Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Melatonin  COVID-19 treatment studies for Melatonin  C19 studies: Melatonin  Melatonin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  

Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19

Hosseinzadeh et al., Life Sciences, doi:10.1016/j.lfs.2022.120866 (Review)
Hosseinzadeh et al., Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19, Life Sciences, doi:10.1016/j.lfs.2022.120866 (Review)
Aug 2022   Source   PDF  
  All Studies   Meta
Review of the mechanisms and potential benefits of melatonin against coagulopathy induced by SARS-CoV-2 infection.
Hosseinzadeh et al., 6 Aug 2022, peer-reviewed, 7 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperMelatoninAll
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19
Azam Hosseinzadeh, Abolfazl Bagherifard, Fereshteh Koosha, Shiva Amiri, Arman Karimi-Behnagh, Russel J Reiter, Saeed Mehrzadi
Life Sciences, doi:10.1016/j.lfs.2022.120866
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interests None declared. References J o u r n a l P r e -p r o o f
Ackermann, Verleden, Kuehnel, Haverich, Welte et al., Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19, New England Journal of Medicine
Acuña-Castroviejo, Escames, Figueira, De La Oliva, Borobia et al., Clinical trial to test the efficacy of melatonin in COVID-19, Journal of pineal research
Ahmad, Rathore, Neurological manifestations and complications of COVID-19: a literature review, Journal of Clinical Neuroscience
Alamili, Bendtzen, Lykkesfeldt, Rosenberg, Gögenur, Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model, Journal of critical care
Ali, Rahman, Hao, Li, Liu et al., Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation, Journal of pineal research
Alvarez-García, González, Alonso-González, Martínez-Campa, Cos, Antiangiogenic effects of melatonin in endothelial cell cultures, Microvascular research
Alvarez-García, González, Alonso-González, Martínez-Campa, Cos, Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells, Journal of Pineal Research
Ashy, Shroff, Evaluation of the potential drug interaction of melatonin and warfarin: a case series, Life Sci J
Barnes, Adrover, Baxter-Stoltzfus, Borczuk, Cools-Lartigue et al., Targeting potential drivers of COVID-19: Neutrophil extracellular traps, Journal of Experimental Medicine
Bathen, Linder, Spin Seebeck effect and thermoelectric phenomena in superconducting hybrids with magnetic textures or spin-orbit coupling, Scientific Reports
Becker, Chappell, Bruegger, Annecke, Jacob, Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential, Cardiovasc Res
Becker, Chappell, Jacob, Endothelial glycocalyx and coronary vascular permeability: the fringe benefit, Basic Res Cardiol
Bekyarova, Tancheva, Hristova, The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Methods and findings in experimental and clinical pharmacology
Bernlochner, Steinhubl, Braun, Morath, Jaitner et al., Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment, Thrombosis and haemostasis
Bikdeli, Madhavan, Jimenez, Chuich, Dreyfus et al., COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review, Journal of the American college of cardiology
Boga, Coto-Montes, Rosales-Corral, Tan, Reiter, Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman"?, Reviews in medical virology
Bondy, Naderi, Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species, Biochemical pharmacology
Bourgonje, Abdulle, Timens, Hillebrands, Navis et al., Angiotensinconverting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19), J Pathol
Brunkhorst, Pfeilschifter, Rajkovic, Pfeffer, Fischer et al., Diurnal regulation of sphingolipids in blood, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
Cardinali, Brown, Sr, Can melatonin be a potential "silver bullet" in treating COVID-19 patients?, Diseases
Cardinali, Furio, Brusco, Clinical aspects of melatonin intervention in Alzheimer's disease progression, Current Neuropharmacology
Cardinali, High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection, Melatonin Research
Carrillo-Vico, Guerrero, Lardone, Reiter, A review of the multiple actions of melatonin on the immune system, Endocrine
Cavezzi, Troiani, Corrao, COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clinics and practice
Cecchini, Cecchini, SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression, Medical hypotheses
Chan, Kok, Zhu, Chu, To et al., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan, Emerg Microbes Infect
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The lancet
Chinetti-Gbaguidi, Copin, Derudas, Marx, Eechkoute et al., Peroxisome Proliferator-Activated Receptor <i>γ</i> Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages, PPAR Research
