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12 tixagevimab/cilgavimab COVID-19 controlled studies, 5 RCTs
https://c19early.org/tcmeta.html
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0.25
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0.75
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1.5
1.75
2+ TACKLE Montgom.. (DB RCT) 0% 1.00 [0.32-3.07] death 6/452 6/451 Improvement, RR [CI] Treatment Control TACKLE Montgom.. (DB RCT) 50% 0.50 [0.29-0.86] severe case 18/407 37/415 TACKLE Montgom.. (DB RCT) 57% 0.43 [0.25-0.75] hosp. 17/413 40/421 Lombardi -368% 4.68 [0.31-71.6] death 1/19 1/89 OT1 Lombardi 33% 0.67 [0.09-5.13] hosp. 1/19 7/89 OT1 Lombardi -24% 1.24 [0.90-1.70] viral+ 14/19 53/89 OT1 ACTIV-3-TICO Holland (DB RCT) 30% 0.70 [0.50-0.97] death 61/710 86/707 ACTIV-3-TICO Holland (DB RCT) 7% 0.93 [0.83-1.03] no recov. 710 (n) 707 (n) FDA (DB RCT) 40% 0.60 [0.35-1.03] symp. case 28/749 23/372 FDA (DB RCT) 33% 0.67 [0.36-1.24] symp. case 23/749 17/372 PROVENT Levin (DB RCT) 86% 0.14 [0.01-2.98] death 0/3,441 2/1,731 PROVENT Levin (DB RCT) 82% 0.18 [0.09-0.35] symp. case 11/3,441 31/1,731 PROVENT Levin (DB RCT) 76% 0.24 [0.10-0.55] symp. case 8/3,441 17/1,731 Young-Xu (PSM) 64% 0.36 [0.18-0.73] death 1,733 (n) 6,354 (n) Immunocompromised Young-Xu (PSM) 69% 0.31 [0.18-0.53] cases/death/hosp. 17/1,733 206/6,354 Immunocompromised Young-Xu (PSM) 87% 0.13 [0.02-0.99] hosp. 1,733 (n) 6,354 (n) Immunocompromised Young-Xu (PSM) 66% 0.34 [0.13-0.87] cases 1,733 (n) 6,354 (n) Immunocompromised Kertes 92% 0.08 [0.01-0.54] death/hosp. 1/825 63/4,299 Immunocompromised Kertes 47% 0.53 [0.32-0.85] cases 29/825 308/4,299 Immunocompromised Najjar-Debbiny 59% 0.41 [0.19-0.89] hosp. 72/703 377/2,812 Najjar-Debbiny 25% 0.75 [0.58-0.96] cases 72/703 377/2,812 Levin (DB RCT) 75% 0.25 [0.01-6.10] severe case 0/749 1/372 Levin (DB RCT) 42% 0.58 [0.34-1.00] symp. case 27/749 23/372 Levin (DB RCT) 33% 0.67 [0.36-1.24] symp. case 23/749 17/372 Sindu (PSM) -1% 1.01 [0.14-7.21] death 2/17 2/17 Sindu (PSM) -96% 1.96 [0.18-21.6] ventilation n/a n/a Sindu (PSM) -210% 3.10 [0.32-29.8] ICU n/a n/a Sindu (PSM) 53% 0.47 [0.16-1.40] hosp. n/a n/a Sindu 29% 0.71 [0.46-1.11] symp. case 24/203 57/343 Din 19% 0.81 [0.32-2.04] hosp. 5/23 11/41 Desai 12% 0.88 [0.33-2.35] hosp. 391 (n) 391 (n) Desai -35% 1.35 [0.87-2.10] cases 391 (n) 391 (n) Tixagevimab/cilgavimab COVID-19 outcomes c19 early1 OT: comparison with other treatment Favors tixagevimab/ci.. Favors control
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