Consequence of Antivirals Versus Standard Care on Clinical Situation in Patients With COVID-19

DOI record: { "DOI": "10.1097/ipc.0000000000001336", "ISSN": [ "1536-9943", "1056-9103" ], "URL": "http://dx.doi.org/10.1097/IPC.0000000000001336", "abstract": "<jats:title>Abstract</jats:title>\n <jats:p>Favipiravir and remdesivir have recently received more clinical interest for the management of COVID-19. The study aimed to explore the effectiveness of favipiravir or remdesivir on the clinical outcome of SARS-CoV-2 patients in comparison with standard care. All patients were given standard care before being randomized into the following 3 groups: standard care group (standard care only), remdesivir group (remdesivir and standard care), and favipiravir group (group 3, favipiravir and standard care). The primary endpoint of the study was time to recovery or the clinical condition of patients on day 14. A total of 156 patients underwent randomization (53 assigned to standard care group, 51 to favipiravir group, and 52 to remdesivir group). The percentage of death in favipiravir and remdesivir groups was higher than those in the standard care group and likewise the liver enzymes. Studying the time to starting therapy showed that early administration of antivirals resulted in lower percentage of mortality. The ratio of hazard for early favipiravir and remdesivir was lower in comparison with those treated with late administration of the same drugs (hazard ratio, 0.62; 95% confidence interval [CI], 0.62–0.73 vs 3.22; 95% CI, 3.21–3.44, respectively, for favipiravir and 0.11; 95% CI, 0.10–0.12 vs 3.44; 95% CI, 3.43–3.55, respectively, for remdesivir). For favipiravir or remdesivir to have more beneficial effects than standard care alone for SARS-CoV-2 patients, they need to be started as early as possible. However, regular monitoring of liver function is required.</jats:p>", "author": [ { "affiliation": [ { "name": "Alshifaa Hospital, Nineveh Health Directorate" } ], "family": "Alsaraj", "given": "Marwa N.", "sequence": "first" }, { "affiliation": [], "family": "Qazzaz", "given": "Mohannad E.", "sequence": "additional" }, { "affiliation": [], "family": "Abed", "given": "Mohammed N.", "sequence": "additional" }, { "affiliation": [], "family": "Alassaf", "given": "Fawaz A.", "sequence": "additional" }, { "affiliation": [], "family": "Alfahad", "given": "Mohanad A.", "sequence": "additional" }, { "affiliation": [], "family": "Jasim", "given": "Mahmood H.M.", "sequence": "additional" } ], "container-title": "Infectious Diseases in Clinical Practice", "container-title-short": "Infect Dis Clin Pract", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2024, 1, 10 ] ], "date-time": "2024-01-10T13:01:03Z", "timestamp": 1704891663000 }, "deposited": 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coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)—anatomic pathology perspective on current knowledge", "doi-asserted-by": "crossref", "first-page": "103", "issue": "1", "journal-title": "Diagn Pathol", "key": "bib1-20240318", "volume": "15", "year": "2020" }, { "article-title": "Compatibility of the ligand binding sites in the spike glycoprotein of COVID-19 with those in the aminopeptidase and the caveolins 1, 2 proteins", "first-page": "4760", "issue": "9", "journal-title": "Res J Pharm Technol", "key": "bib2-20240318", "volume": "14", "year": "2021" }, { "DOI": "10.1016/j.jiph.2020.07.014", "article-title": "COVID-19 and comorbidities: deleterious impact on infected patients", "doi-asserted-by": "crossref", "first-page": "1833", "issue": "12", "journal-title": "J Infect Public Health", "key": "bib3-20240318", "volume": "13", "year": "2020" }, { "DOI": "10.1016/j.jiph.2021.12.014", "article-title": "The SARS-CoV-2 mutations versus vaccine effectiveness: new opportunities to new challenges", "doi-asserted-by": "crossref", "first-page": "228", "issue": "2", "journal-title": "J Infect Public Health", "key": "bib4-20240318", "volume": "15", "year": "2022" }, { "DOI": "10.1038/s41579-020-00459-7", "article-title": "Characteristics of SARS-CoV-2 and COVID-19", "doi-asserted-by": "crossref", "first-page": "141", "issue": "3", "journal-title": "Nat Rev Microbiol", "key": "bib5-20240318", "volume": "19", "year": "2021" }, { "DOI": "10.1016/j.ejphar.2020.173348", "article-title": "Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus", "doi-asserted-by": "crossref", "first-page": "173348", "journal-title": "Eur