Choudhary, Sharma, Silakari, The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options, Microb Pathog
Chrusciel, Goch, Banach, Mikhailidis, Rysz et al., Circadian changes in the hemostatic system in healthy men and patients with cardiovascular diseases, Med Sci Monit
Claustrat, Brun, Chazot, The basic physiology and pathophysiology of melatonin, Sleep medicine reviews
Costa, Potje, Fraga-Silva, Da Silva-Neto, Barros et al., Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage, Vascular pharmacology
Cross, Landis, Sehgal, Payne, Melatonin in Early Treatment for COVID-19: A Narrative Review of Current Evidence and Possible Efficacy
Dahm, Østerud, Hjeltnes, Sandset, Iversen, Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: does daylight affect coagulation?, Journal of Thrombosis and Haemostasis
Deb, Arrighi, Potential effects of COVID-19 on cytochrome P450-mediated drug metabolism and disposition in infected patients, European Journal of Drug Metabolism and Pharmacokinetics
Deguchi, Yegneswaran, Griffin, Sphingolipids as bioactive regulators of thrombin generation, Journal of Biological Chemistry
Del Zar, Martinuzzo, Falcón, Dp, Lo et al., Inhibition of human platelet aggregation and thromboxane-B2 production by melatonin: evidence for a diurnal variation, The Journal of Clinical Endocrinology & Metabolism
Delgado-Roche, Mesta, Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection, Archives of medical research
Dikalov, Nazarewicz, Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxidants & redox signaling
Feitosa, Júnior, Neto, Matos, Moura et al., COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor, International Journal of Medical Sciences
Frye, Schneider, Frye, Feldman, Plasma levels of TNF-α and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure, Journal of cardiac failure
Gandhi, Mancera, The structure of glycosaminoglycans and their interactions with proteins, Chem Biol Drug Des
García, Volt, Venegas, Doerrier, Escames et al., Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice, The FASEB Journal
Gheban, Rosca, Crisan, The morphological and functional characteristics of the pineal gland, Medicine and pharmacy reports
Giordano, Murano, Mondini, Perugini, Smorlesi et al., Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis, Journal of lipid research
Girish, Paul, Thushara, Hemshekhar, Sundaram et al., Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage, Biochem Biophys Res Commun
Gunata, Parlakpinar, Acet, Melatonin: A review of its potential functions and effects on neurological diseases, Revue neurologique
Guo, Fan, Chen, Wu, Zhang et al., Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19), JAMA Cardiol
Gurunathan, Qasim, Kang, Kim, Role and therapeutic potential of melatonin in various type of cancers, OncoTargets and therapy
Guzik, Mohiddin, Dimarco, Patel, Savvatis et al., COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options, Cardiovasc Res
Hansson, Inflammation, Atherosclerosis, and Coronary Artery Disease, New England Journal of Medicine
Harbrecht, Frye, Zenati, Branch, Peitzman, Cytochrome P-450 activity is differentially altered in severely injured patients, Critical care medicine
Hasan, Atrakji, Mehuaiden, The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients, International Journal of Infectious Diseases
Hernández-Reséndiz, Vega, Contreras, Crespo-Avilan, Rodriguez-Montesinos et al., Responses of endothelial cells towards ischemic conditioning following acute myocardial infarction, Conditioning medicine
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, cell
Hosseinzadeh, Javad-Moosavi, Reiter, Hemati, Ghaznavi et al., Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin, Life Sci
Jiang, Zhang, -N, Meng, -F et al., SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70, Cellular & Molecular Immunology
Jin, Wang, Zhou, Liu, Zhang et al., Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells, Journal of Pineal Research
Jose, Manuel, COVID-19 cytokine storm: the interplay between inflammation and coagulation, Lancet Respir Med
Juybari, Hosseinzadeh, Ghaznavi, Kamali, Sedaghat et al., Melatonin as a modulator of degenerative and regenerative signaling pathways in injured retinal ganglion cells, Current pharmaceutical design
Juybari, Pourhanifeh, Hosseinzadeh, Hemati, Mehrzadi, Melatonin potentials against viral infections including COVID-19: Current evidence and new findings, Virus Res
Katkar, Sundaram, Hemshekhar, Sharma, Santhosh et al., Melatonin alleviates E chis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress, Journal of pineal research
Khakpour, Wilhelmsen, Hellman, Vascular endothelial cell Toll-like receptor pathways in sepsis, Innate immunity
