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All Studies   Meta Analysis    Recent:   

Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19

Reiter et al., Frontiers in Medicine, doi:10.3389/fmed.2020.00226
May 2020  
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Melatonin for COVID-19
11th treatment shown to reduce risk in December 2020
 
*, now with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Review of melatonin's action as an antiinflammatory, antioxidant, and antiviral (against other viruses) agent, and proposed therapeutic algorithm for use with COVID-19.
Reviews covering melatonin for COVID-19 include1-20.
Reiter et al., 15 May 2020, peer-reviewed, 4 authors.
This PaperMelatoninAll
Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19
Russel J Reiter, Pedro Abreu-Gonzalez, Paul E Marik, Alberto Dominguez-Rodriguez
Frontiers in Medicine, doi:10.3389/fmed.2020.00226
The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of thousands of individuals worldwide. This highly infectious condition continues to ravage the world population and has yet to reach it peak infective rate in some countries. Many conventional drugs including hydroxychloroquine/chloroquine, lopinavir, remdesivir, etc., have been repurposed as treatments for this often deadly disease, but there is no specifically-designed effective drug available; also, the drugs mentioned have significant side effects and their efficacy is unknown. New drugs and vaccines are being designed as COVID-19 treatment, but their development and testing will require months to years. Time is not a luxury that this crisis has. Thus, there is a serious unmet need for the identification of currently-available and safe molecules which can be used to slow or treat COVID-19 disease. Here, we suggest melatonin be given consideration for prophylactic use or treatment alone or in combination with other drugs. Melatonin's multiple actions as an anti-inflammatory, anti-oxidant, and anti-viral (against other viruses) make it a reasonable choice for use. Melatonin is readily available, can be easily synthesized in large quantities, is inexpensive, has a very high safety profile and can be easily self-administered. Melatonin is endogenously-produced molecule in small amounts with its production diminishing with increased age. Under the current critical conditions, large doses of melatonin alone or in combination with currently-recommended drugs, e.g., hydroxychloroquine/chloroquine, to resist COVID-19 infection would seem judicious.
AUTHOR CONTRIBUTIONS RR: conceptualization, writing-review, and editing. PA-G and PM: writing-review and editing. AD-R: resources, writing original draft, review, and editing. All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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