Association of physical activity and the risk of COVID-19 hospitalization: a dose-response meta-analysis

DOI record: { "DOI": "10.1101/2022.06.22.22276789", "URL": "http://dx.doi.org/10.1101/2022.06.22.22276789", "abstract": "<jats:p>Background: Many people have experienced a high burden due to the spread of the coronavirus disease (COVID-19) and its serious consequences for health and everyday life. Prior studies have reported that physical activity (PA) may lower the risk of COVID-19 hospitalization. The present meta-analysis (PROSPERO registration number: CRD42022339672) explored the dose–response relationship between PA and the risk of COVID-19 hospitalization.\nMethods: Epidemiological observational studies on the relationship between PA and the risk of COVID-19 hospitalization were included. Categorical dose–response relationships between PA and the risk of COVID-19 hospitalization were assessed using random effect models. Robust error meta-regression models assessed the continuous relationship between PA (metabolic equivalent [MET]–h/week) and COVID-19 hospitalization risk across studies reporting quantitative PA estimates.\nResults: Seventeen observational studies (cohort\\case–control\\cross-section) met the criteria for inclusion in the meta-analysis. Categorical dose-relationship analysis showed a 40% (risk ratio (RR) 0.60, 95% confidence intervals (CI): 0.48–0.71) reduction in the risk of COVID-19 hospitalization compared to the lowest dose of PA. The results of the continuous dose–response relationship showed a non-linear inverse relationship (Pnon-linearity &lt; 0.05) between PA and the risk of COVID-19 hospitalization. When total PA was less than or greater than 10 Met-h/week, an increase of 4 Met-h/week was associated with a 14% (RR = 0.83, 95%CI: 0.85–0.87) and 11% (RR = 0.89, 95%CI: 0.87–0.90) reduction in the risk of COVID-19 hospitalization, respectively.\nConclusions: There was an inverse non-linear dose–response relationship between PA level and the risk of COVID-19 hospitalization. Doses of the guideline-recommended minimum PA levels by WTO may be required for more substantial reductions in the COVID-19 hospitalization risk.</jats:p>", "accepted": { "date-parts": [ [ 2022, 6, 23 ] ] }, "author": [ { "affiliation": [], "family": "Li", "given": "Dan", "sequence": "first" }, { "affiliation": [], "family": "Jin", "given": "Shengzhen", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-4549-9496", "affiliation": [], "authenticated-orcid": false, "family": "Lu", "given": "Songtao", "sequence": "additional" } ], "container-title": [], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 6, 24 ] ], "date-time": "2022-06-24T02:05:10Z", "timestamp": 1656036310000 }, "deposited": { "date-parts": [ [ 2022, 6, 24 ] ], "date-time": "2022-06-24T02:05:12Z", "timestamp": 1656036312000 }, "group-title": "Sports Medicine", "indexed": { "date-parts": [ [ 2022, 6, 24 ] ], "date-time": "2022-06-24T02:41:18Z", "timestamp": 1656038478024 }, "institution": [ { "name": "medRxiv" } ], "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 6, 23 ] ] }, "link": [ { "URL": "https://syndication.highwire.org/content/doi/10.1101/2022.06.22.22276789", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "246", "original-title": [], "posted": { "date-parts": [ [ 2022, 6, 23 ] ] }, "prefix": "10.1101", "published": { "date-parts": [ [ 2022, 6, 23 ] ] }, "publisher": "Cold Spring Harbor Laboratory", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "http://medrxiv.org/lookup/doi/10.1101/2022.06.22.22276789" } }, "score": 1, "short-title": [], "source": "Crossref", "subtitle": [], "subtype": "preprint", "title": "Association of physical activity and the risk of COVID-19 hospitalization: a dose-response meta-analysis", "type": "posted-content" }