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Baseline physical activity and the risk of severe illness and mortality from COVID-19: A dose–response meta-analysis

Liu et al., Preventive Medicine Reports, doi:10.1016/j.pmedr.2023.102130
Feb 2023  
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Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Meta analysis of 14 studies showing a negative dose-response relationship between the level of physical activity and COVID-19 severity and mortality.
6 meta analyses show significant improvements with exercise for mortality Ezzatvar, Halabchi, Liu, Rahmati, Sittichai, ICU admission Rahmati, hospitalization Ezzatvar, Halabchi, Li, Rahmati, severity Ezzatvar, Liu, Sittichai, and cases Ezzatvar.
Currently there are 66 exercise for COVID-19 studies, showing 48% lower mortality [38‑57%], 46% lower ventilation [32‑57%], 41% lower ICU admission [35‑47%], 33% lower hospitalization [25‑40%], and 23% fewer cases [14‑31%].
Liu et al., 11 Feb 2023, peer-reviewed, 3 authors. Contact: songtaozhenzhen@sina.com.
This PaperExerciseAll
Baseline physical activity and the risk of severe illness and mortality from COVID-19: A dose–response meta-analysis
Junjie Liu, Zhiguang Guo, Songtao Lu
Preventive Medicine Reports, doi:10.1016/j.pmedr.2023.102130
To provide a scientific basis for improved exercise-based immunity, a meta-analysis was used to explore the dose-response relationship between physical activity (PA) and the risk of severe illness and mortality related to COVID-19 (coronavirus disease 2019). To this end, we searched PubMed, Web of Science databases from January 2020 through April 2022. 14 observational studies met the criteria for inclusion in the meta-analysis, including 2840 cases of severe illness and death from COVID-19. Categorical dose-relationship analysis showed that the risks of severe illness and mortality from COVID-19 were, respectively, 46% (risk ratio (RR): 0.54; confidence intervals (CIs): 0.41-0.68) and 59% (RR = 0.41; 95%CI: 0.23-0.58) lower for the highest dose of PA compared with the lowest dose of PA. The results of the continuous dose-response analysis show an inverse nonlinear relationship (P non-linearity < 0.05) between PA and both the risk of severe illness and mortality from COVID-19. For PA below 10 MET-h/week (MET-h/week: metabolic equivalent of task-hours/week), an increase of 4 MET-h/ week (1 h of moderate-intensity or 0.5 h of high-intensity PA) was associated with 8% and 11% reductions in the risk of severe illness and mortality from COVID-19. PA above 10 MET-h/week lowered the risk of severe illness and mortality from COVID-19 by 7% and 9%, respectively, for each 4 MET-h/week increase. Doses of WHOrecommended PA levels (10 MET-h/week) may be required for more substantial reductions in the risk of severe illness and mortality from COVID-19.
Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.pmedr.2023.102130.
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