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All Studies   Meta Analysis    Recent:   

Melatonin and viral infections: A review focusing on therapeutic effects and SARS-CoV-2

Chacin-Bonilla et al., Melatonin Research, doi:10.32794/mr112500168
Apr 2024  
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Melatonin for COVID-19
11th treatment shown to reduce risk in December 2020
 
*, now with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Review of the potential therapeutic effects of melatonin on viral infections, with a focus on SARS-CoV-2 and COVID-19. Authors highlight melatonin's potent anti-inflammatory, antioxidant, and immunomodulatory properties, which suggest its potential to treat the cytokine storm and hyper-inflammation associated with severe COVID-19. Melatonin has been shown to reduce pro-inflammatory cytokines, increase anti-inflammatory cytokines, and potentially inhibit SARS-CoV-2 replication by interfering with virus-cell coupling and intracellular processes. Clinical trials have documented melatonin's efficacy as a prophylactic or therapeutic for COVID-19, reducing symptom severity and mortality. The review also discusses melatonin's potential to address gut dysbiosis, which may play a role in COVID-19 severity through modulation of the immune response and systemic inflammation.
Reviews covering melatonin for COVID-19 include1-20.
Chacin-Bonilla et al., 19 Apr 2024, peer-reviewed, 2 authors.
This PaperMelatoninAll
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