Baseline physical activity and the risk of severe illness and mortality from COVID-19: A dose–response meta-analysis
Liu et al.,
Baseline physical activity and the risk of severe illness and mortality from COVID-19: A dose–response..,
Preventive Medicine Reports, doi:10.1016/j.pmedr.2023.102130 (meta analysis)
Meta analysis of 14 studies showing a negative dose-response relationship between the level of physical activity and COVID-19 severity and mortality.
Currently there are
53 exercise studies and meta analysis shows:
Liu et al., 11 Feb 2023, peer-reviewed, 3 authors.
Contact:
songtaozhenzhen@sina.com.
Abstract: Preventive Medicine Reports 32 (2023) 102130
Contents lists available at ScienceDirect
Preventive Medicine Reports
journal homepage: www.elsevier.com/locate/pmedr
Review article
Baseline physical activity and the risk of severe illness and mortality from
COVID-19: A dose–response meta-analysis
Junjie Liu a, 1, Zhiguang Guo b, 1, Songtao Lu a, *
a
b
School of Sports, Wuhan University of Science and Technology, Wuhan 430081, China
School of Sports Health, HuBei University of Chinese Medicine. Wuhan 430081, China
A R T I C L E I N F O
A B S T R A C T
Keywords:
Physical activity
COVID-19
Mortality
Severe illness
Meta-analysis
Dose–response
To provide a scientific basis for improved exercise-based immunity, a meta-analysis was used to explore the
dose–response relationship between physical activity (PA) and the risk of severe illness and mortality related to
COVID-19 (coronavirus disease 2019). To this end, we searched PubMed, Web of Science databases from January
2020 through April 2022. 14 observational studies met the criteria for inclusion in the meta-analysis, including
2840 cases of severe illness and death from COVID-19. Categorical dose–relationship analysis showed that the
risks of severe illness and mortality from COVID-19 were, respectively, 46% (risk ratio (RR): 0.54; confidence
intervals (CIs): 0.41–0.68) and 59% (RR = 0.41; 95%CI: 0.23–0.58) lower for the highest dose of PA compared
with the lowest dose of PA. The results of the continuous dose–response analysis show an inverse nonlinear
relationship (Pnon-linearity < 0.05) between PA and both the risk of severe illness and mortality from COVID-19.
For PA below 10 MET-h/week (MET-h/week: metabolic equivalent of task-hours/week), an increase of 4 MET-h/
week (1 h of moderate-intensity or 0.5 h of high-intensity PA) was associated with 8% and 11% reductions in the
risk of severe illness and mortality from COVID-19. PA above 10 MET-h/week lowered the risk of severe illness
and mortality from COVID-19 by 7% and 9%, respectively, for each 4 MET-h/week increase. Doses of WHOrecommended PA levels (10 MET-h/week) may be required for more substantial reductions in the risk of se
vere illness and mortality from COVID-19.
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