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Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study

Ekblom-Bak et al., International Journal of Behavioral Nutrition and Physical Activity, doi:10.1186/s12966-021-01198-5
Oct 2021  
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Severe case 48% Improvement Relative Risk Exercise for COVID-19  Ekblom-Bak et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective study in Sweden Lower severe cases with higher activity levels (p=0.023) c19early.org Ekblom-Bak et al., Int. J. Behavioral .., Oct 2021 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 857 severe COVID-19 cases and matched controls in Sweden, showing lower risk of severe COVID-19 with higher cardiorespiratory fitness.
risk of severe case, 47.6% lower, OR 0.52, p = 0.02, inverted to make OR<1 favor high activity levels, case control OR, model 3, high vs. very low CRF.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ekblom-Bak et al., 19 Oct 2021, retrospective, Sweden, peer-reviewed, 13 authors.
This PaperExerciseAll
Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study
Elin Ekblom-Bak, Daniel Väisänen, Björn Ekblom, Victoria Blom, Lena V Kallings, Erik Hemmingsson, Gunnar Andersson, Peter Wallin, Jane Salier Eriksson, Tobias Holmlund, Magnus Lindwall, Andreas Stenling, Amanda Lönn
International Journal of Behavioral Nutrition and Physical Activity, doi:10.1186/s12966-021-01198-5
Background: The impact of cardiorespiratory fitness (CRF) and other lifestyle-related factors on severe COVID-19 risk is understudied. The present study aims to investigate lifestyle-related and socioeconomic factors as possible predictors of COVID-19, with special focus on CRF, and to further study whether these factors may attenuate obesity-and hypertension-related risks, as well as mediate associations between socioeconomic factors and severe COVID-19 risk. Methods: Out of initially 407,131 participants who participated in nationwide occupational health service screening between 1992 and 2020, n = 857 cases (70% men, mean age 49.9 years) of severe COVID-19 were identified. CRF was estimated using a sub-maximum cycle test, and other lifestyle variables were self-reported. Analyses were performed including both unmatched, n = 278,598, and sex-and age-matched, n = 3426, controls. Severe COVID-19 included hospitalization, intensive care or death due to COVID-19. Results: Patients with more severe COVID-19 had significantly lower CRF, higher BMI, a greater presence of comorbidities and were more often daily smokers. In matched analyses, there was a graded decrease in odds for severe COVID-19 with each ml in CRF (OR = 0.98, 95% CI 0.970 to 0.998), and a two-fold increase in odds between the lowest and highest (< 32 vs. ≥ 46 ml•min −1 •kg −1 ) CRF group. Higher BMI (per unit increase, OR = 1.09, 1.06 to 1.12), larger waist circumference (per cm, OR = 1.04, 1.02 to 1.06), daily smoking (OR = 0.60, 0.41 to 0.89) and high overall stress (OR = 1.36, 1.001 to 1.84) also remained significantly associated with severe COVID-19 risk. Obesity-and blood pressure-related risks were attenuated by adjustment for CRF and lifestyle variables. Mediation through CRF, BMI and smoking accounted for 9% to 54% of the associations between low education, low income and blue collar/low skilled occupations and severe COVID-19 risk. The results were consistent using either matched or unmatched controls. Conclusions: Both lifestyle-related and socioeconomic factors were associated with risk of severe COVID-19. However, higher CRF attenuated the risk associated with obesity and high blood pressure, and mediated the risk associated with various socioeconomic factors. This emphasises the importance of interventions to maintain or increase CRF in the general population to strengthen the resilience to severe COVID-19, especially in high-risk individuals.
