Association between physical activity and risk of COVID-19 infection or clinical outcomes of the patients with COVID-19; A systematic review and meta-analysis
Systematic review and meta analysis showing significantly lower COVID-19 mortality and hospitalization with regular physical activity.
6 meta analyses show significant improvements with exercise for mortality
Ezzatvar, Halabchi, Liu, Rahmati, Sittichai, ICU admission
Rahmati, hospitalization
Ezzatvar, Halabchi, Li, Rahmati, severity
Ezzatvar, Liu, Sittichai, and cases
Ezzatvar.
Currently there are
61 exercise for COVID-19 studies, showing 50% lower mortality
[39‑60%], 46% lower ventilation
[32‑57%], 41% lower ICU admission
[35‑47%], 35% lower hospitalization
[27‑42%], and 23% fewer cases
[13‑32%].
risk of death, 39.0% lower, OR 0.61, p < 0.001, RR approximated with OR.
|
risk of hospitalization, 46.0% lower, OR 0.54, p < 0.001, RR approximated with OR.
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Halabchi et al., 1 Aug 2023, peer-reviewed, 5 authors, trial PROSPERO
CRD42021291451.
Abstract: J PREV MED HYG 2023; 64: E123-E136
OPEN ACCESS
COVID-19
Association between physical activity
and risk of COVID‑19 infection or clinical outcomes
of the patients with COVID‑19:
A systematic review and meta-analysis
FARZIN HALABCHI1, BEHNAZ MAHDAVIANI2, BEHNAZ TAZESH2, SAKINEH SHAB-BIDAR3,
MARYAM SELK-GHAFFARI2*
1
Department of Sports and Exercise Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran;
2
Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran;
3
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Keywords
Exercise • COVID‑19 • SARS-CoV-2 • Systematic Review • Meta-analysis
Summary
Objective. The COVID‑19 pandemic has caused serious conse‑
quences for global health and economy. The important question
is whether the level of physical activity might influence the risk of
COVID‑19 incidence or clinical outcomes, including the severity
or mortality of infected patients. The objective of this systematic
review and meta-analysis is to evaluate the association between
sufficient physical activity and incidence, hospitalization, sever‑
ity, recovery, and mortality of COVID‑19.
Methods. A systematic search of Web of Sciences, PubMed, and
Scopus between December 2019 and November 2021 was con‑
ducted. Studies were screened based on the inclusion criteria, i.e.
observational studies (case-control, prospective or retrospective
longitudinal designs, and cross-sectional studies) which have
determined the association of physical activity, exercise, sports
participation, or sedentary behavior with COVID‑19 incidence
or outcomes, including mortality, severity, recovery and hospi‑
talization in healthy population or population with any specific
comorbidity.
Results. Based on eligibility criteria, 27 articles were finally
included in the qualitative synthesis. The meta-analysis of
five studies evaluating the association of physical activity and
COVID‑19 mortality showed a weighted OR of OR of 0.61
(CI 95%: 0.50‑0.75) with heterogeneity (I2 = 45.8%, P < 0.001)
and in seven studies regarding physical activity and COVID‑19
hospitalization, weighted OR was 0.541 (CI 95%: 0.491-0.595)
with heterogeneity (I2 = 81.7%, P < 0.001).
Conclusion. Participating in sufficient physical activity might
decrease COVID‑19 related COVID‑19-related hospitalization
and mortality. Developing programs to increase physical activity
during the COVID‑19 pandemic might be an appropriate health
strategy.
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit