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Montelukast in hospitalized patients diagnosed with COVID-19

Khan et al., Journal of Asthma, doi:10.1080/02770903.2021.1881967
Mar 2021  
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Progression 64% Improvement Relative Risk Hospitalization time 12% Montelukast for COVID-19  Khan et al.  LATE TREATMENT Is late treatment with montelukast beneficial for COVID-19? Retrospective 92 patients in the USA Lower progression (p=0.085) and shorter hospitalization (p=0.33), not sig. Khan et al., J. Asthma, March 2021 Favorsmontelukast Favorscontrol 0 0.5 1 1.5 2+
28th treatment shown to reduce risk in November 2021
*, now with p = 0.0045 from 8 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments.
Retrospective 92 hospitalized patients showing lower clinical deterioration with montelukast treatment, without statistical significance in multivariable analysis. The treatment group was older.
risk of progression, 63.5% lower, RR 0.36, p = 0.09, treatment 3 of 30 (10.0%), control 20 of 62 (32.3%), NNT 4.5, adjusted per study, odds ratio converted to relative risk, multivariable.
hospitalization time, 12.5% lower, relative time 0.88, p = 0.33, treatment median 7.0 IQR 6.5 n=30, control median 8.0 IQR 6.0 n=62.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Khan et al., 4 Mar 2021, retrospective, USA, peer-reviewed, 16 authors. Contact:
This PaperMontelukastAll
Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial
Amjad Khan, Somia Iqtadar, Sami Ullah Mumtaz, Michael Heinrich, Domingo A Pascual-Figal, Shona Livingstone, Sajid Abaidullah
Frontiers in Pharmacology, doi:10.3389/fphar.2022.898062
Background: Curcumin, quercetin, and vitamin D3 (cholecalciferol) are common natural ingredients of human nutrition and reportedly exhibit promising anti-inflammatory, immunomodulatory, broad-spectrum antiviral, and antioxidant activities. Objective: The present study aimed to investigate the possible therapeutic benefits of a single oral formulation containing supplements curcumin, quercetin, and cholecalciferol (combinedly referred to here as CQC) as an adjuvant therapy for early-stage of symptomatic coronavirus disease 2019 in a pilot open-label, randomized controlled trial conducted at
ETHICS STATEMENT The study was approved by the Institutional Review Board (IRB) of King Edward Medical University, Lahore, with approval No. 785/RC/KEMU. The patients/participants provided their written informed consent to participate in this study. AUTHOR CONTRIBUTIONS AK contributed to the study design, data interpretation, writing of the manuscript, and literature search; SI, SM, and SA contributed to the study design, data collection, data interpretation, and literature search; DP-F and MH critically reviewed and edited the manuscript; and SL helped in data analysis and revision of the manuscript. All authors approved the final manuscript. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors, and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Copyright © 2022 Khan, Iqtadar, Mumtaz, Heinrich, Pascual-Figal, Livingstone and Abaidullah. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided..
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop