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Does pre-existent physical inactivity have a role in the severity of COVID-19?

Yuan et al., Therapeutic Advances in Respiratory Disease, doi:10.1177/17534666211025221
Jun 2021  
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Mortality 91% Improvement Relative Risk Severe case 70% Exercise for COVID-19  Yuan et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 164 patients in China (February - March 2020) Lower severe cases with higher activity levels (p=0.033) c19early.org Yuan et al., Therapeutic Advances in R.., Jun 2021 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Retrospective 164 COVID-19 patients in China, showing physical inactivity associated with an increased risk of severe COVID-19.
risk of death, 90.5% lower, RR 0.09, p = 0.09, high activity levels 0 of 61 (0.0%), low activity levels 6 of 103 (5.8%), NNT 17, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), excluded in exclusion analyses: excessive unadjusted differences between groups.
risk of severe case, 70.0% lower, RR 0.30, p = 0.03, high activity levels 3 of 61 (4.9%), low activity levels 26 of 103 (25.2%), NNT 4.9, adjusted per study, inverted to make RR<1 favor high activity levels, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yuan et al., 20 Jun 2021, retrospective, China, peer-reviewed, 9 authors, study period 15 February, 2020 - 14 March, 2020.
This PaperExerciseAll
Does pre-existent physical inactivity have a role in the severity of COVID-19?
Qilin Yuan, Hua-Yao Huang, Xiao-Ling Chen, Rong-Hua Chen, Yixian Zhang, Xiao-Bin Pan, Jun-Nian Chen, Nan Liu, Houwei Du
Therapeutic Advances in Respiratory Disease, doi:10.1177/17534666211025221
Background and Aims: Physical inactivity is considered an important lifestyle factor for overweight and cardiovascular disease. We aimed to investigate the association between preexistent physical inactivity and the risk of severe coronavirus disease 2019 (COVID-19). Methods: We included 164 (61.8 ± 13.6 years) patients with COVID-19 who were admitted between 15 February and 14 March 2020 in this retrospective study. We evaluated the association between pre-existent physical inactivity and severe COVID-19 using a logistic regression model. Results: Of 164 eligible patients with COVID-19, 103 (62.8%) were reported to be physically inactive. Univariable logistic regression analysis showed that physical inactivity was associated with an increased risk of severe COVID-19 [unadjusted odds ratio (OR) 6.53, 95% confidence interval (CI) 1.88-22.62]. In the multivariable regression analysis, physical inactivity remained significantly associated with an increased risk of severe COVID-19 (adjusted OR 4.12, 95% CI 1.12-15.14) after adjustment for age, sex, stroke, and overweight. Conclusion: Our data showed that pre-existent physical inactivity was associated with an increased risk of experiencing severe COVID-19. Our findings indicate that people should be encouraged to keep physically active to be at a lower risk of experiencing a severe illness when COVID-19 infection seems unpredicted. The reviews of this paper are available via the supplemental material section.
Conflict of interest statement The authors declare that there is no conflict of interest. Funding The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Fujian Natural Science Foundation (2018J01309) and the Fujian Provincial Natural and Science Innovation Project (No. 2016B014). On behalf of the Fujian Medical Team Support Wuhan for COVID-19. ORCID iD Qilin Yuan https://orcid.org/0000-0001-8941-0863 Supplemental material The reviews of this paper are available via the supplemental material section.
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