Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All melatonin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchMelatoninMelatonin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Melatonin interferes with COVID-19 at several distinct ROS-related steps

Camp et al., Journal of Inorganic Biochemistry, doi:10.1016/j.jinorgbio.2021.111546
Jul 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Review discussing how melatonin may improve COVID-19 prognosis by acting to reduce oxygen deficiency and hypoxia, vitamin B12 deficiency, NO deficiency, oxidative stress, and sleep disturbance.
Reviews covering melatonin for COVID-19 include Alomari, Behl, Camp, Castle, Charaa, Cross, DiNicolantonio, Hosseinzadeh, Langen, Lempesis, Loh, Ramos, Reiter, Reiter (B), Shneider, Tan, Zhang.
Camp et al., 17 Jul 2021, peer-reviewed, 5 authors.
This PaperMelatoninAll
Melatonin interferes with COVID-19 at several distinct ROS-related steps
Olivia G Camp, David Bai, Damla C Gonullu, Neha Nayak, Husam M Abu-Soud
Journal of Inorganic Biochemistry, doi:10.1016/j.jinorgbio.2021.111546
Recent studies have shown a correlation between COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the distinct, exaggerated immune response titled "cytokine storm". This immune response leads to excessive production and accumulation of reactive oxygen species (ROS) that cause clinical signs characteristic of COVID-19 such as decreased oxygen saturation, alteration of hemoglobin properties, decreased nitric oxide (NO) bioavailability, vasoconstriction, elevated cytokines, cardiac and/or renal injury, enhanced D-dimer, leukocytosis, and an increased neutrophil to lymphocyte ratio. Particularly, neutrophil myeloperoxidase (MPO) is thought to be especially abundant and, as a result, contributes substantially to oxidative stress and the pathophysiology of COVID-19. Conversely, melatonin, a potent MPO inhibitor, has been noted for its anti-inflammatory, anti-oxidative, anti-apoptotic, and neuroprotective actions. Melatonin has been proposed as a safe therapeutic agent for COVID-19 recently, having been given with a US Food and Drug Administration emergency authorized cocktail, REGEN-COV2, for management of COVID-19 progression. This review distinctly highlights both how the destructive interactions of HOCl with tetrapyrrole rings may contribute to oxygen deficiency and hypoxia, vitamin B12 deficiency, NO deficiency, increased oxidative stress, and sleep disturbance, as well as how melatonin acts to prevent these events, thereby improving COVID-19 prognosis.
References
Abu-Soud, Hazen, None, Biochemistry
Abu-Soud, Hazen, None, J. Biol. Chem
Abu-Soud, Maitra, Byun, Souza, Banerjee et al., None, Free Radic. Biol. Med
Abu-Soud, Maitra, Shaeib, Khan, Byun et al., None, J. Inorg. Biochem
Ali, Khan, Chatzicharalampous, Bai, Abu-Soud, None, J. Inorg. Biochem
Andersen, Gogenur, Rosenberg, Reiter, None, Clin. Drug Investig
Anderson, Reiter, None, Rev. Med. Virol
