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Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy

Cross et al., Endocrine Practice, doi:10.1016/j.eprac.2021.06.001
Jun 2021  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Review of the potential benefits of melatonin for COVID-19.
Reviews covering melatonin for COVID-19 include Alomari, Behl, Camp, Castle, Charaa, Cross, DiNicolantonio, Hosseinzadeh, Langen, Lempesis, Loh, Ramos, Reiter, Reiter (B), Shneider, Tan, Zhang.
Cross et al., 10 Jun 2021, peer-reviewed, 4 authors.
This PaperMelatoninAll
Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
MS Kristina M Cross, BA Dylan M Landis, BS Laveena Sehgal, DO J Drew Payne
Endocrine Practice, doi:10.1016/j.eprac.2021.06.001
Objective: To discuss the use of melatonin as an early treatment option on the first day of diagnosis for COVID-19. Methods: Medical Subject Headings terms "COVID-19" and "viral diseases" were manually searched on PubMed, and relevant articles were included. Results: The results showed that melatonin acts to reduce reactive oxygen speciesemediated damage, cytokine-induced inflammation, and lymphopenia in viral diseases similar to COVID-19. Conclusion: These conclusions provide evidence for potential benefits in melatonin use for COVID-19 treatment as early as the day of diagnosis.
Author Contributions K.M.C., D.M.L., and L.S. are co-first authors. J.D.P is senior author. Disclosure The authors have no multiplicity of interest to disclose.
Acuña-Castroviejo, Escames, Figueira, De La Oliva, Borobia et al., Clinical trial to test the efficacy of melatonin in COVID-19, J Pineal Res
Adamczyk-Sowa, Sowa, Adamczyk, Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone, J Physiol Pharmacol
Ameri, Asadi, Kamali, Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: a structured summary of a study protocol for a randomized controlled trial, Trials
Andersen, G€ Ogenur, Rosenberg, Reiter, The safety of melatonin in humans, Clin Drug Investig
Anderson, Maes, Markus, Rodriguez, Ebola virus: melatonin as a readily available treatment option, J Med Virol
Anderson, Reiter, Melatonin: roles in influenza, Covid-19, and other viral infections, Rev Med Virol
Araghi-Niknam, Lane, Watson, Physical inactivity of murine retrovirus infected C57BL/6 mice is prevented by melatonin and dehydroepiandrosterone, Proc Soc Exp Biol Med
Artigas, Coma, Matos-Filipe, In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm, PLoS One
Balduini, Weiss, Carloni, Melatonin pharmacokinetics and dose extrapolation after enteral infusion in neonates subjected to hypothermia, J Pineal Res
Banerjee, Czinn, Reiter, Blanchard, Crosstalk between endoplasmic reticulum stress and anti-viral activities: a novel therapeutic target for COVID-19, Life Sci
Ben-Nathan, Maestroni, Lustig, Conti, Protective effects of melatonin in mice infected with encephalitis viruses, Arch Virol
Besag, Vasey, Lao, Wong, Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review, CNS Drugs
Boga, Coto-Montes, Rosales-Corral, Tan, Reiter, Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman, Rev Med Virol
Bonilla, Valero, Bonilla, Melatonin increases interleukin-1beta and decreases tumor necrosis factor alpha in the brain of mice infected with the Venezuelan equine encephalomyelitis virus, Neurochem Res
Campos, Cipolla-Neto, Amaral, Michelini, Bader et al., The angiotensin-melatonin axis, Int J Hypertens
Cardinali, Brown, Reiter, Sr, Elderly as a high-risk group during COVID-19 pandemic: effect of circadian misalignment, sleep dysregulation and melatonin administration, Sleep Vigil
Cardinali, High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection, Melatonin Res
Chitimus, Popescu, Voiculescu, Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease, Biomolecules
Citera, Arias, Maldonado-Cocco, The effect of melatonin in patients with fibromyalgia: a pilot study, Clin Rheumatol
Crespo, San-Miguel, Di, Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin, J Pineal Res
El-Missiry, El-Missiry, Othman, Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19, Eur J Pharmacol
Elmahallawy, Luque, Aloweidi, Potential relevance of melatonin against some infectious agents: a review and assessment of recent research, Curr Med Chem
Feitosa, Júnior, Neto, COVID-19: rational discovery of the therapeutic potential of melatonin as a SARS-CoV-2 main protease inhibitor, Int J Med Sci
Gim, Vm, Prado, Diez, Manucha et al., New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment, Nanomedicine (Lond)
Hardeland, Melatonin and inflammation-story of a double-edged blade, J Pineal Res
Herrera, Gonz Alez-Candia, Comment on melatonin as a potential adjuvant treatment for COVID-19, Life Sci
Hojyo, Uchida, Tanaka, How COVID-19 induces cytokine storm with high mortality, Inflamm Regen
Huang, Cao, Liu, Shi, Wei, Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice, J Pineal Res
Juybari, Pourhanifeh, Hosseinzadeh, Hemati, Mehrzadi, Melatonin potentials against viral infections including COVID-19: current evidence and new findings, Virus Res
