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0 0.5 1 1.5 2+ Progression 63% Improvement Relative Risk Progression (b) 52% Progression (c) 43% Exercise for COVID-19  Malisoux et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 224 patients in Luxembourg (May 2020 - June 2021) Lower progression with higher activity levels (p=0.045) c19early.org Malisoux et al., BMJ Open, April 2022 Favors exercise Favors inactivity

Associations between physical activity prior to infection and COVID-19 disease severity and symptoms: results from the prospective Predi-COVID cohort study

Malisoux et al., BMJ Open, doi:10.1136/bmjopen-2021-057863, NCT04380987
Apr 2022  
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Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 452 participants in Luxembourg, showing lower risk of moderate cases with higher physical activity.
risk of progression, 63.0% lower, OR 0.37, p = 0.045, high activity levels 115, low activity levels 108, moderate case, >82 vs. <30 MET-hour/week, RR approximated with OR.
risk of progression, 52.0% lower, OR 0.48, p = 0.14, high activity levels 116, low activity levels 108, moderate case, >52-82 vs. <30 MET-hour/week, RR approximated with OR.
risk of progression, 43.0% lower, OR 0.57, p = 0.28, high activity levels 113, low activity levels 108, moderate case, 30-52 vs. <30 MET-hour/week, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Malisoux et al., 29 Apr 2022, retrospective, Luxembourg, peer-reviewed, survey, median age 42.0, 6 authors, study period May 2020 - June 2021, trial NCT04380987 (history).
This PaperExerciseAll
Associations between physical activity prior to infection and COVID-19 disease severity and symptoms: results from the prospective Predi-COVID cohort study
Dr Laurent Malisoux, Anne Backes, Aurélie Fischer, Gloria Aguayo, Markus Ollert, Guy Fagherazzi
BMJ Open, doi:10.1136/bmjopen-2021-057863
Objective To investigate if the physical activity (PA) prior to infection is associated with the severity of the disease in patients positively tested for COVID-19, as well as with the most common symptoms. Design A cross-sectional study using baseline data from a prospective, hybrid cohort study (Predi-COVID) in Luxembourg. Data were collected from May 2020 to June 2021. Setting Real-life setting (at home) and hospitalised patients. Participants All volunteers aged >18 years with confirmed SARS-CoV-2 infection, as determined by reverse transcription-PCR, and having completed the PA questionnaire (n=452). Primary and secondary outcome measures The primary outcome was disease severity (asymptomatic, mild illness and moderate illness). The secondary outcomes were self-reported symptoms. Results From the 452 patients included, 216 (48%) were female, the median (IQR) age was 42 (31-51) years, 59 (13%) were classified as asymptomatic, 287 (63%) as mild illness and 106 (24%) as moderate illness. The most prevalent symptoms were fatigue (n=294; 65%), headache (n=281; 62%) and dry cough (n=241; 53%). After adjustment, the highest PA level was associated with a lower risk of moderate illness (OR 0.37; 95% CI 0.14 to 0.98, p=0.045), fatigue (OR 0.54; 95% CI 0.30 to 0.97, p=0.040), dry cough (OR 0.55; 95% CI 0.32 to 0.96, p=0.034) and chest pain (OR 0.32; 95% CI 0.14 to 0.77, p=0.010). Conclusions PA before COVID-19 infection was associated with a reduced risk of moderate illness severity and a reduced risk of experiencing fatigue, dry cough and chest pain, suggesting that engaging in PA may be an effective approach to minimise the severity of COVID-19. Trial registration number NCT04380987.
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Data were collected from May 2020 to June ' '2021.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Real-life setting ' '(at home) and hospitalised ' 'patients.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>All ' 'volunteers aged &gt;18 years with confirmed SARS-CoV-2 infection, as determined by reverse ' 'transcription-PCR, and having completed the PA questionnaire ' '(n=452).</jats:p></jats:sec><jats:sec><jats:title>Primary and secondary outcome ' 'measures</jats:title><jats:p>The primary outcome was disease severity (asymptomatic, mild ' 'illness and moderate illness). The secondary outcomes were self-reported ' 'symptoms.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>From the 452 ' 'patients included, 216 (48%) were female, the median (IQR) age was 42 (31–51) years, 59 (13%) ' 'were classified as asymptomatic, 287 (63%) as mild illness and 106 (24%) as moderate illness. 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