Kleszczyński, Slominski, Steinbrink, Reiter, Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed, Nutrients
Kornblihtt, Finocchiaro, Molinas, Inhibitory effect of melatonin on platelet activation induced by collagen and arachidonic acid, Journal of pineal research
Kostovski, Dahm, Iversen, Hjeltnes, Østerud et al., Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium, Blood
Kumari, Dash, Melatonin elevates intracellular free calcium in human platelets by inositol 1, 4, 5-trisphosphate independent mechanism, FEBS letters
Lansink, Görlinger, Hartmann, De Groot, Effenberger-Neidnicht, Melatonin does not affect disseminated intravascular coagulation but diminishes decreases in platelet count during subacute endotoxaemia in rats, Thrombosis research
Legrand, Bell, Forni, Joannidis, Koyner et al., Pathophysiology of COVID-19-associated acute kidney injury, Nat Rev Nephrol
Lei, Zhang, Schiavon, He, Chen et al., SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2, Circulation research
Lenoir, Daali, Rollason, Curtin, Gloor et al., Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva Cocktail, Clinical Pharmacology & Therapeutics
Lenoir, Terrier, Gloor, Curtin, Rollason et al., Impact of SARS-CoV-2
Letelier, Jara-Sandoval, Molina-Berríos, Faúndez, Aracena-Parks et al., Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism, Chemico-Biological Interactions
Letelier, Molina-Berríos, Cortés-Troncoso, Sandoval, Müller et al., Comparative effects of superoxide anion and hydrogen peroxide on microsomal and cytosolic glutathione S-transferase activities of rat liver, Biological
Libby, Lüscher, COVID-19 is, in the end, an endothelial disease, European heart journal
Lissoni, Mandala, Rossini, Fumagalli, Barni, Thrombopoietic property of the pineal hormone melatonin, Hematology
Liu, Gan, Xu, Luo, Ren et al., Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue, Journal of Pineal Research
Loh, The potential of melatonin in the prevention and attenuation of oxidative hemolysis and myocardial injury from cd147 SARS-CoV-2 spike protein receptor binding, Melatonin Research
Long, Brady, Koyfman, Gottlieb, Cardiovascular complications in COVID-19, Am J Emerg Med
Lotufo, Yamashita, Farsky, Markus, Melatonin effect on endothelial cells reduces vascular permeability increase induced by leukotriene B4, European journal of pharmacology
Lv, Xu, Cheng, Ke, Zhang et al., A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries, Experimental Cell Research
Läubli, Varki, Sialic acid-binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses, Cellular and Molecular Life Sciences
Mauriz, Collado, Veneroso, Reiter, González-Gallego, A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives, Journal of pineal research
Mayo, Sainz, Tan, Antolín, Rodríguez et al., Melatonin and Parkinson's disease, Endocrine
Mccracken, Saginc, He, Huseynov, Daniels et al., Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells, Circulation
Mehrzadi, Hemati, Reiter, Hosseinzadeh, Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment, Expert Opinion on Therapeutic Targets
Mohamed, Sherif, Effects of melatonin administration on blood coagulability and lipid profile in experimentally diabetic albino rats
Mulivor, Lipowsky, Role of glycocalyx in leukocyte-endothelial cell adhesion, Am J Physiol Heart Circ Physiol
Naskar, Prabhakar, Singh, Dutta, Mohanakumar, Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinsonism in mice, Journal of pineal research
Nyagolov, Stancheva, Decheva, Pashalieva, Negrev, Melatonin and luzindole effects on the activity of plasma clotting factors V, XI, XII and XIII in rat, Comptes rendus de l'Аcademie bulgare des sciences
Obayashi, Saeki, Kurumatani, Higher melatonin secretion is associated with lower leukocyte and platelet counts in the general elderly population: the HEIJO-KYO cohort, Journal of Pineal Research
Panmanee, Nopparat, Chavanich, Shukla, Mukda et al., Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells, Journal of Pineal Research
Parlakpinar, Polat, Acet, Pharmacological agents under investigation in the treatment of coronavirus disease 2019 and the importance of melatonin, Fundamental & Clinical Pharmacology
Pashalieva, Decheva, Stancheva, Nyagolov, Negrev, Melatonin and luzindole-induced effects on integral blood coagulation parameters in rats, Comptes rendus de L'Academie bulgare des Sciences
Pashalieva, Stancheva, Decheva, Nyagolov, Negrev, Experimental data about melatonin effects on platelet count and functional activity, Comptes rendus de l'Аcademie bulgare des sciences (Reports of the Bulgarian Academy of Sciences)
Pennathur, Heinecke, Oxidative stress and endothelial dysfunction in vascular disease, Current diabetes reports