J Pharmacol", "key": "bib6-20240318", "volume": "883", "year": "2020" }, { "article-title": "The journey of remdesivir: from Ebola to COVID-19", "first-page": "1", "journal-title": "Drugs Context", "key": "bib7-20240318", "volume": "9", "year": "2020" }, { "DOI": "10.1002/rmv.2187", "article-title": "Efficacy and safety of remdesivir in hospitalized Covid-19 patients: systematic review and meta-analysis including network meta-analysis", "doi-asserted-by": "crossref", "first-page": "e2187", "issue": "4", "journal-title": "Rev Med Virol", "key": "bib8-20240318", "volume": "31", "year": "2021" }, { "DOI": "10.1016/j.biopha.2021.111313", "article-title": "An update review of emerging small-molecule therapeutic options for COVID-19", "doi-asserted-by": "crossref", "first-page": "111313", "journal-title": "Biomed Pharmacother", "key": "bib9-20240318", "volume": "137", "year": "2021" }, { "DOI": "10.1016/j.cegh.2020.07.011", "article-title": "Remdesivir and its antiviral activity against COVID-19: a systematic review", "doi-asserted-by": "crossref", "first-page": "123", "journal-title": "Clin Epidemiol Glob Health", "key": "bib10-20240318", "volume": "9", "year": "2021" }, { "DOI": "10.1016/j.ijid.2020.10.069", "article-title": "Role of favipiravir in the treatment of COVID-19", "doi-asserted-by": "crossref", "first-page": "501", "journal-title": "Int J Infect Dis", "key": "bib11-20240318", "volume": "102", "year": "2021" }, { "DOI": "10.1016/j.pharmthera.2020.107512", "article-title": "Favipiravir, an anti-influenza drug against life-threatening RNA virus infections", "doi-asserted-by": "crossref", "first-page": "107512", "journal-title": "Pharmacol Ther", "key": "bib12-20240318", "volume": "209", "year": "2020" }, { "DOI": "10.1038/s41467-020-18463-z", "article-title": "Rapid incorporation of favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis", "doi-asserted-by": "crossref", "first-page": "4682", "issue": "1", "journal-title": "Nat Commun", "key": "bib13-20240318", "volume": "11", "year": "2020" }, { "DOI": "10.2147/IJGM.S332458", "article-title": "Effectiveness of remdesivir, lopinavir/ritonavir, and favipiravir for COVID-19 treatment: a systematic review", "doi-asserted-by": "crossref", "first-page": "8557", "journal-title": "Int J Gen Med", "key": "bib14-20240318", "volume": "14", "year": "2021" }, { "DOI": "10.1056/NEJMoa2007764", "article-title": "Remdesivir for the treatment of COVID-19—final report", "doi-asserted-by": "crossref", "first-page": "1813", "issue": "19", "journal-title": "N Engl J Med", "key": "bib15-20240318", "volume": "383", "year": "2020" }, { "DOI": "10.1001/jama.2020.16349", "article-title": "Effect of remdesivir vs standard care on clinical status at 11 days in patients with moderate COVID-19", "doi-asserted-by": "crossref", "first-page": "1048", "issue": "11", "journal-title": "JAMA", "key": "bib16-20240318", "volume": "324", "year": "2020" }, { "DOI": "10.1038/s41586-020-2423-5", "article-title": "Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2", "doi-asserted-by": "crossref", "first-page": "273", "issue": "7824", "journal-title": "Nature", "key": "bib17-20240318", "volume": "585", "year": "2020" }, { "DOI": "10.1016/j.ijid.2020.06.093", "article-title": "Case report study of the first five COVID-19 patients treated with remdesivir in France", "doi-asserted-by": "crossref", "first-page": "290", "journal-title": "Int J Infect Dis", "key": "bib18-20240318", "volume": "98", "year": "2020" }, { "DOI": "10.1093/ofid/ofaa345", "article-title": "Remdesivir treatment for severe COVID-19 in third-trimester pregnancy: case report and management discussion", "doi-asserted-by": "crossref", "first-page": "ofaa345", "issue": "9", "journal-title": "Open Forum Infect Dis", "key": "bib19-20240318", "volume": "7", "year": "2020" }, { "DOI": "10.1007/s12072-020-10077-3", "article-title": "Liver injury in remdesivir-treated COVID-19 patients", "doi-asserted-by": "crossref", "first-page": "881", "issue": "5", "journal-title": "Hepatol Int", "key": "bib20-20240318", "volume": "14", "year": "2020" } ], "reference-count": 20, "references-count": 20, "relation": {}, "resource": { "primary": { "URL": 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