Arroyo, Garcia-Martinez, Salvatella, None, J. Hepatol
Banerjee, Maitra, Diamond, Abu-Soud, None, J. Pineal Res
Banerjee, Ragsdale, None, Annu. Rev. Biochem
Beckman, Chen, Ischiropoulos, Crow, None, Methods Enzymol
Bjornsdottir, Welin, Michaelsson, Osla, Berg et al., None, Free Radic. Biol. Med
Bonini, Siraki, Atanassov, Mason, None, Free Radic. Biol. Med
Bonnefont-Rousselot, Collin, None, Toxicology
Burner, Furtmuller, Kettle, Koppenol, Obinger, None, J. Biol. Chem
Cardinali, Brown, Pandi-Perumal, None, Diseases
Carrillo-Vico, Guerrero, Lardone, Reiter, None, Endocrine
Collin, None, Int. J. Mol. Sci
Davies, Hawkins, Pattison, Rees, None, Antioxid. Redox Signal
De Pinho, Da Silva, De Castro Cortes, Da Silva Vasconcelos, Sousa et al., None, Exp. Parasitol
Dondorp, Hayat, Aryal, Beane, Schultz, None, Am. J. Trop. Med. Hyg
Fang, Jiang, Su, Shu, Liu et al., None, Free Radic. Biol. Med
Floris, Wever, None, Eur. J. Biochem
Forstermann, Sessa, None, Eur. Heart J
Franchina, Dostert, Brenner, None, Trends Immunol
Furtmuller, Burner, Jantschko, Regelsberger, Obinger, None, Redox Rep
Galano, Tan, Reiter, None, J. Pineal Res
Galijasevic, Abdulhamid, Abu-Soud, None, Biochemistry
Galijasevic, Abdulhamid, Abu-Soud, None, Free Radic. Biol. Med
Gebicka, Banasiak, None, Toxicol. in Vitro
Gomez, Raba, Cerutti, Silva, None, J. Pineal Res
Goud, Bai, Abu-Soud, None, Int. J. Biol. Sci
Grisham, Jefferson, Thomas, None, J. Biol. Chem
Gulcin, Buyukokuroglu, Kufrevioglu, None, J. Pineal Res
Hallingback, Gabdoulline, Wade, None, Biochemistry
Halliwell, None, Br. J. Exp. Pathol
Hardeland, None, J. Pineal Res
Hawkins, Brown, Davies, None, Arch. Biochem. Biophys
Ikeda, Asai, Moriya, Sagara, Inoue et al., None, Brain Res
Jacob, None, Clin. Immunol
Jeelani, Maitra, Chatzicharalampous, Najeemuddin, Morris et al., None, J. Pineal Res
Johnson, Fatemi, Winlow, None, Front. Cardiovasc. Med
Jomova, Valko, None, Toxicology
Jovic, Ali, Ibrahim, Jessop, Tarassoli et al., None, Nutrients
Kettle, Albrett, Chapman, Dickerhof, Forbes et al., None, Biochim. Biophys. Acta
Khomich, Kochetkov, Bartosch, Ivanov, None, Viruses
Klinger, Abman, Gladwin, None, Am. J. Respir. Crit. Care Med
Kohgo, Ikuta, Ohtake, Torimoto, Kato, None, Int. J. Hematol
Koyuncu, Budayeva, Miteva, Ricci, Silhavy et al., None, mBio
Li, Raman, Glaser, Blasko, Young et al., None, J. Biol. Chem
Liu, Zhou, Yang, None, Cell. Mol. Immunol
Lu, Galijasevic, Abdulhamid, Abu-Soud, None, Br. J. Pharmacol
Maitra, Abdulhamid, Diamond, Saed, Abu-Soud, None, J. Pineal Res
Maitra, Ali, Abdulridha, Shaeib, Khan et al., None, PLoS One
Maitra, Byun, Andreana, Abdulhamid, Diamond et al., None, Free Radic. Biol. Med
Maitra, Byun, Andreana, Abdulhamid, Saed et al., None, Free Radic. Biol. Med
Maitra, Shaeib, Abdulhamid, Abdulridha, Saed et al., None, Free Radic. Biol. Med
Miller, Pandi-Perumal, Esquifino, Cardinali, Maestroni, None, Int. J. Exp. Pathol
Minigh, XPharm: The Comprehensive Pharmacology Reference