Pinotti, Bertolucci, Portaluppi, Colognesi, Frigato et al., Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity, Arterioscler Thromb Vasc Biol
Popławski, Derlacz, How does melatonin function? Postepy biochemii
Pourhanifeh, Mehrzadi, Kamali, Hosseinzadeh, Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways, European journal of pharmacology
Puntarulo, Cederbaum, Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes, Free Radical Biology and Medicine
Rahim, Djerdjouri, Sayed, Fernández-Ortiz, Fernández-Gil et al., Melatonin administration to wild-type mice and nontreated NLRP 3 mutant mice share similar inhibition of the inflammatory response during sepsis, Journal of pineal research
Reiter, Ma, Sharma, Treatment of Ebola and other infectious diseases: melatonin "goes viral, Melatonin Research
Reiter, Mayo, Tan, Sainz, Jimenez et al., Melatonin as an antioxidant: under promises but over delivers, Journal of pineal research
Reiter, Rosales-Corral, Tan, Acuna-Castroviejo, Qin et al., Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis, International journal of molecular sciences
Reiter, Sharma, Rosales-Corral, De Campos Zuccari, De et al., Melatonin: A mitochondrial resident with a diverse skill set, Life Sciences
Reiter, Sharma, Tan, Neel, Simko et al., Melatonin use for SARS-CoV-2 infection: Time to diversify the treatment portfolio, Journal of Medical Virology
Reiter, Tan, Paredes, Fuentes-Broto, Beneficial effects of melatonin in cardiovascular disease, Annals of medicine
Reitsma, Slaaf, Vink, Van Zandvoort, Egbrink, The endothelial glycocalyx: composition, functions, and visualization, Pflugers Arch
Renton, Regulation of drug metabolism and disposition during inflammation and infection. Expert opinion on drug metabolism & toxicology
Rincón, Correia, Arcaya, Finol, Fernández et al., Role of Angiotensin II type 1 receptor on renal NAD (P) H oxidase, oxidative stress and inflammation in nitric oxide inhibition inducedhypertension, Life sciences
Sahebnasagh, Nabavi, Kashani, Abdollahian, Habtemariam et al., Anti-VEGF agents: As appealing targets in the setting of COVID-19 treatment in critically ill patients, International Immunopharmacology
Sarkar, Chattopadhyay, Bandyopadhyay, Multiple strategies of melatonin protecting against cardiovascular injury related to inflammation: A comprehensive overview, Melatonin Research
Scheer, Shea, Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle, Blood
Schoergenhofer, Hobl, Schellongowski, Heinz, Speidl et al., Clopidogrel in critically ill patients, Clinical Pharmacology & Therapeutics
Sharma, Katkar, Sundaram, Paul, Naveenkumar et al., Oxidative stress-induced methemoglobinemia is the silent killer during snakebite: a novel and strategic neutralization by melatonin, Journal of Pineal Research
Shohrati, Mohammadi, Najafi, Sharifzadeh, Sharifnia et al., Evaluation of the Effects of Melatonin Supplementation on Coagulation in Patients with Haemorrhagic Stroke; A Randomized, Double-Blind, Controlled Trial, Frontiers in Emergency Medicine
Sidelmann, Gram, Jespersen, Kluft, Editors, Fibrin clot formation and lysis: basic mechanisms
Song, Kang, Lee, Park, Lee et al., The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury, Oxidative
Tan, Korkmaz, Reiter, Manchester, Ebola virus disease: potential use of melatonin as a treatment, J Pineal Res
Tan, Korkmaz, Reiter, Manchester, Ebola virus disease: potential use of melatonin as a treatment, Journal of pineal research
Testa, Paoletti, Pierfranceschi, Pan, Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients. Internal and emergency medicine
Testa, Prandoni, Paoletti, Morandini, Tala et al., Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience, Journal of Thrombosis and Haemostasis
Thakur, Ratho, Kumar, Bhatia, Bora et al., Multi-organ involvement in COVID-19: beyond pulmonary manifestations, J Clin Med
Todisco, Rossi, Melatonin for refractory idiopathic thrombocytopenic purpura: a report of 3 cases, American journal of therapeutics
Torres Filho, Torres, Salgado, Dubick, Novel adjunct drugs reverse endothelial glycocalyx damage after hemorrhagic shock in rats. Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches
Trendowski, Charif, Dinh, Travis, Dolan, Genetic and modifiable risk factors contributing to cisplatin-induced toxicities, Clinical Cancer Research
Tunac, Kohn, Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage, Google Patents
Tunali, Sener, Yarat, Emekli, Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury, Life sciences
Tyagi, Agrawal, Nath, Shukla, Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain, European journal of pharmacology
