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All Studies   Meta Analysis    Recent:   

Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections

DiNicolantonio et al., Open Heart, doi:10.1136/openhrt-2020-001568
Mar 2021  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Review of melatonin for COVID-19 and the result of Ramlall et al., suggesting that vitamin D, zinc, and melatonin supplementation may have general utility for the prevention and treatment of RNA virus infections, such as COVID-19 and influenza.
Reviews covering melatonin for COVID-19 include Alomari, Behl, Camp, Castle, Charaa, Cross, DiNicolantonio, Hosseinzadeh, Langen, Lempesis, Loh, Ramos, Reiter, Reiter (B), Shneider, Tan, Zhang.
DiNicolantonio et al., 19 Mar 2021, peer-reviewed, 3 authors.
This PaperMelatoninAll
Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections
Dr James J Dinicolantonio, Mark Mccarty, Jorge Barroso-Aranda
Open Heart, doi:10.1136/openhrt-2020-001568
A recent retrospective study has provided evidence that COVID-19 infection may be notably less common in those using supplemental melatonin. It is suggested that this phenomenon may reflect the fact that, via induction of silent information regulator 1 (Sirt1), melatonin can upregulate K63 polyubiquitination of the mitochondrial antiviral-signalling protein, thereby boosting virally mediated induction of type 1 interferons. Moreover, Sirt1 may enhance the antiviral efficacy of type 1 interferons by preventing hyperacetylation of high mobility group box 1 (HMGB1), enabling its retention in the nucleus, where it promotes transcription of interferon-inducible genes. This nuclear retention of HMGB1 may also be a mediator of the anti-inflammatory effect of melatonin therapy in COVID-19-complementing melatonin's suppression of nuclear factor kappa B activity and upregulation of nuclear factor erythroid 2-related factor 2. If these speculations are correct, a nutraceutical regimen including vitamin D, zinc and melatonin supplementation may have general utility for the prevention and treatment of RNA virus infections, such as COVID-19 and influenza.
References
Abba, Hassim, Hamzah, Antiviral activity of resveratrol against human and animal viruses, Adv Virol, doi:10.1155/2015/184241
Andersson, Ottestad, Tracey, Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?, Mol Med, doi:10.1186/s10020-020-00172-4
Arentz, Hunter, Yang, Zinc for the prevention and treatment of SARS-CoV-2 and other acute viral respiratory infections: a rapid review, Adv Integr Med, doi:10.1016/j.aimed.2020.07.009
Aucoin, Cooley, Saunders, The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: a rapid review, Adv Integr Med, doi:10.1016/j.aimed.2020.07.007
Beard, Bearden, Striker, Vitamin D and the anti-viral state, J Clin Virol, doi:10.1016/j.jcv.2010.12.006
Bonaldi, Talamo, Scaffidi, Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion, Embo J, doi:10.1093/emboj/cdg516
Brice, Diamond, Antiviral activities of human host defense peptides, Curr Med Chem, doi:10.2174/0929867326666190805151654
Castillo, Quizon, Juco, Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 pro): a case series, Melatonin Res, doi:10.32794/mr11250063
Chen, Zhou, Mueller-Steiner, SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling, J Biol Chem, doi:10.1074/jbc.M509329200
Chimento, Amicis, Sirianni, Progress to improve oral bioavailability and beneficial effects of resveratrol, Int J Mol Sci, doi:10.3390/ijms20061381
Costford, Bajpeyi, Pasarica, Skeletal muscle NAMPT is induced by exercise in humans, Am J Physiol Endocrinol Metab, doi:10.1152/ajpendo.00318.2009
De, Brasiel, The key role of zinc in elderly immunity: a possible approach in the COVID-19 crisis, Clin Nutr ESPEN, doi:10.1016/j.clnesp.2020.06.003
Dinicolantonio, Barroso-Aranda, Mccarty, Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion, Immunol Lett, doi:10.1016/j.imlet.2020.09.008
Dinicolantonio, Mccarty, Targeting casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health, Med Hypotheses, doi:10.1016/j.mehy.2020.109800
Dinicolantonio, None, Open Heart
Early, Menon, Wyse, Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2, Proc Natl Acad Sci U S A, doi:10.1073/pnas.1800431115
Ehlers, Xie, Agapov, BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes, Mucosal Immunol, doi:10.1038/mi.2017.24
