Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
Cross et al.
, Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
, Endocrine Practice, doi:10.1016/j.eprac.2021.06.001 (Review)
Review of the potential benefits of melatonin for COVID-19.
Cross et al., 10 Jun 2021, peer-reviewed, 4 authors.
Abstract: Endocrine Practice 27 (2021) 850e855
Contents lists available at ScienceDirect
journal homepage: www.endocrinepractice.org
Melatonin for the Early Treatment of COVID-19: A Narrative Review of
Current Evidence and Possible Efﬁcacy
Kristina M. Cross, MS 1, *, Dylan M. Landis, BA 1, Laveena Sehgal, BS 1, J. Drew Payne, DO 2
School of Medicine, Texas Tech University Health Science Center, Lubbock, Texas
Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas
a r t i c l e i n f o
a b s t r a c t
Received 31 March 2021
Received in revised form
24 May 2021
Accepted 2 June 2021
Available online 10 June 2021
Objective: To discuss the use of melatonin as an early treatment option on the ﬁrst day of diagnosis for
Methods: Medical Subject Headings terms “COVID-19” and “viral diseases” were manually searched on
PubMed, and relevant articles were included.
Results: The results showed that melatonin acts to reduce reactive oxygen speciesemediated damage,
cytokine-induced inﬂammation, and lymphopenia in viral diseases similar to COVID-19.
Conclusion: These conclusions provide evidence for potential beneﬁts in melatonin use for COVID-19
treatment as early as the day of diagnosis.
© 2021 AACE. Published by Elsevier Inc. All rights reserved.
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