Molteni, Principi, Esposito, None, Free Radic. Res
Nybo, Davies, Rogowska-Wrzesinska, None, Redox Biol
O'leary, Samman, None, Nutrients
Ogino, Than, Hosako, Ozaki, Omori et al., None, Adv. Exp. Med. Biol
Ong, Halliwell, None, Ann. N. Y. Acad. Sci
Parker, Winterbourn, None, Front. Immunol
Pattison, Davies, None, Chem. Res. Toxicol
Pedrosa, Weinlich, Mognol, Robbs, Viola et al., None, J. Immunol
Pennathur, Maitra, Byun, Sliskovic, Abdulhamid et al., None, Free Radic. Biol. Med
Pieretti, Rubilar, Weller, Tortella, Seabra, None, Virus Res
Podrez, Abu-Soud, Hazen, None, Free Radic. Biol. Med
Pullar, Vissers, Winterbourn, None, IUBMB Life
Qin, Li, Zhu, Gao, Fan et al., None, Aging
Ramlall, Zucker, Tatonetti, None, medRxiv
Reiter, Abreu-Gonzalez, Marik, Dominguez-Rodriguez, None, Front. Med
Reiter, Korkmaz, Ma, Rosales-Corral, Tan, None, Mutat. Res. Rev. Mutat. Res
Reiter, Mayo, Tan, Sainz, Alatorre-Jimenez et al., None, J. Pineal Res
Rudra, Pal, Maiti, Reiter, Swarnakar, None, J. Pineal Res
Schonrich, Raftery, Samstag, None, Adv. Biol. Regul
Sethuram, Bai, Abu-Soud, Potential role of zinc in the COVID-19 disease process and its probable impact on reproduction, Reprod. Sci, doi:10.1007/s43032-020-00400-6
Seyoum, Enawgaw, Melku, None, Thromb. J
Shaeib, Banerjee, Maitra, Diamond, Abu-Soud, None, Free Radic. Biol. Med
Shaeib, Khan, Ali, Najafi, Maitra et al., None, PLoS One
Shahbaz, Xu, Osman, Sligl, Shields et al., None, Stem Cell Reports
Shakoor, Feehan, Mikkelsen, Al Dhaheri, Ali et al., None, Maturitas
Shang, Xu, Wu, Jiang, Wu et al., None, Chin. Med. J
Siwik, Colucci, None, Heart Fail. Rev
Sliskovic, Abdulhamid, Sharma, Abu-Soud, None, Free Radic. Biol. Med
Solun, Shoenfeld, None, Med. Drug Discov
Souza, Maitra, Saed, Diamond, Moura et al., None, PLoS One
Stocker, Keaney, None, Physiol. Rev
Stover, None, Curr. Opin. Clin. Nutr. Metab. Care
Summers, Morgan, Davies, Hawkins, None, Chem. Res. Toxicol
Sun, Lee, Kao, Chiang, Sung et al., None, J. Pineal Res
Tan, Ho, Kalimuddin, Cherng, Teh et al., None, Nutrition
Tay, Poh, Renia, Macary, Ng, None, Nat. Rev. Immunol
Trinder, Fox, Vautier, Olynyk, None, Gut
Ueland, Holter, Holten, Muller, Lind et al., None, J. Inf. Secur
Ulfig, Bader, Varatnitskaya, Lupilov, Winklhofer et al., None, Redox Biol
Ulfig, Leichert, None, Cell. Mol. Life Sci
Vissers, Stern, Kuypers, Van Den Berg, Winterbourn, None, Free Radic. Biol. Med
Wade, Ford, Crawford, Mcconnachie, Nir et al., None, BMC Med
Williamson, Walker, Bhaskaran, Bacon, Bates et al., None, Nature
Ximenes, Silva, Rodrigues, Catalani, Maghzal et al., None, J. Biol. Chem
Zavodnik, Lapshina, Zavodnik, Soszynski, Bartosz et al., None, Bioelectrochemistry
Zhang, He, Chen, Su, Yan et al., None, Aging
Zhang, Tecson, Mccullough, None, Rev. Cardiovasc. Med
Zhang, Wang, Ni, Di, Ma et al., None, Life Sci
Zhou, Hou, Shen, Mehra, Kallianpur et al., None, PLoS Biol
Zou, Shi, Cohen, None, J. Clin. Invest
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit