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All Studies   Meta Analysis    Recent:   

Pattern of medication utilization in hospitalized patients with COVID-19 in three District Headquarters Hospitals in the Punjab province of Pakistan

Mustafa et al., Exploratory Research in Clinical and Social Pharmacy, doi:10.1016/j.rcsop.2021.100101
Dec 2021  
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Mortality 33% Improvement Relative Risk Remdesivir  Mustafa et al.  LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 444 patients in Pakistan Lower mortality with remdesivir (not stat. sig., p=0.21) c19early.org Mustafa et al., Exploratory Research i.., Dec 2021 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 444 hospitalized patients in Pakistan, showing lower mortality with remdesivir treatment in unadjusted results, not reaching statistical significance.
Gérard, Zhou, Wu, Kamo, Choi show significantly increased risk of acute kidney injury with remdesivir.
Remdesivir efficacy disappears with longer followup. Mixed-effects meta-regression of efficacy as a function of followup duration across all remdesivir studies shows decreasing efficacy with longer followup6. This may reflect antiviral efficacy being offset by serious adverse effects of treatment.
Followup duration (days) Efficacy Remdesivir mortality efficacy decreases with longer followup 0 15 30 45 60 75 90 105 -25% 0% 25% 50% c19early.org October 2024 mixed-effects meta-regression slope -0.58 [95% CI -0.92 to -0.24] p=0.00089
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers aspirin, remdesivir, and ivermectin.
risk of death, 32.7% lower, RR 0.67, p = 0.21, treatment 16 of 200 (8.0%), control 29 of 244 (11.9%), NNT 26.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mustafa et al., 29 Dec 2021, retrospective, Pakistan, peer-reviewed, 7 authors.
This PaperRemdesivirAll
Pattern of medication utilization in hospitalized patients with COVID-19 in three District Headquarters Hospitals in the Punjab province of Pakistan
Zia Ul Mustafa, Chia Siang Kow, Muhammad Salman, Mahpara Kanwal, Muhammad Bilal Riaz, Samina Parveen, Syed Shahzad Hasan
Exploratory Research in Clinical and Social Pharmacy, doi:10.1016/j.rcsop.2021.100101
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
to 2.5 times the upper limit of normal Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J o u r n a l P r e -p r o o f
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Late treatment
is less effective
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