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All Studies   Meta Analysis    Recent:   

Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy

Cross et al., Endocrine Practice, doi:10.1016/j.eprac.2021.06.001
Jun 2021  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Review of the potential benefits of melatonin for COVID-19.
Reviews covering melatonin for COVID-19 include Alomari, Behl, Camp, Castle, Charaa, Cross, DiNicolantonio, Hosseinzadeh, Langen, Lempesis, Loh, Ramos, Reiter, Reiter (B), Shneider, Tan, Zhang.
Cross et al., 10 Jun 2021, peer-reviewed, 4 authors.
This PaperMelatoninAll
Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
MS Kristina M Cross, BA Dylan M Landis, BS Laveena Sehgal, DO J Drew Payne
Endocrine Practice, doi:10.1016/j.eprac.2021.06.001
Objective: To discuss the use of melatonin as an early treatment option on the first day of diagnosis for COVID-19. Methods: Medical Subject Headings terms "COVID-19" and "viral diseases" were manually searched on PubMed, and relevant articles were included. Results: The results showed that melatonin acts to reduce reactive oxygen speciesemediated damage, cytokine-induced inflammation, and lymphopenia in viral diseases similar to COVID-19. Conclusion: These conclusions provide evidence for potential benefits in melatonin use for COVID-19 treatment as early as the day of diagnosis.
Author Contributions K.M.C., D.M.L., and L.S. are co-first authors. J.D.P is senior author. Disclosure The authors have no multiplicity of interest to disclose.
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