Fulco, Cen, Zhao, Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of NAMPT, Dev Cell, doi:10.1016/j.devcel.2008.02.004
García, Volt, Venegas, Disruption of the NF-ΰB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice, Faseb J, doi:10.1096/fj.15-273656
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients2020, doi:10.3390/nu12040988
Hardeland, Melatonin and inflammation-Story of a double-edged blade, J Pineal Res, doi:10.1111/jpi.12525
Hong-Ji, Chen-Hui, Li-Tian, Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-κB/p65, J Neurochem, doi:10.1111/jnc.15258
Huang, Li, Zhang, RIG-1 and MDA-5 signaling pathways contribute to IFN-β production and viral replication in porcine circovirus virus type 2-infected PK-15 cells in vitro, Vet Microbiol, doi:10.1016/j.vetmic.2017.09.022
Jolliffe, Camargo, Sluyter, Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials, medRxiv, doi:10.1101/2020.07.14.20152728
Jung, Kwak, The Nrf2 system as a potential target for the development of indirect antioxidants, Molecules, doi:10.3390/molecules15107266
Liu, Zhang, Chu, The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination, Nat Immunol, doi:10.1038/ni.3641
Mariani, Giménez, Bergam, Association between vitamin D deficiency and COVID-19 incidence, complications, and mortality in 46 countries: an ecological study, Health Secur, doi:10.1089/hs.2020.0137
Mclachlan, The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms, Clin Hypertens, doi:10.1186/s40885-020-00147-x
Mercola, Grant, Wagner, Evidence regarding vitamin D and risk of COVID-19 and its severity, Nutrients, doi:10.3390/nu12113361
Milne, Lambert, Schenk, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, doi:10.1038/nature06261
Mossink, Zinc as nutritional intervention and prevention measure for COVID-19 disease, BMJ Nutr Prev Health, doi:10.1136/bmjnph-2020-000095
Nogueira-Machado, De, Volpe, HMGB-1 as a target for inflammation controlling, Recent Pat Endocr Metab Immune Drug Discov, doi:10.2174/187221412802481784
Ong, Lee, Leong, Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells, PLoS One, doi:10.1371/journal.pone.0041932
Patel, Zhong, Grant, Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure, Circ Res, doi:10.1161/CIRCRESAHA.116.307708
Peters, Smith, Stark, IRF-3-dependent, NFkappa B-and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA, Proc Natl Acad Sci U S A, doi:10.1073/pnas.092133199
Prasad, Beck, Bao, Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress, Am J Clin Nutr, doi:10.1093/ajcn/85.3.837
Pryke, Duggan, White, Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages, J Cell Physiol, doi:10.1002/jcp.1041420327
Saenwongsa, Nithichanon, Chittaganpitch, Metformininduced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes, Sci Rep, doi:10.1038/s41598-020-60213-0
Song, Qi, Cao, MAVS O-GlcNAcylation is essential for host antiviral immunity against lethal RNA viruses, Cell Rep, doi:10.1016/j.celrep.2019.07.085
Street, HMGB1: a possible crucial therapeutic target for COVID-19?, Horm Res Paediatr, doi:10.1159/000508291
Telcian, Zdrenghea, Edwards, Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro, Antiviral Res, doi:10.1016/j.antiviral.2016.11.004
Tripathi, Tecle, Verma, The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins, J Gen Virol, doi:10.1099/vir.0.045013-0
Wei, Gao, Dai, SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury, Am J Physiol Renal Physiol, doi:10.1152/ajprenal.00119.2018
Xu, Lu, Yao, Novel role of resveratrol: suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury, Shock, doi:10.1097/SHK.0000000000000225
Zainal, Chang, Cheng, Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection, Sci Rep, doi:10.1038/srep42998
Zhang, Fang, Wu, Acetylation-Dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity, Mol Cell, doi:10.1016/j.molcel.2020.06.020
Zhou, Hou, Shen, A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19, PLoS Biol, doi:10.1371/journal.pbio.3000970
Zhou, Zhang, Zhang, CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1, Hepatology, doi:10.1002/hep.26992
Zhu, Li, Zhang, TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity, Embo J, doi:10.15252/embj.2019102075
Çelebier, İbrahim Celalettin, Could targeting HMGB1 be useful for the clinical management of COVID-19 infection?, Comb Chem High Throughput Screen, doi:10.2174/1386207323999200728114927
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