Kleszczy Nski, Slominski, Steinbrink, Reiter, Clinical trials for use of melatonin to fight against COVID-19 are urgently needed, Nutrients
Laforge, Elbim, Fr Ere, Tissue damage from neutrophil-induced oxidative stress in COVID-19, Nat Rev Immunol
Laliena, Miguel, Crespo, Alvarez, Gonz Alez-Gallego et al., Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin, J Pineal Res
Lissoni, Vigor E L, Rescaldani, Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3: a biological phase-II study, J Biol Regul Homeost Agents
Longatti, Perin, Comai, A study of tryptophan metabolism via serotonin in ventricular cerebrospinal fluid in HIV-1 infection using a neuroendoscopic technique, Curr HIV Res
Lynn, Wong, Neuroimmunopathogenesis of ts1 MoMuLV viral infection, Neuroimmunomodulation
Ma, Tang, Song, The reduced level of plasma melatonin in HFRS patients is correlated with disease severity and stage. Article in Chinese
Maestroni, The immunoneuroendocrine role of melatonin, J Pineal Res
Medina-Leendertz, Valero, Bonilla, High intensity light increases olfactory bulb melatonin in Venezuelan equine encephalitis virus infection, Neurochem Res
Montiel, Bonilla, Valero, Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus, Antivir Chem Chemother
Naveenkumar, Hemshekhar, Jagadish, Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system, J Pineal Res
Niu, Li, Clinical study of novel coronavirus pneumonia prevention by melatonin, Reprod Biomed Online
Nunes Oda, Rde, Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with acyclovir, J Pineal Res
Omez-Moreno, Guardia, Ferrera, Cutando, Reiter, Melatonin in diseases of the oral cavity, Oral Dis
Oztürk, Akbulut, Güney, Melatonin, aging, and COVID-19: could melatonin be beneficial for COVID-19 treatment in the elderly?, Turk J Med Sci
Paemanee, Hitakarun, Roytrakul, Smith, Screening of melatonin, atocopherol, folic acid, acetyl-L-carnitine and resveratrol for anti-dengue 2 virus activity, BMC Res Notes
Pierpaoli, Yi, The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone, J Neuroimmunol
Reiter, Tan, Sainz, Mayo, Lopez-Burillo, Melatonin: reducing the toxicity and increasing the efficacy of drugs, J Pharm Pharmacol
Rodríguez-Rubio, Figueira, Acuña-Castroviejo, Borobia, Escames et al., A phase II, single-center, double-blind, randomized placebocontrolled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial, Trials
S Anchez-Barcel O Ej, Mediavilla, Tan, Reiter, Clinical uses of melatonin: evaluation of human trials, Curr Med Chem
Salles, Correspondence COVID-19: melatonin as a potential adjuvant treatment, Life Sci
San-Miguel, Crespo, Vallejo, Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus, J Pineal Res
Seabra, Bignotto, Jr, Tufik, Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment, J Pineal Res
Sehirli, Sayiner, Serakinci, Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147), Mol Biol Rep
Shiu, Reiter, Tan, Pang, Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug?, J Pineal Res
Shneider, Kudriavtsev, Vakhrusheva, Can melatonin reduce the severity of COVID-19 pandemic?, Int Rev Immunol
Silvestri, Rossi, Melatonin: its possible role in the management of viral infections-a brief review, Ital J Pediatr
Simko, Hrenak, Dominguez-Rodriguez, Reiter, Melatonin as a putative protection against myocardial injury in COVID-19 infection, Expert Rev Clin Pharmacol
Simko, Reiter, Is melatonin deficiency a unifying pathomechanism of high risk patients with COVID-19?, Life Sci
Srinivasan, Mohamed, Kato, Melatonin in bacterial and viral infections with focus on sepsis: a review, Recent Pat Endocr Metab Immune Drug Discov
Tan, Hardeland, Targeting host defense system and rescuing compromised mitochondria to increase tolerance against pathogens by melatonin may impact outcome of deadly virus infection pertinent to COVID-19, Molecules
Tan, Korkmaz, Reiter, Manchester, Ebola virus disease: potential use of melatonin as a treatment, J Pineal Res
Tesarik, Melatonin to reduce death toll due to COVID-19: from innate to adaptive immune response, Glob J Med Res: K Interdisciplinary
Tuñ On, San-Miguel, Crespo, Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin, J Pineal Res
Valero, Bonilla, Pons, Melatonin induces changes to serum cytokines in mice infected with the Venezuelan equine encephalomyelitis virus, Trans R Soc Trop Med Hyg
Valero, Espina, Mosquera, Melatonin decreases nitric oxide production, inducible nitric oxide synthase expression and lipid peroxidation induced by Venezuelan encephalitis equine virus in neuroblastoma cell cultures, Neurochem Res
Valero, Mosquera, Alcocer, Bonilla, Salazar et al., Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis, Brain Res
Vielma, Bonilla, Chacín-Bonilla, Mora, Medina-Leendertz et al., Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: a review, Acta Trop
Walton, Grayson, Venezuelan equine encephalomyelitis
Wei, Smits, Tang, Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials, Sleep Med
Zhang, Wang, Ni, COVID-19: melatonin as a potential adjuvant treatment, Life Sci
Zhang, Zhang, Melatonin: a well-documented antioxidant with conditional pro-oxidant actions, J Pineal Res
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