Table 5 Indirect effects of socioeconomic factors on severe COVID-19 in matched analyses Adjusted for sex, age, year HPA was performed, civil status, country of birth, and number of previous diseases as confounders of the exposure-mediator, exposureoutcome, and mediator-outcome relation a Smoking was coded as a binary variable (0 = never/seldom, 1 = daily smoker) ab Indirect effect, HPD CI Highest posterior density credibility interval, BMI Body mass index, CRF Cardiorespiratory fitness, Q Quartile, WCHS White-collar high-skilled, WCLS White-collar low-skilled, BCLS Blue-collar low-skilled, BCHS Blue-collar high-skilled Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s12966-021-01198-5. Additional file 1: Authors' information Not applicable. Authors' contributions EEB, AL, VB, LVK, BE, GA, PW contributed to the conception or design of the work. EEB, AL, DV, EH, JSE, ML, AS, TH contributed to the acquisition, analysis, or interpretation of data for the work. EEB, AL, VB, LVK, BE, EH drafted the manuscript. DV, GA, PW, JSE, ML, AS, TH revised it critically for important intellectual content. All authors critically revised the manuscript, gave final approval, and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The corresponding author, EEB, is the manuscripts..
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The present study aims to ' 'investigate lifestyle-related and socioeconomic factors as possible predictors of COVID-19, ' 'with special focus on CRF, and to further study whether these factors may attenuate obesity- ' 'and hypertension-related risks, as well as mediate associations between socioeconomic factors ' 'and severe COVID-19 risk.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Out of initially 407,131 participants who participated in nationwide ' 'occupational health service screening between 1992 and 2020, ' '<jats:italic>n</jats:italic>\u2009=\u2009857 cases (70% men, mean age 49.9\xa0years) of ' 'severe COVID-19 were identified. CRF was estimated using a sub-maximum cycle test, and other ' 'lifestyle variables were self-reported. Analyses were performed including both unmatched, ' '<jats:italic>n</jats:italic>\u2009=\u2009278,598, and sex-and age-matched, ' '<jats:italic>n</jats:italic>\u2009=\u20093426, controls. Severe COVID-19 included ' 'hospitalization, intensive care or death due to COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Patients with more severe COVID-19 had significantly lower CRF, ' 'higher BMI, a greater presence of comorbidities and were more often daily smokers. In matched ' 'analyses, there was a graded decrease in odds for severe COVID-19 with each ml in CRF ' '(OR\u2009=\u20090.98, 95% CI 0.970 to 0.998), and a two-fold increase in odds between the ' 'lowest and highest (&lt;\u200932 vs.\u2009≥\u200946\xa0' 'ml·min<jats:sup>−1</jats:sup>·kg<jats:sup>−1</jats:sup>) CRF group. Higher BMI (per unit ' 'increase, OR\u2009=\u20091.09, 1.06 to 1.12), larger waist circumference (per cm, OR\u2009' '=\u20091.04, 1.02 to 1.06), daily smoking (OR\u2009=\u20090.60, 0.41 to 0.89) and high ' 'overall stress (OR\u2009=\u20091.36, 1.001 to 1.84) also remained significantly associated ' 'with severe COVID-19 risk. 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' '2021;49(4):377–83.', 'journal-title': 'Scand J Public Health'}], 'container-title': ['International Journal of Behavioral Nutrition and Physical Activity'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12966-021-01198-5.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s12966-021-01198-5/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12966-021-01198-5.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 10, 19]], 'date-time': '2021-10-19T10:24:55Z', 'timestamp': 1634639095000}, 'score': 1, 'resource': {'primary': {'URL': 'https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-021-01198-5'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 10, 19]]}, 'references-count': 49, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2021, 12]]}}, 'alternative-id': ['1198'], 'URL': 'http://dx.doi.org/10.1186/s12966-021-01198-5', 'relation': {}, 'ISSN': ['1479-5868'], 'issn-type': [{'value': '1479-5868', 'type': 'electronic'}], 'subject': [ 'Nutrition and Dietetics', 'Physical Therapy, Sports Therapy and Rehabilitation', 'Medicine (miscellaneous)'], 'published': {'date-parts': [[2021, 10, 19]]}, 'assertion': [ { 'value': '1 June 2021', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '2 September 2021', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '19 October 2021', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The protocols used were approved by the institutional review boards of the ' 'institutions involved in this study and all participants provided informed ' 'consent prior to data collection. The study was approved by the Stockholm ' 'Ethics Review Board (Dnr 2020–02727), and adhered to the Declaration of ' 'Helsinki.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'Author GA (responsible for research and method) and PW (CEO and responsible for ' 'research and method) are employed by HPI Health Profile Institute. The ' 'remaining authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '135'}
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