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Association of physical activity and the risk of COVID-19 hospitalization: a dose-response meta-analysis

Jun 2022  
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0 0.5 1 1.5 2+ Hospitalization 40% Improvement Relative Risk Exercise for COVID-19  Li et al.  META ANALYSIS c19early.org Favors exercise Favors inactivity
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Meta analysis of 17 studies, showing a dose-response relationship with higher levels of physical activity reducing risk of COVID-19 hospitalization.
6 meta analyses show significant improvements with exercise for mortality1-5, ICU admission1, hospitalization1,2,5,6, severity2-4, and cases2.
Currently there are 66 exercise for COVID-19 studies, showing 48% lower mortality [38‑57%], 46% lower ventilation [32‑57%], 41% lower ICU admission [35‑47%], 33% lower hospitalization [25‑40%], and 23% fewer cases [14‑31%].
risk of hospitalization, 40.0% lower, RR 0.60, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Li et al., 23 Jun 2022, preprint, 3 authors. Contact: lidanscerlett@126.com, whtyjinsz@163.com, songtaozhenzhenl@sina.com.
This PaperExerciseAll
Association of physical activity and the risk of COVID-19 hospitalization: a dose–response meta-analysis
Dan Li, Shengzhen Jin, Songtao Lu
doi:10.1101/2022.06.22.22276789
Background Many people have experienced a high burden due to the spread of the coronavirus disease (COVID-19) and its serious consequences for health and everyday life. Prior studies have reported that physical activity (PA) may lower the risk of COVID-19 hospitalization. The present meta-analysis (PROSPERO registration number: CRD42022339672) explored the doseresponse relationship between PA and the risk of COVID-19 hospitalization. Methods Epidemiological observational studies on the relationship between PA and the risk of COVID-19 hospitalization were included. Categorical dose-response relationships between PA and the risk of COVID-19 hospitalization were assessed using random effect models. Robust error meta-regression models assessed the continuous relationship between PA (metabolic equivalent [MET]-h/week) and COVID-19 hospitalization risk across studies reporting quantitative PA estimates. Results Seventeen observational studies (cohort\case-control\cross-section) met the criteria for inclusion in the meta-analysis. Categorical dose-relationship analysis showed a 40% (risk ratio (RR) 0.60, 95% confidence intervals (CI): 0.48-0.71) reduction in the risk of COVID-19 hospitalization compared to the lowest dose of PA. The results of the continuous dose-response . NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. / 14 relationship showed a non-linear inverse relationship (Pnon-linearity < 0.05) between PA and the risk of COVID-19 hospitalization. When total PA was less than or greater than 10 Met-h/week, an increase of 4 Met-h/week was associated with a 14% (RR = 0.83, 95%CI: 0.85-0.87) and 11% (RR = 0.89, 95%CI: 0.87-0.90) reduction in the risk of COVID-19 hospitalization, respectively. Conclusions There was an inverse non-linear dose-response relationship between PA level and the risk of COVID-19 hospitalization. Doses of the guideline-recommended minimum PA levels by WTO may be required for more substantial reductions in the COVID-19 hospitalization risk.
Author Contributions
References
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