Melatonin and viral infections: A review focusing on therapeutic effects and SARS-CoV-2

{ 'indexed': {'date-parts': [[2024, 4, 26]], 'date-time': '2024-04-26T00:27:36Z', 'timestamp': 1714091256969}, 'reference-count': 0, 'publisher': 'ST Bio-life', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 4, 19]], 'date-time': '2024-04-19T00:00:00Z', 'timestamp': 1713484800000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>\xa0\xa0\xa0 \xa0\xa0Viral infections can cause serious diseases which lead to ' 'significant morbidity and mortality of patients. In most cases, effective therapeutic ' 'approaches are lacking. Melatonin (MEL), a multifunctional molecule produced in the pineal ' 'gland and many other organs, is known as a potent anti-inflammatory and antioxidant, a ' 'positive regulator of immune functions and a suppressor of apoptosis, with therapeutic ' 'effects in diverse diseases. These actions suggest the potential of MEL to treat viral ' 'infections. A variety of studies have shown that MEL supplementation is effective against a ' 'number of viral infections. Many of these reports have strongly suggested its use as an ' 'adjuvant or therapeutic agent. Notably, the efficacy of this molecule as a prophylactic or ' 'therapeutic weapon against COVID-19 has been demonstrated both in experimental conditions and ' 'in clinical trials, and it can reduce the severity and mortality of the patients. This review ' 'summarizes actions of MEL on viral infections and focuses on its therapeutic effects against ' 'COVID-19 and generally highlights MEL as an attractive therapy in other viral infections.\xa0' '</jats:p>', 'DOI': '10.32794/mr112500168', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 25]], 'date-time': '2024-04-25T16:29:24Z', 'timestamp': 1714062564000}, 'page': '47-83', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Melatonin and viral infections: A review focusing on therapeutic effects and SARS-CoV-2', 'prefix': '10.32794', 'volume': '7', 'author': [ {'given': 'Leonor', 'family': 'Chacin-Bonilla', 'sequence': 'first', 'affiliation': []}, {'given': 'Ernesto', 'family': 'Bonilla', 'sequence': 'first', 'affiliation': []}], 'member': '18079', 'published-online': {'date-parts': [[2024, 4, 19]]}, 'container-title': 'Melatonin Research', 'original-title': [], 'deposited': { 'date-parts': [[2024, 4, 25]], 'date-time': '2024-04-25T16:29:29Z', 'timestamp': 1714062569000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.melatonin-research.net/index.php/MR/article/view/256'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4, 19]]}, 'references-count': 0, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 4, 25]]}}, 'URL': 'http://dx.doi.org/10.32794/mr112500168', 'relation': {}, 'ISSN': ['2641-0281'], 'subject': [], 'container-title-short': 'Melatonin Res.', 'published': {'date-parts': [[2024, 4, 19]]}}