; egil@uvigo.es
Health Research Institute, Hospital Universitario de la Princesa, 28006 Madrid, Spain; javier.egea@inv.uam.es
Molecular Neuroinflammation and Neuronal Plasticity Research Laboratory, Hospital Universitario Santa
Cristina, Instituto de Investigación Sanitaria-Hospital Universitario de la Princesa, 28006 Madrid, Spain
Department of Pharmacology and Therapeutic, Teófilo Hernando Institute, Faculty of Medicine, Universidad
Autónoma de Madrid, Av. Arzobispo Morcillo 4, 28029 Madrid, Spain;
iris.alvarez@estudiante.uam.es (I.Á.-M.); jesusmiguel.hernandez@uam.es (J.M.H.-G.)
Ramón y Cajal Institute for Health Research (IRYCIS), Hospital Ramón y Cajal, Carretera de Colmenar Viejo,
Km. 9100, 28029 Madrid, Spain
Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, India;
sakshipainuli@geu.ac.in (S.P.); semwal.prabhakar@geu.ac.in (P.S.)
Uttarakhand State Council for Science and Technology, Dehradun, Uttarakhand 248007, India
Faculty of Medicine, Institute for Research and Innovation in Health (i3S), University of Porto, Alameda Prof.
Hernâni Monteiro, 4200-319 Porto, Portugal; ncmartins@med.up.pt
Institute for Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino
Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal
Correspondence: manarome@ucm.es; Tel.: +34-913-943970
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