Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Melatonin  COVID-19 treatment studies for Melatonin  C19 studies: Melatonin  Melatonin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
Prophylactic Treatment Protocol against the Severity of COVID-19 Using Melatonin
Charaa et al., SSRN, doi:10.2139/ssrn.3601861 (Review) (Preprint)
Charaa et al., Prophylactic Treatment Protocol against the Severity of COVID-19 Using Melatonin, SSRN, doi:10.2139/ssrn.3601861 (Review) (Preprint)
May 2020   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Review of the potential benefits of melatonin for COVID-19, and a proposed prophylactic treatment protocol.
Charaa et al., 4 May 2020, preprint, 4 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperMelatoninAll
Abstract: May 4, 2020 Review iew ed Prophylactic treatment protocol against the severity of COVID-19 using melatonin Dr Nejib CHARAA1 *, Pr Mohamed CHAHED2 , Pr Habib GHEDIRA 3 , Pr Riadh DAGHFOUS4 er r ev Abstract The Corona Virus Disease 2019 (COVID-19) pandemic reached more than 150 countries in all continent in two months, after triggering in Wuhan, China in late December 2019. One of the main features of this pandemic is the increased severity of the disease with age and the highest proportion of serious cases among males. Most severe cases were caused by an intensive immune response with massive release of cytokines which induces acute respiratory distress syndrome and multi-visceral failure. Melatonin is the major neuro-hormone secreted by the pineal gland. The synthesis of this hormone shows a circadian pattern. Melatonin secretion gradually decreases with age and becomes clear in people over the age of 60. This deprivation is inversely proportional to the increase in mortality due to COVID-19 with age. Also the level of this hormone seems to be higher in women. It is assumed that melatonin with its immunomodulatory and antiviral actions plays a protective role against the severity of SARS-CoV-2 infection. Following our review, we concluded that this hypothesis was highly plausible and we proposed a prophylactic treatment protocol against the severity of COVID-19 using a melatonin supplementation. Keywords COVID-19 — SARS-CoV-2 — Coronavirus — Melatonin — Prophylaxis — Treatment 1 Preventive Health Director. Regional Health Directorate of Kebili, Tunisia of Epidemiology and Public Health, Faculty of Medicine of Tunis, Tunis-El Manar University, Tunis, Tunisia 3 Head of Pulmonary Diseases Dpt I - A. Mami Chest Diseases Hospital, Ariana 2080, Tunisia 4 National Center of Pharmacovigilance General Director. University of Tunis El Manar Department of Basic Sciences B, Tunisia. *Corresponding author: n.charaa@gmail.com Contents
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit