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0 0.5 1 1.5 2+ Mortality -15% Improvement Relative Risk Remdesivir for COVID-19  Burhan et al.  ICU PATIENTS Is very late treatment with remdesivir beneficial for COVID-19? Retrospective 559 patients in Indonesia (January 2020 - March 2021) No significant difference in mortality c19early.org Burhan et al., PLOS ONE, September 2023 Favors remdesivir Favors control

Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave

Burhan et al., PLOS ONE, doi:10.1371/journal.pone.0290964
Sep 2023  
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Retrospective 559 COVID-19 ICU patients in Indonesia, showing higher mortality with remdesivir in unadjusted results, without statistical significance. Note that confounding by indication should be less significant for ICU studies compared to studies of all hospitalized patients, because all patients are in critical condition.
Gérard, Wu, Zhou show significantly increased risk of acute kidney injury with remdesivir.
Study covers HCQ and remdesivir.
risk of death, 14.8% higher, RR 1.15, p = 0.23, treatment 33 of 43 (76.7%), control 345 of 516 (66.9%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Burhan et al., 25 Sep 2023, retrospective, Indonesia, peer-reviewed, 26 authors, study period January 2020 - March 2021. Contact: eva.marwali@pjnhk.go.id.
This PaperRemdesivirAll
Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave
Erlina Burhan, Keibun Liu, Eva M Marwali, Samuel Huth, Navy G H M L Wulung, Dafsah A Juzar, Muhammad A Taufik, Surya O Wijaya, Dyah K Wati, Neurinda P Kusumastuti, Saptadi Yuliarto, Bhirowo Y Pratomo, Erwin Pradian, Dadang H Somasetia, Desy Rusmawatiningtyas, Arie Z Fatoni, Jose M Mandei, Eka Y Lantang, Fajar Perdhana, Bambang P Semedi, Muhammad Rayhan, Tiffany R S Tarigan, Nicole White, Gianluigi L Bassi, Jacky Y Suen, John F Fraser
PLOS ONE, doi:10.1371/journal.pone.0290964
Background Indonesia's national response to COVID-19 evolved rapidly throughout 2020. Understanding pandemic response and outcomes is crucial for better mitigation strategies ahead. This study describes the characteristics and outcomes of patients admitted to ICU during the early stages of the pandemic. Methods This is a multi-centre prospective observational study including patients from twelve collaborating hospitals in Indonesia. All patients were clinically suspected or laboratory-confirmed COVID-19 cases admitted to ICU between January 2020 and March 2021. The primary outcome was monthly ICU mortality. Descriptive statistics of patient characteristics and treatment were generated as secondary outcomes.
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Late treatment
is less effective
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