Undar, Ertugrul, Altunbas, Akca, Circadian variations in natural coagulation inhibitors protein C, protein S and antithrombin in healthy men: a possible association with interleukin-6, Thromb Haemost
Vacas, Zar Mdlm, Martinuzzo, Cardinali, Binding sites for [3H]-melatonin in human platelets, Journal of pineal research
Valente, Yoshida, Murthy, Sakamuri, Katsuyama et al., Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18, American Journal of Physiology-Heart and Circulatory Physiology
Valente, Yoshida, Murthy, Sakamuri, Katsuyama et al., Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18, American Journal of Physiology-Heart and Circulatory Physiology
Varga, Flammer, Steiger, Haberecker, Andermatt et al., Endothelial cell infection and endotheliitis in COVID-19, The Lancet
Varjú, Kolev, Networks that stop the flow: A fresh look at fibrin and neutrophil extracellular traps, Thrombosis research
Venegas, García, Escames, Ortiz, López et al., Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations, Journal of pineal research
Violi, Oliva, Cangemi, Ceccarelli, Pignatelli et al., Nox2 activation in Covid-19, Redox Biology
Vj, Illescas-Montes, Puerta-Puerta, Ruiz, Melguizo-Rodríguez, SARS-CoV-2 infection: The role of cytokines in COVID-19 disease, Cytokine & Growth Factor Reviews
Wang, Ni, Wang, Lu, Ren et al., The protective effect of melatonin on smokeinduced vascular injury in rats and humans: a randomized controlled trial, Journal of pineal research
Wang, Saguner, An, Ning, Yan et al., Dysfunctional coagulation in COVID-19: from cell to bedside, Advances in therapy
Wang, Wang, Wang, Lau, Zhang et al., COVID-19 in early 2021: current status and looking forward, Signal Transduct Target Ther
Wei, Sowers, Nistala, Gong, Uptergrove et al., Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells, Journal of Biological Chemistry
Wen, Finite size panoramic optical system integrated design, Optik
White, Wang, Fu, Cardenas, Martin et al., Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury, Free Radical Biology and Medicine
Wirtz, Bartschi, Spillmann, Ehlert, Kanel, Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized placebo-controlled study, J Pineal Res
Wirtz, Spillmann, Bärtschi, Ehlert, Känel, Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men, Journal of pineal research
Wu, Mai, Sheu, Chen, Liu et al., Melatonin inhibits microglial activation, reduces pro-inflammatory cytokine levels, and rescues hippocampal neurons of adult rats with acute Klebsiella pneumoniae meningitis, Journal of pineal research
Wu, Wang, Zhang, Xu, Chen et al., Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress, Redox biology
Xu, Fei, Huang, Li, Xie et al., Dynamic changes in coagulation parameters and correlation with disease severity and mortality in patients with COVID-19, Aging
Xu, Wang, Ning, Zhao, Chen, Maternally administered melatonin differentially regulates lipopolysaccharide-induced proinflammatory and anti-inflammatory cytokines in maternal serum, amniotic fluid, fetal liver, and fetal brain, Journal of pineal research
Yang, Chen, Liu, Zhao, Vaziri et al., Natural products against reninangiotensin system for antifibrosis therapy, European journal of medicinal chemistry
Yang, Zhou, Ye, Cheung, Chan et al., The Effect and Underlying Mechanism of Melatonin on Platelet Formation and Survival in a Thrombocytopenic Model, American Society of Hematology
Yu, Kubota, Okita, Maeda, The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells, PLoS One
Zablocki, Sadoshima, Angiotensin II and oxidative stress in the failing heart. Antioxidants & redox signaling
Zangar, Davydov, Verma, Mechanisms that regulate production of reactive oxygen species by cytochrome P450, Toxicology and applied pharmacology
Zarezadeh, Khorshidi, Emami, Janmohammadi, Kord-Varkaneh et al., Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials, European Journal of Nutrition
Zhang, Li, Grailer, Wang, Wang et al., Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome, Journal of pineal research
Zhang, Wang, Ni, Di, Ma et al., COVID-19: Melatonin as a potential adjuvant treatment, Life sciences
Zhang, Xiang, Huo, Zhou, Jiang et al., Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy, Signal Transduct Target Ther
Zhou, Li, Zhu, Hu, Hu et al., Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARgamma/FUNDC1/mitophagy pathways, J Pineal Res
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, The lancet
Zisapel, New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation, British journal of pharmacology
Zou, Chen, Zou, Han, Hao et al., Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection, Front Med
Özdemir, Ergün, Bakariş, Kılınç, Durdu et al., Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats, Eye
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop